NO167741C - Analogifremgangsmaate for fremstilling av terapeutiske rebeccamycinanaloger. - Google Patents

Analogifremgangsmaate for fremstilling av terapeutiske rebeccamycinanaloger.

Info

Publication number
NO167741C
NO167741C NO874857A NO874857A NO167741C NO 167741 C NO167741 C NO 167741C NO 874857 A NO874857 A NO 874857A NO 874857 A NO874857 A NO 874857A NO 167741 C NO167741 C NO 167741C
Authority
NO
Norway
Prior art keywords
alkyl
rebeccamycin
alkoxycarbonyl
carboxyl
mono
Prior art date
Application number
NO874857A
Other languages
English (en)
Norwegian (no)
Other versions
NO874857L (no
NO167741B (no
NO874857D0 (no
Inventor
Takushi Kaneko
Henry S Wong
Jacob J Utzig
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of NO874857D0 publication Critical patent/NO874857D0/no
Publication of NO874857L publication Critical patent/NO874857L/no
Publication of NO167741B publication Critical patent/NO167741B/no
Publication of NO167741C publication Critical patent/NO167741C/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/044—Pyrrole radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/23—Heterocyclic radicals containing two or more heterocyclic rings condensed among themselves or condensed with a common carbocyclic ring system, not provided for in groups C07H19/14 - C07H19/22

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
NO874857A 1986-11-21 1987-11-20 Analogifremgangsmaate for fremstilling av terapeutiske rebeccamycinanaloger. NO167741C (no)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/933,428 US4785085A (en) 1986-11-21 1986-11-21 Rebeccamycin analogs

Publications (4)

Publication Number Publication Date
NO874857D0 NO874857D0 (no) 1987-11-20
NO874857L NO874857L (no) 1988-05-24
NO167741B NO167741B (no) 1991-08-26
NO167741C true NO167741C (no) 1991-12-04

Family

ID=25463937

Family Applications (1)

Application Number Title Priority Date Filing Date
NO874857A NO167741C (no) 1986-11-21 1987-11-20 Analogifremgangsmaate for fremstilling av terapeutiske rebeccamycinanaloger.

Country Status (28)

Country Link
US (1) US4785085A (fr)
EP (1) EP0269025B1 (fr)
JP (1) JPS63198695A (fr)
KR (1) KR910000897B1 (fr)
CN (1) CN1019806B (fr)
AT (1) ATE84539T1 (fr)
AU (1) AU614068B2 (fr)
CA (1) CA1287349C (fr)
CS (1) CS265248B2 (fr)
CY (1) CY1701A (fr)
DE (1) DE3783577T2 (fr)
DK (1) DK165986C (fr)
EG (1) EG18409A (fr)
ES (1) ES2053510T3 (fr)
FI (1) FI86189C (fr)
GR (1) GR3006776T3 (fr)
HK (1) HK49093A (fr)
HU (1) HU201773B (fr)
IE (1) IE60595B1 (fr)
IL (1) IL84515A (fr)
MX (1) MX9202849A (fr)
MY (1) MY102722A (fr)
NO (1) NO167741C (fr)
NZ (1) NZ222544A (fr)
PT (1) PT86188B (fr)
SG (1) SG25193G (fr)
YU (1) YU46087B (fr)
ZA (1) ZA878714B (fr)

