NO179995C - Fremgangsmåte for fremstilling av legemiddel-lipidsystemer med lav toksisitet inneholdende polyen-antibiotika - Google Patents

Fremgangsmåte for fremstilling av legemiddel-lipidsystemer med lav toksisitet inneholdende polyen-antibiotika

Info

Publication number
NO179995C
NO179995C NO884391A NO884391A NO179995C NO 179995 C NO179995 C NO 179995C NO 884391 A NO884391 A NO 884391A NO 884391 A NO884391 A NO 884391A NO 179995 C NO179995 C NO 179995C
Authority
NO
Norway
Prior art keywords
lipid
compositions
preparation
low
systems containing
Prior art date
Application number
NO884391A
Other languages
English (en)
Norwegian (no)
Other versions
NO884391D0 (no
NO884391L (no
NO179995B (no
Inventor
Andrew Stuart Janoff
Lawrence Boni
Thomas D Madden
Pieter R Cullis
Robert P Lenk
John J Kearns
Anthony G Durning
Robert Klimchak
Joel Portnoff
Original Assignee
Liposome Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27361805&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO179995(C) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Liposome Co Inc filed Critical Liposome Co Inc
Publication of NO884391D0 publication Critical patent/NO884391D0/no
Publication of NO884391L publication Critical patent/NO884391L/no
Priority to NO944071A priority Critical patent/NO180147C/no
Publication of NO179995B publication Critical patent/NO179995B/no
Publication of NO179995C publication Critical patent/NO179995C/no
Priority to NO1998013C priority patent/NO1998013I1/no

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/543—Lipids, e.g. triglycerides; Polyamines, e.g. spermine or spermidine
    • A61K47/544—Phospholipids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1277—Processes for preparing; Proliposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • G—PHYSICS
    • G03—PHOTOGRAPHY; CINEMATOGRAPHY; ANALOGOUS TECHNIQUES USING WAVES OTHER THAN OPTICAL WAVES; ELECTROGRAPHY; HOLOGRAPHY
    • G03B—APPARATUS OR ARRANGEMENTS FOR TAKING PHOTOGRAPHS OR FOR PROJECTING OR VIEWING THEM; APPARATUS OR ARRANGEMENTS EMPLOYING ANALOGOUS TECHNIQUES USING WAVES OTHER THAN OPTICAL WAVES; ACCESSORIES THEREFOR
    • G03B2227/00—Photographic printing apparatus
    • G03B2227/32—Projection printing apparatus, e.g. enlarging apparatus, copying camera
    • G03B2227/325—Microcapsule copiers

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Dispersion Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
  • Vehicle Step Arrangements And Article Storage (AREA)
  • Catalysts (AREA)
  • Vehicle Interior And Exterior Ornaments, Soundproofing, And Insulation (AREA)
NO884391A 1987-03-05 1988-10-04 Fremgangsmåte for fremstilling av legemiddel-lipidsystemer med lav toksisitet inneholdende polyen-antibiotika NO179995C (no)

Priority Applications (2)

Application Number Priority Date Filing Date Title
NO944071A NO180147C (no) 1987-03-05 1994-10-26 Fremgangsmåte for fremstilling av HDLC eller et liposom innbefattende et polyen-antisopp-antibiotikum og et lipid
NO1998013C NO1998013I1 (no) 1987-03-05 1998-03-25 Amfotericin B Lipid-kompleks

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US2215787A 1987-03-05 1987-03-05
US6990887A 1987-07-06 1987-07-06
US7930987A 1987-07-29 1987-07-29
PCT/US1988/000647 WO1988006443A1 (en) 1987-03-05 1988-03-03 Low toxicity drug-lipid systems

Publications (4)

Publication Number Publication Date
NO884391D0 NO884391D0 (no) 1988-10-04
NO884391L NO884391L (no) 1988-11-24
NO179995B NO179995B (no) 1996-10-21
NO179995C true NO179995C (no) 1997-01-29

Family

ID=27361805

Family Applications (4)

