NO20032625L - Indazolyl-substituerte pyrrolinforbindelser som kineaseinhibitorer - Google Patents

Indazolyl-substituerte pyrrolinforbindelser som kineaseinhibitorer

Info

Publication number
NO20032625L
NO20032625L NO20032625A NO20032625A NO20032625L NO 20032625 L NO20032625 L NO 20032625L NO 20032625 A NO20032625 A NO 20032625A NO 20032625 A NO20032625 A NO 20032625A NO 20032625 L NO20032625 L NO 20032625L
Authority
NO
Norway
Prior art keywords
indazolyl
kinase inhibitors
kinase
substituted pyrroline
compounds
Prior art date
Application number
NO20032625A
Other languages
English (en)
Norwegian (no)
Other versions
NO20032625D0 (no
Inventor
Han-Cheng Zhang
Bruce E Maryanoff
Bruce Conway
Kimberly White
Hong Ye
Leonard R Hecker
David F Mccomsey
Original Assignee
Ortho Mcneil Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ortho Mcneil Pharm Inc filed Critical Ortho Mcneil Pharm Inc
Publication of NO20032625D0 publication Critical patent/NO20032625D0/no
Publication of NO20032625L publication Critical patent/NO20032625L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Pulmonology (AREA)
  • Dermatology (AREA)
  • Psychiatry (AREA)
  • Virology (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Communicable Diseases (AREA)
  • Rheumatology (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Obesity (AREA)
  • Hospice & Palliative Care (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
NO20032625A 2000-12-08 2003-06-10 Indazolyl-substituerte pyrrolinforbindelser som kineaseinhibitorer NO20032625L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US25416600P 2000-12-08 2000-12-08
PCT/US2001/047689 WO2002046183A2 (fr) 2000-12-08 2001-12-06 Composes de pyrroline substitues par l'indazolyle comme inhibiteurs de kinase

Publications (2)

Publication Number Publication Date
NO20032625D0 NO20032625D0 (no) 2003-06-10
NO20032625L true NO20032625L (no) 2003-08-05

Family

ID=22963185

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20032625A NO20032625L (no) 2000-12-08 2003-06-10 Indazolyl-substituerte pyrrolinforbindelser som kineaseinhibitorer

Country Status (26)

Country Link
US (4) US6849643B2 (fr)
EP (1) EP1362047B1 (fr)
JP (1) JP2004515499A (fr)
KR (1) KR20040016828A (fr)
CN (1) CN1230434C (fr)
AT (1) ATE326464T1 (fr)
AU (1) AU2002230727A1 (fr)
BR (1) BR0116468A (fr)
CA (1) CA2431166A1 (fr)
CY (1) CY1106125T1 (fr)
CZ (1) CZ20031594A3 (fr)
DE (1) DE60119790T2 (fr)
DK (1) DK1362047T3 (fr)
ES (1) ES2263681T3 (fr)
HK (1) HK1057370A1 (fr)
HU (1) HUP0303855A3 (fr)
IL (1) IL156339A0 (fr)
MX (1) MXPA03005140A (fr)
NO (1) NO20032625L (fr)
NZ (1) NZ526356A (fr)
PL (1) PL362576A1 (fr)
PT (1) PT1362047E (fr)
RU (1) RU2003117078A (fr)
WO (1) WO2002046183A2 (fr)
YU (1) YU46603A (fr)
ZA (1) ZA200305239B (fr)

