NO174510C - - Google Patents

Info

Publication number
NO174510C
NO174510C NO861621A NO861621A NO174510C NO 174510 C NO174510 C NO 174510C NO 861621 A NO861621 A NO 861621A NO 861621 A NO861621 A NO 861621A NO 174510 C NO174510 C NO 174510C
Authority
NO
Norway
Prior art keywords
sup
ethylene
compounds
general formula
effects
Prior art date
Application number
NO861621A
Other languages
English (en)
Norwegian (no)
Other versions
NO174510B (no
NO861621L (no
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Publication of NO861621L publication Critical patent/NO861621L/no
Publication of NO174510B publication Critical patent/NO174510B/no
Publication of NO174510C publication Critical patent/NO174510C/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C07F9/65616—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
NO861621A 1985-04-25 1986-04-24 Anlogifremgangsmaate for fremstilling av terapeutisk aktivt 9-(2- fosfonylmethoxyethyl)-adenin NO174510B (no)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CS853017A CS263951B1 (en) 1985-04-25 1985-04-25 9-(phosponylmethoxyalkyl)adenines and method of their preparation

Publications (3)

Publication Number Publication Date
NO861621L NO861621L (no) 1986-10-27
NO174510B NO174510B (no) 1994-02-07
NO174510C true NO174510C (fr) 1994-05-18

Family

ID=5369028

Family Applications (1)

Application Number Title Priority Date Filing Date
NO861621A NO174510B (no) 1985-04-25 1986-04-24 Anlogifremgangsmaate for fremstilling av terapeutisk aktivt 9-(2- fosfonylmethoxyethyl)-adenin

Country Status (13)

Country Link
US (1) US4808716A (fr)
EP (1) EP0206459B1 (fr)
JP (1) JPS61275289A (fr)
AT (1) ATE78259T1 (fr)
AU (1) AU580151B2 (fr)
CA (1) CA1295614C (fr)
CS (1) CS263951B1 (fr)
DE (1) DE3686002T2 (fr)
DK (1) DK173625B1 (fr)
EG (1) EG18079A (fr)
HK (1) HK213296A (fr)
NO (1) NO174510B (fr)
NZ (1) NZ215925A (fr)

