NO180375C - Analogifremgangsmåte for fremstilling av terapeutisk aktivt 4-amino-2-(4-n-propylpiperazin-1-yl)-5-(2,3,5-triklorfenyl)pyrimidin - Google Patents

Analogifremgangsmåte for fremstilling av terapeutisk aktivt 4-amino-2-(4-n-propylpiperazin-1-yl)-5-(2,3,5-triklorfenyl)pyrimidin

Info

Publication number
NO180375C
NO180375C NO912100A NO912100A NO180375C NO 180375 C NO180375 C NO 180375C NO 912100 A NO912100 A NO 912100A NO 912100 A NO912100 A NO 912100A NO 180375 C NO180375 C NO 180375C
Authority
NO
Norway
Prior art keywords
hydrogen
halo
amino
alkyl
propylpiperazin
Prior art date
Application number
NO912100A
Other languages
English (en)
Norwegian (no)
Other versions
NO180375B (no
NO912100L (no
NO912100D0 (no
Inventor
Michael John Leach
Malcolm Stuart Nobbs
Ramachandran Iyer
Clive Leonard Yeates
Philip Alan Skone
Original Assignee
Wellcome Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wellcome Found filed Critical Wellcome Found
Publication of NO912100D0 publication Critical patent/NO912100D0/no
Publication of NO912100L publication Critical patent/NO912100L/no
Priority to NO954109A priority Critical patent/NO954109D0/no
Publication of NO180375B publication Critical patent/NO180375B/no
Publication of NO180375C publication Critical patent/NO180375C/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48—Two nitrogen atoms
    • C07D239/49—Two nitrogen atoms with an aralkyl radical, or substituted aralkyl radical, attached in position 5, e.g. trimethoprim
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48—Two nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Psychiatry (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Liquid Crystal Substances (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Paper (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
NO912100A 1990-06-01 1991-05-31 Analogifremgangsmåte for fremstilling av terapeutisk aktivt 4-amino-2-(4-n-propylpiperazin-1-yl)-5-(2,3,5-triklorfenyl)pyrimidin NO180375C (no)

Priority Applications (1)

Application Number Priority Date Filing Date Title
NO954109A NO954109D0 (no) 1990-06-01 1995-10-16 Analogifremgangsmåte for fremstilling av terapeutisk aktive substituerte 5-arylpyrimidiner

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB909012316A GB9012316D0 (en) 1990-06-01 1990-06-01 Pharmacologically active cns compounds

Publications (4)

Publication Number Publication Date
NO912100D0 NO912100D0 (no) 1991-05-31
NO912100L NO912100L (no) 1991-12-02
NO180375B NO180375B (no) 1996-12-30
NO180375C true NO180375C (no) 1997-04-09

Family

ID=10676964

Family Applications (1)

Application Number Title Priority Date Filing Date
NO912100A NO180375C (no) 1990-06-01 1991-05-31 Analogifremgangsmåte for fremstilling av terapeutisk aktivt 4-amino-2-(4-n-propylpiperazin-1-yl)-5-(2,3,5-triklorfenyl)pyrimidin

Country Status (25)

