ATE135705T1 - Neue 2,6-dialkyl-4-silyl-phenole als antiatherosclerotische mittel und als antioxidantien - Google Patents

Neue 2,6-dialkyl-4-silyl-phenole als antiatherosclerotische mittel und als antioxidantien

Info

Publication number
ATE135705T1
ATE135705T1 AT91111252T AT91111252T ATE135705T1 AT E135705 T1 ATE135705 T1 AT E135705T1 AT 91111252 T AT91111252 T AT 91111252T AT 91111252 T AT91111252 T AT 91111252T AT E135705 T1 ATE135705 T1 AT E135705T1
Authority
AT
Austria
Prior art keywords
silyl
phenols
dialkyl
antioxidants
new
Prior art date
Application number
AT91111252T
Other languages
English (en)
Inventor
Roger A Parker
Simon Jen Tan Mao
Original Assignee
Merrell Dow Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharma filed Critical Merrell Dow Pharma
Application granted granted Critical
Publication of ATE135705T1 publication Critical patent/ATE135705T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
    • C09K15/00—Anti-oxidant compositions; Compositions inhibiting chemical change
    • C09K15/04—Anti-oxidant compositions; Compositions inhibiting chemical change containing organic compounds
    • C09K15/32—Anti-oxidant compositions; Compositions inhibiting chemical change containing organic compounds containing two or more of boron, silicon, phosphorus, selenium, tellurium or a metal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/0803—Compounds with Si-C or Si-Si linkages
    • C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Materials Engineering (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Anti-Oxidant Or Stabilizer Compositions (AREA)
AT91111252T 1990-07-05 1991-07-05 Neue 2,6-dialkyl-4-silyl-phenole als antiatherosclerotische mittel und als antioxidantien ATE135705T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/548,052 US5155250A (en) 1990-07-05 1990-07-05 2,6-di-alkyl-4-silyl-phenols as antiatheroscerotic agents

Publications (1)

Publication Number Publication Date
ATE135705T1 true ATE135705T1 (de) 1996-04-15

Family

ID=24187205

Family Applications (1)

Application Number Title Priority Date Filing Date
AT91111252T ATE135705T1 (de) 1990-07-05 1991-07-05 Neue 2,6-dialkyl-4-silyl-phenole als antiatherosclerotische mittel und als antioxidantien

Country Status (20)

Country Link
US (2) US5155250A (de)
EP (1) EP0464852B1 (de)
JP (1) JP2963556B2 (de)
KR (1) KR0186005B1 (de)
CN (1) CN1029615C (de)
AT (1) ATE135705T1 (de)
AU (1) AU639576B2 (de)
CA (1) CA2046051C (de)
DE (1) DE69118028T2 (de)
DK (1) DK0464852T3 (de)
ES (1) ES2087180T3 (de)
FI (1) FI101703B1 (de)
GR (1) GR3019393T3 (de)
HU (1) HU211074B (de)
IE (1) IE912340A1 (de)
IL (1) IL98712A (de)
NO (1) NO180490C (de)
NZ (1) NZ238808A (de)
PT (1) PT98220B (de)
ZA (1) ZA915074B (de)

