NO20033911L - Somatostatin antagonister - Google Patents
Somatostatin antagonisterInfo
- Publication number
- NO20033911L NO20033911L NO20033911A NO20033911A NO20033911L NO 20033911 L NO20033911 L NO 20033911L NO 20033911 A NO20033911 A NO 20033911A NO 20033911 A NO20033911 A NO 20033911A NO 20033911 L NO20033911 L NO 20033911L
- Authority
- NO
- Norway
- Prior art keywords
- aer
- optionally substituted
- amino acid
- alkyl
- group
- Prior art date
Links
- 102000005157 Somatostatin Human genes 0.000 title abstract 2
- 108010056088 Somatostatin Proteins 0.000 title abstract 2
- 239000005557 antagonist Substances 0.000 title abstract 2
- NHXLMOGPVYXJNR-ATOGVRKGSA-N somatostatin Chemical compound C([C@H]1C(=O)N[C@H](C(N[C@@H](CO)C(=O)N[C@@H](CSSC[C@@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC=2C3=CC=CC=C3NC=2)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N1)[C@@H](C)O)NC(=O)CNC(=O)[C@H](C)N)C(O)=O)=O)[C@H](O)C)C1=CC=CC=C1 NHXLMOGPVYXJNR-ATOGVRKGSA-N 0.000 title abstract 2
- 229960000553 somatostatin Drugs 0.000 title abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 235000008206 alpha-amino acids Nutrition 0.000 abstract 3
- -1 aromatic α-amino acid Chemical class 0.000 abstract 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 2
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000000304 alkynyl group Chemical group 0.000 abstract 1
- 150000001408 amides Chemical class 0.000 abstract 1
- 150000001412 amines Chemical class 0.000 abstract 1
- 235000001014 amino acid Nutrition 0.000 abstract 1
- 125000003277 amino group Chemical group 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/31—Somatostatins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/08—Peptides having 5 to 11 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
- A61P5/04—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin for decreasing, blocking or antagonising the activity of the hypothalamic hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/655—Somatostatins
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Zoology (AREA)
- Hematology (AREA)
- Biophysics (AREA)
- Toxicology (AREA)
- Obesity (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Emergency Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Dermatology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US27430801P | 2001-03-08 | 2001-03-08 | |
| PCT/US2002/006676 WO2002072602A2 (en) | 2001-03-08 | 2002-03-05 | Somatostatin antagonists |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO20033911D0 NO20033911D0 (no) | 2003-09-04 |
| NO20033911L true NO20033911L (no) | 2003-10-29 |
Family
ID=23047655
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20033911A NO20033911L (no) | 2001-03-08 | 2003-09-04 | Somatostatin antagonister |
Country Status (16)
| Country | Link |
|---|---|
| US (3) | US7378488B2 (cs) |
| EP (1) | EP1372688B1 (cs) |
| JP (3) | JP4204322B2 (cs) |
| AR (1) | AR035942A1 (cs) |
| AT (1) | ATE394114T1 (cs) |
| AU (1) | AU2002258465B2 (cs) |
| CA (1) | CA2439498A1 (cs) |
| CZ (1) | CZ299362B6 (cs) |
| DE (1) | DE60226419D1 (cs) |
| DK (1) | DK1372688T3 (cs) |
| ES (1) | ES2306766T3 (cs) |
| HU (1) | HUP0401535A3 (cs) |
| NO (1) | NO20033911L (cs) |
| PL (1) | PL362838A1 (cs) |
| RU (2) | RU2263678C2 (cs) |
| WO (1) | WO2002072602A2 (cs) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100707408B1 (ko) * | 2000-10-20 | 2007-04-13 | 더 어드미니스트레이터즈 오브 더 튜래인 어듀케이셔널 훤드 | 유로텐신-ⅱ 작용제 및 길항제 |
| DE60226419D1 (de) | 2001-03-08 | 2008-06-19 | Univ Tulane | Somatostatin-antagonisten |
| CZ20032707A3 (cs) * | 2001-04-09 | 2004-01-14 | The Administrators Of The Tulane Educational Fund | Agonisté somatostatinu |
