NO20021520L - Substituerte pyridiner og pyridaziner med angiogeneseinhiberende aktivitet - Google Patents

Substituerte pyridiner og pyridaziner med angiogeneseinhiberende aktivitet

Info

Publication number
NO20021520L
NO20021520L NO20021520A NO20021520A NO20021520L NO 20021520 L NO20021520 L NO 20021520L NO 20021520 A NO20021520 A NO 20021520A NO 20021520 A NO20021520 A NO 20021520A NO 20021520 L NO20021520 L NO 20021520L
Authority
NO
Norway
Prior art keywords
pyridazines
inhibitory activity
substituted pyridines
angiogenesis inhibitory
angiogenesis
Prior art date
Application number
NO20021520A
Other languages
English (en)
Norwegian (no)
Other versions
NO20021520D0 (no
Inventor
Jacques P Dumas
Stephen James Boyer
Julie A Dixon
Teddy Kite Joe
Harold Clinton Eugene Kluender
Wendy Lee
Dhanapalan Nagarathnam
Robert N Sibley
Ning Su
Original Assignee
Bayer Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag filed Critical Bayer Ag
Publication of NO20021520D0 publication Critical patent/NO20021520D0/no
Publication of NO20021520L publication Critical patent/NO20021520L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Rheumatology (AREA)
  • Vascular Medicine (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyridine Compounds (AREA)
NO20021520A 1999-09-28 2002-03-26 Substituerte pyridiner og pyridaziner med angiogeneseinhiberende aktivitet NO20021520L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US40760099A 1999-09-28 1999-09-28
PCT/US2000/026500 WO2001023375A2 (en) 1999-09-28 2000-09-26 Substituted pyridines and pyridazines with angiogenesis inhibiting activity

Publications (2)

Publication Number Publication Date
NO20021520D0 NO20021520D0 (no) 2002-03-26
NO20021520L true NO20021520L (no) 2002-05-23

Family

ID=23612752

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20021520A NO20021520L (no) 1999-09-28 2002-03-26 Substituerte pyridiner og pyridaziner med angiogeneseinhiberende aktivitet

Country Status (35)

Country Link
EP (1) EP1228063B1 (cs)
JP (1) JP4919567B2 (cs)
KR (3) KR100890473B1 (cs)
CN (3) CN100422173C (cs)
AR (3) AR025752A1 (cs)
AT (1) ATE422494T1 (cs)
AU (1) AU782820B2 (cs)
BG (1) BG65860B1 (cs)
BR (1) BRPI0014382B8 (cs)
CA (1) CA2385817C (cs)
CO (1) CO5200835A1 (cs)
CZ (1) CZ304767B6 (cs)
DE (1) DE60041548D1 (cs)
DO (1) DOP2000000070A (cs)
EE (1) EE05258B1 (cs)
ES (1) ES2320525T3 (cs)
GT (1) GT200000158A (cs)
HR (1) HRP20020308A2 (cs)
HU (1) HU230223B1 (cs)
IL (3) IL148880A0 (cs)
MA (1) MA25563A1 (cs)
MX (1) MXPA02003156A (cs)
MY (3) MY143580A (cs)
NO (1) NO20021520L (cs)
NZ (1) NZ518589A (cs)
PA (1) PA8503201A1 (cs)
PE (1) PE20010607A1 (cs)
PL (1) PL205957B1 (cs)
RS (1) RS50369B (cs)
RU (1) RU2260008C2 (cs)
SK (1) SK287417B6 (cs)
TW (1) TW593315B (cs)
UA (1) UA75053C2 (cs)
WO (1) WO2001023375A2 (cs)
ZA (1) ZA200202760B (cs)

