NO143222C - Analogifremgangsmaate for fremstilling av nye substituerte pyridylsulfinyl-benzimidazoler med terapeutisk aktivitet - Google Patents
Analogifremgangsmaate for fremstilling av nye substituerte pyridylsulfinyl-benzimidazoler med terapeutisk aktivitetInfo
- Publication number
- NO143222C NO143222C NO75752851A NO752851A NO143222C NO 143222 C NO143222 C NO 143222C NO 75752851 A NO75752851 A NO 75752851A NO 752851 A NO752851 A NO 752851A NO 143222 C NO143222 C NO 143222C
- Authority
- NO
- Norway
- Prior art keywords
- pyridylsulphinyl
- benzimidazoles
- therapeutic activity
- new substituted
- preparing new
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D235/28—Sulfur atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Priority Applications (28)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE7406513A SE416649B (sv) | 1974-05-16 | 1974-05-16 | Forfarande for framstellning av foreningar som paverkar magsyrasekretionen |
FI752327A FI63756C (fi) | 1974-05-16 | 1975-08-15 | Foerfarande foer framstaellning av 2-(2-pyridylmetylsulfinyl)-bensimidazolderivat med magsyrasekretionsinhiberande verkan |
NO75752851A NO143222C (no) | 1974-05-16 | 1975-08-15 | Analogifremgangsmaate for fremstilling av nye substituerte pyridylsulfinyl-benzimidazoler med terapeutisk aktivitet |
DK372175AA DK140840B (da) | 1974-05-16 | 1975-08-18 | Analogifremgangsmåde til fremstilling af benzimidazolderivater eller syreadditionssalte deraf. |
CY1125A CY1125A (en) | 1974-05-16 | 1975-10-20 | 2-(heterocaclic asbstituted alkylsulphinyl)-benzinmidazoles and their pharmaceutical compositions |
ZA00756600A ZA756600B (en) | 1974-05-16 | 1975-10-20 | Gastric acid secretion agents |
GB43039/75A GB1525958A (en) | 1974-05-16 | 1975-10-20 | 2-(heterocyclic substituted alkylsulphinyl)-benzimidazoles and their pharmaceutical compositions |
IE2313/75A IE42451B1 (en) | 1974-05-16 | 1975-10-23 | 2-(heterocyclic substituted alkylsulphinyl)-benzimidazoles and their pharmaceutical compositions |
DE19752548340 DE2548340A1 (de) | 1974-05-16 | 1975-10-29 | Benzimidazole, verfahren zu deren herstellung und sie enthaltende mittel |
AT838075A AT337697B (de) | 1974-05-16 | 1975-11-04 | Verfahren zur herstellung von neuen benzimidazolderivaten und ihren salzen |
CS757458A CS196289B2 (en) | 1974-05-16 | 1975-11-05 | Process for preparing new compounds |
NL7513141A NL7513141A (nl) | 1974-05-16 | 1975-11-10 | Benzimidazoolderivaten en werkwijze voor het be- reiden daarvan alsmede preparaten voor het bein- vloeden van de maagzuursecretie. |
US05/630,916 US4045563A (en) | 1974-05-16 | 1975-11-11 | Substituted 2-[pyridylalkylenesulfinyl]-benzimidazoles with gastric acid secretion inhibiting effects |
HU75HE00000696A HU172653B (hu) | 1974-05-16 | 1975-11-12 | Sposob poluchenija zamehhennykh 2-skobka-2-piridil-metil-sul'finil-skobka zakryta-benzimidazolov |
SU752189960A SU602118A3 (ru) | 1974-05-16 | 1975-11-13 | Способ получени производных бензимидазола или их солей |
CA239,643A CA1055033A (en) | 1974-05-16 | 1975-11-14 | 2-(2-heterocyclic-methylsulphinyl)-benzimidazole compounds |
CH1481475A CH623814A5 (en) | 1974-05-16 | 1975-11-14 | Process for the preparation of novel benzimidazoles |
DD189463A DD122534A5 (US06897227-20050524-C00065.png) | 1974-05-16 | 1975-11-14 | |
FR7534910A FR2331340A1 (fr) | 1974-05-16 | 1975-11-14 | Nouveaux derives du benzimidazole, procede pour leur obtention et compositions pharmaceutiques les contenant |
JP50137712A JPS5262275A (en) | 1974-05-16 | 1975-11-15 | Production of organic compound |
FR7616732A FR2392021A1 (fr) | 1974-05-16 | 1976-06-03 | Nouveaux derives du benzimidazole et procede pour leur obtention |
AT752276A AT351524B (de) | 1974-05-16 | 1976-10-11 | Verfahren zur herstellung von neuen benzimida- zolderivaten, ihren salzen und optischen isomeren |
