NO20033300L - 1-aryl- eller 1-arylsulfonylbenzazolderivater som 5- hydroksytryptamin-6 ligander - Google Patents

1-aryl- eller 1-arylsulfonylbenzazolderivater som 5- hydroksytryptamin-6 ligander

Info

Publication number
NO20033300L
NO20033300L NO20033300A NO20033300A NO20033300L NO 20033300 L NO20033300 L NO 20033300L NO 20033300 A NO20033300 A NO 20033300A NO 20033300 A NO20033300 A NO 20033300A NO 20033300 L NO20033300 L NO 20033300L
Authority
NO
Norway
Prior art keywords
arylsulfonylbenzazole
hydroxytryptamine
ligands
aryl
derivatives
Prior art date
Application number
NO20033300A
Other languages
English (en)
Norwegian (no)
Other versions
NO20033300D0 (no
Inventor
Michael Gerard Kelly
Ping Zhou
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of NO20033300D0 publication Critical patent/NO20033300D0/no
Publication of NO20033300L publication Critical patent/NO20033300L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Psychology (AREA)
  • Anesthesiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Cardiology (AREA)
  • Addiction (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Child & Adolescent Psychology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Dermatology (AREA)
  • Nutrition Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
NO20033300A 2001-01-23 2003-07-22 1-aryl- eller 1-arylsulfonylbenzazolderivater som 5- hydroksytryptamin-6 ligander NO20033300L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US26342501P 2001-01-23 2001-01-23
PCT/US2002/001950 WO2002059088A1 (fr) 2001-01-23 2002-01-18 Derives de 1-aryl-ou 1-alkylsulfonylbenzazole utilises en tant que ligands de 5-hydroxytryptamine-6

Publications (2)

Publication Number Publication Date
NO20033300D0 NO20033300D0 (no) 2003-07-22
NO20033300L true NO20033300L (no) 2003-09-03

Family

ID=23001722

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20033300A NO20033300L (no) 2001-01-23 2003-07-22 1-aryl- eller 1-arylsulfonylbenzazolderivater som 5- hydroksytryptamin-6 ligander

Country Status (23)

Country Link
US (4) US6509357B1 (fr)
EP (1) EP1353904B9 (fr)
JP (1) JP4208573B2 (fr)
KR (1) KR20030068591A (fr)
CN (1) CN1273450C (fr)
AR (1) AR034203A1 (fr)
AT (1) ATE312078T1 (fr)
AU (1) AU2002251811B2 (fr)
BR (1) BR0206633A (fr)
CA (1) CA2435566A1 (fr)
DE (1) DE60207815T2 (fr)
DK (1) DK1353904T3 (fr)
EA (1) EA006057B1 (fr)
ES (1) ES2250638T3 (fr)
HU (1) HUP0401009A3 (fr)
IL (1) IL157059A0 (fr)
MX (1) MXPA03006479A (fr)
NO (1) NO20033300L (fr)
NZ (1) NZ527051A (fr)
PL (1) PL364568A1 (fr)
TW (1) TW593278B (fr)
WO (1) WO2002059088A1 (fr)
ZA (1) ZA200306542B (fr)