Families Citing this family (86)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5047533A (en) * 1983-05-24 1991-09-10 Sri International Acyclic purine phosphonate nucleotide analogs
US4845084A (en) * 1984-01-26 1989-07-04 Merck & Co., Inc. Phosphate derivatives of substituted butyl guanines, antiviral compositions containing them, and methods of treating viral infections with them
CS264222B1 (en) * 1986-07-18 1989-06-13 Holy Antonin N-phosphonylmethoxyalkylderivatives of bases of pytimidine and purine and method of use them
US5650510A (en) * 1986-11-18 1997-07-22 Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic Antiviral phosphonomethoxyalkylene purine and pyrimidine derivatives
IL84477A (en) * 1986-11-18 1995-12-08 Bristol Myers Squibb Co History of Phosphonomethoxyalkylene Purinopyrimidine and Pharmaceutical Preparations Containing Them
US5247085A (en) * 1987-11-30 1993-09-21 Beecham Group P.L.C. Antiviral purine compounds
PT89098B (pt) * 1987-11-30 1993-03-31 Beecham Group Plc Processo para a preparacao de derivados de guanina
EP0335770B1 (fr) * 1988-04-01 1997-01-15 Merrell Pharmaceuticals Inc. Dérivés de nucléotides de fluorophosphonates
EP0339161A1 (fr) * 1988-04-01 1989-11-02 Merrell Dow Pharmaceuticals Inc. Dérivés de nucléotides de fluorophosphonates
US5284837A (en) * 1988-05-06 1994-02-08 Medivir Ab Derivatives of purine, process for their preparation and a pharmaceutical preparation
EP0353955A3 (fr) * 1988-08-02 1991-08-14 Beecham Group Plc Composés chimiques
US5744600A (en) * 1988-11-14 1998-04-28 Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic Phosphonomethoxy carbocyclic nucleosides and nucleotides
US4966895A (en) * 1989-02-02 1990-10-30 Merck & Co. Inc. Cyclic monophosphates of purine and pyrimidine acyclonucleosides as anti-retroviral agents
US5688778A (en) * 1989-05-15 1997-11-18 Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic Nucleoside analogs
GB8912043D0 (en) * 1989-05-25 1989-07-12 Beecham Group Plc Novel compounds
US5302585A (en) * 1990-04-20 1994-04-12 Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic Use of chiral 2-(phosphonomethoxy)propyl guanines as antiviral agents
CS276072B6 (en) * 1990-08-06 1992-03-18 Ustav Organicke Chemie A Bioch (2R)-2-/DI(2-PROPYL)PHOSPHONYLMETHOXY/-3-p-TOLUENESULFONYLOXY -1- TRIMETHYLACETOXYPROPANE AND PROCESS FOR PREPARING THEREOF
WO1992002511A1 (fr) * 1990-08-10 1992-02-20 Bristol-Myers Squibb Company Nouveau procede de preparation de nucleotides
DE10399025I2 (de) * 1990-09-14 2007-11-08 Acad Of Science Czech Republic Wirkstoffvorläufer von Phosphonaten
US5208221A (en) * 1990-11-29 1993-05-04 Bristol-Myers Squibb Company Antiviral (phosphonomethoxy) methoxy purine/pyrimidine derivatives
US6057305A (en) 1992-08-05 2000-05-02 Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic Antiretroviral enantiomeric nucleotide analogs
US5514798A (en) * 1993-06-02 1996-05-07 Gilead Sciences, Inc. Method and cyclic carbonates for nucleotide analogues
JPH09506333A (ja) * 1993-09-17 1997-06-24 ギリアード サイエンシーズ，インコーポレイテッド 治療化合物の投薬方法
US5656745A (en) * 1993-09-17 1997-08-12 Gilead Sciences, Inc. Nucleotide analogs
US5798340A (en) * 1993-09-17 1998-08-25 Gilead Sciences, Inc. Nucleotide analogs
DE4408534A1 (de) * 1994-03-14 1995-09-28 Hoechst Ag Substituierte N-Ethyl-Glycinderivate zur Herstellung von PNA und PNA-/DNA-Hybriden
US6465650B1 (en) 1995-03-13 2002-10-15 Aventis Pharma Deutschland Gmbh Substituted N-ethylglycine derivatives for preparing PNA and PNA/DNA hybrids