DK783659A DK365978A (da) | 1974-05-16 | 1978-08-18 | Mellemprodukt til anvendelse ved fremstilling af benzimidazolderivater |
CS786886A CS196290B2 (en) | 1974-05-16 | 1978-10-23 | Process for preparing new compounds |
CH976079A CH623582A5 (en) | 1974-05-16 | 1979-10-31 | Process for the preparation of benzimidazoles |
FI811747A FI65617C (fi) | 1974-05-16 | 1981-06-04 | Mellanprodukt foer framstaellning av magsyrasekretionsinhiberande 2-(2-pyridylmetylsulfinyl)-benzimidazolderivat |
HK87/82A HK8782A (en) | 1974-05-16 | 1982-02-25 | 2-(heterocyclic substituted alkylsulphinyl)-benzimidazoles and their pharmaceutical compositions |
MY159/82A MY8200159A (en) | 1974-05-16 | 1982-12-30 | 2-[heterocylic substituted alkylsulphinyl]-benzimidazoles and their pharmaceutical compositions |
Applications Claiming Priority (25)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE7406513A SE416649B (sv) | 1974-05-16 | 1974-05-16 | Forfarande for framstellning av foreningar som paverkar magsyrasekretionen |
NO75752851A NO143222C (no) | 1974-05-16 | 1975-08-15 | Analogifremgangsmaate for fremstilling av nye substituerte pyridylsulfinyl-benzimidazoler med terapeutisk aktivitet |
FI752327A FI63756C (fi) | 1974-05-16 | 1975-08-15 | Foerfarande foer framstaellning av 2-(2-pyridylmetylsulfinyl)-bensimidazolderivat med magsyrasekretionsinhiberande verkan |
DK372175AA DK140840B (da) | 1974-05-16 | 1975-08-18 | Analogifremgangsmåde til fremstilling af benzimidazolderivater eller syreadditionssalte deraf. |
ZA00756600A ZA756600B (en) | 1974-05-16 | 1975-10-20 | Gastric acid secretion agents |
GB43039/75A GB1525958A (en) | 1974-05-16 | 1975-10-20 | 2-(heterocyclic substituted alkylsulphinyl)-benzimidazoles and their pharmaceutical compositions |
IE2313/75A IE42451B1 (en) | 1974-05-16 | 1975-10-23 | 2-(heterocyclic substituted alkylsulphinyl)-benzimidazoles and their pharmaceutical compositions |
DE19752548340 DE2548340A1 (de) | 1974-05-16 | 1975-10-29 | Benzimidazole, verfahren zu deren herstellung und sie enthaltende mittel |
AT838075A AT337697B (de) | 1974-05-16 | 1975-11-04 | Verfahren zur herstellung von neuen benzimidazolderivaten und ihren salzen |
CS757458A CS196289B2 (en) | 1974-05-16 | 1975-11-05 | Process for preparing new compounds |
NL7513141A NL7513141A (nl) | 1974-05-16 | 1975-11-10 | Benzimidazoolderivaten en werkwijze voor het be- reiden daarvan alsmede preparaten voor het bein- vloeden van de maagzuursecretie. |
US05/630,916 US4045563A (en) | 1974-05-16 | 1975-11-11 | Substituted 2-[pyridylalkylenesulfinyl]-benzimidazoles with gastric acid secretion inhibiting effects |
HU75HE00000696A HU172653B (hu) | 1974-05-16 | 1975-11-12 | Sposob poluchenija zamehhennykh 2-skobka-2-piridil-metil-sul'finil-skobka zakryta-benzimidazolov |
SU752189960A SU602118A3 (ru) | 1974-05-16 | 1975-11-13 | Способ получени производных бензимидазола или их солей |
CA239,643A CA1055033A (en) | 1974-05-16 | 1975-11-14 | 2-(2-heterocyclic-methylsulphinyl)-benzimidazole compounds |
CH1481475A CH623814A5 (en) | 1974-05-16 | 1975-11-14 | Process for the preparation of novel benzimidazoles |
DD189463A DD122534A5 (US06897227-20050524-C00065.png) | 1974-05-16 | 1975-11-14 | |
FR7534910A FR2331340A1 (fr) | 1974-05-16 | 1975-11-14 | Nouveaux derives du benzimidazole, procede pour leur obtention et compositions pharmaceutiques les contenant |
JP50137712A JPS5262275A (en) | 1974-05-16 | 1975-11-15 | Production of organic compound |
FR7616732A FR2392021A1 (fr) | 1974-05-16 | 1976-06-03 | Nouveaux derives du benzimidazole et procede pour leur obtention |
AT752276A AT351524B (de) | 1974-05-16 | 1976-10-11 | Verfahren zur herstellung von neuen benzimida- zolderivaten, ihren salzen und optischen isomeren |
DK783659A DK365978A (da) | 1974-05-16 | 1978-08-18 | Mellemprodukt til anvendelse ved fremstilling af benzimidazolderivater |