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JPH07113027B2 (ja) * 1987-12-24 1995-12-06 協和醗酵工業株式会社 Ｋ−２５２誘導体
US5438050A (en) * 1988-02-06 1995-08-01 Godecke Aktiengesellschaft Indolocarbazole derivatives, processes for their preparation and compositions containing them
DE3835842A1 (de) * 1988-10-21 1990-04-26 Goedecke Ag Indolocarbazol-derivate, verfahren zu deren herstellung und deren verwendung als arzneimittel
US5015578A (en) * 1989-03-23 1991-05-14 Bristol-Myers Squibb Company BMY-41950 antitumor antibiotic
IL94274A0 (en) * 1989-05-05 1991-03-10 Goedecke Ag Maleinimide derivatives,process for the preparation thereof and pharmaceutical compositions containing the same
US5496809A (en) * 1989-05-10 1996-03-05 Bristol-Myers Squibb Co Stable solutions of rebeccamycin analog
IL97233A (en) * 1990-03-06 1995-03-30 Bristol Myers Squibb Co Analogs of rabamycin, their manufacture and pharmaceutical preparations containing them
JPH0725787B2 (ja) * 1990-03-06 1995-03-22 ブリストル−マイヤーズ スクイブ カンパニー 臭化物前駆物質物質供給によるレベカマイシン類似体
US5158938A (en) * 1990-03-06 1992-10-27 Bristol-Myers Squibb Company Rebeccamycin
US5344823A (en) * 1990-03-06 1994-09-06 Bristol-Myers Squibb Company Antitumor antibiotic BMY-41219
US5478813A (en) * 1990-05-11 1995-12-26 Banyu Pharmaceutical Co., Ltd. Antitumor substance BE-13793C derivatives
EP0528030B1 (fr) * 1990-05-11 1997-09-17 Banyu Pharmaceutical Co., Ltd. Derive antitumoral de be-13793c
US5437996A (en) * 1992-11-24 1995-08-01 Banyu Pharmaceutical Co., Ltd. Microtetraspora strain for preparation of indolopyrrolocarbazole derivatives
NZ245203A (en) * 1991-11-29 1997-07-27 Banyu Pharma Co Ltd 5h-indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6h)-dione derivatives substituted in position-13 by a pentose or hexose group; corresponding indolo-furano(anhydride)intermediates
US5589365A (en) * 1991-11-29 1996-12-31 Banyu Pharmaceutical Co., Ltd. Process for producing glycosylated indolopyrrolocarbazole derivatives by culturing certain microorganisms
US5591842A (en) * 1991-11-29 1997-01-07 Banyu Pharmaceutical Co., Ltd. Indolopyrrolocarbazole derivatives
CA2130836A1 (fr) * 1992-03-20 1993-09-30 Martin J. Slater Autres derives indoles a activite antivirale
JP3603322B2 (ja) * 1992-12-14 2004-12-22 萬有製薬株式会社 インドロピロロカルバゾール誘導体の製造法
US5843935A (en) * 1993-12-07 1998-12-01 Eli Lilly And Company Protein kinase C inhibitors
US5541347A (en) * 1993-12-07 1996-07-30 Eli Lilly And Company Synthesis of bisindolylmaleimides
US5624949A (en) * 1993-12-07 1997-04-29 Eli Lilly And Company Protein kinase C inhibitors
HU219709B (hu) * 1993-12-07 2001-06-28 Eli Lilly And Co. Proteinkináz C gátló hatású kondenzált indolszármazékok, eljárás előállításukra, és az ezeket tartalmazó gyógyászati készítmények
ES2134910T3 (es) * 1993-12-07 1999-10-16 Lilly Co Eli Sintesis de bisindolilmaleimidas.
US5723456A (en) * 1993-12-07 1998-03-03 Eli Lilly & Company Therapeutic treatment for cardiovascular diseases
PT817627E (pt) * 1993-12-23 2005-07-29 Lilly Co Eli Inibidores da proteina cinase c
US5545636A (en) * 1993-12-23 1996-08-13 Eli Lilly And Company Protein kinase C inhibitors
US5922860A (en) * 1994-05-09 1999-07-13 Banyu Pharmaceutical Co., Ltd. Antitumor indolopyrrolocarbazole derivatives
US5804564A (en) * 1994-05-09 1998-09-08 Banyu Pharmaceutical Co., Ltd. Antitumor indolopyrrolocarbazole derivatives
WO1995030682A1 (fr) * 1994-05-09 1995-11-16 Banyu Pharmaceutical Co., Ltd. Derive d'indolopyrolocarbazole antitumoral
USRE37206E1 (en) * 1994-06-13 2001-06-05 Banyu Pharmaceutical Co, Ltd Gene encoding glycosyltransferase and its uses
US5481003A (en) * 1994-06-22 1996-01-02 Eli Lilly And Company Protein kinase C inhibitors
US5491242A (en) * 1994-06-22 1996-02-13 Eli Lilly And Company Protein kinase C inhibitors
DE69505470T2 (de) * 1994-08-04 1999-05-12 F. Hoffmann-La Roche Ag, Basel Pyrrolocarbazol
WO1997009339A1 (fr) * 1995-09-05 1997-03-13 Banyu Pharmaceutical Co., Ltd. Derives antitumoraux d'indolopyrrolocarbazole
AU2217797A (en) * 1996-03-20 1997-10-10 Eli Lilly And Company Synthesis of indolylmaleimides
US5859261A (en) * 1997-03-20 1999-01-12 Eli Lilly And Company Synthesis of indolylmaleimides
US6677450B2 (en) 2000-10-06 2004-01-13 Bristol-Myers Squibb Company Topoisomerase inhibitors
US6653290B2 (en) 2000-10-06 2003-11-25 Bristol-Myers Squibb Company Tumor proliferation inhibitors
US6610727B2 (en) 2000-10-06 2003-08-26 Bristol-Myers Squibb Company Anhydro sugar derivatives of indolocarbazoles
BR0208322A (pt) 2001-03-22 2004-10-13 Bristol Myers Squibb Co Derivados de açúcar citotóxixo seletivo da topoisomerase i de indolopirrolocarbazóis
ATE445838T1 (de) 2001-07-25 2009-10-15 Raptor Pharmaceutical Inc Zusammensetzungen und verfahren zur modulation des transports durch die blut-hirn-schranke
CA2393720C (fr) * 2002-07-12 2010-09-14 Eli Lilly And Company Monochlorhydrate de 3-(1-methyl-1h-indol-3-yl)-4-[[1-(pyridin-2-ylmethyl)piperidin-4-yl]-1h-indol-3-yl]-1h-pyrrole-2,5-dione cristallin
WO2005026185A1 (fr) * 2003-09-16 2005-03-24 Banyu Pharmaceutical Co., Ltd. Nouveau derive d'indolopyrrolocarbazole a active anti-tumeur
EP2671508B1 (fr) 2005-04-28 2020-09-16 Proteus Digital Health, Inc. Système pharma-informatique
CA2663377A1 (fr) 2006-09-18 2008-03-27 Raptor Pharmaceutical Inc. Traitement des troubles hepatiques par l'administration de conjugues de proteine associee au recepteur (rap)
ES2326459B1 (es) 2008-04-08 2010-05-28 Universidad De Oviedo Indolocarbazoles glicosilados, su procedimiento de obtencion y sus usos.
HUE059078T2 (hu) 2009-02-20 2022-10-28 Enhanx Biopharm Inc Glutation-alapú hatóanyagszállító rendszer
JP2012526144A (ja) 2009-05-06 2012-10-25 ラボラトリー スキン ケア インコーポレイテッド 活性物質−リン酸カルシウム粒子複合体を含む経皮送達組成物およびその使用方法
US20120077778A1 (en) 2010-09-29 2012-03-29 Andrea Bourdelais Ladder-Frame Polyether Conjugates
CN102898489B (zh) * 2010-11-24 2014-04-02 河南师范大学 具有抗癌活性的蝴蝶霉素类似物及合成方法
CN102125578B (zh) * 2010-11-24 2013-03-27 河南师范大学 具有抗癌活性的蝴蝶霉素类似物及合成方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4552842A (en) * 1983-01-28 1985-11-12 Bristol-Myers Company Process for producing rebeccamycin
US4487925A (en) * 1983-01-28 1984-12-11 Bristol-Myers Company Rebeccamycin and process for its preparation
US4524145A (en) * 1984-09-04 1985-06-18 Bristol-Myers Company 4'-Deschlororebeccamycin pharmaceutical composition and method of use
JPS62220196A (ja) * 1986-03-20 1987-09-28 Kyowa Hakko Kogyo Co Ltd 新規物質ｕｃｎ―０１

