ZA915074B - Novel 2,6-di-alkyl-4-silyl-phenols as antiatherosclerotic agents - Google Patents

Novel 2,6-di-alkyl-4-silyl-phenols as antiatherosclerotic agents

Info

Publication number
ZA915074B
ZA915074B ZA915074A ZA915074A ZA915074B ZA 915074 B ZA915074 B ZA 915074B ZA 915074 A ZA915074 A ZA 915074A ZA 915074 A ZA915074 A ZA 915074A ZA 915074 B ZA915074 B ZA 915074B
Authority
ZA
South Africa
Prior art keywords
silyl
phenols
alkyl
novel
antiatherosclerotic agents
Prior art date
Application number
ZA915074A
Other languages
English (en)
Inventor
Roger Alan Parker
Alan Parker Roger
Simon Jen Tan Mao
Jen Tan Mao Simon
Original Assignee
Merrell Dow Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharma filed Critical Merrell Dow Pharma
Publication of ZA915074B publication Critical patent/ZA915074B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
    • C09K15/00—Anti-oxidant compositions; Compositions inhibiting chemical change
    • C09K15/04—Anti-oxidant compositions; Compositions inhibiting chemical change containing organic compounds
    • C09K15/32—Anti-oxidant compositions; Compositions inhibiting chemical change containing organic compounds containing two or more of boron, silicon, phosphorus, selenium, tellurium or a metal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/0803—Compounds with Si-C or Si-Si linkages
    • C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Materials Engineering (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Endocrinology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Anti-Oxidant Or Stabilizer Compositions (AREA)
ZA915074A 1990-07-05 1991-07-01 Novel 2,6-di-alkyl-4-silyl-phenols as antiatherosclerotic agents ZA915074B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/548,052 US5155250A (en) 1990-07-05 1990-07-05 2,6-di-alkyl-4-silyl-phenols as antiatheroscerotic agents

Publications (1)

Publication Number Publication Date
ZA915074B true ZA915074B (en) 1992-04-29

Family

ID=24187205

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA915074A ZA915074B (en) 1990-07-05 1991-07-01 Novel 2,6-di-alkyl-4-silyl-phenols as antiatherosclerotic agents

Country Status (20)

Country Link
US (2) US5155250A (no)
EP (1) EP0464852B1 (no)
JP (1) JP2963556B2 (no)
KR (1) KR0186005B1 (no)
CN (1) CN1029615C (no)
AT (1) ATE135705T1 (no)
AU (1) AU639576B2 (no)
CA (1) CA2046051C (no)
DE (1) DE69118028T2 (no)
DK (1) DK0464852T3 (no)
ES (1) ES2087180T3 (no)
FI (1) FI101703B (no)
GR (1) GR3019393T3 (no)
HU (1) HU211074B (no)
IE (1) IE912340A1 (no)
IL (1) IL98712A (no)
NO (1) NO180490C (no)
NZ (1) NZ238808A (no)
PT (1) PT98220B (no)
ZA (1) ZA915074B (no)