CS786886A CS196290B2 (en) | 1974-05-16 | 1978-10-23 | Process for preparing new compounds |
HU8782 | 1982-02-25 | ||
MY159/82A MY8200159A (en) | 1974-05-16 | 1982-12-30 | 2-[heterocylic substituted alkylsulphinyl]-benzimidazoles and their pharmaceutical compositions |
Publications (3)
Publication Number | Publication Date |
---|---|
NO752851L NO752851L (US06897227-20050524-C00065.png) | 1977-02-16 |
NO143222B NO143222B (no) | 1980-09-22 |
NO143222C true NO143222C (no) | 1981-01-02 |
Family
ID=40486266
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO75752851A NO143222C (no) | 1974-05-16 | 1975-08-15 | Analogifremgangsmaate for fremstilling av nye substituerte pyridylsulfinyl-benzimidazoler med terapeutisk aktivitet |
Country Status (22)
Families Citing this family (125)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IN148930B (US06897227-20050524-C00065.png) * | 1977-09-19 | 1981-07-25 | Hoffmann La Roche | |
AT375365B (de) * | 1978-04-14 | 1984-07-25 | Haessle Ab | Verfahren zur herstellung von neuen 2-pyridylalkyl-sulfinyl-benzimidazolen, von deren hydraten, stereoisomeren und salzen |
AT406119B (de) * | 1978-04-14 | 2000-02-25 | Haessle Ab | Verfahren zur herstellung von granulaten bzw. tabletten oder kapseln zur oralen verabreichung |
SE7804231L (sv) * | 1978-04-14 | 1979-10-15 | Haessle Ab | Magsyrasekretionsmedel |
US4359465A (en) * | 1980-07-28 | 1982-11-16 | The Upjohn Company | Methods for treating gastrointestinal inflammation |
CH644116A5 (de) * | 1980-08-21 | 1984-07-13 | Hoffmann La Roche | Imidazolderivate. |
IL66340A (en) * | 1981-08-13 | 1986-08-31 | Haessle Ab | Pharmaceutical compositions comprising pyridylmethyl-thiobenzimidazole derivatives,certain such novel derivatives and their preparation |
US4472409A (en) * | 1981-11-05 | 1984-09-18 | Byk Gulden Lomberg Chemische Fabrik Gesellschaft Mit Beschrankter Haftung | 2-Pyridylmethyl thio(sulfinyl)benzimidazoles with gastric acid secretion inhibiting effects |
KR840002371A (ko) * | 1981-11-05 | 1984-06-25 | 귄터 미카엘, 헤르페르트 수키 | 치환된 벤즈 이미다졸의 제조방법 |
DE3216843C2 (de) * | 1982-05-05 | 1986-10-23 | Ludwig Heumann & Co GmbH, 8500 Nürnberg | 3-Thiomethyl-pyridin-Derivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel |
SE8300736D0 (sv) * | 1983-02-11 | 1983-02-11 | Haessle Ab | Novel pharmacologically active compounds |
SE8301182D0 (sv) * | 1983-03-04 | 1983-03-04 | Haessle Ab | Novel compounds |
HU195220B (en) * | 1983-05-03 | 1988-04-28 | Byk Gulden Lomberg Chem Fqb | Process for production of new fluor-alkoxi-benzimidasole-derivatives and medical compositions containig them |
IL71665A (en) * | 1983-05-03 | 1988-05-31 | Byk Gulden Lomberg Chem Fab | Fluoro-(2-pyridyl-methylthio)-dioxolo-(and dioxino-)benzimidazoles,processes for their preparation and pharmaceutical compositions containing the same |
CA1259070A (en) * | 1983-07-01 | 1989-09-05 | Upjohn Company (The) | Substituted 2-¬monoannelated(3,4-,4,5-, and 5,6-)- pyridylalkylenesulfinyl|-benzimidazoles |
US5077407A (en) * | 1983-07-01 | 1991-12-31 | The Upjohn Company | Substituted 2-[monoannelated (3,4-,4,5-, and 5,6-) pyridylalkylenesulfinyl]benzimidazoles |
DE3333314A1 (de) * | 1983-09-15 | 1985-03-28 | Hoechst Ag, 6230 Frankfurt | Substituierte pyrido(1,2-c)imidazo(1,2-a)benzimidazole, verfahren zu ihrer herstellung, ihre verwendung sowie pharmazeutische praeparate auf basis dieser verbindungen |
US4575554A (en) * | 1983-12-05 | 1986-03-11 | The Upjohn Company | Substituted 2-pyridylmethylthio- and sulfinyl-benzimidazoles as gastric antisecretory agents |
PH23995A (en) * | 1984-01-09 | 1990-02-09 | Janssen Pharmaceutica Nv | 4((bicycle heterocyclyl)-methyl and hetero)piperidines |
