NO152839C - Analogifremgangsmaate for fremstilling av terapeutisk aktive karbostyrilderivater. - Google Patents

Analogifremgangsmaate for fremstilling av terapeutisk aktive karbostyrilderivater.

Info

Publication number
NO152839C
NO152839C NO790521A NO790521A NO152839C NO 152839 C NO152839 C NO 152839C NO 790521 A NO790521 A NO 790521A NO 790521 A NO790521 A NO 790521A NO 152839 C NO152839 C NO 152839C
Authority
NO
Norway
Prior art keywords
carbostyric
derivatives
preparation
therapeutic active
analogy procedure
Prior art date
Application number
NO790521A
Other languages
English (en)
Norwegian (no)
Other versions
NO790521L (no
NO152839B (no
Inventor
Erich Mueller
Josef Nickl
Berthold Narr
Walter Haarmann
Johannes Maximili Weisenberger
Josef Roch
Original Assignee
Thomae Gmbh Dr K
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19782806721 external-priority patent/DE2806721A1/de
Priority claimed from DE19782853314 external-priority patent/DE2853314A1/de
Application filed by Thomae Gmbh Dr K filed Critical Thomae Gmbh Dr K
Publication of NO790521L publication Critical patent/NO790521L/no
Publication of NO152839B publication Critical patent/NO152839B/no
Publication of NO152839C publication Critical patent/NO152839C/no

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D215/00Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20Oxygen atoms
    • C07D215/22Oxygen atoms attached in position 2 or 4
    • C07D215/227Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/04Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04Indoles; Hydrogenated indoles
    • C07D209/30Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32Oxygen atoms
    • C07D209/34Oxygen atoms in position 2
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D215/00Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20Oxygen atoms
    • C07D215/24Oxygen atoms attached in position 8
    • C07D215/26Alcohols; Ethers thereof
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D215/00Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/36Sulfur atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D215/00Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38Nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cardiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Indole Compounds (AREA)
NO790521A 1978-02-17 1979-02-16 Analogifremgangsmaate for fremstilling av terapeutisk aktive karbostyrilderivater. NO152839C (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19782806721 DE2806721A1 (de) 1978-02-17 1978-02-17 Neue carbostyril-derivate
DE19782853314 DE2853314A1 (de) 1978-12-09 1978-12-09 Neue carbostyril- und oxindolderivate, ihre herstellung und ihre verwendung als arzneimittel

Publications (3)

Publication Number Publication Date
NO790521L NO790521L (no) 1979-08-20
NO152839B NO152839B (no) 1985-08-19
NO152839C true NO152839C (no) 1985-11-27

Family

ID=25773852

Family Applications (1)

Application Number Title Priority Date Filing Date
NO790521A NO152839C (no) 1978-02-17 1979-02-16 Analogifremgangsmaate for fremstilling av terapeutisk aktive karbostyrilderivater.

Country Status (24)

Country Link
EP (1) EP0003771B1 (da)
JP (1) JPS54132581A (da)
AT (1) AT374183B (da)
AU (1) AU523147B2 (da)
CA (1) CA1116600A (da)
CS (1) CS227005B2 (da)
DD (1) DD141829A5 (da)
DE (1) DE2963868D1 (da)
DK (1) DK157017C (da)
ES (3) ES477517A1 (da)
FI (1) FI69064C (da)
GR (1) GR66565B (da)
HK (1) HK50485A (da)
HU (1) HU177522B (da)
IE (1) IE48179B1 (da)
IL (1) IL56677A (da)
NO (1) NO152839C (da)
NZ (1) NZ189685A (da)
PH (1) PH16698A (da)
PL (3) PL119177B1 (da)
PT (1) PT69244A (da)
RO (2) RO82013A (da)
SU (2) SU843739A3 (da)
YU (1) YU41146B (da)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1171624B (it) * 1980-11-12 1987-06-10 Thomae Gmbh Dr K Indolinoni dotati di proprieta' farmaceutiche e procedimento per la loro produzione
US4442111A (en) * 1981-07-25 1984-04-10 Dr. Karl Thomae Gesellschaft Mit Beschrankter Haftung Antithrombotic sulfimino and sulfoximino indolinones-2
DE3217012A1 (de) * 1982-05-06 1983-11-10 Dr. Karl Thomae Gmbh, 7950 Biberach Benzoxazin-2-one, deren herstellung und diese verbindungen enthaltende arzneimittel
WO1993004042A1 (fr) * 1991-08-23 1993-03-04 Otsuka Pharmaceutical Co., Ltd. Derive de carbostyrile et antiagregant plaquettaire
JP2004529110A (ja) 2001-03-06 2004-09-24 アストラゼネカ アクチボラグ 脈管損傷活性を有するインドール誘導体
MY129350A (en) 2001-04-25 2007-03-30 Bristol Myers Squibb Co Aripiprazole oral solution

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5082218A (da) * 1973-11-10 1975-07-03
US3904761A (en) * 1974-01-25 1975-09-09 Hoechst Co American Method of preventing thrombosis
FI59246C (fi) * 1974-06-24 1981-07-10 Otsuka Pharma Co Ltd Foerfarande foer framstaellning av benscykloamidderivat anvaendbara vid trombos- och emboliterapin
JPS5321176A (en) * 1976-08-09 1978-02-27 Otsuka Pharmaceut Co Ltd Carbostyryl derivatives
NZ187452A (en) * 1977-06-10 1980-05-27 Otsuka Pharma Co Ltd N- substituted-aminocarbonylpropoxy-carbostyrils and their preparation

Also Published As

Publication number Publication date
JPS54132581A (en) 1979-10-15
PL213471A1 (da) 1980-02-25
NO790521L (no) 1979-08-20
DK157017B (da) 1989-10-30
DD141829A5 (de) 1980-05-21
PL117771B1 (en) 1981-08-31
FI69064C (fi) 1985-12-10
AT374183B (de) 1984-03-26
EP0003771B1 (de) 1982-10-20
FI69064B (fi) 1985-08-30
PL119177B1 (en) 1981-12-31
ES477517A1 (es) 1980-01-16
ATA93379A (de) 1983-08-15
PH16698A (en) 1984-01-16
AU523147B2 (en) 1982-07-15
YU36679A (en) 1983-02-28
RO76683A (ro) 1981-05-30
IE48179B1 (en) 1984-10-17
HU177522B (en) 1981-10-28
FI790507A (fi) 1979-08-18
AU4432979A (en) 1979-08-23
RO82013B (ro) 1983-05-30
EP0003771A1 (de) 1979-09-05
NO152839B (no) 1985-08-19
IL56677A0 (en) 1979-05-31
PT69244A (de) 1979-03-01
ES484634A1 (es) 1980-05-16
SU852170A3 (ru) 1981-07-30
RO82013A (ro) 1983-06-01
NZ189685A (en) 1984-07-06
IL56677A (en) 1982-09-30
ES484633A1 (es) 1980-05-16
HK50485A (en) 1985-07-12
CS227005B2 (en) 1984-04-16
CA1116600A (en) 1982-01-19
DE2963868D1 (en) 1982-11-25
GR66565B (da) 1981-03-27
JPS6331464B2 (da) 1988-06-23
DK69679A (da) 1979-08-18
DK157017C (da) 1990-03-26
YU41146B (en) 1986-12-31
SU843739A3 (ru) 1981-06-30
PL119423B1 (en) 1981-12-31
IE790313L (en) 1979-08-17

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