NO20005628D0 - Fremgangsmåte for utvelgelse av et virus - Google Patents

Fremgangsmåte for utvelgelse av et virus

Info

Publication number
NO20005628D0
NO20005628D0 NO20005628A NO20005628A NO20005628D0 NO 20005628 D0 NO20005628 D0 NO 20005628D0 NO 20005628 A NO20005628 A NO 20005628A NO 20005628 A NO20005628 A NO 20005628A NO 20005628 D0 NO20005628 D0 NO 20005628D0
Authority
NO
Norway
Prior art keywords
virus
polypeptide
fusion
selecting
propagating
Prior art date
Application number
NO20005628A
Other languages
English (en)
Other versions
NO20005628L (no
NO329172B1 (no
Inventor
Lutz Riechmann
Peter Kristensen
Jean-Luc Jestin
Gregory Paul Winter
Original Assignee
Diversys Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9810228.8A external-priority patent/GB9810228D0/en
Priority claimed from GBGB9810223.9A external-priority patent/GB9810223D0/en
Application filed by Diversys Ltd filed Critical Diversys Ltd
Publication of NO20005628D0 publication Critical patent/NO20005628D0/no
Publication of NO20005628L publication Critical patent/NO20005628L/no
Publication of NO329172B1 publication Critical patent/NO329172B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/02—Libraries contained in or displayed by microorganisms, e.g. bacteria or animal cells; Libraries contained in or displayed by vectors, e.g. plasmids; Libraries containing only microorganisms or vectors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1037—Screening libraries presented on the surface of microorganisms, e.g. phage display, E. coli display
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation
    • C07K2319/41—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation containing a Myc-tag
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation
    • C07K2319/43—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation containing a FLAG-tag
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/50—Fusion polypeptide containing protease site
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/735—Fusion polypeptide containing domain for protein-protein interaction containing a domain for self-assembly, e.g. a viral coat protein (includes phage display)

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Control Of Indicators Other Than Cathode Ray Tubes (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Vehicle Body Suspensions (AREA)
  • Circuits Of Receivers In General (AREA)
  • Air Bags (AREA)
NO20005628A 1998-05-13 2000-11-08 Fremgangsmate for seleksjon av et korrekt foldet fusjonspolypeptid NO329172B1 (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB9810228.8A GB9810228D0 (en) 1998-05-13 1998-05-13 Selection method
GBGB9810223.9A GB9810223D0 (en) 1998-05-13 1998-05-13 Selection system
PCT/GB1999/001526 WO1999058655A2 (en) 1998-05-13 1999-05-13 Phage display selection system for folded proteins

Publications (3)

Publication Number Publication Date
NO20005628D0 true NO20005628D0 (no) 2000-11-08
NO20005628L NO20005628L (no) 2001-01-12
NO329172B1 NO329172B1 (no) 2010-09-06

Family

ID=26313668

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20005628A NO329172B1 (no) 1998-05-13 2000-11-08 Fremgangsmate for seleksjon av et korrekt foldet fusjonspolypeptid

Country Status (14)