US5977061A (en) * 1995-04-21 1999-11-02 Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic N6 - substituted nucleotide analagues and their use
US5877166A (en) * 1996-04-29 1999-03-02 Sri International Enantiomerically pure 2-aminopurine phosphonate nucleotide analogs as antiviral agents
US5733788A (en) * 1996-07-26 1998-03-31 Gilead Sciences, Inc. PMPA preparation
ATE240339T1 (de) * 1996-07-26 2003-05-15 Gilead Sciences Inc Nukleotidanaloga
US5935946A (en) * 1997-07-25 1999-08-10 Gilead Sciences, Inc. Nucleotide analog composition and synthesis method
JP4173202B2 (ja) * 1997-07-25 2008-10-29 ギリアード サイエンシーズ，インコーポレイテッド ヌクレオチドアナログ組成物および合成方法
AU2645199A (en) * 1998-11-18 2000-06-05 Viktor Veniaminovich Tets Dialkyl-1-aryl-1-(2,4-dioxo-5-amino-1,3-pyrimidin-5-yl)methy lphosphonates
US7205404B1 (en) * 1999-03-05 2007-04-17 Metabasis Therapeutics, Inc. Phosphorus-containing prodrugs
KR100767432B1 (ko) 2000-07-21 2007-10-17 길리애드 사이언시즈, 인코포레이티드 포스포네이트 뉴클레오티드 유사체의 전구 약물과 그것의 선택 및 제조 방법
IL159494A0 (en) * 2001-06-29 2004-06-01 Acad Of Science Czech Republic 6-2'-(phosphonomethoxy) alkoxy pyrimidine derivatives having antiviral activity
IL161901A0 (en) * 2001-11-14 2005-11-20 Biocryst Pharmaceuticals Inc A Nucleosides, preparation thereof and use as inhibiDevice for the reading and the signalling of environmental parameters tors of rna viral polymerases
US7388002B2 (en) 2001-11-14 2008-06-17 Biocryst Pharmaceuticals, Inc. Nucleosides, preparation thereof and use as inhibitors of RNA viral polymerases
NZ536328A (en) * 2002-05-13 2007-11-30 Metabasis Therapeutics Inc Novel phosphonic acid based prodrugs of PMEA and its analogues
JP4332496B2 (ja) * 2002-05-13 2009-09-16 メタバシス・セラピューティクス・インコーポレイテッド Ｐｍｅａおよびｐｍｐａ環生成合成
AU2003284800A1 (en) * 2002-11-12 2004-06-03 Tianjin Kinsly Pharmaceutical Co., Ltd. A new crystal form of adefovir dipivoxil and its composition
DE602004014470D1 (de) 2003-01-14 2008-07-31 Gilead Sciences Inc Zusammensetzungen und verfahren zur antiviralen kombinationstherapie
NZ543864A (en) 2003-06-16 2009-10-30 Leuven K U Res & Dev Pyrimidine compounds having phosphonate groups as antiviral nucleotide analogs
AU2004260789B2 (en) * 2003-07-30 2011-06-30 Gilead Sciences, Inc. Nucleobase phosphonate analogs for antiviral treatment
RU2006138907A (ru) * 2004-06-08 2008-07-20 Метабазис Терапеутикс Синтез сложных циклических эфиров с применением кислоты льюиса
CN100338080C (zh) * 2004-06-16 2007-09-19 山东中科泰斗化学有限公司 9－[2－(膦羧基甲氧基)乙基]腺嘌呤双环醇酯及其制备方法
UA93354C2 (ru) 2004-07-09 2011-02-10 Гилиад Сайенсиз, Инк. Местный противовирусный препарат
WO2006066074A2 (fr) 2004-12-16 2006-06-22 The Regents Of The University Of California Medicaments destines au poumon
WO2006130217A2 (fr) * 2005-04-01 2006-12-07 The Regents Of The University Of California Esters de phosphate de phosphonates de nucleosides substitues
TWI375560B (en) 2005-06-13 2012-11-01 Gilead Sciences Inc Composition comprising dry granulated emtricitabine and tenofovir df and method for making the same
TWI471145B (zh) 2005-06-13 2015-02-01 Bristol Myers Squibb & Gilead Sciences Llc 單一式藥學劑量型
EP2305696A3 (fr) 2005-07-25 2011-10-12 Intermune, Inc. Inhibiteurs macrocycliques de la multiplication du virus de L'Hépatite C
US7737273B2 (en) * 2005-07-26 2010-06-15 Hetero Drugs Limited Process for acyclic phosphonate nucleotide analogs
KR20080056295A (ko) * 2005-10-11 2008-06-20 인터뮨, 인크. Ｃ형 간염 바이러스 복제를 억제하기 위한 화합물 및 방법
KR20080091767A (ko) * 2005-12-14 2008-10-14 씨아이피엘에이 엘티디. (테노포비어 및 라미뷰딘과 같은) 뉴클레오티드 역전사효소억제제 및 뉴클레오시드 역전사효소 억제제를 투여 단위의상이한 부분에 포함하는 약제학적 조합물