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NZ238807A (en) * 1990-07-05 1994-03-25 Merrell Dow Pharma Bis[4-(2,6-dialkyl)phenol]silane derivatives and antiatherosclerotic compositions
US5304668A (en) * 1990-07-05 1994-04-19 Merrell Dow Pharmaceuticals Bis-[4-(2,6-di-alkyl)phenolisilane derivatives as antiatherosclerotic agents
FR2707989B1 (fr) * 1993-07-22 1995-10-13 Pf Medicament Nouveaux dérivés de benzylamines silylées, leurs sels, leurs procédés de fabrication et les compositions pharmaceutiques les renfermant.
CA2177968C (en) * 1993-12-10 2000-03-28 Simon J. T. Mao Method of lowering serum cholesterol levels with 2,6-di-alkyl-4-silyl-phenols
US5677291A (en) * 1993-12-10 1997-10-14 Hoechst Marion Roussel, Inc. Method of lowering serum cholesterol levels with 2,6-di-alkyl-4-silyl-phenols
EP0734398B1 (de) * 1993-12-15 2002-02-27 Smithkline Beecham Corporation Verbindungen und verfahren
FR2722198B1 (fr) * 1994-07-08 1996-10-04 Pf Medicament 1derives de silylmethyl-anilines, le2fabrication, et leur utilisation co
US5608095A (en) * 1996-04-30 1997-03-04 Hoechst Marion Roussel, Inc. Alkyl-4-silyl-phenols and esters thereof as antiatherosclerotic agents
WO1997040837A1 (en) * 1996-04-30 1997-11-06 Hoechst Marion Roussel, Inc. Method of inhibiting vascular cell adhesion molecule-1 and treating chronic inflammatory diseases with 2,6-di-alkyl-4-silyl-phenols
US5795876A (en) * 1996-04-30 1998-08-18 Hoechst Marion Rousssel, Inc. Method of inhibiting vascular cell adhesion molecule-1 and treating chronic inflammatory diseases with 2, 6-di-alkyl-4-silyl-phenols
US6127489A (en) * 1996-05-20 2000-10-03 Smithkline Beecham Corporation Silyl linker for solid phase organic synthesis of aryl-containing molecules
US6114572A (en) * 1996-11-20 2000-09-05 Hoechst Marion Roussel, Inc. Substituted phenols and thiophenols useful as antioxidant agents
PL207885B1 (pl) * 1997-05-14 2011-02-28 Atherogenics Inc Pochodna probukolu i kompozycja zawierająca pochodną probukolu
US6670398B2 (en) * 1997-05-14 2003-12-30 Atherogenics, Inc. Compounds and methods for treating transplant rejection
US6121463A (en) * 1997-06-24 2000-09-19 Hoechst Marion Roussel, Inc. Alkyl-4-silylheterocyclic phenols and thiophenols useful as antioxidant agents
EP0998477B1 (de) * 1997-06-24 2003-03-26 Aventis Pharmaceuticals Inc. Alkyl-4-silylheterocyclische Phenole und Thiophenole als Antioxidansmittel
US6133467A (en) * 1997-06-25 2000-10-17 Hoechst Marion Roussel, Inc. 2,6-di-t-butyl-4-[(dimethyl-4-methoxyphenylsilyl)-methyl-oxy]phenol and 2,6-di-t-butyl-4-[(dimethyl-2-methoxy-phenylsilyl)methyloxy]phenol
CA2295232A1 (en) * 1997-06-25 1998-12-30 Hoechst Marion Roussel, Inc. 2,6-di-t-butyl-4-[ (dimethyl-4-methoxyphenylsilyl) -methyloxy]phenol and 2,6-di-t-butyl-4-[ (dimethyl-2-methoxy-phenylsilyl) -methyloxy]phenol
CN1261803A (zh) * 1997-07-01 2000-08-02 埃瑟若詹尼克斯公司 抗氧化剂增强对细胞过度增生性疾病的治疗
JP2002529740A (ja) * 1998-11-09 2002-09-10 アセロジエニクス・インコーポレイテツド 血漿コレステロールレベルを低下させるための方法及び組成物
US6887712B1 (en) 1998-11-09 2005-05-03 Atherogenics, Inc. Methods and compositions to lower plasma cholesterol levels
JP4408982B2 (ja) * 1999-03-31 2010-02-03 東レ・ダウコーニング株式会社 フェノール基含有有機ケイ素化合物およびその製造方法
US6545007B2 (en) 2000-11-17 2003-04-08 Idenix (Cayman) Limited Methods for inhibiting the transmission of HIV using topically applied substituted 6-benzyl-4-oxopyrimidines
JP2005514344A (ja) * 2001-10-25 2005-05-19 アセロジエニクス・インコーポレイテツド 移植拒絶治療のための化合物と方法
CA2466081A1 (en) * 2001-11-09 2003-05-15 Atherogenics, Inc. Methods of reversing and preventing cardiovascular pathologies
WO2003053368A2 (en) * 2001-12-19 2003-07-03 Atherogenics, Inc. Chalcone derivatives and their use to treat diseases
WO2004007423A1 (en) * 2002-07-12 2004-01-22 Atherogenics, Inc. Novel salt forms of poorly soluble probucol esters and ethers
AU2003266165A1 (en) * 2002-09-13 2004-04-30 Hossein Dovlatabadi Methods and compositons for the use of d-malic acid to decrease serum triglyceride, cholesterol, and lipoprotein levels
US20040181075A1 (en) * 2002-12-19 2004-09-16 Weingarten M. David Process of making chalcone derivatives
MXPA05007548A (es) * 2003-01-13 2005-10-20 Atherogenics Inc Procedimiento para preparar esteres y eteres de probucol y derivados del mismo.
WO2004108094A2 (en) * 2003-06-06 2004-12-16 Atherogenics, Inc. Sulfonamide-substituted chalcone derivatives and their use to treat diseases
WO2005039596A1 (en) * 2003-10-17 2005-05-06 Amylin Pharmaceuticals, Inc. Silyl phenols for promoting vascular health
WO2005037251A1 (en) * 2003-10-17 2005-04-28 Amylin Pharmaceuticals, Inc. Self-emulsifying drug delivery systems for hydrophobic therapeutic compounds
WO2005037250A1 (en) * 2003-10-17 2005-04-28 Amylin Pharmaceuticals, Inc. Self emulsifying drug delivery systems for hydrophobic therapeutic compounds
US20070260087A1 (en) 2004-04-20 2007-11-08 Atherogenics, Inc. Process of Preparing Esters and Ethers of Probucol and Derivatives Thereof
WO2005112914A2 (en) 2004-04-20 2005-12-01 Atherogenics, Inc. Phenolic antioxidants for the treatment of disorders including arthritis, asthma and coronary artery disease
WO2006004903A2 (en) * 2004-06-28 2006-01-12 Atherogenics, Inc. 1,2-bis-(substituted-phenyl)-2-propen-1-ones and pharmaceutical compositions thereof
JP2008505097A (ja) * 2004-07-01 2008-02-21 アセロジエニクス・インコーポレイテツド 糖尿病性血管疾患を治療するための化合物および方法
EP2139320A4 (de) * 2007-03-26 2010-09-08 Salutria Pharmaceuticals Llc Verfahren und zusammensetzungen von probucol-derivaten für die behandlung von diabetes
US20080280985A1 (en) * 2007-03-27 2008-11-13 Scott Robert A D Methods and Compositions Using Certain Phenolic Derivatives for the Treatment of Diabetes
DE102007015948A1 (de) * 2007-04-03 2008-10-09 Bayer Materialscience Ag Modifizierte Polycarbonate, Polyestercarbonate und Polyester mit verbessertem Dehnverhalten und Flammwidrigkeit
US20090254425A1 (en) * 2008-04-02 2009-10-08 Evan Horowitz Wiki-type collective intelligence mechanism for implementing a url redirect

