NL940020I2 - Fenethylaminederivaten en tussenprodukten daarvoor. - Google Patents
Fenethylaminederivaten en tussenprodukten daarvoor.Info
- Publication number
- NL940020I2 NL940020I2 NL940020C NL940020C NL940020I2 NL 940020 I2 NL940020 I2 NL 940020I2 NL 940020 C NL940020 C NL 940020C NL 940020 C NL940020 C NL 940020C NL 940020 I2 NL940020 I2 NL 940020I2
- Authority
- NL
- Netherlands
- Prior art keywords
- intermediates therefor
- phenethylamine derivatives
- phenethylamine
- derivatives
- intermediates
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/04—1,3-Oxazines; Hydrogenated 1,3-oxazines
- C07D265/12—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems
- C07D265/14—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
- C07C215/42—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having amino groups or hydroxy groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
- C07C215/46—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
- C07C215/64—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with rings other than six-membered aromatic rings being part of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
- C07C215/68—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings and hydroxy groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
- C07C215/70—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings and hydroxy groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with rings other than six-membered aromatic rings being part of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/32—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
- C07C235/34—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
- C07C255/32—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring
- C07C255/36—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by hydroxy groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
- C07C255/32—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring
- C07C255/37—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by etherified hydroxy groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/04—Systems containing only non-condensed rings with a four-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/18—Systems containing only non-condensed rings with a ring being at least seven-membered
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US44903282A | 1982-12-13 | 1982-12-13 | |
| US48659483A | 1983-04-19 | 1983-04-19 | |
| GB838316646A GB8316646D0 (en) | 1983-06-18 | 1983-06-18 | Phenethylamine derivatives |
| US06/545,701 US4535186A (en) | 1983-04-19 | 1983-10-26 | 2-Phenyl-2-(1-hydroxycycloalkyl or 1-hydroxycycloalk-2-enyl)ethylamine derivatives |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NL940020I1 NL940020I1 (nl) | 1994-12-16 |
| NL940020I2 true NL940020I2 (nl) | 1999-07-01 |
Family
ID=27449489
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NL940020C NL940020I2 (nl) | 1982-12-13 | 1994-10-28 | Fenethylaminederivaten en tussenprodukten daarvoor. |
Country Status (7)
| Country | Link |
|---|---|
| EP (1) | EP0112669B1 (nl) |
| AU (1) | AU567524B2 (nl) |
| DE (2) | DE3372753D1 (nl) |
| GB (2) | GB2133788B (nl) |
| IE (1) | IE56324B1 (nl) |
| LU (1) | LU88750I2 (nl) |
| NL (1) | NL940020I2 (nl) |
Families Citing this family (54)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU566673B2 (en) * | 1983-09-15 | 1987-10-29 | F. Hoffmann-La Roche Ag | Phenethylamine derivatives |
| GB8501192D0 (en) * | 1985-01-17 | 1985-02-20 | Boots Co Plc | Therapeutic agents |
| US4609758A (en) | 1985-05-09 | 1986-09-02 | American Home Products Corporation | Phenoxyethylamine derivatives |
| GB8902209D0 (en) * | 1989-02-01 | 1989-03-22 | Wyeth John And Brother Limited | Preparation of cyclohexanol derivatives and novel thioamide intermediates |
| US6440457B1 (en) * | 1993-05-27 | 2002-08-27 | Alza Corporation | Method of administering antidepressant dosage form |
| DK1738753T3 (da) * | 1993-06-28 | 2008-08-11 | Wyeth Corp | Nye behandlinger under anvendelse af phenethylaminderivater |