| EP1522311A1 (fr) | 2003-10-10 | 2005-04-13 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Utilisation de la somatostine ou d'un de ses analogues pour préparer un médicament destiné à réguler la réserve folliculaire ovarienne chez la femme non ménopausée |
| US8017575B2 (en) * | 2004-12-15 | 2011-09-13 | Wilfred Wayne Lautt | Treatment of insulin resistance by modulating somatostatin using somatostatin receptor antagonists |
| DK2076535T3 (da) * | 2006-10-16 | 2013-06-10 | Salk Inst For Biological Studi | Receptor(SSTR2)-selektive somatostatinantagonister |
| US8691761B2 (en) | 2006-10-16 | 2014-04-08 | Jean E. F. Rivier | Somatostatin receptor 2 antagonists |
| EP2168983A1 (fr) | 2008-09-30 | 2010-03-31 | Ipsen Pharma | Nouveaux composés octapeptidiques et leur utilisation thérapeutique |
| CN102203274B (zh) | 2008-10-29 | 2017-04-05 | 株式会社钟化 | L‑氨基酸的制造方法 |
| EP2399931A1 (fr) * | 2010-06-22 | 2011-12-28 | Ipsen Pharma S.A.S. | Nouveaux composés octapeptidiques et leur utilisation thérapeutique |
| JP6989529B2 (ja) * | 2016-02-09 | 2022-01-05 | シーディーアールディー ベンチャーズ インコーポレイテッド | ソマトスタチン受容体アンタゴニスト化合物及びその使用方法 |
| WO2021111503A1 (ja) * | 2019-12-02 | 2021-06-10 | 花王株式会社 | 光吸収層及びその製造方法、分散液、光電変換素子、並びに太陽電池 |
Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IE54936B1 (en) * | 1980-02-14 | 1990-03-28 | Sandoz Ltd | A method for the total synthesis of cyclosporins, novel cyclosporins and novel intermediates and methods for their production |
| JPS63146850A (ja) | 1986-11-12 | 1988-06-18 | メルク エンド カムパニー インコーポレーテツド | フエニルアラニル−ヒスチジン代用成分を有するレニン阻害剤 |
| EP0278158A3 (en) | 1986-11-12 | 1990-05-23 | Merck & Co. Inc. | Renin inhibitors containing phenylalanyl-histidine replacements |
| EP0273696A2 (en) | 1987-01-02 | 1988-07-06 | Merck & Co. Inc. | Renin inhibitors containing histidine replacements |
| CH679045A5 (cs) | 1987-06-29 | 1991-12-13 | Sandoz Ag | |
| JPS6426599U (cs) | 1987-08-10 | 1989-02-15 | ||
| DE68928278T2 (de) | 1988-02-10 | 1998-03-12 | Tap Pharmaceuticals Inc | Lhrh-analog |
| EP0457888B1 (en) * | 1989-12-08 | 1996-07-10 | The Administrators of The Tulane Educational Fund | Octapeptide analogs of somatostatin having threonine at the sixth position |
| US7223833B1 (en) * | 1991-05-24 | 2007-05-29 | Isis Pharmaceuticals, Inc. | Peptide nucleic acid conjugates |
| EP0592512A1 (en) | 1991-07-01 | 1994-04-20 | University Technologies International Inc. (Uti) | NON-DESENSITIZING ANALOGS OF GnRH AND OTHER BIOLOGICALLY ACTIVE LIGANDS |
| JP3480848B2 (ja) * | 1992-06-19 | 2003-12-22 | タカラバイオ株式会社 | 環状ペプチドの合成方法 |
| US5569741A (en) * | 1992-07-27 | 1996-10-29 | Biomeasure, Inc. | Cyclic octapeptide neuromedin B receptor antagonists |
| CZ292586B6 (cs) * | 1993-08-09 | 2003-10-15 | Societe De Conseils De Recherches Et D´Application | Somatostatinový nebo bombesidový derivát a jejich použití |
| CN1052730C (zh) * | 1993-12-23 | 2000-05-24 | 诺沃挪第克公司 | 具有生长激素释放特性的化合物 |
| GB9402767D0 (en) | 1994-02-14 | 1994-04-06 | Sandoz Ltd | Improvements in or relating to organic compounds |
| US5696230A (en) * | 1994-08-31 | 1997-12-09 | The Board Of Regents Of The University Of Nebraska | High-affinity response-selective C-terminal analogs of C5a anaphylatoxin |
| US5750499A (en) * | 1995-10-18 | 1998-05-12 | The Salk Institute For Biological Studies | Receptor-selective somatostatin analogs |
| US5846934A (en) * | 1996-02-20 | 1998-12-08 | American Cyanamid Company | Pure somatostatin antagonist and methods of use thereof |
| US6355613B1 (en) * | 1996-07-31 | 2002-03-12 | Peptor Limited | Conformationally constrained backbone cyclized somatostatin analogs |