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KR20030088507A (ko) * 2001-04-20 2003-11-19 와이어쓰 5-하이드록시트립타민-6 리간드로서의헤테로사이클릴알콕시-, -알킬티오- 및-알킬아미노벤즈아졸 유도체
EP1385842A1 (fr) * 2001-04-20 2004-02-04 Wyeth Derives d'heterocyclyloxy-, -thioxy- et aminobenzazol servant de ligands de 5-hydroxytryptamine-6
YU96103A (sh) * 2001-06-07 2006-08-17 F.Hoffmann-La Roche Ag. Novi derivati indola sa afinitetom za 5-ht6 receptor
WO2003068740A1 (fr) * 2002-02-14 2003-08-21 Wyeth Derives de pyrrolylalkylidene-hydrazinecarboxymidamide tels que des ligands 5-hydroxytryptamine-6
WO2003104193A1 (fr) * 2002-06-05 2003-12-18 F. Hoffmann-La Roche Ag Derives de 1-sulfonyl-4-aminoalcoxy-indole et leur utilisation comme modulateurs des recepteurs 5-ht6 en traitement de troubles du snc
AU2003268117A1 (en) * 2002-09-18 2004-04-08 Eli Lilly And Company Histamine h3 receptor antagonists, preparaton and therapeutic uses
WO2004050085A1 (fr) * 2002-12-03 2004-06-17 F. Hoffmann-La Roche Ag Indols aminoalkoxy utilises en tant que ligands du recepteur 5-ht6 pour le traitement de troubles du snc
MXPA05008438A (es) * 2003-02-14 2005-10-19 Wyeth Corp Heterociclil-3-sulfonilindazoles como ligandos de 5-hidroxitriptamina-6.
US7135575B2 (en) 2003-03-03 2006-11-14 Array Biopharma, Inc. P38 inhibitors and methods of use thereof
SE0302760D0 (sv) * 2003-10-20 2003-10-20 Biovitrum Ab New compounds
WO2005085248A1 (fr) 2004-02-27 2005-09-15 F.Hoffmann-La Roche Ag Derives pyrazolo heteroaryl-condenses
RU2006134022A (ru) 2004-02-27 2008-04-10 Ф.Хоффманн-Ля Рош Аг (Ch) Производные индазола и содержащие их фармацевтические композиции
RU2006134020A (ru) 2004-02-27 2008-04-10 Ф.Хоффманн-Ля Рош Аг (Ch) Конденсированные производные пиразола
US7781478B2 (en) 2004-07-14 2010-08-24 Ptc Therapeutics, Inc. Methods for treating hepatitis C
CA2883044C (fr) * 2004-10-08 2017-08-15 Sdb Ip Holdings, Llc Robinet a diaphragme a detecteur de pression electronique
CA2586179C (fr) 2004-11-02 2011-02-08 Pfizer Inc. Derives de sulfonyl benzimidazole
JP5146766B2 (ja) * 2005-08-15 2013-02-20 ワイス・エルエルシー ５−ヒドロキシトリプタミン−６リガンドとしての置換−３−スルホニルインダゾール誘導体
MX2008002588A (es) 2005-08-25 2008-03-18 Hoffmann La Roche Inhibidores de p38-map-cinasa y los metodos para utilizarlos.
TWI387592B (zh) * 2005-08-30 2013-03-01 Novartis Ag 經取代之苯并咪唑及其作為與腫瘤形成相關激酶之抑制劑之方法
SG175599A1 (en) 2006-01-31 2011-11-28 Array Biopharma Inc Kinase inhibitors and methods of use thereof
CN101432274A (zh) * 2006-04-05 2009-05-13 惠氏公司 作为5-羟色胺-6配体的磺酰基-3-杂环吲唑衍生物
WO2007120596A1 (fr) * 2006-04-12 2007-10-25 Wyeth DÉRIVÉS DE DIHYDRO[1,4]DIOXINO[2,3-e]INDAZOLE EN TANT QUE LIGANDS DE 5-HYDROXYTRYPTAMINE-6
CN101432269A (zh) * 2006-06-01 2009-05-13 惠氏公司 作为5-羟色胺-6配体的1-磺酰基吲唑基胺和1-磺酰基吲唑基酰胺衍生物
US20090023925A1 (en) * 2007-06-28 2009-01-22 Wyeth N'-(2-halobenzylidene)sulfonylhydrazides as intermediates in the manufacture of arylsulfonylindazoles
ES2616238T3 (es) 2010-10-06 2017-06-12 Glaxosmithkline Llc, Corporation Service Company Derivados de bencimidazol como inhibidores de PI3 quinasa
US9663498B2 (en) 2013-12-20 2017-05-30 Sunshine Lake Pharma Co., Ltd. Aromatic heterocyclic compounds and their application in pharmaceuticals
US9974785B2 (en) 2014-07-08 2018-05-22 Sunshine Lake Pharma Co., Ltd. Aromatic heterocyclic derivatives and pharmaceutical applications thereof
CA3037587A1 (fr) 2016-09-30 2018-04-05 Epizyme, Inc. Composes bi-ou tri-heterocycliques fusionnes substitues en tant qu'inhibiteurs de l'ehmt2
US11672800B2 (en) 2017-04-21 2023-06-13 Epizyme, Inc. Combination therapies with EHMT2 inhibitors
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CN112847099A (zh) * 2021-03-08 2021-05-28 王佳丽 一种有效调节进给量实现自动切割的砂轮切割机

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Also Published As

Publication number Publication date
HUP0401009A2 (hu) 2004-08-30
MXPA03006479A (es) 2003-09-22
DE60207815D1 (de) 2006-01-12
US20040092564A1 (en) 2004-05-13
JP2004521116A (ja) 2004-07-15
JP4208573B2 (ja) 2009-01-14
NO20033300D0 (no) 2003-07-22
DE60207815T2 (de) 2006-08-24
CA2435566A1 (fr) 2002-08-01
US6509357B1 (en) 2003-01-21
ATE312078T1 (de) 2005-12-15
AU2002251811B2 (en) 2007-06-21
HUP0401009A3 (en) 2004-10-28
KR20030068591A (ko) 2003-08-21
ES2250638T3 (es) 2006-04-16
US20030149018A1 (en) 2003-08-07
TW593278B (en) 2004-06-21
EP1353904B9 (fr) 2006-05-03
AR034203A1 (es) 2004-02-04
ZA200306542B (en) 2005-11-21
WO2002059088A1 (fr) 2002-08-01
EA200300829A1 (ru) 2003-12-25
CN1273450C (zh) 2006-09-06
EP1353904B1 (fr) 2005-12-07
EP1353904A1 (fr) 2003-10-22
PL364568A1 (en) 2004-12-13
NZ527051A (en) 2005-07-29
EA006057B1 (ru) 2005-08-25
US20040087637A1 (en) 2004-05-06
IL157059A0 (en) 2004-02-08
BR0206633A (pt) 2004-02-17
DK1353904T3 (da) 2006-02-20
US6919354B2 (en) 2005-07-19
US6710069B2 (en) 2004-03-23
CN1498209A (zh) 2004-05-19

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