DE3585252D1 (de) * | 1984-07-06 | 1992-03-05 | Fisons Plc | Benzimidazole, und verfahren zu deren herstellung, deren formulierung und verwendung als magensaeuresekretionshemmende verbindungen. |
SE8404065D0 (sv) * | 1984-08-10 | 1984-08-10 | Haessle Ab | Novel biologically active compounds |
JPS6150978A (ja) * | 1984-08-16 | 1986-03-13 | Takeda Chem Ind Ltd | ピリジン誘導体およびその製造法 |
JPS6150979A (ja) * | 1984-08-16 | 1986-03-13 | Takeda Chem Ind Ltd | ピリジン誘導体およびその製造法 |
US4619997A (en) * | 1984-09-06 | 1986-10-28 | The Upjohn Company | Substituted 2-pyridylmethylthio and sulfinyl-benzimidazoles as gastric antisecretory agents |
KR890000387B1 (ko) * | 1984-09-24 | 1989-03-16 | 디 엎존 캄파니 | 2-(피리딜알켄술 피닐)벤즈 이미드아졸류의 n-치환 유도체의 제조방법 |
AU568441B2 (en) * | 1984-09-24 | 1987-12-24 | Upjohn Company, The | 2-(pyridylalkenesulfinyl) benzimidazole derivatives |
DE3579436D1 (de) * | 1984-12-18 | 1990-10-04 | Otsuka Pharma Co Ltd | Tetrahydrochinolin- derivate, verfahren zu deren herstellung und diese enthaltende antimagengeschwuerzusammensetzungen. |
GB8526154D0 (en) * | 1985-02-06 | 1985-11-27 | Kotobuki Seiyaku Co Ltd | 2-substituted cyclo-heptoimidazoles |
DK8600939A (US06897227-20050524-C00065.png) * | 1985-03-05 | 1986-09-06 | ||
FI861772A (fi) * | 1985-05-07 | 1986-11-08 | Chemie Linz Ag | Nya tieno(2,3-d)imidazolderivat och foerfarande for deras framstaellning. |
US5869513A (en) * | 1985-05-24 | 1999-02-09 | G. D. Searle & Co. | 2- (1H-benzimidazol-2-ylsulfinyl)methyl!benzenamines |
EP0204215B1 (en) | 1985-05-24 | 1993-08-11 | G.D. Searle & Co. | 2-[(1H-benzimidazol-2-ylsulfinyl)methyl]-benzenamines |
US4738975A (en) * | 1985-07-02 | 1988-04-19 | Takeda Chemical Industries, Ltd. | Pyridine derivatives, and use as anti-ulcer agents |
DK337086A (da) * | 1985-08-12 | 1987-02-13 | Hoffmann La Roche | Benzimidazolderivater |
AR243167A1 (es) | 1985-08-24 | 1993-07-30 | Hoechst Ag | Procedimiento para la preparacion de toluidinas sustituidas. |
SE8505112D0 (sv) * | 1985-10-29 | 1985-10-29 | Haessle Ab | Novel pharmacological compounds |
US6749864B2 (en) * | 1986-02-13 | 2004-06-15 | Takeda Chemical Industries, Ltd. | Stabilized pharmaceutical composition |
US5433959A (en) * | 1986-02-13 | 1995-07-18 | Takeda Chemical Industries, Ltd. | Stabilized pharmaceutical composition |
SE8600658D0 (sv) * | 1986-02-14 | 1986-02-14 | Haessle Ab | Novel composition of matter |
ES2032394T3 (es) * | 1986-02-20 | 1993-02-16 | Hoechst Aktiengesellschaft | Procedimiento para preparar derivados de tienoimidazol sustituidos. |
WO1987005296A1 (en) * | 1986-03-07 | 1987-09-11 | Pfizer Inc. | 2-[(2-pyridyl)methylsulfinyl]thienoimidazoles and related compounds as antiulcer agents |
ES2038612T3 (es) * | 1986-03-28 | 1993-08-01 | Otsuka Pharmaceutical Co., Ltd. | Compuestos de hidroquinolina, composiciones que los contienen y procedimientos para prepararlas. |
US4687775A (en) * | 1986-07-17 | 1987-08-18 | G. D. Searle & Co. | 2-[(Imidazo[1,2-a]pyridinylmethyl)sulfinyl]-1H-benzimidazoles |
US4772619A (en) * | 1986-07-17 | 1988-09-20 | G. D. Searle & Co. | [(1H-benzimidazol-2-ylsulfinyl)methyl]-2-pyridinamines |
US4721718A (en) * | 1986-08-18 | 1988-01-26 | G. D. Searle & Co. | 2-[(imidazo[1,2-a]pyridin-3-ylmethyl)sulfinyl]-1H-benzimidazoles useful in the treatment and prevention of ulcers |
SE8604998D0 (sv) | 1986-11-21 | 1986-11-21 | Haessle Ab | Novel pharmacological compounds |
NZ234564A (en) | 1986-11-21 | 1991-04-26 | Haessle Ab | 1-substituted benzimidazoles and pharmaceutical compositions |
DE3639926A1 (de) * | 1986-11-22 | 1988-06-01 | Hoechst Ag | Substituierte thienoimidazoltoluidin-derivate, verfahren zu ihrer herstellung, sie enthaltende pharmazeutische zubereitungen und ihre verwendung als magensaeuresekretionshemmer |
GB8630080D0 (en) * | 1986-12-17 | 1987-01-28 | Glaxo Group Ltd | Medicaments |