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US3328450A (en) * 1963-01-09 1967-06-27 Dow Corning Silylalkyl phenols
US3506674A (en) * 1967-07-03 1970-04-14 Gen Electric Certain pyridyl thio ether silanes
GB1232394A (de) * 1967-08-17 1971-05-19
US3853776A (en) * 1972-09-29 1974-12-10 Monsanto Co Low pour point fluids and blends containing same
US3801617A (en) * 1973-07-24 1974-04-02 Nasa Thiophenyl ether disiloxanes and trisiloxanes useful as lubricant fluids
DE2933206A1 (de) * 1978-08-18 1980-02-28 Ciba Geigy Ag Phenolhaltige silane und deren verwendung als schmiermittelzusaetze
US4624909A (en) * 1984-04-27 1986-11-25 Nec Corporation Silicon-containing novolak resin and resist material and pattern forming method using same
JPS61263988A (ja) * 1985-05-16 1986-11-21 Shionogi & Co Ltd シリル置換エ−テル類および殺虫・殺ダニ剤
US4636573A (en) * 1985-09-09 1987-01-13 Pastor Stephen D Hindered silicon ester stabilizers
DE3604781A1 (de) * 1986-02-13 1987-08-27 Schering Ag Neue silane, verfahren zu ihrer herstellung und diese verbindungen enthaltende einsektizide mittel
US4804653A (en) * 1986-05-02 1989-02-14 Uniroyal Chemical Company, Inc. Thiomethyl-substituted organosilane compounds and their use as pesticides
DE3638073A1 (de) * 1986-11-07 1988-05-11 Swf Auto Electric Gmbh Vorrichtung, insbesondere hubwischeranlage fuer kraftfahrzeuge
US4783495A (en) * 1987-11-20 1988-11-08 Ciba-Geigy Corporation (Hydroxyphenyl) silane stabilizers
US5138012A (en) * 1988-07-29 1992-08-11 General Electric Company Silicone release coating compositions
DE4031001A1 (de) * 1990-10-01 1992-04-02 Hoechst Ag Verfahren zur herstellung von 4-ethoxyphenyl-3-arylpropyl-(dimethyl)silanen

Also Published As

Publication number Publication date
FI913252L (fi) 1992-01-06
EP0464852A1 (de) 1992-01-08
PT98220B (pt) 1998-12-31
NO180490B (no) 1997-01-20
KR0186005B1 (ko) 1999-05-15
CA2046051C (en) 2001-06-05
JP2963556B2 (ja) 1999-10-18
IL98712A0 (en) 1992-07-15
FI913252A0 (fi) 1991-07-04
GR3019393T3 (en) 1996-06-30
HU912272D0 (en) 1991-12-30
IE912340A1 (en) 1992-01-15
CN1029615C (zh) 1995-08-30
US5532400A (en) 1996-07-02
EP0464852B1 (de) 1996-03-20
KR920002617A (ko) 1992-02-28
JPH04230393A (ja) 1992-08-19
CA2046051A1 (en) 1992-01-06
DE69118028D1 (de) 1996-04-25
NO912630D0 (no) 1991-07-04
NZ238808A (en) 1994-02-25
HU211074B (en) 1995-10-30
AU639576B2 (en) 1993-07-29
CN1057843A (zh) 1992-01-15
NO180490C (no) 1997-04-30
ES2087180T3 (es) 1996-07-16
DK0464852T3 (da) 1996-04-15
DE69118028T2 (de) 1996-11-28
PT98220A (pt) 1992-05-29
FI101703B (fi) 1998-08-14
ZA915074B (en) 1992-04-29
AU8011691A (en) 1992-01-09
NO912630L (no) 1992-01-06
US5155250A (en) 1992-10-13
HUT58749A (en) 1992-03-30
FI101703B1 (fi) 1998-08-14
IL98712A (en) 1995-11-27

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee