NL8502681A - Carbapenem-antibiotica. - Google Patents

Carbapenem-antibiotica. Download PDF

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Publication number
NL8502681A
NL8502681A NL8502681A NL8502681A NL8502681A NL 8502681 A NL8502681 A NL 8502681A NL 8502681 A NL8502681 A NL 8502681A NL 8502681 A NL8502681 A NL 8502681A NL 8502681 A NL8502681 A NL 8502681A
Authority
NL
Netherlands
Prior art keywords
alkyl
carbon atoms
group
ring
alkylamino
Prior art date
Application number
NL8502681A
Other languages
English (en)
Dutch (nl)
Original Assignee
Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Co filed Critical Bristol Myers Co
Publication of NL8502681A publication Critical patent/NL8502681A/nl

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
    • C07D477/16—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
    • C07D477/20—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
NL8502681A 1984-10-02 1985-10-01 Carbapenem-antibiotica. NL8502681A (nl)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US65683884 1984-10-02
US06/656,838 US4683301A (en) 1982-04-08 1984-10-02 Carbapenem antibiotics

Publications (1)

Publication Number Publication Date
NL8502681A true NL8502681A (nl) 1986-05-01

Family

ID=24634788

Family Applications (1)

Application Number Title Priority Date Filing Date
NL8502681A NL8502681A (nl) 1984-10-02 1985-10-01 Carbapenem-antibiotica.

Country Status (24)

Country Link
US (1) US4683301A (ja)
JP (1) JPS6187682A (ja)
KR (1) KR910009270B1 (ja)
AT (1) AT395151B (ja)
AU (1) AU575432B2 (ja)
BE (1) BE903353A (ja)
CA (1) CA1260945A (ja)
CH (1) CH665640A5 (ja)
DE (1) DE3535196A1 (ja)
DK (1) DK446685A (ja)
ES (2) ES8703880A1 (ja)
FI (1) FI79317C (ja)
FR (1) FR2571054B1 (ja)
GB (1) GB2165247B (ja)
GR (1) GR852336B (ja)
HU (1) HU194240B (ja)
IL (1) IL76539A0 (ja)
IT (1) IT1190396B (ja)
LU (1) LU86105A1 (ja)
NL (1) NL8502681A (ja)
OA (1) OA08113A (ja)
PT (1) PT81236B (ja)
SE (1) SE466202B (ja)
ZA (1) ZA857581B (ja)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4732977A (en) * 1982-09-28 1988-03-22 Bristol Myers Company Carbapenem antibiotics
US5116833A (en) * 1990-10-19 1992-05-26 Bristol-Myers Squibb Company Antibiotic c-3 dithioacetal-substituted carbapenem compounds, compositions, and methods of use thereof
AR002507A1 (es) * 1995-06-28 1998-03-25 Merck & Co Inc Proceso mejorado para sintetizar intermediarios de carbapenem
US5823718A (en) * 1996-07-25 1998-10-20 Alnet (Proprietary) Limited Pillar bag