Country Link
EP (2) EP0679645A1 (cs)
JP (1) JPH06340634A (cs)
KR (1) KR920000733A (cs)
AT (1) ATE141263T1 (cs)
AU (2) AU652753B2 (cs)
CA (1) CA2043640A1 (cs)
CZ (1) CZ281070B6 (cs)
DE (1) DE69121317T2 (cs)
DK (1) DK0459819T3 (cs)
ES (1) ES2093078T3 (cs)
FI (1) FI912623A7 (cs)
GB (1) GB9012316D0 (cs)
GR (1) GR3021237T3 (cs)
HU (2) HUT58707A (cs)
IE (1) IE911861A1 (cs)
IL (2) IL98330A (cs)
MY (2) MY136248A (cs)
NO (1) NO180375C (cs)
NZ (3) NZ238360A (cs)
PL (2) PL170373B1 (cs)
PT (1) PT97827B (cs)
RU (1) RU2091374C1 (cs)
SK (1) SK278444B6 (cs)
TW (1) TW224460B (cs)
ZA (1) ZA914165B (cs)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI895821A7 (fi) * 1988-12-07 1990-06-08 The Wellcome Foundation Ltd Farmaseuttisesti aktivisia CNS-yhdisteitä
AU653203B2 (en) * 1991-01-30 1994-09-22 Wellcome Foundation Limited, The Water-dispersible tablets
US5629016A (en) * 1991-01-30 1997-05-13 Glaxo Wellcome Inc. Water-dispersible tablets
GB9215908D0 (en) * 1992-07-27 1992-09-09 Wellcome Found Water dispersible tablets
GB9226377D0 (en) * 1992-12-18 1993-02-10 Babbedge Rachel C Pharmaceutical compositions
WO1994014780A1 (en) * 1992-12-18 1994-07-07 The Wellcome Foundation Limited Pyrimidine, pyridine, pteridinone and indazole derivatives as enzyme inhibitors
US5698226A (en) * 1993-07-13 1997-12-16 Glaxo Wellcome Inc. Water-dispersible tablets
GB9319341D0 (en) * 1993-09-17 1993-11-03 Wellcome Found Novel process
FR2741879A1 (fr) * 1995-12-05 1997-06-06 Esteve Labor Dr Derives de fluorophenyl-triazines et pyrimidines, leur preparation et leur application en tant que medicament
US6440965B1 (en) * 1997-10-15 2002-08-27 Krenitsky Pharmaceuticals, Inc. Substituted pyrimidine derivatives, their preparation and their use in the treatment of neurodegenerative or neurological disorders of the central nervous system
DE19751949A1 (de) * 1997-11-24 1999-05-27 Bayer Ag Verwendung von substituierten Aminomethyl-Chromanen zur Verhinderung der neuronalen Degeneration und zur Förderung der neuronalen Regeneration
GB9726987D0 (en) 1997-12-22 1998-02-18 Glaxo Group Ltd Compounds
US6583148B1 (en) 1999-04-08 2003-06-24 Krenitsky Pharmaceuticals, Inc. Neurotrophic substituted pyrimidines
DE19918325A1 (de) * 1999-04-22 2000-10-26 Euro Celtique Sa Verfahren zur Herstellung von Arzneiformen mit regulierter Wirkstofffreisetzung mittels Extrusion
DK1219609T3 (da) 1999-09-16 2007-05-21 Tanabe Seiyaku Co Aromatiske nitrogenholdige 6-leddede ringforbindelser
ATE293962T1 (de) * 2000-02-25 2005-05-15 Hoffmann La Roche Adenosin-rezeptor modulatoren
CN1657523A (zh) 2000-04-28 2005-08-24 田边制药株式会社 环状化合物
US7273868B2 (en) 2000-04-28 2007-09-25 Tanabe Seiyaku Co., Ltd. Pyrazine derivatives
CA2416442C (en) * 2000-07-24 2010-06-08 Krenitsky Pharmaceuticals, Inc. Substituted 5-alkynyl pyrimidines having neurotrophic activity
MXPA03007623A (es) 2001-02-26 2003-12-04 Tanabe Seiyaku Co Derivado de piridopirimidina o naftiridina.
MXPA04007612A (es) * 2002-02-05 2004-11-10 Novo Nordisk As Aril- y heteroarilpiperazinas novedosas.
TW200637556A (en) * 2005-01-31 2006-11-01 Basf Ag Substituted 5-phenyl pyrimidines I in therapy
AU2006264966B2 (en) 2005-07-04 2013-02-21 High Point Pharmaceuticals, Llc Histamine H3 receptor antagonists
WO2007135111A1 (en) 2006-05-23 2007-11-29 High Point Pharmaceuticals, Llc 6- (4-cyclopropylpiperazin-1-yl) -2 ' -methyl- [3, 4 ' ] -bipyridine and its use as a medicament
CN102295606A (zh) 2006-05-29 2011-12-28 高点制药有限责任公司 合成3-（1，3-苯并间二氧杂环戊烯-5-基）-6-（4-环丙基哌嗪-1-基）-哒嗪的方法及其适用的中间体
EP2014656A3 (en) 2007-06-11 2011-08-24 High Point Pharmaceuticals, LLC New heteocyclic h3 antagonists
EP2718270B1 (en) 2011-06-10 2022-04-27 Merck Patent GmbH Compositions and methods for the production of pyrimidine and pyridine compounds with btk inhibitory activity
WO2015107493A1 (en) 2014-01-17 2015-07-23 Novartis Ag 1 -pyridazin-/triazin-3-yl-piper(-azine)/idine/pyrolidine derivatives and and compositions thereof for inhibiting the activity of shp2
JO3517B1 (ar) 2014-01-17 2020-07-05 Novartis Ag ان-ازاسبيرو الكان حلقي كبديل مركبات اريل-ان مغايرة وتركيبات لتثبيط نشاط shp2
MX383856B (es) 2016-06-14 2025-03-14 Novartis Ag Compuestos y composiciones para inhibir la actividad de shp2.
EP3568204B1 (en) 2017-01-10 2023-08-30 Novartis AG Pharmaceutical combination comprising an alk inhibitor and an shp2 inhibitor