Application Number Title Priority Date Filing Date
NO884391A NO179995C (no) 1987-03-05 1988-10-04 Fremgangsmåte for fremstilling av legemiddel-lipidsystemer med lav toksisitet inneholdende polyen-antibiotika
NO944071A NO180147C (no) 1987-03-05 1994-10-26 Fremgangsmåte for fremstilling av HDLC eller et liposom innbefattende et polyen-antisopp-antibiotikum og et lipid
NO1998012C NO1998012I1 (no) 1987-03-05 1998-03-25 Amfotericin B Lipid-kompleks
NO1998013C NO1998013I1 (no) 1987-03-05 1998-03-25 Amfotericin B Lipid-kompleks

Family Applications After (3)

Application Number Title Priority Date Filing Date
NO944071A NO180147C (no) 1987-03-05 1994-10-26 Fremgangsmåte for fremstilling av HDLC eller et liposom innbefattende et polyen-antisopp-antibiotikum og et lipid
NO1998012C NO1998012I1 (no) 1987-03-05 1998-03-25 Amfotericin B Lipid-kompleks
NO1998013C NO1998013I1 (no) 1987-03-05 1998-03-25 Amfotericin B Lipid-kompleks

Country Status (20)

Country Link
EP (1) EP0282405B2 (ko)
KR (1) KR970002870B1 (ko)
CN (1) CN1044093C (ko)
AT (1) ATE118169T1 (ko)
AU (1) AU622405B2 (ko)
CA (1) CA1338701C (ko)
DE (1) DE3852961T3 (ko)
DK (1) DK176010B1 (ko)
ES (1) ES2070131T5 (ko)
FI (1) FI102724B1 (ko)
GR (1) GR3015916T3 (ko)
HK (1) HK1007495A1 (ko)
IE (1) IE67152B1 (ko)
IL (1) IL85607A (ko)
LU (1) LU88684I2 (ko)
NL (1) NL990004I1 (ko)
NO (4) NO179995C (ko)
NZ (1) NZ223660A (ko)
PT (1) PT86913B (ko)
WO (1) WO1988006443A1 (ko)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5830498A (en) * 1987-10-16 1998-11-03 Board Of Regents, The University Of Texas System Liposomal-polyene preliposomal powder and method for its preparation
US5178875A (en) * 1991-01-14 1993-01-12 The Board Of Regents, The University Of Texas System Liposomal-polyene preliposomal powder and method for its preparation
AU598958B2 (en) 1987-11-12 1990-07-05 Vestar, Inc. Improved amphotericin b liposome preparation
JP2798302B2 (ja) * 1989-03-31 1998-09-17 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア リポソームおよび脂質複合体組成物の調製
US5188951A (en) * 1990-04-17 1993-02-23 The Liposome Company, Inc. Enzymatic synthesis of soluble phosphatides from phospholipids
US5556637A (en) * 1990-08-06 1996-09-17 A. Nattermann & Cie. Gmbh Water containing liposome system
DE4108902A1 (de) * 1990-08-06 1992-02-13 Nattermann A & Cie Wasserhaltiges liposomensystem
US5534502A (en) * 1990-11-06 1996-07-09 Nippon Shinyaku Co. Ltd. Process for producing fat emulsion
WO1992007571A1 (fr) * 1990-11-06 1992-05-14 Nippon Shinyaku Co., Ltd. Procede de production d'une emulsion grasse
CA2113272A1 (en) * 1991-08-14 1993-03-04 Francis J. Martin Hiv-treatment method with low-toxicity amphotericin b
DK0699068T3 (da) * 1993-05-21 2002-03-11 Liposome Co Inc Reduktion af liposominducerede fysiologiske bivirkninger
US5716526A (en) * 1994-01-14 1998-02-10 The Liposome Company, Inc. Method of separating materials from liposomes or lipid complexes
US5902604A (en) * 1995-06-06 1999-05-11 Board Of Regents, The University Of Texas System Submicron liposome suspensions obtained from preliposome lyophilizates
GB2326337A (en) 1997-06-20 1998-12-23 Phares Pharma Holland Homogeneous lipid compositions for drug delivery
US6165997A (en) * 1997-11-20 2000-12-26 Statens Serum Institut Phospholipids having antimicrobial activity with or without the presence of antimicrobials
JP2009519250A (ja) * 2005-12-08 2009-05-14 ワイス リポソーム組成物
KR101132626B1 (ko) * 2009-10-12 2012-04-02 주식회사 녹십자 난용성 약물의 전달을 위한 고밀도지단백 나노입자의 제조방법
WO2012023955A1 (en) 2010-08-20 2012-02-23 Dr. Reddy's Laboratories, Ltd. Phospholipid depot
EP2629779B1 (en) 2010-10-22 2017-06-21 Dr. Reddy's Laboratories SA. Use of storage stable viscous phospholipid depot to treat wounds
RU2678433C2 (ru) 2012-05-10 2019-01-29 Пейнреформ Лтд. Депо-составы гидрофобного активного ингредиента и способы их получения
US10799456B2 (en) 2015-06-15 2020-10-13 University Of Washington Multiple drug lipid nanoparticle composition and related methods for extended drug levels in blood and lymph tissue

