NO180490C - Analogifremgangsmåte for fremstilling av terapeutisk aktive 2,6-dialkyl-4-silylfenoler - Google Patents

Analogifremgangsmåte for fremstilling av terapeutisk aktive 2,6-dialkyl-4-silylfenoler

Info

Publication number
NO180490C
NO180490C NO912630A NO912630A NO180490C NO 180490 C NO180490 C NO 180490C NO 912630 A NO912630 A NO 912630A NO 912630 A NO912630 A NO 912630A NO 180490 C NO180490 C NO 180490C
Authority
NO
Norway
Prior art keywords
silyl
phenols
dialkyl
therapeutically active
analogous process
Prior art date
Application number
NO912630A
Other languages
English (en)
Other versions
NO912630L (no
NO912630D0 (no
NO180490B (no
Inventor
Roger Alan Parker
Simon Jen Tan Mao
Original Assignee
Merrell Dow Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharma filed Critical Merrell Dow Pharma
Publication of NO912630D0 publication Critical patent/NO912630D0/no
Publication of NO912630L publication Critical patent/NO912630L/no
Publication of NO180490B publication Critical patent/NO180490B/no
Publication of NO180490C publication Critical patent/NO180490C/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
    • C09K15/00—Anti-oxidant compositions; Compositions inhibiting chemical change
    • C09K15/04—Anti-oxidant compositions; Compositions inhibiting chemical change containing organic compounds
    • C09K15/32—Anti-oxidant compositions; Compositions inhibiting chemical change containing organic compounds containing two or more of boron, silicon, phosphorus, selenium, tellurium or a metal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/0803—Compounds with Si-C or Si-Si linkages
    • C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Materials Engineering (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Anti-Oxidant Or Stabilizer Compositions (AREA)
NO912630A 1990-07-05 1991-07-04 Analogifremgangsmåte for fremstilling av terapeutisk aktive 2,6-dialkyl-4-silylfenoler NO180490C (no)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/548,052 US5155250A (en) 1990-07-05 1990-07-05 2,6-di-alkyl-4-silyl-phenols as antiatheroscerotic agents

Publications (4)

Publication Number Publication Date
NO912630D0 NO912630D0 (no) 1991-07-04
NO912630L NO912630L (no) 1992-01-06
NO180490B NO180490B (no) 1997-01-20
NO180490C true NO180490C (no) 1997-04-30

Family

ID=24187205

Family Applications (1)

Application Number Title Priority Date Filing Date
NO912630A NO180490C (no) 1990-07-05 1991-07-04 Analogifremgangsmåte for fremstilling av terapeutisk aktive 2,6-dialkyl-4-silylfenoler

Country Status (20)

Country Link
US (2) US5155250A (no)
EP (1) EP0464852B1 (no)
JP (1) JP2963556B2 (no)
KR (1) KR0186005B1 (no)
CN (1) CN1029615C (no)
AT (1) ATE135705T1 (no)
AU (1) AU639576B2 (no)
CA (1) CA2046051C (no)
DE (1) DE69118028T2 (no)
DK (1) DK0464852T3 (no)
ES (1) ES2087180T3 (no)
FI (1) FI101703B1 (no)
GR (1) GR3019393T3 (no)
HU (1) HU211074B (no)
IE (1) IE912340A1 (no)
IL (1) IL98712A (no)
NO (1) NO180490C (no)
NZ (1) NZ238808A (no)
PT (1) PT98220B (no)
ZA (1) ZA915074B (no)

Families Citing this family (42)