Families Citing this family (61)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
YU46603A (sh) * 2000-12-08 2006-05-25 Ortho-Mcneil Pharmaceutical Inc. Indazolil-supstituisana jedinjenja pirolina, kao inhibitori kinaze
US20030143185A1 (en) * 2001-10-29 2003-07-31 Shearwater Corporation Polymer conjugates of protein kinase C inhibitors
ES2276048T3 (es) 2002-03-05 2007-06-16 Eli Lilly And Company Derivados de purina como inhibidores de cinasa.
WO2003076398A2 (fr) 2002-03-08 2003-09-18 Eli Lilly And Company Inhibiteurs de kinases
ATE387444T1 (de) * 2002-05-08 2008-03-15 Janssen Pharmaceutica Nv Substituierte pyrroline als kinase inhibitoren
EP1513520B1 (fr) * 2002-06-05 2008-09-24 Janssen Pharmaceutica N.V. Pyrrolines substituees en tant qu'inhibiteurs de kinase
WO2004094422A1 (fr) * 2003-03-27 2004-11-04 Janssen Pharmaceutica N.V. Pyrrolines substitues inhibiteurs de kinase
KR20060021890A (ko) * 2003-06-13 2006-03-08 얀센 파마슈티카 엔.브이. 키나제 저해제로서의 치환된 인다졸릴(인돌릴)말레이미드유도체
CA2530679A1 (fr) * 2003-06-30 2005-04-07 Hif Bio, Inc. Composes, compositions et procedes
WO2005027629A2 (fr) * 2003-09-19 2005-03-31 Children's Hospital Medical Center Regulation de la contractilite cardiaque et de la propension a l'insuffisance cardiaque
AU2004275720B2 (en) * 2003-09-23 2008-04-24 Merck Sharp & Dohme Corp. Isoquinoline potassium channel inhibitors
CA2588181A1 (fr) * 2004-11-23 2006-06-01 International Bio-Therapeutic Research Inc. Procede d'administration d'ions, d'alliages et de sels de metaux therapeutiques
US8017395B2 (en) 2004-12-17 2011-09-13 Lifescan, Inc. Seeding cells on porous supports
CA2592771A1 (fr) 2005-01-10 2006-07-13 Astrazeneca Ab Derives de 1,1-dioxydes d'isothiazol-3(2h)-one utilises comme modulateurs du recepteur x du foie
SE0500058D0 (sv) * 2005-01-10 2005-01-10 Astrazeneca Ab Therapeutic agents 5
SE0500055D0 (sv) 2005-01-10 2005-01-10 Astrazeneca Ab Therapeutic agents 3
RU2007138264A (ru) * 2005-03-17 2009-09-10 Новартис АГ (CH) N-[3-(1-АМИНО-5,6,7,8-ТЕТРАГИДРО-2,4,4b-ТРИАЗАФЛУОРЕН-9-ИЛ)ФЕНИЛ]БЕНЗАМИДЫ В КАЧЕСТВЕ ИНГИБИТОРОВ ТИРОЗИН/ТРЕОНИНКИНАЗ, ПРЕЖДЕ ВСЕГО КИНАЗ В-RAF
PL1888123T3 (pl) 2005-06-08 2013-06-28 Janssen Biotech Inc Terapia komórkowa chorób degeneracyjnych oka
WO2007008514A2 (fr) * 2005-07-07 2007-01-18 Georgetown University Inhibiteurs glycogene synthase kinase 3
CA2624378A1 (fr) * 2005-09-29 2007-04-12 Janssen Pharmaceutica N.V. Composes macroheterocycliques en tant qu'inhibiteurs de kinase
US8741643B2 (en) 2006-04-28 2014-06-03 Lifescan, Inc. Differentiation of pluripotent stem cells to definitive endoderm lineage
WO2007143119A2 (fr) * 2006-06-01 2007-12-13 The Board Of Trustees Of The Leland Stanford Junior University Méthode pour prévenir une progression d'insuffisance cardiaque induite par une hypertension avec des peptides pkc
ES2446269T3 (es) 2006-12-19 2014-03-06 The Board Of Trustees Of The University Of Illinois 3-Benzofuranil-4-indolil-maleimidas como potentes inhibidores de GSK-3 para trastornos neurodegenerativos
WO2008100867A2 (fr) * 2007-02-12 2008-08-21 Intermune, Inc. Nouveaux inhibiteurs de réplication du virus de l'hépatite c
US9080145B2 (en) 2007-07-01 2015-07-14 Lifescan Corporation Single pluripotent stem cell culture
EP2185693B1 (fr) 2007-07-31 2019-07-03 Lifescan, Inc. Différenciation de cellules souches embryonnaires humaines
EP2229434B1 (fr) 2007-11-27 2011-09-07 Lifescan, Inc. Différentiation des cellules souches embryonnaires humaines
CA2959401C (fr) 2008-02-21 2021-12-07 Centocor Ortho Biotech Inc. Procedes, plaques a surface modifiee et compositions permettant la fixation, la culture et le detachement de cellules
US8623648B2 (en) * 2008-04-24 2014-01-07 Janssen Biotech, Inc. Treatment of pluripotent cells
EP2310492B1 (fr) 2008-06-30 2015-07-22 Janssen Biotech, Inc. Différenciation de cellules souches pluripotentes
CA2742268C (fr) 2008-10-31 2020-02-18 Centocor Ortho Biotech Inc. Differenciation de cellules souches embryonnaires humaines en la lignee endocrine pancreatique
US9012218B2 (en) 2008-10-31 2015-04-21 Janssen Biotech, Inc. Differentiation of human embryonic stem cells
RU2555538C2 (ru) 2008-11-20 2015-07-10 Сентокор Орто Байотек Инк. Культура плюрипотентных стволовых клеток на микроносителях
AU2009316583B2 (en) 2008-11-20 2016-04-21 Janssen Biotech, Inc. Methods and compositions for cell attachment and cultivation on planar substrates
CN102482640B (zh) 2009-07-20 2015-03-11 詹森生物科技公司 人胚胎干细胞的分化
GB2485113B (en) 2009-07-20 2016-12-28 Janssen Biotech Inc Differentiation of human embryonic stem cells into cells of the pancreatic endoderm lineage
BR112012001480A2 (pt) 2009-07-20 2015-09-01 Janssen Biotech Inc Diferenciação de células-tronco embriônicas humanas
RU2664864C1 (ru) 2009-12-23 2018-08-23 Янссен Байотек, Инк. Способы увеличения экспрессии ngn3 и nkx6.1 в эндокринных клетках поджелудочной железы
US9150833B2 (en) 2009-12-23 2015-10-06 Janssen Biotech, Inc. Differentiation of human embryonic stem cells
WO2011109279A2 (fr) 2010-03-01 2011-09-09 Centocor Ortho Biotech Inc. Procédés de purification de cellules issues de cellules souches pluripotentes
US8293738B2 (en) 2010-05-12 2012-10-23 Abbott Laboratories Indazole inhibitors of kinase
CN102884176B (zh) 2010-05-12 2017-09-05 詹森生物科技公司 人胚胎干细胞的分化
PL2611909T3 (pl) 2010-08-31 2018-05-30 Janssen Biotech, Inc Zróżnicowanie ludzkich embrionalnych komórek macierzystych
PL2611910T3 (pl) 2010-08-31 2018-06-29 Janssen Biotech, Inc Różnicowanie ludzkich embrionalnych komórek macierzystych
RU2673946C1 (ru) 2010-08-31 2018-12-03 Янссен Байотек, Инк. Дифференцирование плюрипотентных стволовых клеток
BR112014015417A8 (pt) 2011-12-22 2017-07-04 Janssen Biotech Inc diferenciação de células-tronco embrionárias humanas em células positivas de insulina hormonal únicas
AU2013230020B2 (en) 2012-03-07 2018-08-09 Janssen Biotech, Inc. Defined media for expansion and maintenance of pluripotent stem cells
CN104334719B (zh) 2012-06-08 2018-02-13 詹森生物科技公司 人胚胎干细胞向胰腺内分泌细胞的分化
JP2016504299A (ja) 2012-12-10 2016-02-12 セントジーン アーゲー 白血病を予防および治療するためのマレイミド誘導体の使用
RU2018116647A (ru) 2012-12-31 2018-10-24 Янссен Байотек, Инк. Культивация эмбриональных стволовых клеток человека в воздушно-жидкостной зоне взаимодействия с целью их дифференцировки в панкреатические эндокринные клетки
US10370644B2 (en) 2012-12-31 2019-08-06 Janssen Biotech, Inc. Method for making human pluripotent suspension cultures and cells derived therefrom
MX2015008578A (es) 2012-12-31 2015-09-07 Janssen Biotech Inc Diferenciacion de celulas madre embrionarias humanas en celulas endocrinas pancreaticas mediante el uso de relugadores de hb9.
MX2015008619A (es) 2012-12-31 2016-01-12 Janssen Biotech Inc Suspension y agrupamiento de celulas humanas pluripotentes para la diferenciacion a celulas endocrinas pancreaticas.
RU2694311C2 (ru) 2014-05-16 2019-07-11 Янссен Байотек, Инк. Применение малых молекул для увеличения экспрессии mafa в панкреатических эндокринных клетках
GB201509885D0 (en) * 2015-06-08 2015-07-22 Ucb Biopharma Sprl Therapeutic agents
MA45479A (fr) 2016-04-14 2019-02-20 Janssen Biotech Inc Différenciation de cellules souches pluripotentes en cellules de l'endoderme de l'intestin moyen
SG10201910821XA (en) 2016-12-30 2020-01-30 Frequency Therapeutics Inc 1h-pyrrole-2,5-dione compounds and methods of using them to induce self-renewal of stem/progenitor supporting cells
US10383881B2 (en) 2016-12-30 2019-08-20 Frequency Therapeutics, Inc. 1,5-dihydro-2H-pyrrol-2-one compounds and methods of using same
CN113490668A (zh) 2018-10-05 2021-10-08 安娜普尔纳生物股份有限公司 用于治疗与apj受体活性有关的疾病的化合物和组合物
WO2020163812A1 (fr) 2019-02-08 2020-08-13 Frequency Therapeutics, Inc. Composés d'acide valproïque et agonistes wnt pour le traitement de troubles de l'oreille
IL295281A (en) 2020-02-07 2022-10-01 Gasherbrum Bio Inc Heterocyclic glp-1 agonists