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3950357A (en) * 1974-11-25 1976-04-13 Merck & Co., Inc. Antibiotics
US4235920A (en) * 1975-11-21 1980-11-25 Merck & Co., Inc. N-Alkylated derivatives of thienamycin
AU4061378A (en) * 1977-10-19 1980-04-17 Merck & Co., Inc. 1-azabicyclo (3.2.0) hept-2-enes
AU531084B2 (en) * 1977-10-19 1983-08-11 Merck & Co., Inc. Azetidine derivatives
US4218463A (en) * 1977-12-28 1980-08-19 Merck & Co., Inc. 3-Substituted thio-6-amido-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid
US4174316A (en) * 1978-08-14 1979-11-13 Merck & Co., Inc. 4-Iodomethylazetidin-2-one
US4208422A (en) * 1978-10-24 1980-06-17 Merck & Co., Inc. 1-Substituted-pen-2-em-3-carboxylic acids
EP0010317B1 (en) * 1978-10-24 1983-12-21 Merck & Co. Inc. 6-, 1- and 2-substituted-1-carbapen-2-em-3-carboxylic acids, processes for the preparation of such compounds and pharmaceutical composition comprising such compounds
US4232036A (en) * 1978-10-24 1980-11-04 Merck & Co., Inc. 6-, 1- and 2-Substituted-1-carbadethiapen-2-em-3-carboxylic acids
US4318912A (en) * 1979-01-02 1982-03-09 Merck & Co., Inc. 6-(1-Hydroxyethyl)-3-substituted-1-azabicyclo(3.2.0)-hept-2-en-7-one-2-carboxylic acid
EP0017992A1 (en) * 1979-04-19 1980-10-29 Merck & Co. Inc. 2-Substituted-6-substituted-1-carbadethiapen-2-em-3-carboxylic acids, processes for preparing them, antibiotic pharmaceutical compositions containing same and process for preparing intermediates
US4376774A (en) * 1979-05-29 1983-03-15 Merck & Co., Inc. Antibiotic N-heterocyclyl thienamycin
EP0055990B1 (en) * 1979-08-10 1986-06-11 Beecham Group Plc Beta-lactam antibiotics, their preparation and use
IE52147B1 (en) * 1980-03-27 1987-07-08 Merck & Co Inc 4-(3-carboxy-2-oxopropyl)-azetidin-2-ones and process for their preparation
US4309346A (en) * 1980-03-27 1982-01-05 Merck & Co., Inc. Process for the preparation of 1-carbapenems and intermediates via trithioorthoacetates
DE3169321D1 (en) * 1980-03-27 1985-04-25 Merck & Co Inc Process for the preparation of 1-carbapenems and intermediates via silyl-substituted dithioacetals
EP0038869A1 (en) * 1980-04-30 1981-11-04 Merck & Co. Inc. Process for the preparation of 1-carbapenems, and intermediates for their preparation
JPS56161393A (en) * 1980-05-16 1981-12-11 Sanraku Inc Beta-lactam compound
US4378315A (en) * 1980-05-29 1983-03-29 Merck & Co., Inc. Process for the preparation of thienamycin and intermediates
US4350631A (en) * 1980-12-18 1982-09-21 Merck & Co., Inc. 6- and 4-Substituted-1-azabicyclo[3.2.0]heptan-3,7-dione-2-carboxylates
ES514240A0 (es) * 1981-08-03 1984-04-16 Merck & Co Inc Un procedimiento para la prepracion de nuevos derivados de acidos 2-carbamimidoil-1-,carbadestiapen-2-en-3-carboxilados.
EP0074599A1 (en) * 1981-09-09 1983-03-23 Takeda Chemical Industries, Ltd. 5,6-cis-Carbapenem derivatives, their production and use
US4640915A (en) * 1982-03-29 1987-02-03 Fujisawa Pharmaceutical Co., Ltd. 1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid derivatives
CA1198440A (en) * 1982-04-08 1985-12-24 Choung U. Kim Carbapenem antibiotics
US4536335A (en) * 1982-06-18 1985-08-20 Bristol-Myers Company Carbapenem antibiotics
EP0113101A1 (en) * 1982-12-30 1984-07-11 Merck & Co. Inc. 6-(1-Hydroxyethyl)-2-SR8-1-methyl-1-carbadethiapen-2-em-3-carboxylic acid esters
DK140584A (da) * 1983-03-08 1984-09-09 Bristol Myers Co Fremgangsmaade til fremstilling af carbapenemderivater

Also Published As

Publication number Publication date
ES8800223A1 (es) 1987-11-01
GB8524125D0 (en) 1985-11-06
GB2165247A (en) 1986-04-09
FI853748A0 (fi) 1985-09-27
OA08113A (fr) 1987-03-31
FR2571054A1 (fr) 1986-04-04
BE903353A (fr) 1986-04-01
DE3535196A1 (de) 1986-04-10
GR852336B (ja) 1986-02-04
FI853748L (fi) 1986-04-03
IT1190396B (it) 1988-02-16
KR860003257A (ko) 1986-05-21
GB2165247B (en) 1988-08-10
AU575432B2 (en) 1988-07-28
US4683301A (en) 1987-07-28
JPS6187682A (ja) 1986-05-06
PT81236A (en) 1985-11-01
AU4810285A (en) 1986-04-10
ZA857581B (en) 1986-05-28
FR2571054B1 (fr) 1988-09-30
IL76539A0 (en) 1986-02-28
PT81236B (pt) 1988-02-17
HUT38641A (en) 1986-06-30
FI79317C (fi) 1989-12-11
FI79317B (fi) 1989-08-31
ES547438A0 (es) 1987-03-01
SE466202B (sv) 1992-01-13
DK446685D0 (da) 1985-10-01
ATA284985A (de) 1992-02-15
LU86105A1 (fr) 1986-06-11
SE8504538D0 (sv) 1985-10-01
IT8522317A0 (it) 1985-10-01
ES8703880A1 (es) 1987-03-01
HU194240B (en) 1988-01-28
KR910009270B1 (ko) 1991-11-08
DK446685A (da) 1986-04-03
AT395151B (de) 1992-10-12
CH665640A5 (de) 1988-05-31
CA1260945A (en) 1989-09-26
SE8504538L (sv) 1986-04-03
ES553605A0 (es) 1987-11-01

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DNT Communications of changes of names of applicants whose applications have been laid open to public inspection

Free format text: BRISTOL-MYERS SQUIBB COMPANY

BA A request for search or an international-type search has been filed
BB A search report has been drawn up
BC A request for examination has been filed
BV The patent application has lapsed