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CN101337930B (zh) 2003-11-11 2010-09-08 卫材R&D管理有限公司 脲衍生物的制备方法
KR100553398B1 (ko) * 2004-03-12 2006-02-16 한미약품 주식회사 티에노[3,2-ｃ]피리딘 유도체의 제조 방법 및 이에사용되는 중간체
EP1797877A4 (en) 2004-09-13 2010-12-15 Eisai Co Ltd JOINT USE OF A SULFONAMIDE-BASED COMPOUND AND AN ANGIOGENESIS INHIBITOR
US8772269B2 (en) 2004-09-13 2014-07-08 Eisai R&D Management Co., Ltd. Use of sulfonamide-including compounds in combination with angiogenesis inhibitors
DE602005013990D1 (de) 2004-09-17 2009-05-28 Eisai R&D Man Co Ltd Medizinische zusammensetzung mit verbesserter stabilität und reduzierten gelierungseigenschaften
JP4989476B2 (ja) 2005-08-02 2012-08-01 エーザイ・アール・アンド・ディー・マネジメント株式会社 血管新生阻害物質の効果を検定する方法
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CN101511793B (zh) 2006-08-28 2011-08-03 卫材R&D管理有限公司 针对未分化型胃癌的抗肿瘤剂
CN101600694A (zh) 2007-01-29 2009-12-09 卫材R&D管理有限公司 未分化型胃癌治疗用组合物
KR101513326B1 (ko) 2007-11-09 2015-04-17 에자이 알앤드디 매니지먼트 가부시키가이샤 혈관 신생 저해 물질과 항종양성 백금 착물의 병용
CN101481380B (zh) * 2008-01-08 2012-10-17 浙江医药股份有限公司新昌制药厂 噻吩并哒嗪类化合物及其制备方法、药物组合物及其用途
RU2560683C2 (ru) 2010-06-25 2015-08-20 Эйсай Ар Энд Ди Менеджмент Ко., Лтд. Противоопухолевое средство, задействующее соединения с ингибирующим эффектом к киназам в комбинации
KR101762999B1 (ko) 2011-04-18 2017-07-28 에자이 알앤드디 매니지먼트 가부시키가이샤 종양 치료제
ES2841809T3 (es) 2011-06-03 2021-07-09 Eisai R&D Man Co Ltd Biomarcadores para pronosticar y evaluar el grado de respuesta de sujetos con cáncer de tiroides y de riñón a compuestos de lenvatinib
BR112015009004A8 (pt) 2012-12-21 2021-07-20 Eisai R&D Man Co Ltd forma amorfa de derivado de quinolina e método de produção da mesma
US10517861B2 (en) 2013-05-14 2019-12-31 Eisai R&D Management Co., Ltd. Biomarkers for predicting and assessing responsiveness of endometrial cancer subjects to lenvatinib compounds
CN103396361B (zh) * 2013-07-24 2016-05-04 中国人民解放军第二军医大学 3,4-二氢异喹啉类抗肿瘤化合物及其制备方法与应用
KR102512940B1 (ko) 2014-08-28 2023-03-23 에자이 알앤드디 매니지먼트 가부시키가이샤 고순도의 퀴놀린 유도체 및 이를 제조하는 방법
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KR102662228B1 (ko) 2015-03-04 2024-05-02 머크 샤프 앤드 돔 코포레이션 암을 치료하기 위한 pd-1 길항제 및 vegfr/fgfr/ret 티로신 키나제 억제제의 조합
CN104804008B (zh) * 2015-03-27 2016-03-23 亿腾药业（泰州）有限公司 一种工业化生产甲磺酸特拉替尼的方法
WO2016204193A1 (ja) 2015-06-16 2016-12-22 株式会社ＰＲＩＳＭ Ｐｈａｒｍａ 抗がん剤
KR102587702B1 (ko) 2015-08-20 2023-10-12 에자이 알앤드디 매니지먼트 가부시키가이샤 종양 치료제
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Also Published As

Publication number Publication date
HUP0202704A2 (hu) 2002-12-28
WO2001023375A3 (en) 2002-05-02
DOP2000000070A (es) 2002-02-28
AU1569601A (en) 2001-04-30
ZA200202760B (en) 2003-10-29
KR100895572B1 (ko) 2009-04-29
PA8503201A1 (es) 2002-08-26
MXPA02003156A (es) 2002-09-30
KR20080091505A (ko) 2008-10-13
CO5200835A1 (es) 2002-09-27
RU2260008C2 (ru) 2005-09-10
IL193367A0 (en) 2009-02-11
HRP20020308A2 (en) 2004-06-30
UA75053C2 (en) 2006-03-15
EP1228063B1 (en) 2009-02-11
HK1091819A1 (zh) 2007-01-26
MY135058A (en) 2008-01-31
MY143377A (en) 2011-05-13
KR20020038775A (ko) 2002-05-23
AR082232A2 (es) 2012-11-21
HRP20020308B1 (cs) 2013-01-31
KR100890473B1 (ko) 2009-03-26
CZ304767B6 (cs) 2014-10-08
TW593315B (en) 2004-06-21
BG65860B1 (bg) 2010-03-31
AR025752A1 (es) 2002-12-11
BR0014382A (pt) 2003-06-24
CN100374435C (zh) 2008-03-12
IL193368A0 (en) 2009-02-11
SK287417B6 (sk) 2010-09-07
CN1420879A (zh) 2003-05-28
WO2001023375A2 (en) 2001-04-05
NO20021520D0 (no) 2002-03-26
RS50369B (sr) 2009-11-10
CN1769282A (zh) 2006-05-10
EE05258B1 (et) 2010-02-15
DE60041548D1 (de) 2009-03-26
IL193368A (en) 2011-05-31
ES2320525T3 (es) 2009-05-25
PL366342A1 (en) 2005-01-24
PE20010607A1 (es) 2001-07-12
EE200200161A (et) 2003-08-15
CA2385817A1 (en) 2001-04-05
AU782820B2 (en) 2005-09-01
CA2385817C (en) 2010-05-04
CN100422172C (zh) 2008-10-01
KR100895571B1 (ko) 2009-04-29
YU22902A (sh) 2004-12-31
EP1228063A2 (en) 2002-08-07
CZ20021444A3 (cs) 2002-08-14
JP4919567B2 (ja) 2012-04-18
PL205957B1 (pl) 2010-06-30
JP2003526632A (ja) 2003-09-09
BR0014382B1 (pt) 2014-04-01
IL193367A (en) 2011-03-31
HK1091818A1 (zh) 2007-01-26
BG106637A (bg) 2003-02-28
MY143580A (en) 2011-05-31
KR20080086547A (ko) 2008-09-25
AR082231A2 (es) 2012-11-21
HUP0202704A3 (en) 2003-12-29
SK5912002A3 (en) 2003-01-09
GT200000158A (es) 2002-03-16
CN1769283A (zh) 2006-05-10
NZ518589A (en) 2005-03-24
ATE422494T1 (de) 2009-02-15
CN100422173C (zh) 2008-10-01
BRPI0014382B8 (pt) 2021-05-25
HU230223B1 (en) 2015-10-28
IL148880A0 (en) 2002-09-12
MA25563A1 (fr) 2002-10-01

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