NO173440C - Analogifremgangsmaate for fremstilling av terapeutisk aktive cyclodextrinclathrater av carbacyclinanaloger - Google Patents

Analogifremgangsmaate for fremstilling av terapeutisk aktive cyclodextrinclathrater av carbacyclinanaloger

Info

Publication number
NO173440C
NO173440C NO874632A NO874632A NO173440C NO 173440 C NO173440 C NO 173440C NO 874632 A NO874632 A NO 874632A NO 874632 A NO874632 A NO 874632A NO 173440 C NO173440 C NO 173440C
Authority
NO
Norway
Prior art keywords
therapeutically active
analogous procedures
cyclodextrin clathrates
preparing therapeutically
carbacycline
Prior art date
Application number
NO874632A
Other languages
English (en)
Norwegian (no)
Other versions
NO874632L (no
NO173440B (no
NO874632D0 (no
Inventor
Werner Skuballa
Helmut Vorbruggen
Helmut Dahl
Claus-Steffen Sturzebecher
Karl-Heinz Thierauch
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Ag filed Critical Schering Ag
Publication of NO874632L publication Critical patent/NO874632L/no
Publication of NO874632D0 publication Critical patent/NO874632D0/no
Publication of NO173440B publication Critical patent/NO173440B/no
Publication of NO173440C publication Critical patent/NO173440C/no

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6949—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes
    • A61K47/6951—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes using cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C07C405/005—Analogues or derivatives having the five membered ring replaced by other rings
    • C07C405/0075—Analogues or derivatives having the five membered ring replaced by other rings having the side-chains or their analogues or derivatives attached to a condensed ring system
    • C07C405/0083—Analogues or derivatives having the five membered ring replaced by other rings having the side-chains or their analogues or derivatives attached to a condensed ring system which is only ortho or peri condensed, e.g. carbacyclins
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
    • C08B37/0009—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid alpha-D-Glucans, e.g. polydextrose, alternan, glycogen; (alpha-1,4)(alpha-1,6)-D-Glucans; (alpha-1,3)(alpha-1,4)-D-Glucans, e.g. isolichenan or nigeran; (alpha-1,4)-D-Glucans; (alpha-1,3)-D-Glucans, e.g. pseudonigeran; Derivatives thereof
    • C08B37/0012—Cyclodextrin [CD], e.g. cycle with 6 units (alpha), with 7 units (beta) and with 8 units (gamma), large-ring cyclodextrin or cycloamylose with 9 units or more; Derivatives thereof
    • C08B37/0015—Inclusion compounds, i.e. host-guest compounds, e.g. polyrotaxanes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Nanotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Epidemiology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Biochemistry (AREA)
  • Materials Engineering (AREA)
  • Polymers & Plastics (AREA)
  • Medical Informatics (AREA)
  • Biophysics (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pulmonology (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Medicinal Preparation (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
NO874632A 1986-03-07 1987-11-06 Analogifremgangsmaate for fremstilling av terapeutisk aktive cyclodextrinclathrater av carbacyclinanaloger NO173440C (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3608088A DE3608088C2 (de) 1986-03-07 1986-03-07 Pharmazeutische Präparate, enthaltend Cyclodextrinclathrate von Carbacyclinderivaten
PCT/DE1987/000106 WO1987005294A1 (en) 1986-03-07 1987-03-09 Cyclodextrinclathrates of carbacycline derivatives and their use as medicinal drugs

Publications (4)

Publication Number Publication Date
NO874632L NO874632L (no) 1987-11-06
NO874632D0 NO874632D0 (no) 1987-11-06
NO173440B NO173440B (no) 1993-09-06
NO173440C true NO173440C (no) 1993-12-15

Family

ID=6296073

Family Applications (1)

Application Number Title Priority Date Filing Date
NO874632A NO173440C (no) 1986-03-07 1987-11-06 Analogifremgangsmaate for fremstilling av terapeutisk aktive cyclodextrinclathrater av carbacyclinanaloger

Country Status (22)

Country Link
US (1) US4886788A (sv)
EP (1) EP0259468B1 (sv)
JP (2) JPH07107020B2 (sv)
AT (1) AT397084B (sv)
AU (2) AU6988687A (sv)
CA (1) CA1309087C (sv)
CH (1) CH672313A5 (sv)
CS (1) CS270558B2 (sv)
DD (1) DD258942A5 (sv)
DE (3) DE3608088C2 (sv)
ES (1) ES2004543A6 (sv)
FI (1) FI92388C (sv)
GB (2) GB2189783A (sv)
GR (1) GR870363B (sv)
HU (1) HU198906B (sv)
IE (1) IE59760B1 (sv)
IL (1) IL81802A (sv)
NO (1) NO173440C (sv)
NZ (1) NZ219508A (sv)
SU (1) SU1632371A3 (sv)
WO (1) WO1987005294A1 (sv)
ZA (1) ZA871663B (sv)