FR2908133B1 (fr) * 2006-11-08 2012-12-14 Centre Nat Rech Scient Nouveaux analogues de nucleotides comme molecules precurseurs d'antiviraux
PT2159224E (pt) 2007-06-18 2012-10-24 Sunshine Lake Pharma Co Ltd Tiazolil dihidropirimidinas substituídas com bromo-fenilo
TWI444384B (zh) 2008-02-20 2014-07-11 Gilead Sciences Inc 核苷酸類似物及其在治療惡性腫瘤上的用途
US20110059921A1 (en) * 2008-03-27 2011-03-10 Ektar Therapeutics Oligomer-Nitrogenous Base Conjugates
US7935817B2 (en) * 2008-03-31 2011-05-03 Apotex Pharmachem Inc. Salt form and cocrystals of adefovir dipivoxil and processes for preparation thereof
AU2009249443A1 (en) * 2008-04-15 2009-11-26 Intermune, Inc. Novel macrocyclic inhibitors of hepatitis C virus replication
US8173621B2 (en) 2008-06-11 2012-05-08 Gilead Pharmasset Llc Nucleoside cyclicphosphates
TW201010692A (en) 2008-06-19 2010-03-16 Public Univ Corp Nagoya City Univ Pharmaceutical composition for treatment or prevention of hbv infection
EA201170441A1 (ru) * 2008-10-15 2012-05-30 Интермьюн, Инк. Терапевтические противовирусные пептиды
NZ593647A (en) 2008-12-23 2013-08-30 Gilead Pharmasset Llc Synthesis of purine nucleosides
MX2011006891A (es) 2008-12-23 2011-10-06 Pharmasset Inc Fosforamidatos de nucleosidos.
EP2376514A2 (fr) 2008-12-23 2011-10-19 Pharmasset, Inc. Analogues de nucléoside
WO2010110622A2 (fr) 2009-03-26 2010-09-30 Daewoong Pharmaceutical Co., Ltd. Nouvelles formes cristallisées de l'adéfovir dipivoxil et leurs procédés de préparation
EA201290128A1 (ru) * 2009-09-28 2013-01-30 Интермьюн, Инк. Новые макроциклические ингибиторы репликации вируса гепатита с
WO2011041551A1 (fr) * 2009-10-01 2011-04-07 Intermune, Inc. Peptides antiviraux thérapeutiques
AU2011235112B2 (en) 2010-03-31 2015-07-09 Gilead Pharmasset Llc Nucleoside phosphoramidates
WO2011156594A2 (fr) 2010-06-09 2011-12-15 Vaccine Technologies, Incorporated Immunisation thérapeutique chez des patients infectés par le vih recevant un traitement antirétroviral stable
US20130216590A1 (en) 2010-06-11 2013-08-22 Quarraisha Abdool Karim Topical antiviral formulations for prevention of transmission of hsv-2
BR112013014485B1 (pt) 2010-12-10 2021-03-30 Sigmapharm Laboratories, Llc Composições farmacêuticas compreendendo pró-fármacos análogos de nucleotídeos de fosfonato ativos por via oral e sistema de embalagem de recipiente/fechamento contendo as ditas composições
WO2012154698A2 (fr) * 2011-05-06 2012-11-15 Mckenna Charles E Procédé d'amélioration de l'activité antivirale de médicaments analogues de nucléotides
CN103665043B (zh) 2012-08-30 2017-11-10 江苏豪森药业集团有限公司 一种替诺福韦前药及其在医药上的应用
AU2013340559B2 (en) 2012-10-29 2018-03-15 Cipla Limited Antiviral phosphonate analogues and process for preparation thereof
BR112015023705A8 (pt) 2013-03-15 2020-03-17 Univ California compostos, composições farmacêuticas, usos de um composto, e método para síntese do composto da fórmula (ia)
US10449210B2 (en) 2014-02-13 2019-10-22 Ligand Pharmaceuticals Inc. Prodrug compounds and their uses
US10167302B2 (en) * 2014-05-23 2019-01-01 University College Cork Phosphonate nucleosides useful in the treatment of viral diseases
CN106687118A (zh) 2014-07-02 2017-05-17 配体药物公司 前药化合物及其用途
PL3194411T3 (pl) 2014-09-15 2022-06-20 The Regents Of The University Of California Analogi nukleotydów
WO2017048956A1 (fr) 2015-09-15 2017-03-23 The Regents Of The University Of California Analogues nucléotidiques
EP3372227A1 (fr) 2017-03-06 2018-09-12 MH10 Spolka z ograniczona odpowiedzialnoscia Formulation de comprimé d'adéfovir dipivoxil
AU2019207625A1 (en) 2018-01-09 2020-07-30 Ligand Pharmaceuticals, Inc. Acetal compounds and therapeutic uses thereof