| TW344661B (en) * | 1993-11-24 | 1998-11-11 | Lilly Co Eli | Pharmaceutical composition for treatment of incontinence |
| PE57198A1 (es) * | 1996-03-25 | 1998-10-10 | American Home Prod | Formula de liberacion prolongada |
| EP1331003B1 (en) * | 1996-03-25 | 2015-08-26 | Wyeth LLC | Extended release formulation containing venlafaxine |
| US6342533B1 (en) * | 1998-12-01 | 2002-01-29 | Sepracor, Inc. | Derivatives of (−)-venlafaxine and methods of preparing and using the same |
| US6197828B1 (en) * | 1998-12-01 | 2001-03-06 | Sepracor, Inc. | Derivatives of (+)-venlafaxine and methods of preparing and using the same |
| PT1466889E (pt) * | 1999-04-06 | 2008-07-02 | Sepracor Inc | Succinato de o-desmetilvenlafaxina |
| TWI228118B (en) * | 2000-08-30 | 2005-02-21 | Ciba Sc Holding Ag | Process for the preparation of substituted phenylacetonitriles |
| WO2002036542A1 (en) | 2000-10-31 | 2002-05-10 | Ciba Specialty Chemicals Holding Inc. | Crystalline forms of venlafaxine hydrochloride |
| AU2001235970A1 (en) * | 2000-12-07 | 2002-06-18 | Dr. Reddy's Research Foundation | Novel crystalline polymorphic forms of venlafaxine hydrochloride and a process for their preparation |
| DK1360169T3 (da) * | 2001-02-12 | 2007-11-26 | Wyeth Corp | Succinatsalt af O-desmethyl-venlafaxin |
| US6350912B1 (en) | 2001-02-28 | 2002-02-26 | Council Of Scientific And Industrial Research | One pot process for the preparation of 1-[2-dimethylamino-(4-methoxyphenyl)-ethyl]cyclohexanol |
| DE60111349T2 (de) * | 2001-02-28 | 2006-05-18 | Council Of Scientific And Industrial Research | Verfahren zur Herstellung von 1-(2-Dimethylamino-(4-methoxyphenyl)-ethyl)cyclohexanol |
| ATE411986T1 (de) | 2001-04-10 | 2008-11-15 | Alembic Ltd | Zwischenprodukt zur herstellung von 1-ä2- dimethylamino-1-(4-methoxyphenyl)-ethylü- cyclohexanol |
| GB0126036D0 (en) * | 2001-10-30 | 2001-12-19 | Amedis Pharm Ltd | Silicon compounds |
| DE10161818A1 (de) | 2001-12-14 | 2003-06-26 | Gruenenthal Gmbh | Substituierte 1,5-Diaminopentan-3-ol-Verbindungen |
| US7001920B2 (en) | 2002-06-10 | 2006-02-21 | Wyeth | Formate salt of O-desmethyl-venlafaxine |
| WO2004094436A1 (en) * | 2003-04-24 | 2004-11-04 | Amedis Pharmaceuticals Ltd. | 1-(2-amino-1-phenyl-ethyl) 1- silacyclohexan-1- ol derivatives and use thereof in the preparation of a medicament |
| WO2005049560A2 (en) * | 2003-09-29 | 2005-06-02 | Sun Pharmaceutical Industries Limited | Process for the preparation of anti-depressant compound |
| TW200523258A (en) * | 2003-10-02 | 2005-07-16 | Wyeth Corp | Process for the preparation of 1-[cyano(phenyl)methyl]-cyclohexanol compounds |
| DE10359154A1 (de) | 2003-12-16 | 2005-07-28 | Krka Tovarna Zdravil, D.D. | Verfahren zur Herstellung von Venlafaxin und Venlafaxinhydrochlorid der Form I |
| BRPI0612896A2 (pt) * | 2005-06-29 | 2009-12-08 | Wyeth Corp | processo para a preparação de compostos de 1 - [ciano (fenil) metil] cicloexanol |
| PT1954669E (pt) * | 2005-12-01 | 2015-10-23 | Auspex Pharmaceuticals Inc | Feniletilaminas substituídas com actividade serotoninérgica e/ou norepinefrinérgica |
| CN101336226B (zh) * | 2005-12-01 | 2012-05-23 | 奥斯拜客斯制药有限公司 | 具有5-羟色胺能活性和/或去甲肾上腺素能活性的取代的苯乙胺 |
| WO2007071404A1 (en) | 2005-12-20 | 2007-06-28 | Synthon B.V. | Process for making desvenlafaxine |
| WO2007094008A2 (en) * | 2006-02-16 | 2007-08-23 | Unichem Laboratories Limited | A novel process for preparation of venlafaxine hydrochloride and its intermediates |
| MX2007016179A (es) | 2006-04-17 | 2008-03-11 | Teva Pharma | Formas cristalinas de o-desmetilvenlafaxina. |
| WO2008013993A2 (en) * | 2006-07-26 | 2008-01-31 | Teva Pharmaceutical Industries Ltd. | Processes for the synthesis of o-desmethylvenlafaxine |
| WO2008013990A2 (en) | 2006-07-26 | 2008-01-31 | Teva Pharmaceutical Industries Ltd. | Processes for the synthesis of o-desmethylvenlafaxine |
| FR2909089B1 (fr) | 2006-11-23 | 2009-02-27 | Ppg Sipsy Soc Par Actions Simp | Procede in situ ou "one pot" d'hydrogenation et d'amination reductrice |