US5330982A (en) * | 1986-12-17 | 1994-07-19 | Glaxo Group Limited | Pharmaceutical composition containing a 5-HT receptor antagonist and an H+ K+ Atpase inhibitor and a method of treating gastrointestingal disorders therewith |
DE3723327A1 (de) * | 1987-07-15 | 1989-02-02 | Hoechst Ag | Substituierte thienoimidazol-derivate, verfahren zu ihrer herstellung, sie enthaltende pharmazeutische zubereitungen und ihre verwendung als magensaeuresekretionshemmer, magenschutzmittel sowie als medikament gegen intestinale entzuendungen |
EP0338066A1 (en) * | 1987-10-30 | 1989-10-25 | Aktiebolaget Hässle | 2-pyridinylmethyl (sulfinyl or thio)benzimidazoles for treatment of diseases related to bone loss |
KR920003928B1 (ko) * | 1988-09-20 | 1992-05-18 | 히사미쯔세이야꾸 가부시기가이샤 | 신규의 디벤즈[b,e]옥세핀유도체 |
IE64199B1 (en) * | 1988-12-22 | 1995-07-12 | Haessle Ab | Compound with gastric acid inhibitory effect and process for its preparation |
SE8804629D0 (sv) | 1988-12-22 | 1988-12-22 | Ab Haessle | New therapeutically active compounds |
SE8804628D0 (sv) | 1988-12-22 | 1988-12-22 | Ab Haessle | New compounds |
ES2057338T3 (es) * | 1989-11-29 | 1994-10-16 | Toa Eiyo Ltd | Derivados de cicloheptenopiridina, procedimiento para su preparacion y agentes antiulcerosos que los contienen. |
US5049674A (en) | 1989-12-20 | 1991-09-17 | Aktiebolaget Hassle | Therapeutically active fluoro substituted benzimidazoles |
US5274099A (en) * | 1989-12-20 | 1993-12-28 | Aktiebolaget Hassle | Therapeutically active fluoro substituted benzimidazoles |
US4965269A (en) * | 1989-12-20 | 1990-10-23 | Ab Hassle | Therapeutically active chloro substituted benzimidazoles |
JP2524420B2 (ja) * | 1990-05-16 | 1996-08-14 | 明治製菓株式会社 | ピペリジン誘導体及びそれらを有効成分とする抗潰瘍剤 |
SE9002206D0 (sv) | 1990-06-20 | 1990-06-20 | Haessle Ab | New compounds |
US5364875A (en) * | 1992-05-11 | 1994-11-15 | The Du Pont Merck Pharmaceutical Company | Imidazoles linked to bicyclic heterocyclic groups for the treatment of atherosclerosis |
PL307026A1 (en) * | 1992-07-08 | 1995-05-02 | Monsanto Co | Method of producing ppaliative effect in respect to swine gastric ulcers |
SK279554B6 (sk) * | 1992-07-28 | 1998-12-02 | Astra Aktiebolag | Jeho analógy |
TW280770B (US06897227-20050524-C00065.png) | 1993-10-15 | 1996-07-11 | Takeda Pharm Industry Co Ltd | |
US5945425A (en) * | 1994-04-29 | 1999-08-31 | G.D. Searle & Co. | Method of using (H+ /K+)ATPase inhibitors as antiviral agents |
EP0849259A4 (en) * | 1995-07-17 | 1998-11-11 | Fuji Photo Film Co Ltd | BENZIMIDAZOLE COMPOUNDS |
US5824339A (en) * | 1995-09-08 | 1998-10-20 | Takeda Chemical Industries, Ltd | Effervescent composition and its production |
DK1092434T3 (da) * | 1995-09-21 | 2004-07-26 | Pharma Pass Ii Llc | Hidtil ukendt sammensætning indeholdende lansoprazol og fremgangsmåde til fremstilling deraf |
CN1169807C (zh) * | 1997-07-11 | 2004-10-06 | 卫材株式会社 | 制备吡啶衍生物的方法 |
US6174548B1 (en) | 1998-08-28 | 2001-01-16 | Andrx Pharmaceuticals, Inc. | Omeprazole formulation |
US6096340A (en) * | 1997-11-14 | 2000-08-01 | Andrx Pharmaceuticals, Inc. | Omeprazole formulation |
GB9805558D0 (en) * | 1998-03-17 | 1998-05-13 | Knoll Ag | Chemical process` |
CN1195500C (zh) | 1998-05-18 | 2005-04-06 | 武田药品工业株式会社 | 可口腔崩解的片剂 |
US6093734A (en) * | 1998-08-10 | 2000-07-25 | Partnership Of Michael E. Garst, George Sachs, And Jai Moo Shin | Prodrugs of proton pump inhibitors |
CA2338311C (en) | 1998-08-10 | 2007-01-23 | Michael E. Garst | Prodrugs of the pyridyl methyl sulfinyl benzimidazoles |
US6166213A (en) * | 1998-08-11 | 2000-12-26 | Merck & Co., Inc. | Omeprazole process and compositions thereof |
US6733778B1 (en) | 1999-08-27 | 2004-05-11 | Andrx Pharmaceuticals, Inc. | Omeprazole formulation |
US6852739B1 (en) | 1999-02-26 | 2005-02-08 | Nitromed Inc. | Methods using proton pump inhibitors and nitric oxide donors |