Country Link
US (2) US7442159B1 (no)
EP (2) EP1078051B1 (no)
JP (2) JP4493846B2 (no)
AT (1) ATE380865T1 (no)
AU (1) AU762814B2 (no)
CA (1) CA2328422A1 (no)
CY (1) CY1107293T1 (no)
DE (1) DE69937735T2 (no)
DK (1) DK1078051T3 (no)
ES (1) ES2299244T3 (no)
GB (1) GB2361237A (no)
NO (1) NO329172B1 (no)
PT (1) PT1078051E (no)
WO (1) WO1999058655A2 (no)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU5122499A (en) 1998-07-27 2000-02-21 Genentech Inc. Improved transformation efficiency in phage display through modification of a coat protein
DE60041119D1 (de) 1999-07-20 2009-01-29 Morphosys Ag Verfahren zur präsentation von (poly)peptiden/proteinen auf bakteriophagenpartikeln via disulfidbindungen
GB2375112A (en) * 2000-02-03 2002-11-06 Domantis Ltd Combinatorial protein domains
GB0019049D0 (en) * 2000-08-04 2000-09-27 Neutec Pharma Plc Combinatorial chemistry method
AU2001277614A1 (en) * 2000-08-07 2002-02-18 Domantis Limited Novel proteins
DE10135039C1 (de) * 2001-07-18 2003-03-13 Nemod Immuntherapie Ag Verfahren zur Isolierung großer Varianzen spezifischer Moleküle für ein Zielmolekül aus Phagemid-Gen-Bibliotheken
EP2357237A1 (en) 2003-05-14 2011-08-17 Domantis Limited A process for recovering polypeptides that unfold reversibly from a polypeptide repertoire
NZ564695A (en) * 2005-07-08 2009-02-28 Univ Zuerich Phage display using cotranslational translocation of fusion polypeptides
GB2428293A (en) * 2005-07-13 2007-01-24 Domantis Ltd Phage display libraries
EP1915617B1 (en) * 2005-07-21 2011-09-14 Aebi Ltd. Methods and compositions for identifying a peptide having an intermolecular interaction with a target of interest
GB0515115D0 (en) 2005-07-22 2005-08-31 Isogenica Ltd Peptide characterisation
JP5564249B2 (ja) * 2006-06-23 2014-07-30 アレシア・バイオセラピューティクス・インコーポレーテッド 癌に関与するポリヌクレオチド配列およびポリペプチド配列
CA2688433A1 (en) 2007-06-06 2008-12-11 Domantis Limited Methods for selecting protease resistant polypeptides
ES2403904T3 (es) 2007-08-21 2013-05-22 Morphosys Ag Métodos para la formación de enlaces disulfuro
KR101710472B1 (ko) 2007-11-30 2017-02-27 글락소 그룹 리미티드 항원-결합 작제물
BRPI0921805A2 (pt) 2008-11-03 2016-11-01 Alethia Biotherapeutics Inc anticorpos que especificamente bloqueiam a atividade biológica de um antígeno de tumor
EP2364326B1 (en) 2008-12-05 2018-07-04 Glaxo Group Limited Methods for selecting protease resistant polypeptides
CA2753287A1 (en) 2009-02-24 2010-09-02 Glaxo Group Limited Antigen-binding constructs
JP2012518400A (ja) 2009-02-24 2012-08-16 グラクソ グループ リミテッド 多価および／または複数特異的ｒａｎｋｌ結合性構築物
WO2010097386A1 (en) 2009-02-24 2010-09-02 Glaxo Group Limited Antigen-binding constructs
BR112013013003A2 (pt) 2010-11-24 2016-08-09 Glaxo Group Ltd proteína de ligação de antígeno, e, composição farmacêutica
CN106146664B (zh) 2011-03-31 2021-09-07 Adc治疗股份有限公司 针对肾相关抗原1的抗体及其抗原结合片段
AU2012288846B2 (en) 2011-07-27 2016-05-19 Glaxo Group Limited Anti-VEGF single variable domains fused to fc domains
AU2012327806B2 (en) 2011-10-27 2018-07-19 The Governors Of The University Of Alberta Device and method for bacterial culture and assay
SI2802351T1 (sl) 2012-01-09 2019-07-31 ADC Therapeutics SA, Biopole Sredstva za zdravljenje trojno negativnega raka dojke
US20150087810A1 (en) * 2013-09-25 2015-03-26 Cytomx Therapeutics, Inc. Matrix Metalloproteinase Substrates And Other Cleavable Moieties And Methods Of Use Thereof
DK3628328T3 (da) 2014-01-31 2022-12-05 Cytomx Therapeutics Inc Matriptase- og u-plasminogen-aktivatorsubstrater og andre spaltelige dele og fremgangsmåder til anvendelse deraf
EP3218479A1 (en) * 2014-11-11 2017-09-20 Nanocore ApS Method for identification of molecules with desired characteristics
MA41374A (fr) 2015-01-20 2017-11-28 Cytomx Therapeutics Inc Substrats clivables par métalloprotéase matricielle et clivables par sérine protéase et procédés d'utilisation de ceux-ci
WO2016156466A1 (en) * 2015-03-31 2016-10-06 Vhsquared Limited Peptide construct having a protease-cleavable linker
CN114008195A (zh) * 2019-06-21 2022-02-01 勃林格殷格翰国际有限公司 控制rna病毒复制和基因表达的新机制