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ227850A (en) 1988-02-10 1991-11-26 Hoffmann La Roche Indole substituted pyrrole derivatives; preparatory process and medicaments for use against inflammatory immunological, bronchopulmonary or vascular disorders
MC2096A1 (fr) 1989-02-23 1991-02-15 Hoffmann La Roche Pyrroles substitues
GB8904161D0 (en) 1989-02-23 1989-04-05 Hoffmann La Roche Substituted pyrroles
DE4005969A1 (de) 1990-02-26 1991-08-29 Boehringer Mannheim Gmbh Neue trisubstituierte pyrrole, verfahren zu ihrer herstellung sowie arzneimittel, die diese verbindungen enthalten
DE4005970A1 (de) 1990-02-26 1991-08-29 Boehringer Mannheim Gmbh Neue trisubstituierte maleinimide, verfahren zu ihrer herstellung sowie arzneimittel, die diese verbindungen enthalten
US5624949A (en) 1993-12-07 1997-04-29 Eli Lilly And Company Protein kinase C inhibitors
EP0817627B1 (fr) 1993-12-23 2005-03-09 Eli Lilly And Company Inhibiteurs de la proteine-kinase c
SE9603283D0 (sv) 1996-09-10 1996-09-10 Astra Ab New compounds
EP1057484A4 (fr) 1998-02-23 2002-11-20 Sagami Chem Res Inhibiteurs de la mort cellulaire
CA2338866A1 (fr) 1998-07-30 2000-02-10 Japan Tobacco Inc. Composes de maleimide disubstitues et leur utilisation en pharmaceutique
ES2234300T3 (es) 1998-10-08 2005-06-16 Smithkline Beecham Plc 3-(3-cloro-4-hidroxifenilamino)-4-(2-nitrofenil)-1h-pirrol-2,5-diona como inhibidor de glucogeno cinasa-3 (gsk-3)sintetasa.
YU46603A (sh) * 2000-12-08 2006-05-25 Ortho-Mcneil Pharmaceutical Inc. Indazolil-supstituisana jedinjenja pirolina, kao inhibitori kinaze
ATE387444T1 (de) * 2002-05-08 2008-03-15 Janssen Pharmaceutica Nv Substituierte pyrroline als kinase inhibitoren
EP1513520B1 (fr) * 2002-06-05 2008-09-24 Janssen Pharmaceutica N.V. Pyrrolines substituees en tant qu'inhibiteurs de kinase
MXPA04012188A (es) * 2002-06-05 2005-07-25 Johnson & Johnson Derivados de bisindolil-maleimida como inhibidores de cinasa.
WO2004094422A1 (fr) * 2003-03-27 2004-11-04 Janssen Pharmaceutica N.V. Pyrrolines substitues inhibiteurs de kinase
KR20060021890A (ko) * 2003-06-13 2006-03-08 얀센 파마슈티카 엔.브이. 키나제 저해제로서의 치환된 인다졸릴(인돌릴)말레이미드유도체

