NO163185C - Analogifremgangsmaate for fremstilling av nye terapeutisk aktive piperazinderivater. - Google Patents
Analogifremgangsmaate for fremstilling av nye terapeutisk aktive piperazinderivater.Info
- Publication number
- NO163185C NO163185C NO851298A NO851298A NO163185C NO 163185 C NO163185 C NO 163185C NO 851298 A NO851298 A NO 851298A NO 851298 A NO851298 A NO 851298A NO 163185 C NO163185 C NO 163185C
- Authority
- NO
- Norway
- Prior art keywords
- derivative
- benzyl
- preparation
- condensing
- addition salt
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP59064464A JPS60222472A (ja) | 1984-03-30 | 1984-03-30 | 新規なピペラジン誘導体および該化合物を有効成分とする医薬組成物 |
Publications (2)
Publication Number | Publication Date |
---|---|
NO851298L NO851298L (no) | 1985-10-01 |
NO163185C true NO163185C (no) | 1990-04-18 |
Family
ID=13258978
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO851298A NO163185C (no) | 1984-03-30 | 1985-03-29 | Analogifremgangsmaate for fremstilling av nye terapeutisk aktive piperazinderivater. |
Country Status (10)
Country | Link |
---|---|
US (1) | US4663325A (fr) |
EP (1) | EP0159566B1 (fr) |
JP (1) | JPS60222472A (fr) |
AT (1) | ATE31411T1 (fr) |
CA (1) | CA1248110A (fr) |
DE (1) | DE3561199D1 (fr) |
ES (3) | ES8702393A1 (fr) |
FI (1) | FI79101C (fr) |
GR (1) | GR850787B (fr) |
NO (1) | NO163185C (fr) |
Families Citing this family (31)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS61161272A (ja) * | 1985-01-11 | 1986-07-21 | Kanebo Ltd | 新規なピペラジン誘導体および該化合物を有効成分とする医薬組成物 |
JPS62277370A (ja) * | 1986-02-04 | 1987-12-02 | Terumo Corp | ジエン誘導体およびこれを含有する血管拡張剤 |
FR2614021B1 (fr) * | 1987-04-14 | 1991-03-01 | Andre Buzas | Derives de la 1-((1,1-diphenyl)-1-alcenyl)-piperazine, procede d'obtention et compositions pharmaceutiques les contenant |
DE4108527A1 (de) * | 1991-03-15 | 1992-09-17 | Basf Ag | Neue 1-(4-cyano-4-aryl-cyclohexyl)piperazine, ihre herstellung und verwendung |
AU646926B2 (en) * | 1991-03-20 | 1994-03-10 | Duphar International Research B.V. | Alkylenedioxyphenyl ether derivatives having anti-ischaemic, memory enhancing and anti-convulsive activity |
ATE199716T1 (de) * | 1993-12-08 | 2001-03-15 | Alcon Lab Inc | Verbindungen die sowohl starke calcium- antagonistische und antioxydatieve aktivitaet haben und deren verwendung als zellschuetzende mittel. |
US6387910B1 (en) | 1998-01-29 | 2002-05-14 | Akzo Nobel N.V. | Drug of improving optic nerve head circulation disorder |
GEP20074134B (en) | 2002-08-19 | 2007-06-25 | Pfizer Prod Inc | Combination therapy for hyperproliferative diseases |
US7433519B2 (en) | 2003-04-04 | 2008-10-07 | Avid Technology, Inc. | Bitstream format for compressed image data |
US7403561B2 (en) | 2003-04-04 | 2008-07-22 | Avid Technology, Inc. | Fixed bit rate, intraframe compression and decompression of video |
US20050159403A1 (en) * | 2003-04-22 | 2005-07-21 | Pharmacia Corporation | Compositions of a cyclooxygenase-2 selective inhibitor and a calcium modulating agent for the treatment of central nervous system damage |
WO2004093813A2 (fr) * | 2003-04-22 | 2004-11-04 | Pharmacia Corporation | Compositions renfermant un inhibiteur selectif a l'egard de la cyclooxygenase 2 et un agent de modulation du calcium pour le traitement de la douleur, de l'inflammation ou de troubles dus a l'inflammation |
NZ543741A (en) * | 2003-05-30 | 2009-10-30 | Ranbaxy Lab Ltd | Substituted pyrrole derivatives and their use as HMG-Co inhibitors |
US20050037063A1 (en) * | 2003-07-21 | 2005-02-17 | Bolton Anthony E. | Combined therapies |
AU2006223212A1 (en) * | 2005-03-11 | 2006-09-21 | Hong Kong Nitric Oxide Limited | Combination therapy for endothelial dysfunction, angina and diabetes |
US7741317B2 (en) | 2005-10-21 | 2010-06-22 | Bristol-Myers Squibb Company | LXR modulators |
EP2351569B1 (fr) | 2005-10-26 | 2012-08-22 | Asahi Kasei Pharma Corporation | Fasudil dans des thérapies combinées pour le traitement de l'hypertension artérielle pulmonaire |
EP2111863B1 (fr) | 2005-10-26 | 2012-03-28 | Asahi Kasei Pharma Corporation | Combinaison du fasudil et bosentan pour le traitement de l'hypertension artérielle pulmonaire |