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US5304668A (en) * 1990-07-05 1994-04-19 Merrell Dow Pharmaceuticals Bis-[4-(2,6-di-alkyl)phenolisilane derivatives as antiatherosclerotic agents
FR2707989B1 (fr) * 1993-07-22 1995-10-13 Pf Medicament Nouveaux dérivés de benzylamines silylées, leurs sels, leurs procédés de fabrication et les compositions pharmaceutiques les renfermant.
AU681731B2 (en) * 1993-12-10 1997-09-04 Aventis Inc. Method of lowering serum cholesterol levels with 2,6-di-alkyl-4-silyl-phenols
US5677291A (en) * 1993-12-10 1997-10-14 Hoechst Marion Roussel, Inc. Method of lowering serum cholesterol levels with 2,6-di-alkyl-4-silyl-phenols
WO1995016712A1 (en) * 1993-12-15 1995-06-22 Smithkline Beecham Corporation Compounds and methods
FR2722198B1 (fr) * 1994-07-08 1996-10-04 Pf Medicament 1derives de silylmethyl-anilines, le2fabrication, et leur utilisation co
BR9709189A (pt) * 1996-04-30 1999-08-10 Hoechst Marion Roussel Inc Método de inibiç o de molécula-1 de ades o de células vasculares e tratamento de doenças inflamátorias crônicas com 2,6-dialquil-4-silil-fenóis
US5608095A (en) * 1996-04-30 1997-03-04 Hoechst Marion Roussel, Inc. Alkyl-4-silyl-phenols and esters thereof as antiatherosclerotic agents
US5795876A (en) * 1996-04-30 1998-08-18 Hoechst Marion Rousssel, Inc. Method of inhibiting vascular cell adhesion molecule-1 and treating chronic inflammatory diseases with 2, 6-di-alkyl-4-silyl-phenols
US6127489A (en) * 1996-05-20 2000-10-03 Smithkline Beecham Corporation Silyl linker for solid phase organic synthesis of aryl-containing molecules
US6114572A (en) * 1996-11-20 2000-09-05 Hoechst Marion Roussel, Inc. Substituted phenols and thiophenols useful as antioxidant agents
PL194329B1 (pl) * 1997-05-14 2007-05-31 Atherogenics Inc Zastosowanie monoestru probukolu kwasu bursztynowego lub jego farmaceutycznie dopuszczalnej soli dowytwarzania leku do leczenia choroby, której mediatorem jest VCAM-1
US6670398B2 (en) * 1997-05-14 2003-12-30 Atherogenics, Inc. Compounds and methods for treating transplant rejection
US6121463A (en) * 1997-06-24 2000-09-19 Hoechst Marion Roussel, Inc. Alkyl-4-silylheterocyclic phenols and thiophenols useful as antioxidant agents
KR20010014118A (ko) * 1997-06-24 2001-02-26 게리 디. 스트리트, 스티븐 엘. 네스비트 항산화제로서의 알킬-4-실릴헤테로고리형 페놀 및 티오페놀
US6133467A (en) * 1997-06-25 2000-10-17 Hoechst Marion Roussel, Inc. 2,6-di-t-butyl-4-[(dimethyl-4-methoxyphenylsilyl)-methyl-oxy]phenol and 2,6-di-t-butyl-4-[(dimethyl-2-methoxy-phenylsilyl)methyloxy]phenol
JP2002506443A (ja) * 1997-06-25 2002-02-26 アベンティス・ファーマスーティカルズ・インコーポレイテッド ２，６−ジ−ｔ−ブチル−４−［（ジメチル−４−メトキシフェニルシリル）メチルオキシ］フェノール及び２，６−ジ−ｔ−ブチル−４−［（ジメチル−２−メトキシフェニルシリル）メチルオキシ］フェノール
WO1999001118A2 (en) * 1997-07-01 1999-01-14 Atherogenics, Inc. Antioxidant enhancement of therapy for hyperproliferative conditions
US6887712B1 (en) 1998-11-09 2005-05-03 Atherogenics, Inc. Methods and compositions to lower plasma cholesterol levels
CN1332849A (zh) * 1998-11-09 2002-01-23 埃瑟若詹尼克斯公司 降低血浆胆固醇水平的方法和组合物
JP4408982B2 (ja) * 1999-03-31 2010-02-03 東レ・ダウコーニング株式会社 フェノール基含有有機ケイ素化合物およびその製造方法
BR0115474A (pt) 2000-11-17 2006-01-31 Idenix Cayman Ltd Composição e método para inibição da transmissão de hiv que usam 6-benzil-4-oxopirimidinas substituìdas aplicada por via tópica
AU2002363318B2 (en) * 2001-10-25 2008-09-11 Atherogenics, Inc. Compounds and methods for treating transplant rejection
IL161741A0 (en) * 2001-11-09 2005-11-20 Atherogenics Inc Methods of reversing and preventingcardiovascular pathologies
TW200303302A (en) * 2001-12-19 2003-09-01 Atherogenics Inc Chalcone derivatives and their use to treat diseases
JP4467429B2 (ja) * 2002-07-12 2010-05-26 アセロジエニクス・インコーポレイテツド 低溶解性プロブコールエステル類およびエーテル類の新規な塩形態
US20040110803A1 (en) * 2002-09-13 2004-06-10 Hossein Dovlatabadi Methods and compositions for the use of D-malic acid to decrease serum triglyceride, cholesterol and lipoprotein levels
WO2004056727A2 (en) * 2002-12-19 2004-07-08 Atherogenics, Inc. Process of making chalcone derivatives
BRPI0406738A (pt) * 2003-01-13 2005-12-20 Atherogenics Inc Processo de preparação de ésteres e éteres de probucol e derivados desse
US7173129B2 (en) * 2003-06-06 2007-02-06 Athero Genics, Inc. Sulfonamide-substituted chalcone derivatives and their use to treat diseases
JP2007509054A (ja) * 2003-10-17 2007-04-12 アミリン・ファーマシューティカルズ，インコーポレイテッド 血管健康を促進するシリルフェノール
WO2005037250A1 (en) * 2003-10-17 2005-04-28 Amylin Pharmaceuticals, Inc. Self emulsifying drug delivery systems for hydrophobic therapeutic compounds
WO2005037251A1 (en) * 2003-10-17 2005-04-28 Amylin Pharmaceuticals, Inc. Self-emulsifying drug delivery systems for hydrophobic therapeutic compounds
US20070260087A1 (en) 2004-04-20 2007-11-08 Atherogenics, Inc. Process of Preparing Esters and Ethers of Probucol and Derivatives Thereof
WO2005112914A2 (en) 2004-04-20 2005-12-01 Atherogenics, Inc. Phenolic antioxidants for the treatment of disorders including arthritis, asthma and coronary artery disease
WO2006004903A2 (en) * 2004-06-28 2006-01-12 Atherogenics, Inc. 1,2-bis-(substituted-phenyl)-2-propen-1-ones and pharmaceutical compositions thereof
EP1768660A4 (en) * 2004-07-01 2009-05-13 Atherogenics Inc COMPOUNDS AND METHODS FOR TREATING DIABETIC VASCULAR DISEASES
WO2008118948A1 (en) * 2007-03-26 2008-10-02 Atherogenics, Inc. Methods and compositions of derivatives of probucol for the treatment of diabetes
US20080280985A1 (en) * 2007-03-27 2008-11-13 Scott Robert A D Methods and Compositions Using Certain Phenolic Derivatives for the Treatment of Diabetes
DE102007015948A1 (de) * 2007-04-03 2008-10-09 Bayer Materialscience Ag Modifizierte Polycarbonate, Polyestercarbonate und Polyester mit verbessertem Dehnverhalten und Flammwidrigkeit
US20090254425A1 (en) * 2008-04-02 2009-10-08 Evan Horowitz Wiki-type collective intelligence mechanism for implementing a url redirect