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5223409A (en) * 1988-09-02 1993-06-29 Protein Engineering Corp. Directed evolution of novel binding proteins
JP2919890B2 (ja) 1988-11-11 1999-07-19 メディカル リサーチ カウンスル 単一ドメインリガンド、そのリガンドからなる受容体、その製造方法、ならびにそのリガンドおよび受容体の使用
CA2016842A1 (en) 1989-05-16 1990-11-16 Richard A. Lerner Method for tapping the immunological repertoire
US5723286A (en) * 1990-06-20 1998-03-03 Affymax Technologies N.V. Peptide library and screening systems
GB9015198D0 (en) * 1990-07-10 1990-08-29 Brien Caroline J O Binding substance
DK0585287T3 (da) * 1990-07-10 2000-04-17 Cambridge Antibody Tech Fremgangsmåde til fremstilling af specifikke bindingsparelementer
ES2330052T3 (es) * 1991-03-01 2009-12-03 Dyax Corporation Proteina quimerica que comprende micro-proteinas que tienen dos o mas puentes disulfuro y relaizaciones de las mismas.
DE4122599C2 (de) * 1991-07-08 1993-11-11 Deutsches Krebsforsch Phagemid zum Screenen von Antikörpern
ES2341666T3 (es) 1991-12-02 2010-06-24 Medimmune Limited Produccion de autoanticuerpos de repertorios de segmentos de anticue rpos expresados en la superficie de fagos.

Also Published As

Publication number Publication date
NO20005628L (no) 2001-01-12
AU3941399A (en) 1999-11-29
JP5161865B2 (ja) 2013-03-13
EP1078051B1 (en) 2007-12-12
US8680018B2 (en) 2014-03-25
JP2010148507A (ja) 2010-07-08
PT1078051E (pt) 2008-03-17
ATE380865T1 (de) 2007-12-15
NO329172B1 (no) 2010-09-06
CA2328422A1 (en) 1999-11-18
JP4493846B2 (ja) 2010-06-30
CY1107293T1 (el) 2012-11-21
ES2299244T3 (es) 2008-05-16
DK1078051T3 (da) 2008-04-07
US20090203542A1 (en) 2009-08-13
US7442159B1 (en) 2008-10-28
DE69937735D1 (de) 2008-01-24
WO1999058655A2 (en) 1999-11-18
EP1078051A2 (en) 2001-02-28
DE69937735T2 (de) 2008-11-27
EP1950295A1 (en) 2008-07-30
JP2002514413A (ja) 2002-05-21
GB0026143D0 (en) 2000-12-13
GB2361237A (en) 2001-10-17
AU762814B2 (en) 2003-07-03
WO1999058655A3 (en) 2000-01-27

Similar Documents

Publication Publication Date Title
NO20005628L (no) Fremgangsmåte for utvelgelse av et virus
DK1088084T3 (da) Erythropoietin analog-humant serumalbumin fusionsprotein
DK0816506T3 (da) System til ekspression af heterologe antigener som fusionsproteiner
BR9810654B1 (pt) mÉtodo de preparaÇço de um polipeptÍdeo, molÉculas de anticorpo e composiÇço.
DK1065271T3 (da) Fagmid til screening af antistoffer
ID24490A (id) Metode untuk menggunakan dan metode pembuatan tabung oven-pijar
HK1038244A1 (en) A method for the high level expression of the active form of lymphotoxin- beta receptor immunoglobulin fusion proteins and their purification
DE69633563D1 (de) Neues verfahren zur gewinnung und reinigung von fusionsproteinen
NO20002504L (no) Adenovirusvektorer og fremgangsmÕte for Õ redusere homologe rekombinasjonsfenomener
DK0977873T3 (da) Fremgangsmåde til spaltning af fusionsproteiner
WO2002022662A3 (en) Insect inhibitory bacillus thuringiensis proteins, fusions, and methods of use therefor
AU5854196A (en) Method for refolding insoluble aggregates of hepatitis c vir us protease
NO20052552D0 (no) Loselige Notch-baserte substrater for gamma-sekretase og fremgangsmater og blandinger for anvendelse av samme.
ID24590A (id) Metode dan komposisi untuk pembuatan lensa oftalmil berwarna
WO2000031127A3 (en) Protein fragments for use in protein targeting
DE69534178D1 (en) S?ugetier thymokingene
DE69611896D1 (de) Fusions-DNS-Sequenz, dadurch exprimiertes Fusionsprotein und Verfahren zur Expression dieses Fusionsproteins
DK0829579T3 (da) Farbart bindelag og fremgangsmåde til den fremstilling
WO2000034335A3 (en) 'death domain' containing receptors
DK1078072T3 (da) Nye peptidfragmenter til oprensning af proteiner
AR016145A1 (es) Citoquinas de mamifero; reactivos relacionados
DK0786476T3 (da) Sammensætning og fremgangsmåde til limning af plane strukturer
DE59105878D1 (de) VERFAHREN ZUR ENZYMATISCHEN SPALTUNG REKOMBINANTER PROTEINE UNTER VERWENDUNG VON IgA-PROTEASEN.

Legal Events

Date Code Title Description
MK1K Patent expired