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DE3608088C2 (de) * 1986-03-07 1995-11-16 Schering Ag Pharmazeutische Präparate, enthaltend Cyclodextrinclathrate von Carbacyclinderivaten
DE3740838A1 (de) * 1987-11-27 1989-06-08 Schering Ag Cyclodextrinclathrate von 5-cyano-prostacyclinderivaten und ihre verwendung als arzneimittel
EP0410652B1 (en) * 1989-07-27 1995-05-17 Kabushiki Kaisha Ueno Seiyaku Oyo Kenkyujo Use of 15-keto-prostanoic acid derivatives in the manufacture of a medicament for improvement of excretion of potassium ion
DE3933523A1 (de) * 1989-10-05 1991-04-11 Schering Ag Antimetastatisch wirkende mittel
DE4010355A1 (de) * 1990-03-28 1991-10-02 Schering Ag Bicyclo(3.3.0)octan-derivate, verfahren zu ihrer herstellung und ihre pharmazeutische verwendung
DE4104606C1 (sv) * 1991-02-12 1992-10-15 Schering Ag Berlin Und Bergkamen, 1000 Berlin, De
US5221735A (en) * 1991-02-25 1993-06-22 Hoffmann-La Roche Inc. Cyclodextrin-polyene inclusion complexes
DE4135193C1 (sv) * 1991-10-22 1993-03-11 Schering Ag Berlin Und Bergkamen, 1000 Berlin, De
US6103403A (en) * 1997-05-15 2000-08-15 University Of Kentucky Research Foundation Intellectual Property Development Clathrate structure for electronic and electro-optic applications
DE19808634A1 (de) * 1998-02-24 1999-08-26 Schering Ag Mantel für eine pharmazeutische Zusammensetzung
DE19828881A1 (de) * 1998-06-22 1999-12-23 Schering Ag Oxidationsinhibitor bei Prostan-Derivaten
DE10225551A1 (de) * 2002-06-06 2003-12-24 Schering Ag Verwendung von oral verfügbaren Prostacyclinderivaten für die Herstellung eines Arzneimittels zur Behandlung von Krankheiten, die mit Knochenmarködemen assoziiert sind
AR053710A1 (es) * 2005-04-11 2007-05-16 Xenon Pharmaceuticals Inc Compuestos espiroheterociclicos y sus usos como agentes terapeuticos
MY158766A (en) * 2005-04-11 2016-11-15 Xenon Pharmaceuticals Inc Spiro-oxindole compounds and their uses as therapeutic agents
DK1976828T3 (en) 2005-12-29 2017-03-06 Celtaxsys Inc DIAMINE DERIVATIVES AS INhibitors of Leukotriene A4 HYDROLASE
JPWO2008018592A1 (ja) * 2006-08-11 2010-01-07 大正製薬株式会社 プロスタグランジン誘導体含有外用剤
TW200825091A (en) * 2006-10-12 2008-06-16 Xenon Pharmaceuticals Inc Spiro-oxindole compounds useful in treating sodium channel-mediated diseases or conditions
JP5460324B2 (ja) 2006-10-12 2014-04-02 ゼノン・ファーマシューティカルズ・インコーポレイテッド 治療剤としてのスピロ−オキシインドール化合物の使用
CA2741024A1 (en) 2008-10-17 2010-04-22 Xenon Pharmaceuticals Inc. Spiro-oxindole compounds and their use as therapeutic agents
RU2011119626A (ru) 2008-10-17 2012-11-27 Ксенон Фармасьютикалз Инк. Спирооксиндольные соединения и их применение в качестве терапевтичеких средств
AR077252A1 (es) 2009-06-29 2011-08-10 Xenon Pharmaceuticals Inc Enantiomeros de compuestos de espirooxindol y sus usos como agentes terapeuticos
MY165579A (en) * 2009-10-14 2018-04-05 Xenon Pharmaceuticals Inc Synthetic methods for spiro-oxindole compounds
US20110086899A1 (en) * 2009-10-14 2011-04-14 Xenon Pharmaceuticals Inc. Pharmaceutical compositions for oral administration
US9504671B2 (en) 2010-02-26 2016-11-29 Xenon Pharmaceuticals Inc. Pharmaceutical compositions of spiro-oxindole compound for topical administration and their use as therapeutic agents
US9487535B2 (en) 2012-04-12 2016-11-08 Xenon Pharmaceuticals Inc. Asymmetric syntheses for spiro-oxindole compounds useful as therapeutic agents
AU2014240042C1 (en) 2013-03-14 2019-09-05 Celltaxis, Llc Inhibitors of leukotriene A4 hydrolase
TW201636017A (zh) 2015-02-05 2016-10-16 梯瓦製藥國際有限責任公司 以螺吲哚酮化合物之局部調配物治療帶狀疱疹後遺神經痛之方法
US10100060B2 (en) 2016-06-16 2018-10-16 Xenon Pharmaceuticals Inc. Asymmetric synthesis of funapide
AU2017371353B2 (en) 2016-12-09 2022-02-03 Celltaxis, Llc Monamine and monoamine derivatives as inhibitors of leukotriene A4 hydrolase
AU2017371348B2 (en) 2016-12-09 2022-02-03 Celltaxis, Llc Inhibitors of leukotriene A4 hydrolase
WO2018107167A1 (en) 2016-12-09 2018-06-14 Celtaxsys, Inc. Pendant amines and derivatives as inhibitors of leukotriene a4 hydrolase
HU231212B1 (hu) * 2018-04-16 2021-11-29 CHINOIN Gyógyszer és Vegyészeti Termékek Gyára Zrt. Eljárás iloprost előállítására
RU2741848C1 (ru) * 2019-03-16 2021-01-29 Иванова Мария Ивановна Способ получения клатратных комплексов летучих веществ
JPWO2023037934A1 (sv) * 2021-09-13 2023-03-16