| AR064987A1 (es) * | 2007-01-22 | 2009-05-06 | Medichem Sa | Proceso mejorado para sintetizar desvenlafaxina como base libre y sales o solvatos de la misma |
| AU2008211711A1 (en) * | 2007-01-31 | 2008-08-07 | Generics [Uk] Limited | Process for the preparation of O-desmethyl venlafaxine |
| ES2605371T3 (es) | 2007-03-15 | 2017-03-14 | Auspex Pharmaceuticals, Inc. | D9-Venlafaxina deuterada |
| WO2009017813A1 (en) * | 2007-08-02 | 2009-02-05 | Teva Pharmaceutical Industries Ltd. | O-desmethyl venlafaxine saccharinate |
| US20110046231A1 (en) * | 2007-10-22 | 2011-02-24 | Actavis Group Ptc Ehf | Solid forms of (±)-o-desmethylvenlafaxine salts |
| WO2009070311A2 (en) | 2007-11-26 | 2009-06-04 | Teva Pharmaceutical Industries Ltd. | Crystal forms of o-desmethylvenlafaxine fumarate |
| EP2085377A1 (en) | 2008-01-29 | 2009-08-05 | LEK Pharmaceuticals D.D. | Novel salts of O-desmethyl-venlafaxine |
| WO2009101458A2 (en) * | 2008-02-14 | 2009-08-20 | Egis Gyógyszergyár Nyilvánosan Működő | New polymorph and amorphous forms of desvenlafaxine fumarate |
| WO2009128057A2 (en) | 2008-04-18 | 2009-10-22 | UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN et al | Psycho-pharmaceuticals |
| EP2119696A1 (en) | 2008-05-16 | 2009-11-18 | Krka | Preparation of O-desmethylvenlafaxine salts |
| EP2119695A1 (en) | 2008-05-16 | 2009-11-18 | Krka | Preparation of O-desmethylvenlafaxine salts |
| CZ2008756A3 (cs) * | 2008-11-27 | 2010-03-24 | Zentiva, A. S. | Zpusob prípravy desvenlafaxinu a jeho solí |
| CZ2009454A3 (cs) * | 2009-07-15 | 2010-11-10 | Zentiva, K. S. | Zpusob prípravy desvenlafaxinu a jeho solí |
| US8754261B2 (en) | 2009-12-16 | 2014-06-17 | Pharmathen S.A. | Process for the preparation of O-desmethyl-venlafaxine and salts thereof |
| EP2539313A2 (en) | 2010-03-29 | 2013-01-02 | Pliva Hrvatska D.O.O. | Crystal forms of o-desmethylvenlafaxine fumarate |
| EP2746264A1 (en) | 2012-12-19 | 2014-06-25 | Basf Se | Substituted [1,2,4]triazole and imidazole compounds |
| EP2746255A1 (en) | 2012-12-19 | 2014-06-25 | Basf Se | Substituted [1,2,4]triazole and imidazole compounds |
| US9527800B2 (en) | 2013-10-29 | 2016-12-27 | Council Of Scientific And Industrial Research | Process for total synthesis of venlafaxine |
| CN104529797A (zh) * | 2014-12-05 | 2015-04-22 | 南昌市博泽康医药科技有限公司 | 盐酸文拉法辛手性晶型的制备 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1124485B (de) * | 1960-02-12 | 1962-03-01 | Hoechst Ag | Verfahren zur Herstellung von analeptisch wirksamen Phenylcycloalkylmethylaminen |
| GB1098835A (en) * | 1965-07-13 | 1968-01-10 | Jacques Logeais Sa Lab | Spiro-oxazolidinones, spiro-oxazines, their process of preparation and therapeutic compositions containing said derivatives |
| JPS56113748A (en) * | 1980-02-13 | 1981-09-07 | Kowa Co | Aminoethanol derivative and its preparation |
-
1983
- 1983-11-30 IE IE2818/83A patent/IE56324B1/en not_active IP Right Cessation
- 1983-12-06 AU AU22123/83A patent/AU567524B2/en not_active Expired
- 1983-12-07 LU LU88750C patent/LU88750I2/fr unknown
- 1983-12-07 DE DE8383307435T patent/DE3372753D1/de not_active Expired
- 1983-12-07 EP EP83307435A patent/EP0112669B1/en not_active Expired
- 1983-12-07 DE DE1996175025 patent/DE19675025I2/de active Active
- 1983-12-07 GB GB08332598A patent/GB2133788B/en not_active Expired
-
1986
- 1986-02-17 GB GB08603901A patent/GB2173787B/en not_active Expired
-
1994
- 1994-10-28 NL NL940020C patent/NL940020I2/nl unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU567524B2 (en) | 1987-11-26 |
| GB2133788B (en) | 1987-07-15 |
| IE832818L (en) | 1984-06-13 |
| IE56324B1 (en) | 1991-06-19 |
| NL940020I1 (nl) | 1994-12-16 |
| GB8332598D0 (en) | 1984-01-11 |
| DE3372753D1 (en) | 1987-09-03 |
| GB2173787A (en) | 1986-10-22 |
| GB8603901D0 (en) | 1986-03-26 |
| EP0112669A3 (en) | 1984-11-28 |
| EP0112669B1 (en) | 1987-07-29 |
| GB2133788A (en) | 1984-08-01 |
| LU88750I2 (fr) | 1996-08-23 |
| GB2173787B (en) | 1987-07-15 |
| EP0112669A2 (en) | 1984-07-04 |
| AU2212383A (en) | 1984-06-21 |
| DE19675025I2 (de) | 2003-05-22 |
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