Also Published As

Publication number Publication date
US4785085A (en) 1988-11-15
HUT45543A (en) 1988-07-28
ZA878714B (fr) 1988-05-20
FI875091A0 (fi) 1987-11-18
NO874857L (no) 1988-05-24
IL84515A0 (en) 1988-04-29
JPH05400B2 (fr) 1993-01-05
KR910000897B1 (ko) 1991-02-12
PT86188B (pt) 1990-11-07
NZ222544A (en) 1990-11-27
PT86188A (en) 1987-12-01
NO167741B (no) 1991-08-26
ATE84539T1 (de) 1993-01-15
CA1287349C (fr) 1991-08-06
IL84515A (en) 1991-11-21
DE3783577D1 (de) 1993-02-25
IE873152L (en) 1988-05-21
IE60595B1 (en) 1994-07-27
GR3006776T3 (fr) 1993-06-30
CN87107928A (zh) 1988-08-10
AU8114887A (en) 1988-05-26
ES2053510T3 (es) 1994-08-01
DE3783577T2 (de) 1993-05-19
HU201773B (en) 1990-12-28
SG25193G (en) 1993-05-21
AU614068B2 (en) 1991-08-22
EP0269025A3 (en) 1990-08-29
FI875091A (fi) 1988-05-22
MX9202849A (es) 1992-06-30
JPS63198695A (ja) 1988-08-17
YU208687A (en) 1988-10-31
CN1019806B (zh) 1992-12-30
MY102722A (en) 1992-09-30
DK612987A (da) 1988-05-22
EP0269025A2 (fr) 1988-06-01
CS824987A2 (en) 1989-01-12
DK165986C (da) 1993-07-19
KR880006246A (ko) 1988-07-22
DK612987D0 (da) 1987-11-20
CS265248B2 (en) 1989-10-13
NO874857D0 (no) 1987-11-20
FI86189C (fi) 1992-07-27
CY1701A (en) 1994-01-14
EG18409A (en) 1993-02-28
FI86189B (fi) 1992-04-15
HK49093A (en) 1993-05-27
EP0269025B1 (fr) 1993-01-13
DK165986B (da) 1993-02-22
YU46087B (sh) 1992-12-21

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Legal Events

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MK1K Patent expired