US6245913B1 (en) | 1999-06-30 | 2001-06-12 | Wockhardt Europe Limited | Synthetic procedure for 5-methoxy-2-[(4-methoxy-3,5-dimethyl-2-pyridinyl)-methylthio]-IH-benzimidazole hydrochloride and its conversion to omeprazole |
AU2000254245B2 (en) | 2000-02-24 | 2005-03-03 | Kopran Research Laboratories Limited | Orally administrable acid stable anti-ulcer benzimidazole derivatives |
US6544556B1 (en) | 2000-09-11 | 2003-04-08 | Andrx Corporation | Pharmaceutical formulations containing a non-steroidal antiinflammatory drug and a proton pump inhibitor |
US20020064555A1 (en) * | 2000-09-29 | 2002-05-30 | Dan Cullen | Proton pump inhibitor formulation |
US20040248941A1 (en) * | 2001-09-25 | 2004-12-09 | Keiji Kamiyama | Benzimidazone compound, process for producing the same, and use thereof |
CN100562317C (zh) | 2001-10-17 | 2009-11-25 | 武田药品工业株式会社 | 含大量酸不稳定药物的颗粒 |
US20030228363A1 (en) * | 2002-06-07 | 2003-12-11 | Patel Mahendra R. | Stabilized pharmaceutical compositons containing benzimidazole compounds |
AU2003242390A1 (en) * | 2002-06-14 | 2003-12-31 | Takeda Pharmaceutical Company Limited | Prodrugs of imidazole derivatives, for use as proton pump inhibitors in the treatment of e.g. peptic ulcers |
EP1556371B1 (en) * | 2002-07-19 | 2006-04-19 | Winston Pharmaceuticals LLC | Benzimidazole derivatives and their use as prodrugs of proton pump inhibitor |
EP1534278A4 (en) * | 2002-08-01 | 2006-09-06 | Nitromed Inc | NITROSED PROTONATE PUMP INHIBITORS, COMPOSITIONS AND USE METHOD |
ES2534713T3 (es) | 2002-10-16 | 2015-04-27 | Takeda Pharmaceutical Company Limited | Preparaciones sólidas estables |
MY148805A (en) | 2002-10-16 | 2013-05-31 | Takeda Pharmaceutical | Controlled release preparation |
CA2529984C (en) | 2003-06-26 | 2012-09-25 | Isa Odidi | Oral multi-functional pharmaceutical capsule preparations of proton pump inhibitors |
CA2536902A1 (en) * | 2003-09-03 | 2005-03-10 | Agi Therapeutics Limited | Proton pump inhibitor formulations, and methods of preparing and using such formulations |
US20050075371A1 (en) * | 2003-10-03 | 2005-04-07 | Allergan, Inc. | Methods and compositions for the oral administration of prodrugs of proton pump inhibitors |
US20060241037A1 (en) * | 2003-10-03 | 2006-10-26 | Allergan Inc. | Compositions comprising trefoil factor family peptides and/or mucoadhesives and proton pump ihhibitor prodrugs |
US20070292498A1 (en) * | 2003-11-05 | 2007-12-20 | Warren Hall | Combinations of proton pump inhibitors, sleep aids, buffers and pain relievers |
WO2005077936A1 (en) | 2004-02-11 | 2005-08-25 | Ulkar Kimya Sanayii Ve Ticaret A.S. | Pyridine benzimidazole sulfoxides with high purity |
US20070060621A1 (en) * | 2004-02-18 | 2007-03-15 | Hughes Patrick M | Methods and compositions for the administration of prodrugs of proton pump inhibitors |
BRPI0507837A (pt) * | 2004-02-18 | 2007-07-10 | Allergan Inc | métodos e composições para a administração intravenosa de compostos relacionados a inibidores de bomba de prótons |
US20050239845A1 (en) * | 2004-04-16 | 2005-10-27 | Santarus, Inc. | Combination of proton pump inhibitor, buffering agent, and prokinetic agent |
US8394409B2 (en) | 2004-07-01 | 2013-03-12 | Intellipharmaceutics Corp. | Controlled extended drug release technology |
US20060024362A1 (en) * | 2004-07-29 | 2006-02-02 | Pawan Seth | Composition comprising a benzimidazole and process for its manufacture |
US10624858B2 (en) | 2004-08-23 | 2020-04-21 | Intellipharmaceutics Corp | Controlled release composition using transition coating, and method of preparing same |
CN102775388B (zh) | 2004-09-13 | 2016-01-20 | 武田药品工业株式会社 | 氧化化合物的制备方法和制备装置 |
EP2275088B2 (en) | 2005-02-25 | 2018-09-26 | Takeda Pharmaceutical Company Limited | Method for producing granules |