Also Published As

Publication number Publication date
US7855203B2 (en) 2010-12-21
US20050004202A1 (en) 2005-01-06
HUP0303855A3 (en) 2005-04-28
CZ20031594A3 (cs) 2004-06-16
ZA200305239B (en) 2004-10-07
DE60119790D1 (de) 2006-06-22
MXPA03005140A (es) 2004-10-15
US7329657B2 (en) 2008-02-12
CA2431166A1 (fr) 2002-06-13
YU46603A (sh) 2006-05-25
DK1362047T3 (da) 2006-09-04
PT1362047E (pt) 2006-09-29
JP2004515499A (ja) 2004-05-27
CN1230434C (zh) 2005-12-07
CN1489586A (zh) 2004-04-14
DE60119790T2 (de) 2007-01-25
NZ526356A (en) 2005-02-25
EP1362047A2 (fr) 2003-11-19
US20040259928A1 (en) 2004-12-23
BR0116468A (pt) 2004-06-29
HUP0303855A2 (hu) 2004-03-01
CY1106125T1 (el) 2011-06-08
US20030055097A1 (en) 2003-03-20
US6849643B2 (en) 2005-02-01
KR20040016828A (ko) 2004-02-25
HK1057370A1 (en) 2004-04-02
AU2002230727A1 (en) 2002-06-18
US20080096949A1 (en) 2008-04-24
WO2002046183A3 (fr) 2002-09-06
ES2263681T3 (es) 2006-12-16
EP1362047B1 (fr) 2006-05-17
WO2002046183A2 (fr) 2002-06-13
PL362576A1 (en) 2004-11-02
RU2003117078A (ru) 2004-12-10
IL156339A0 (en) 2004-01-04
ATE326464T1 (de) 2006-06-15
US7304060B2 (en) 2007-12-04
NO20032625D0 (no) 2003-06-10

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