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3328450A (en) * 1963-01-09 1967-06-27 Dow Corning Silylalkyl phenols
US3506674A (en) * 1967-07-03 1970-04-14 Gen Electric Certain pyridyl thio ether silanes
GB1232394A (no) * 1967-08-17 1971-05-19
US3853776A (en) * 1972-09-29 1974-12-10 Monsanto Co Low pour point fluids and blends containing same
US3801617A (en) * 1973-07-24 1974-04-02 Nasa Thiophenyl ether disiloxanes and trisiloxanes useful as lubricant fluids
GB2030581B (en) * 1978-08-18 1983-01-19 Ciba Geigy Ag Lubricant additives
US4624909A (en) * 1984-04-27 1986-11-25 Nec Corporation Silicon-containing novolak resin and resist material and pattern forming method using same
JPS61263988A (ja) * 1985-05-16 1986-11-21 Shionogi & Co Ltd シリル置換エ−テル類および殺虫・殺ダニ剤
US4636573A (en) * 1985-09-09 1987-01-13 Pastor Stephen D Hindered silicon ester stabilizers
DE3604781A1 (de) * 1986-02-13 1987-08-27 Schering Ag Neue silane, verfahren zu ihrer herstellung und diese verbindungen enthaltende einsektizide mittel
US4804653A (en) * 1986-05-02 1989-02-14 Uniroyal Chemical Company, Inc. Thiomethyl-substituted organosilane compounds and their use as pesticides
DE3638073A1 (de) * 1986-11-07 1988-05-11 Swf Auto Electric Gmbh Vorrichtung, insbesondere hubwischeranlage fuer kraftfahrzeuge
US4783495A (en) * 1987-11-20 1988-11-08 Ciba-Geigy Corporation (Hydroxyphenyl) silane stabilizers
US5138012A (en) * 1988-07-29 1992-08-11 General Electric Company Silicone release coating compositions
DE4031001A1 (de) * 1990-10-01 1992-04-02 Hoechst Ag Verfahren zur herstellung von 4-ethoxyphenyl-3-arylpropyl-(dimethyl)silanen

Also Published As

Publication number Publication date
IE912340A1 (en) 1992-01-15
EP0464852B1 (en) 1996-03-20
NO912630L (no) 1992-01-06
CA2046051A1 (en) 1992-01-06
NZ238808A (en) 1994-02-25
NO912630D0 (no) 1991-07-04
AU8011691A (en) 1992-01-09
FI101703B (fi) 1998-08-14
AU639576B2 (en) 1993-07-29
DK0464852T3 (da) 1996-04-15
IL98712A0 (en) 1992-07-15
PT98220B (pt) 1998-12-31
NO180490B (no) 1997-01-20
CN1029615C (zh) 1995-08-30
PT98220A (pt) 1992-05-29
FI101703B1 (fi) 1998-08-14
ATE135705T1 (de) 1996-04-15
DE69118028T2 (de) 1996-11-28
HU912272D0 (en) 1991-12-30
GR3019393T3 (en) 1996-06-30
CN1057843A (zh) 1992-01-15
JP2963556B2 (ja) 1999-10-18
JPH04230393A (ja) 1992-08-19
HUT58749A (en) 1992-03-30
FI913252A (fi) 1992-01-06
ZA915074B (en) 1992-04-29
KR920002617A (ko) 1992-02-28
IL98712A (en) 1995-11-27
ES2087180T3 (es) 1996-07-16
US5155250A (en) 1992-10-13
US5532400A (en) 1996-07-02
CA2046051C (en) 2001-06-05
HU211074B (en) 1995-10-30
DE69118028D1 (de) 1996-04-25
FI913252A0 (fi) 1991-07-04
KR0186005B1 (ko) 1999-05-15
EP0464852A1 (en) 1992-01-08

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Legal Events

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