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NZ238807A (en) * 1990-07-05 1994-03-25 Merrell Dow Pharma Bis[4-(2,6-dialkyl)phenol]silane derivatives and antiatherosclerotic compositions
FR2707989B1 (fr) * 1993-07-22 1995-10-13 Pf Medicament Nouveaux dérivés de benzylamines silylées, leurs sels, leurs procédés de fabrication et les compositions pharmaceutiques les renfermant.
US5677291A (en) * 1993-12-10 1997-10-14 Hoechst Marion Roussel, Inc. Method of lowering serum cholesterol levels with 2,6-di-alkyl-4-silyl-phenols
DK1468692T3 (da) * 1993-12-10 2006-08-28 Aventis Inc Anvendelse af 2,6-di-alkyl-4-silyl-phenoler til behandling af xantom
DE69430006T2 (de) * 1993-12-15 2002-11-28 Smithkline Beecham Corp., Philadelphia Verbindungen und verfahren
FR2722198B1 (fr) * 1994-07-08 1996-10-04 Pf Medicament 1derives de silylmethyl-anilines, le2fabrication, et leur utilisation co
JP2000509070A (ja) * 1996-04-30 2000-07-18 ヘキスト・マリオン・ルセル・インコーポレイテツド ２，６―ジアルキル―４―シリル―フェノールを使用して血管細胞接着分子―１を阻害する方法および慢性炎症性疾患を治療する方法
US5795876A (en) * 1996-04-30 1998-08-18 Hoechst Marion Rousssel, Inc. Method of inhibiting vascular cell adhesion molecule-1 and treating chronic inflammatory diseases with 2, 6-di-alkyl-4-silyl-phenols
US5608095A (en) * 1996-04-30 1997-03-04 Hoechst Marion Roussel, Inc. Alkyl-4-silyl-phenols and esters thereof as antiatherosclerotic agents
US6127489A (en) * 1996-05-20 2000-10-03 Smithkline Beecham Corporation Silyl linker for solid phase organic synthesis of aryl-containing molecules
US6114572A (en) * 1996-11-20 2000-09-05 Hoechst Marion Roussel, Inc. Substituted phenols and thiophenols useful as antioxidant agents
US6670398B2 (en) * 1997-05-14 2003-12-30 Atherogenics, Inc. Compounds and methods for treating transplant rejection
ES2283933T3 (es) * 1997-05-14 2007-11-01 Atherogenics, Inc. Ester del acido succinico de probucol para la inhibicion de la expresion de vcam-1.
US6121463A (en) * 1997-06-24 2000-09-19 Hoechst Marion Roussel, Inc. Alkyl-4-silylheterocyclic phenols and thiophenols useful as antioxidant agents
AU731278B2 (en) * 1997-06-24 2001-03-29 Aventis Pharmaceuticals Inc. Alkyl-4-silylheterocyclic phenols and thiophenols as antioxidant agents
AU7588498A (en) * 1997-06-25 1999-01-04 Hoechst Marion Roussel, Inc. 2,6-di-t-butyl-4-{ (dimethyl-4-methoxyphenylsilyl) -methyloxy}phenol and 2,6-di-t-butyl-4-{ (dimethyl-2-methoxy-phenylsilyl) -methyloxy}phenol
US6133467A (en) * 1997-06-25 2000-10-17 Hoechst Marion Roussel, Inc. 2,6-di-t-butyl-4-[(dimethyl-4-methoxyphenylsilyl)-methyl-oxy]phenol and 2,6-di-t-butyl-4-[(dimethyl-2-methoxy-phenylsilyl)methyloxy]phenol
WO1999001118A2 (en) * 1997-07-01 1999-01-14 Atherogenics, Inc. Antioxidant enhancement of therapy for hyperproliferative conditions
WO2000028332A1 (en) * 1998-11-09 2000-05-18 Atherogenics, Inc. Methods and compositions to lower plasma cholesterol levels
US6887712B1 (en) 1998-11-09 2005-05-03 Atherogenics, Inc. Methods and compositions to lower plasma cholesterol levels
JP4408982B2 (ja) * 1999-03-31 2010-02-03 東レ・ダウコーニング株式会社 フェノール基含有有機ケイ素化合物およびその製造方法
WO2002040021A2 (en) 2000-11-17 2002-05-23 Idenix (Cayman) Limited Methods for inhibiting the transmission of hiv using topically applied substituted 6-benzyl-4-oxopyrimidines
IL161522A0 (en) * 2001-10-25 2004-09-27 Atherogenics Inc Compounds and methods for treating transplant rejection
IL161741A0 (en) * 2001-11-09 2005-11-20 Atherogenics Inc Methods of reversing and preventingcardiovascular pathologies
MXPA04005864A (es) * 2001-12-19 2004-10-29 Atherogenics Inc Derivados de charcona y su uso para tratar enfermedades.
WO2004007423A1 (en) * 2002-07-12 2004-01-22 Atherogenics, Inc. Novel salt forms of poorly soluble probucol esters and ethers
AU2003266165A1 (en) * 2002-09-13 2004-04-30 Hossein Dovlatabadi Methods and compositons for the use of d-malic acid to decrease serum triglyceride, cholesterol, and lipoprotein levels
US20040181075A1 (en) * 2002-12-19 2004-09-16 Weingarten M. David Process of making chalcone derivatives
SG142207A1 (en) * 2003-01-13 2008-05-28 Atherogenics Inc Process of preparing esters and ethers of probucol and derivatives thereof
WO2004108094A2 (en) * 2003-06-06 2004-12-16 Atherogenics, Inc. Sulfonamide-substituted chalcone derivatives and their use to treat diseases
WO2005037251A1 (en) * 2003-10-17 2005-04-28 Amylin Pharmaceuticals, Inc. Self-emulsifying drug delivery systems for hydrophobic therapeutic compounds
WO2005037250A1 (en) * 2003-10-17 2005-04-28 Amylin Pharmaceuticals, Inc. Self emulsifying drug delivery systems for hydrophobic therapeutic compounds
EP1677804A1 (en) * 2003-10-17 2006-07-12 Amylin Pharmaceuticals, Inc. Silyl phenols for promoting vascular health
WO2005102323A2 (en) 2004-04-20 2005-11-03 Atherogenics, Inc. Process of preparing esters and ethers of probucol and derivatives thereof
WO2005112914A2 (en) 2004-04-20 2005-12-01 Atherogenics, Inc. Phenolic antioxidants for the treatment of disorders including arthritis, asthma and coronary artery disease
US20060063828A1 (en) * 2004-06-28 2006-03-23 Weingarten M D 1,2-Bis-(substituted-phenyl)-2-propen-1-ones and pharmaceutical compositions thereof
CA2571589A1 (en) * 2004-07-01 2006-01-19 Atherogenics, Inc. Compounds and methods for treating diabetic vascular diseases
CN101686676A (zh) * 2007-03-26 2010-03-31 沙路特里亚制药有限责任公司 用于治疗糖尿病的方法和普罗布考衍生物的组合物
US20080280985A1 (en) * 2007-03-27 2008-11-13 Scott Robert A D Methods and Compositions Using Certain Phenolic Derivatives for the Treatment of Diabetes
DE102007015948A1 (de) * 2007-04-03 2008-10-09 Bayer Materialscience Ag Modifizierte Polycarbonate, Polyestercarbonate und Polyester mit verbessertem Dehnverhalten und Flammwidrigkeit
US20090254425A1 (en) * 2008-04-02 2009-10-08 Evan Horowitz Wiki-type collective intelligence mechanism for implementing a url redirect