| AU3215597A (en) | 1996-08-30 | 1998-03-19 | Biomeasure Incorporated | Method of inhibiting fibrosis with a somatostatin agonist |
| WO1998010786A2 (en) * | 1996-09-12 | 1998-03-19 | Yarom Cohen | Pharmaceutical composition for the treatment of syndrome x of reaven |
| KR100479149B1 (ko) | 1996-12-04 | 2005-03-25 | 더 어드미니스트레이터즈 오브 더 튜래인 어듀케이셔널 훤드 | 소마토스타틴 길항제 |
| US6887470B1 (en) * | 1999-09-10 | 2005-05-03 | Conjuchem, Inc. | Protection of endogenous therapeutic peptides from peptidase activity through conjugation to blood components |
| JP4294959B2 (ja) | 2001-03-06 | 2009-07-15 | ウニベルシタ・デグリ・ストゥッディ・ディ・フェラーラ | 髄様甲状腺癌の増殖を変調させる方法 |
| DE60226419D1 (de) | 2001-03-08 | 2008-06-19 | Univ Tulane | Somatostatin-antagonisten |
| CZ20032707A3 (cs) | 2001-04-09 | 2004-01-14 | The Administrators Of The Tulane Educational Fund | Agonisté somatostatinu |
-
2002
- 2002-03-05 DE DE60226419T patent/DE60226419D1/de not_active Expired - Lifetime
- 2002-03-05 ES ES02728410T patent/ES2306766T3/es not_active Expired - Lifetime
- 2002-03-05 AT AT02728410T patent/ATE394114T1/de not_active IP Right Cessation
- 2002-03-05 CA CA002439498A patent/CA2439498A1/en not_active Abandoned
- 2002-03-05 RU RU2003129807/04A patent/RU2263678C2/ru not_active IP Right Cessation
- 2002-03-05 AU AU2002258465A patent/AU2002258465B2/en not_active Ceased
- 2002-03-05 HU HU0401535A patent/HUP0401535A3/hu unknown
- 2002-03-05 CZ CZ20032281A patent/CZ299362B6/cs not_active IP Right Cessation
- 2002-03-05 JP JP2002571515A patent/JP4204322B2/ja not_active Expired - Fee Related
- 2002-03-05 US US10/469,836 patent/US7378488B2/en not_active Expired - Lifetime
- 2002-03-05 PL PL02362838A patent/PL362838A1/xx not_active Application Discontinuation
- 2002-03-05 RU RU2005117614/04A patent/RU2328504C2/ru not_active IP Right Cessation
- 2002-03-05 WO PCT/US2002/006676 patent/WO2002072602A2/en active IP Right Grant
- 2002-03-05 EP EP02728410A patent/EP1372688B1/en not_active Expired - Lifetime
- 2002-03-05 DK DK02728410T patent/DK1372688T3/da active
- 2002-03-07 AR ARP020100831A patent/AR035942A1/es not_active Application Discontinuation
-
2003
- 2003-09-04 NO NO20033911A patent/NO20033911L/no not_active Application Discontinuation
-
2006
- 2006-07-05 JP JP2006185373A patent/JP2006342171A/ja active Pending
-
2007
- 2007-08-20 US US11/894,231 patent/US7408024B2/en not_active Expired - Lifetime
-
2008
- 2008-03-11 US US12/075,319 patent/US20080171853A1/en not_active Abandoned
- 2008-05-12 JP JP2008124961A patent/JP2008255120A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| JP2004532824A (ja) | 2004-10-28 |
| US20080171853A1 (en) | 2008-07-17 |
| HUP0401535A3 (en) | 2009-07-28 |
| RU2005117614A (ru) | 2006-11-20 |
| ES2306766T3 (es) | 2008-11-16 |
| CA2439498A1 (en) | 2002-09-19 |
| AR035942A1 (es) | 2004-07-28 |
| NO20033911D0 (no) | 2003-09-04 |
| ATE394114T1 (de) | 2008-05-15 |
| HUP0401535A2 (hu) | 2004-12-28 |
| WO2002072602A2 (en) | 2002-09-19 |
| JP2008255120A (ja) | 2008-10-23 |
| EP1372688A4 (en) | 2006-06-14 |
| CZ20032281A3 (cs) | 2004-01-14 |
| DK1372688T3 (da) | 2008-08-25 |
| EP1372688A2 (en) | 2004-01-02 |
| PL362838A1 (en) | 2004-11-02 |
| US20040181032A1 (en) | 2004-09-16 |
| US7378488B2 (en) | 2008-05-27 |
| WO2002072602A3 (en) | 2003-03-20 |
| US7408024B2 (en) | 2008-08-05 |
| DE60226419D1 (de) | 2008-06-19 |
| JP4204322B2 (ja) | 2009-01-07 |
| AU2002258465B2 (en) | 2006-01-19 |
| US20080020970A1 (en) | 2008-01-24 |
| RU2003129807A (ru) | 2005-03-20 |
| CZ299362B6 (cs) | 2008-07-02 |
| RU2263678C2 (ru) | 2005-11-10 |
| RU2328504C2 (ru) | 2008-07-10 |
| EP1372688B1 (en) | 2008-05-07 |
| JP2006342171A (ja) | 2006-12-21 |
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