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AU476695B2 (en) * 1974-01-15 1975-07-17 Ono Pharmaceutical Co. Ltd Clathrate prostaglandins and compositions containing same
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JPS58192821A (ja) * 1982-04-30 1983-11-10 Dainippon Pharmaceut Co Ltd 脳神経細胞の酸素欠乏性疾患の治療剤
JPS58216140A (ja) * 1982-05-28 1983-12-15 メイ・アンド・ベイカ−・リミテツド 新規なプロスタグランジン類似体
JPS59141536A (ja) * 1983-02-01 1984-08-14 Sumitomo Chem Co Ltd 新規ビシクロオクタン誘導体
DE3306123A1 (de) * 1983-02-18 1984-09-06 Schering AG, 1000 Berlin und 4709 Bergkamen Neue carbacycline, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
FR2547818B1 (fr) * 1983-05-24 1986-09-05 May & Baker Ltd Nouveaux analogues de prostaglandines, leur preparation, les compositions pharmaceutiques qui les contiennent et les intermediaires-cles pour les preparer
DE3405181A1 (de) * 1984-02-10 1985-08-22 Schering AG, 1000 Berlin und 4709 Bergkamen Neue carbacycline, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
JPS6144819A (ja) * 1984-08-09 1986-03-04 Sagami Chem Res Center プロスタグランジンｉ２類縁化合物を含有する循環改善作用を有する薬剤
EP0171992B1 (en) * 1984-08-09 1990-06-06 Mitsubishi Kasei Corporation Pharmaceuticals containing prostaglandin i2
JPS6216A (ja) * 1985-03-19 1987-01-06 Sankyo Co Ltd カルバサイクリン類及びこれを有効成分とする抗潰瘍剤
DE3608088C2 (de) * 1986-03-07 1995-11-16 Schering Ag Pharmazeutische Präparate, enthaltend Cyclodextrinclathrate von Carbacyclinderivaten

Also Published As

Publication number Publication date
JP2634787B2 (ja) 1997-07-30
NO874632L (no) 1987-11-06
FI874406A (sv) 1987-10-07
EP0259468A1 (de) 1988-03-16
GR870363B (en) 1987-06-30
SU1632371A3 (ru) 1991-02-28
DE3790121D2 (en) 1988-03-10
JPS63502665A (ja) 1988-10-06
CH672313A5 (sv) 1989-11-15
NZ219508A (en) 1990-08-28
IL81802A0 (en) 1987-10-20
FI874406A0 (sv) 1987-10-07
HUT45484A (en) 1988-07-28
DE3770085D1 (de) 1991-06-20
AT397084B (de) 1994-01-25
AU6988687A (en) 1987-09-10
WO1987005294A1 (en) 1987-09-11
CS270558B2 (en) 1990-07-12
JPH08193046A (ja) 1996-07-30
IE59760B1 (en) 1994-03-23
CS151187A2 (en) 1989-11-14
GB8725695D0 (en) 1987-12-09
EP0259468B1 (de) 1991-05-15
FI92388B (sv) 1994-07-29
DE3608088A1 (de) 1987-09-10
CA1309087C (en) 1992-10-20
AU609390B2 (en) 1991-05-02
ES2004543A6 (es) 1989-01-16
US4886788A (en) 1989-12-12
GB2199031A (en) 1988-06-29
FI92388C (sv) 1994-11-10
IL81802A (en) 1991-07-18
DE3608088C2 (de) 1995-11-16
AU7160987A (en) 1987-09-28
ZA871663B (en) 1987-08-28
HU198906B (en) 1989-12-28
GB2189783A (en) 1987-11-04
DD258942A5 (de) 1988-08-10
JPH07107020B2 (ja) 1995-11-15
NO173440B (no) 1993-09-06
IE870586L (en) 1987-09-07
GB2199031B (en) 1990-01-10
GB8704982D0 (en) 1987-04-08
NO874632D0 (no) 1987-11-06
ATA900787A (de) 1993-06-15

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