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US3328450A (en) * 1963-01-09 1967-06-27 Dow Corning Silylalkyl phenols
US3506674A (en) * 1967-07-03 1970-04-14 Gen Electric Certain pyridyl thio ether silanes
GB1232394A (no) * 1967-08-17 1971-05-19
US3853776A (en) * 1972-09-29 1974-12-10 Monsanto Co Low pour point fluids and blends containing same
US3801617A (en) * 1973-07-24 1974-04-02 Nasa Thiophenyl ether disiloxanes and trisiloxanes useful as lubricant fluids
GB2030581B (en) * 1978-08-18 1983-01-19 Ciba Geigy Ag Lubricant additives
US4624909A (en) * 1984-04-27 1986-11-25 Nec Corporation Silicon-containing novolak resin and resist material and pattern forming method using same
JPS61263988A (ja) * 1985-05-16 1986-11-21 Shionogi & Co Ltd シリル置換エ−テル類および殺虫・殺ダニ剤
US4636573A (en) * 1985-09-09 1987-01-13 Pastor Stephen D Hindered silicon ester stabilizers
DE3604781A1 (de) * 1986-02-13 1987-08-27 Schering Ag Neue silane, verfahren zu ihrer herstellung und diese verbindungen enthaltende einsektizide mittel
US4804653A (en) * 1986-05-02 1989-02-14 Uniroyal Chemical Company, Inc. Thiomethyl-substituted organosilane compounds and their use as pesticides
DE3638073A1 (de) * 1986-11-07 1988-05-11 Swf Auto Electric Gmbh Vorrichtung, insbesondere hubwischeranlage fuer kraftfahrzeuge
US4783495A (en) * 1987-11-20 1988-11-08 Ciba-Geigy Corporation (Hydroxyphenyl) silane stabilizers
US5138012A (en) * 1988-07-29 1992-08-11 General Electric Company Silicone release coating compositions
DE4031001A1 (de) * 1990-10-01 1992-04-02 Hoechst Ag Verfahren zur herstellung von 4-ethoxyphenyl-3-arylpropyl-(dimethyl)silanen

Also Published As

Publication number Publication date
HUT58749A (en) 1992-03-30
US5532400A (en) 1996-07-02
PT98220A (pt) 1992-05-29
DE69118028T2 (de) 1996-11-28
IL98712A0 (en) 1992-07-15
ATE135705T1 (de) 1996-04-15
NO180490B (no) 1997-01-20
US5155250A (en) 1992-10-13
PT98220B (pt) 1998-12-31
CN1057843A (zh) 1992-01-15
JP2963556B2 (ja) 1999-10-18
NO912630D0 (no) 1991-07-04
IL98712A (en) 1995-11-27
ES2087180T3 (es) 1996-07-16
KR0186005B1 (ko) 1999-05-15
AU639576B2 (en) 1993-07-29
EP0464852A1 (en) 1992-01-08
HU211074B (en) 1995-10-30
FI101703B1 (fi) 1998-08-14
EP0464852B1 (en) 1996-03-20
DE69118028D1 (de) 1996-04-25
FI101703B (fi) 1998-08-14
DK0464852T3 (da) 1996-04-15
AU8011691A (en) 1992-01-09
FI913252A0 (fi) 1991-07-04
CN1029615C (zh) 1995-08-30
HU912272D0 (en) 1991-12-30
JPH04230393A (ja) 1992-08-19
CA2046051C (en) 2001-06-05
CA2046051A1 (en) 1992-01-06
KR920002617A (ko) 1992-02-28
NO912630L (no) 1992-01-06
GR3019393T3 (en) 1996-06-30
IE912340A1 (en) 1992-01-15
NZ238808A (en) 1994-02-25
FI913252A (fi) 1992-01-06
NO180490C (no) 1997-04-30

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