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1523865A (en) * 1974-09-02 1978-09-06 Wellcome Found Purine compunds and salts thereof
US4347360A (en) * 1980-09-16 1982-08-31 Ens Bio Logicals Inc. Ring open nucleoside analogues
CS233665B1 (en) * 1983-01-06 1985-03-14 Antonin Holy Processing of isomere o-phosphonylmethylderivative of anantiomere racemic vicinal diene
EP0145739B1 (fr) * 1983-05-24 1989-02-08 Sri International Nouveaux agents antiviraux
AU8092587A (en) * 1986-11-18 1988-05-19 Bristol-Myers Squibb Company Synthesis of purin-9-ylalkylenoxymethyl phosphonic acids

Also Published As

Publication number Publication date
NO174510B (no) 1994-02-07
JPS61275289A (ja) 1986-12-05
AU5632886A (en) 1986-10-30
EP0206459B1 (fr) 1992-07-15
ATE78259T1 (de) 1992-08-15
NZ215925A (en) 1989-01-27
DK167886A (da) 1986-10-26
DK167886D0 (da) 1986-04-11
EP0206459A2 (fr) 1986-12-30
DK173625B1 (da) 2001-05-07
NO861621L (no) 1986-10-27
CA1295614C (fr) 1992-02-11
DE3686002D1 (de) 1992-08-20
CS263951B1 (en) 1989-05-12
US4808716A (en) 1989-02-28
HK213296A (en) 1996-12-06
DE3686002T2 (de) 1992-12-17
JPH0433798B2 (fr) 1992-06-04
AU580151B2 (en) 1989-01-05
EG18079A (en) 1992-06-30
EP0206459A3 (en) 1987-05-20

Similar Documents

Publication Publication Date Title
AU580151B2 (en) 9-(phosphonylmethoxyalkyl) adenines, the method of preparation and utilization thereof
AU557103B2 (en) S-triazine derivatives and their use as sun screen agents
AU527881B2 (en) 9-(hydroxyalkyl) purines
AU586691B2 (en) Diamino-androstane derivatives, process for their preparation and pharmaceutical compositions containing them
DE3261797D1 (en) Octahydrobenzo(f)quinoline compounds
ES8505518A1 (es) Procedimiento para preparar derivados de aminoacidos
ES8101550A1 (es) Un procedimiento para la preparacion de nuevos derivados de 2-pirrolidin-metanol.
ES8505806A1 (es) Procedimiento para preparar nuevas sales de alquil(mixto) sulfonio de n-fosfonome-tilglicina
ES8705357A1 (es) Procedimiento para preparar nuevos derivados del 1,1,2,2-tetrametil-1,2-bis-(2-fluoro-4-hidroxi-fenil)-etano
DE3672446D1 (en) Pantothenolderivate.
DE3564426D1 (en) Polyprenyl compound, process of producing it and pharmaceutical use
ES8105268A1 (es) Procedimiento para preparar derivados de acido acilaminoben-zoico
ES8504139A1 (es) Procedimiento para preparar derivados de bencimidazol.
AU6306886A (en) Alkylcarboxamides of pyridylalkylamines, their preparation and their use in human and veterinary medicine
ES8600251A1 (es) Metodo de preparar nuevos 2-acilamino-5-feniletenilbencimidazoles
JPS548627A (en) 2-alkoxyalkoxy-5-nitrobenzenesulfonic acid and its salt
AU2172688A (en) Preparation of dien-1-ols, 9-hydroxydodec-10-enyl 1-tert-butyl ether and use thereof as an intermediate for synthesizing, 8,10-dodecadienol
ES8403102A1 (es) Un procedimiento para la preparacion de esteres fluorofenoxibencilicos.
ES8304990A1 (es) Procedimiento para la preparacion de derivados espiro-1 farmaceuticamente activos.