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE518622A (cs) *
FI895821A7 (fi) * 1988-12-07 1990-06-08 The Wellcome Foundation Ltd Farmaseuttisesti aktivisia CNS-yhdisteitä
US5136080A (en) * 1989-12-04 1992-08-04 Burroughs Wellcome Co. Nitrile compounds

Also Published As

Publication number Publication date
NO180375B (no) 1996-12-30
ATE141263T1 (de) 1996-08-15
EP0459819B1 (en) 1996-08-14
GR3021237T3 (en) 1997-01-31
IL113599A0 (en) 1995-08-31
TW224460B (cs) 1994-06-01
HU911826D0 (en) 1991-12-30
MY136248A (en) 2008-08-29
NZ272001A (en) 1997-03-24
IE911861A1 (en) 1991-12-04
EP0459819A3 (en) 1992-03-11
PL166656B1 (pl) 1995-06-30
ZA914165B (en) 1993-03-01
DE69121317D1 (de) 1996-09-19
MY109958A (en) 1997-10-31
DK0459819T3 (da) 1996-09-02
IL113599A (en) 1997-09-30
GB9012316D0 (en) 1990-07-18
IL98330A0 (en) 1992-06-21
EP0459819A2 (en) 1991-12-04
HUT58707A (en) 1992-03-30
FI912623A0 (fi) 1991-05-31
AU7809791A (en) 1991-12-05
CA2043640A1 (en) 1991-12-02
AU680252B2 (en) 1997-07-24
ES2093078T3 (es) 1996-12-16
CS164391A3 (en) 1992-02-19
NO912100L (no) 1991-12-02
FI912623A7 (fi) 1991-12-02
PT97827A (pt) 1992-03-31
JPH06340634A (ja) 1994-12-13
AU652753B2 (en) 1994-09-08
CZ281070B6 (cs) 1996-06-12
NZ248501A (en) 1997-03-24
DE69121317T2 (de) 1997-01-02
RU2091374C1 (ru) 1997-09-27
PT97827B (pt) 1998-10-30
EP0679645A1 (en) 1995-11-02
IL98330A (en) 1996-10-31
AU6745594A (en) 1994-09-15
NZ238360A (en) 1997-03-24
KR920000733A (ko) 1992-01-29
NO912100D0 (no) 1991-05-31
PL170373B1 (pl) 1996-12-31
SK278444B6 (en) 1997-05-07
HU211649A9 (en) 1995-12-28

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