US10064828B1 (en) | 2005-12-23 | 2018-09-04 | Intellipharmaceutics Corp. | Pulsed extended-pulsed and extended-pulsed pulsed drug delivery systems |
WO2007074856A1 (ja) | 2005-12-28 | 2007-07-05 | Takeda Pharmaceutical Company Limited | 口腔内崩壊性固形製剤の製造法 |
US20070199890A1 (en) * | 2006-02-27 | 2007-08-30 | Agion Technologies, Inc. | Antimicrobial activated carbon and use thereof |
US9561188B2 (en) | 2006-04-03 | 2017-02-07 | Intellipharmaceutics Corporation | Controlled release delivery device comprising an organosol coat |
US10960077B2 (en) * | 2006-05-12 | 2021-03-30 | Intellipharmaceutics Corp. | Abuse and alcohol resistant drug composition |
US7786309B2 (en) * | 2006-06-09 | 2010-08-31 | Apotex Pharmachem Inc. | Process for the preparation of esomeprazole and salts thereof |
US20100317689A1 (en) * | 2006-09-19 | 2010-12-16 | Garst Michael E | Prodrugs of proton pump inhibitors including the 1h-imidazo[4,5-b] pyridine moiety |
GB2444593B (en) | 2006-10-05 | 2010-06-09 | Santarus Inc | Novel formulations for immediate release of proton pump inhibitors and methods of using these formulations |
EP2486910A3 (en) | 2006-10-27 | 2012-08-22 | The Curators Of The University Of Missouri | Multi-chambered apparatus comprising a dispenser head |
US9205094B2 (en) | 2006-12-22 | 2015-12-08 | Ironwood Pharmaceuticals, Inc. | Compositions comprising bile acid sequestrants for treating esophageal disorders |
US20130156720A1 (en) | 2010-08-27 | 2013-06-20 | Ironwood Pharmaceuticals, Inc. | Compositions and methods for treating or preventing metabolic syndrome and related diseases and disorders |
WO2013031620A1 (ja) | 2011-08-26 | 2013-03-07 | 国立大学法人名古屋大学 | 骨形成促進剤及びその用途 |
EA026456B1 (ru) | 2011-12-16 | 2017-04-28 | Атопикс Терапьютикс Лимитед | Фармацевтическая композиция на основе антагониста crth2 и ингибитора протонного насоса для лечения эозинофильного эзофагита |
CN108057028A (zh) | 2013-01-15 | 2018-05-22 | 铁木医药有限公司 | 片剂形式的肠溶包衣的胃内滞留口服剂型及其应用和药物组合物 |
US20180015118A1 (en) | 2015-02-03 | 2018-01-18 | Ironwood Pharmaceuticals, Inc. | Methods of treating upper gastrointestinal disorders in ppi refractory gerd |
EP3288556A4 (en) | 2015-04-29 | 2018-09-19 | Dexcel Pharma Technologies Ltd. | Orally disintegrating compositions |
US10736855B2 (en) | 2016-02-25 | 2020-08-11 | Dexcel Pharma Technologies Ltd. | Compositions comprising proton pump inhibitors |
US10076494B2 (en) | 2016-06-16 | 2018-09-18 | Dexcel Pharma Technologies Ltd. | Stable orally disintegrating pharmaceutical compositions |
WO2024075017A1 (en) | 2022-10-04 | 2024-04-11 | Zabirnyk Arsenii | Inhibition of aortic valve calcification |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1234058A (US06897227-20050524-C00065.png) * | 1968-10-21 | 1971-06-03 | ||
DE1903755B2 (de) * | 1969-01-25 | 1971-04-22 | Th Goldschmidt AG, 4300 Essen | Verfahren zur herstellung von zinnhaltigen keramischen farbkoerpern |
SE418966B (sv) * | 1974-02-18 | 1981-07-06 | Haessle Ab | Analogiforfarande for framstellning av foreningar med magsyrasekretionsinhiberande verkan |
-
1974
- 1974-05-16 SE SE7406513A patent/SE416649B/xx not_active IP Right Cessation
-
1975
- 1975-08-15 FI FI752327A patent/FI63756C/fi not_active IP Right Cessation
- 1975-08-15 NO NO75752851A patent/NO143222C/no unknown
- 1975-08-18 DK DK372175AA patent/DK140840B/da not_active IP Right Cessation
- 1975-10-20 CY CY1125A patent/CY1125A/xx unknown
- 1975-10-20 GB GB43039/75A patent/GB1525958A/en not_active Expired
- 1975-10-20 ZA ZA00756600A patent/ZA756600B/xx unknown
- 1975-10-23 IE IE2313/75A patent/IE42451B1/en unknown
- 1975-10-29 DE DE19752548340 patent/DE2548340A1/de active Granted
- 1975-11-04 AT AT838075A patent/AT337697B/de not_active IP Right Cessation
- 1975-11-05 CS CS757458A patent/CS196289B2/cs unknown
- 1975-11-10 NL NL7513141A patent/NL7513141A/xx not_active Application Discontinuation