US8026377B2 (en) * | 2005-11-08 | 2011-09-27 | Ranbaxy Laboratories, Limited | Process for (3R, 5R)-7-[2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-[(4-hydroxy methyl phenyl amino) carbonyl]-pyrrol-1-yl]-3,5-dihydroxy-heptanoic acid hemi calcium salt |
US7888376B2 (en) | 2005-11-23 | 2011-02-15 | Bristol-Myers Squibb Company | Heterocyclic CETP inhibitors |
AR059838A1 (es) * | 2006-03-14 | 2008-04-30 | Ranbaxy Lab Ltd | Formulaciones para dosis estabilizantes de estatina |
WO2008010087A2 (fr) * | 2006-07-14 | 2008-01-24 | Ranbaxy Laboratories Limited | FORMES POLYMORPHES D'UN INHIBITEUR DE LA HMG-CoA-RÉDUCTASE ET LEURS UTILISATIONS |
ATE547394T1 (de) | 2006-12-01 | 2012-03-15 | Bristol Myers Squibb Co | N-((3-benzyl)-2,2-(bis-phenyl)-propan-1- aminderivate als cetp-hemmer für die behandlung von atherosklerose und herz-kreislauf- erkrankungen |
US7964613B2 (en) | 2007-02-28 | 2011-06-21 | Asahi Kasei Pharma Corporation | Sulfonamide compound |
WO2012037665A1 (fr) | 2010-09-24 | 2012-03-29 | Oral Delivery Technology Ltd. | Oxyde nitrique libérant un ester d'acide aminé pour le traitement de l'hypertension pulmonaire et autres états respiratoires |
CN102936233B (zh) * | 2012-11-16 | 2016-01-20 | 葛长乐 | 一种1-(二(4-氟苯基)甲基)-4-(2,3,4-三甲氧苯基)哌嗪二盐酸盐晶型 |
SG11201507496UA (en) | 2013-04-17 | 2015-11-27 | Pfizer | N-piperidin-3-ylbenzamide derivatives for treating cardiovascular diseases |
WO2016055901A1 (fr) | 2014-10-08 | 2016-04-14 | Pfizer Inc. | Composés d'amide substitué |
US10128077B2 (en) * | 2015-10-20 | 2018-11-13 | Korea Research Institute Of Standards And Science | Electron microscope electron gun for facilitating position adjustment and electron microscope including same |
CN109666008A (zh) * | 2018-12-31 | 2019-04-23 | 辰欣药业股份有限公司 | 一种盐酸洛美利嗪的合成方法 |
SG11202107614PA (en) | 2019-01-18 | 2021-08-30 | Astrazeneca Ab | Pcsk9 inhibitors and methods of use thereof |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB705979A (en) * | 1951-03-22 | 1954-03-24 | Henri Morren | 1.4-aralkyl piperazines and process for the preparation thereof |
FR1312427A (fr) * | 1961-04-12 | 1962-12-21 | Science Union Et Compagnie Soc | Nouveaux dérivés de la pipérazine et leurs préparations |
FR1303080A (fr) * | 1961-07-25 | 1962-09-07 | Science Union Et Compagnie Soc | Pipérazines disubstituées |
NL7306771A (fr) * | 1972-06-02 | 1973-12-04 | ||
DE2900810A1 (de) * | 1979-01-11 | 1980-07-24 | Cassella Ag | Substituierte n-benzhydryl-n'-p- hydroxybenzyl-piperazine und verfahren zu ihrer herstellung |
GB8320701D0 (en) * | 1983-08-01 | 1983-09-01 | Wellcome Found | Chemotherapeutic agent |
-
1984
- 1984-03-30 JP JP59064464A patent/JPS60222472A/ja active Granted
-
1985
- 1985-03-25 US US06/715,813 patent/US4663325A/en not_active Expired - Lifetime
- 1985-03-26 CA CA000477468A patent/CA1248110A/fr not_active Expired
- 1985-03-26 FI FI851217A patent/FI79101C/fi not_active IP Right Cessation
- 1985-03-27 EP EP85103707A patent/EP0159566B1/fr not_active Expired
- 1985-03-27 AT AT85103707T patent/ATE31411T1/de not_active IP Right Cessation
- 1985-03-27 DE DE8585103707T patent/DE3561199D1/de not_active Expired
- 1985-03-28 GR GR850787A patent/GR850787B/el unknown
- 1985-03-29 ES ES541728A patent/ES8702393A1/es not_active Expired
- 1985-03-29 NO NO851298A patent/NO163185C/no not_active IP Right Cessation
-
1986
- 1986-07-29 ES ES556981A patent/ES8801237A1/es not_active Expired
- 1986-07-29 ES ES556980A patent/ES8801236A1/es not_active Expired
Also Published As
Publication number | Publication date |
---|---|
US4663325A (en) | 1987-05-05 |
ES541728A0 (es) | 1987-01-01 |
FI851217L (fi) | 1985-10-01 |
FI79101B (fi) | 1989-07-31 |
GR850787B (fr) | 1985-11-25 |
JPH0313232B2 (fr) | 1991-02-22 |
ES8801236A1 (es) | 1988-01-01 |
DE3561199D1 (en) | 1988-01-28 |
ES8702393A1 (es) | 1987-01-01 |
ES8801237A1 (es) | 1988-01-01 |
NO851298L (no) | 1985-10-01 |
CA1248110A (fr) | 1989-01-03 |
FI851217A0 (fi) | 1985-03-26 |
ES556980A0 (es) | 1988-01-01 |
ES556981A0 (es) | 1988-01-01 |
EP0159566A1 (fr) | 1985-10-30 |
JPS60222472A (ja) | 1985-11-07 |
ATE31411T1 (de) | 1988-01-15 |
FI79101C (fi) | 1989-11-10 |
EP0159566B1 (fr) | 1987-12-16 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
MK1K | Patent expired |