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4310506A (en) * 1979-02-22 1982-01-12 California Institute Of Technology Means of preparation and applications of liposomes containing high concentrations of entrapped ionic species
FR2521565B1 (fr) * 1982-02-17 1985-07-05 Dior Sa Parfums Christian Melange pulverulent de constituants lipidiques et de constituants hydrophobes, procede pour le preparer, phases lamellaires lipidiques hydratees et procede de fabrication, compositions pharmaceutiques ou cosmetiques comportant des phases lamellaires lipidiques hydratees
US4604376A (en) * 1982-04-21 1986-08-05 Research Corporation Enteric compounds and complexes
US4436746A (en) * 1982-09-30 1984-03-13 Ciba-Geigy Corporation Thromboxane synthetase inhibitory N-substituted-2-(1-imidazolyl)indoles
US4622219A (en) * 1983-06-17 1986-11-11 Haynes Duncan H Method of inducing local anesthesia using microdroplets of a general anesthetic
IL78930A0 (en) * 1985-07-29 1986-09-30 Abbott Lab Lyophilized emulsion compositions for parenteral administration
IL78929A0 (en) * 1985-07-29 1986-09-30 Abbott Lab Microemulsion compositions for parenteral administration

Also Published As

Publication number Publication date
NO944071L (no) 1988-11-24
NO180147B (no) 1996-11-18
IE880600L (en) 1988-09-05
EP0282405A3 (en) 1989-01-04
FI102724B (fi) 1999-02-15
IE67152B1 (en) 1996-03-06
PT86913B (pt) 1993-07-30
ES2070131T5 (es) 1998-10-01
DK176010B1 (da) 2005-11-28
FI894161A0 (fi) 1989-09-04
NO1998012I1 (no) 1998-03-25
CN1044093C (zh) 1999-07-14
AU1799088A (en) 1988-09-26
ATE118169T1 (de) 1995-02-15
NO1998013I1 (no) 1998-03-25
GR3015916T3 (en) 1995-07-31
EP0282405B1 (en) 1995-02-08
ES2070131T3 (es) 1995-06-01
DK98089D0 (da) 1989-03-01
NO884391D0 (no) 1988-10-04
WO1988006443A1 (en) 1988-09-07
DK98089A (da) 1989-03-01
EP0282405A2 (en) 1988-09-14
LU88684I2 (fr) 1996-04-29
AU622405B2 (en) 1992-04-09
EP0282405B2 (en) 1998-07-22
DE3852961T2 (de) 1995-07-06
NO884391L (no) 1988-11-24
NO944071D0 (no) 1994-10-26
CN88101864A (zh) 1988-09-28
IL85607A0 (en) 1988-08-31
NO179995B (no) 1996-10-21
DE3852961D1 (de) 1995-03-23
FI102724B1 (fi) 1999-02-15
PT86913A (pt) 1989-03-30
KR970002870B1 (ko) 1997-03-12
IL85607A (en) 1992-08-18
DE3852961T3 (de) 1998-12-24
NO180147C (no) 1997-02-26
NL990004I1 (nl) 1999-04-01
KR890700341A (ko) 1989-04-24
HK1007495A1 (en) 1999-04-16
NZ223660A (en) 1990-11-27
CA1338701C (en) 1996-11-12

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