- 1975-11-11 US US05/630,916 patent/US4045563A/en not_active Expired - Lifetime
- 1975-11-12 HU HU75HE00000696A patent/HU172653B/hu unknown
- 1975-11-13 SU SU752189960A patent/SU602118A3/ru active
- 1975-11-14 DD DD189463A patent/DD122534A5/xx unknown
- 1975-11-14 CA CA239,643A patent/CA1055033A/en not_active Expired
- 1975-11-14 FR FR7534910A patent/FR2331340A1/fr active Granted
- 1975-11-14 CH CH1481475A patent/CH623814A5/de not_active IP Right Cessation
- 1975-11-15 JP JP50137712A patent/JPS5262275A/ja active Granted
-
1976
- 1976-06-03 FR FR7616732A patent/FR2392021A1/fr active Granted
- 1976-10-11 AT AT752276A patent/AT351524B/de not_active IP Right Cessation
-
1978
- 1978-08-18 DK DK783659A patent/DK365978A/da unknown
- 1978-10-23 CS CS786886A patent/CS196290B2/cs unknown
-
1979
- 1979-10-31 CH CH976079A patent/CH623582A5/de not_active IP Right Cessation
-
1981
- 1981-06-04 FI FI811747A patent/FI65617C/fi not_active IP Right Cessation
-
1982
- 1982-02-25 HK HK87/82A patent/HK8782A/xx unknown
- 1982-12-30 MY MY159/82A patent/MY8200159A/xx unknown
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
NO143222C (no) | Analogifremgangsmaate for fremstilling av nye substituerte pyridylsulfinyl-benzimidazoler med terapeutisk aktivitet | |
NO143576C (no) | Analogifremgangsmaate for fremstilling av terapeutisk aktive heterocykliske forbindelser | |
NO142402C (no) | Analogifremgangsmaate for fremstilling av farmakologisk aktive benzimidazoler | |
SE434395B (sv) | Analogiforfarande for framstellning av karbostyrilderivat med terapeutisk verkan | |
NO143460C (no) | Analogifremgangsmaate for fremstilling av terapeutisk aktive benzomorfaner. | |
NO141800C (no) | Analogifremgangsmaate for fremstilling av terapeutisk aktive benzomorfaner. | |
SE420727B (sv) | Analogiforfarande for framstellning av bispidin- och bispidonderivat | |
NO144210C (no) | Analogifremgangsmaate til fremstilling av nye dl-tyrosinderivater med farmasoeytisk virkning paa glatte muskler | |
NO144740C (no) | Analogifremgangsmaate ved fremstilling av nye, terapeutisk virksomme, substituerte n-(1-benzyl-pyrrolidinyl-2-alkyl)-benzamider | |
SE423544B (sv) | Analogiforfarande for framstellning av imidazolderivat med antifungisk aktivitet | |
SE412066B (sv) | Forfarande for framstellning av famakologiskt verksamma tienodiazinderivat | |
NO143908C (no) | Analogifremgangsmaate til fremstilling av terapeutisk virksomme, nye penicilliner | |
NO142838C (no) | Analogifremgangsmaate for fremstilling av terapeutisk aktive isokinolinderivater | |
NO143064C (no) | Analogifremgangsmaate for fremstilling av terapeutisk aktive hydroksyalkylxantiner | |
NO143627C (no) | Fremgangsmaate for fremstilling av karboksamider av okso-1, 2-benzotiazin-1,1-dioksyder | |
SE428296B (sv) | Analogiforfarande for framstellning av substituerade difonylsulfider | |
NO141441C (no) | Analogifremgangsmaate for fremstilling av nye terapeutisk aktive derivater av isoindolin-1-on | |
NO145238C (no) | Analogifremgangsmaate for fremstilling av terapeutisk aktive dihydrokarbostyril-derivater | |
NO144704C (no) | Analogifremgangsmaate til fremstilling av terapeutisk aktive 1-alkyl-2-(fenoksymetyl)-5-nitro-imidazoler | |
SE422210B (sv) | Analogiforfarande for framstellning av substituerade indoler | |
NO146672C (no) | Analogifremgangsmaate for fremstilling av terapeutisk aktive cinnolinderivater | |
SE7512292L (sv) | Forfarande for framstellning av naftalenforeningar med terapeutisk verkan | |
NO143844C (no) | Analogifremgangsmaate til fremstilling av nye terapeutisk aktive disubstituerte fenoletere av 3-amino-2-hydroksypropan | |
SE425784B (sv) | Analogiforfarande for framstellning av eburnameninderivat | |
SE404364B (sv) | Forfarande for framstellning av vissa angivna 5-sulfonylfenyl-tetrazolderivat |