NL8202636A - Piperazinederivaten, werkwijzen ter bereiding daarvan en farmaceutische preparaten die deze verbindingen bevatten. - Google Patents
Piperazinederivaten, werkwijzen ter bereiding daarvan en farmaceutische preparaten die deze verbindingen bevatten. Download PDFInfo
- Publication number
- NL8202636A NL8202636A NL8202636A NL8202636A NL8202636A NL 8202636 A NL8202636 A NL 8202636A NL 8202636 A NL8202636 A NL 8202636A NL 8202636 A NL8202636 A NL 8202636A NL 8202636 A NL8202636 A NL 8202636A
- Authority
- NL
- Netherlands
- Prior art keywords
- compound
- formula
- group
- fluorophenyl
- piperazine
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/10—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms
- C07D295/104—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/108—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/092—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings with aromatic radicals attached to the chain
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Hospice & Palliative Care (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Otolaryngology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Priority Applications (12)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
NL8202636A NL8202636A (nl) | 1982-06-29 | 1982-06-29 | Piperazinederivaten, werkwijzen ter bereiding daarvan en farmaceutische preparaten die deze verbindingen bevatten. |
JP58111752A JPS5920275A (ja) | 1982-06-29 | 1983-06-21 | ピペラジン誘導体、その製造法並びにこれらを含有する薬剤処方物 |
PT76909A PT76909B (en) | 1982-06-29 | 1983-06-21 | Piperazine derivatives processes for their preparation and pharmaceutical preparations containing them |
AT83200941T ATE32512T1 (de) | 1982-06-29 | 1983-06-23 | Piperazinderivate, verfahren zu deren herstellung und diese enthaltende pharmazeutische zusammensetzungen. |
EP83200941A EP0099148B1 (de) | 1982-06-29 | 1983-06-23 | Piperazinderivate, Verfahren zu deren Herstellung und diese enthaltende pharmazeutische Zusammensetzungen |
DE8383200941T DE3375690D1 (en) | 1982-06-29 | 1983-06-23 | Piperazine derivatives, processes for their preparation and pharmaceutical preparations containing them |
DK297383A DK297383A (da) | 1982-06-29 | 1983-06-28 | Fremgangsmaade til fremstilling af piperazinderivater |
GR71785A GR77523B (de) | 1982-06-29 | 1983-06-28 | |
ES523689A ES523689A0 (es) | 1982-06-29 | 1983-06-29 | Procedimiento para preparar derivados de piperazina. |
US06/509,168 US4476129A (en) | 1982-06-29 | 1983-06-29 | 4-[2-[Bis(halophenyl)methoxy]-ethyl]-α-(substituted phenyl)-1-piperazinealkanol derivatives, processes for their preparation and pharmaceutical preparations containing them |
ES533068A ES8507130A1 (es) | 1982-06-29 | 1984-06-01 | Procedimiento para preparar derivados de piperazina |
ES533069A ES8502982A1 (es) | 1982-06-29 | 1984-06-01 | Procedimiento para preparar derivados de piperazina |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
NL8202636A NL8202636A (nl) | 1982-06-29 | 1982-06-29 | Piperazinederivaten, werkwijzen ter bereiding daarvan en farmaceutische preparaten die deze verbindingen bevatten. |
NL8202636 | 1982-06-29 |
Publications (1)
Publication Number | Publication Date |
---|---|
NL8202636A true NL8202636A (nl) | 1984-01-16 |
Family
ID=19839950
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NL8202636A NL8202636A (nl) | 1982-06-29 | 1982-06-29 | Piperazinederivaten, werkwijzen ter bereiding daarvan en farmaceutische preparaten die deze verbindingen bevatten. |
Country Status (10)
Country | Link |
---|---|
US (1) | US4476129A (de) |
EP (1) | EP0099148B1 (de) |
JP (1) | JPS5920275A (de) |
AT (1) | ATE32512T1 (de) |
DE (1) | DE3375690D1 (de) |
DK (1) | DK297383A (de) |
ES (3) | ES523689A0 (de) |
GR (1) | GR77523B (de) |
NL (1) | NL8202636A (de) |
PT (1) | PT76909B (de) |
Families Citing this family (41)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
HU196194B (en) * | 1986-04-28 | 1988-10-28 | Richter Gedeon Vegyeszet | Process for producing new 1-4 disubstituted piperazines and pharmaceuticals comprising the compounds |
HU196195B (en) * | 1986-04-28 | 1988-10-28 | Richter Gedeon Vegyeszet | Process for producing 1,4-disubstituted piperazine derivatives and pharmaceuticals comprising the compounds |
FR2601366B1 (fr) * | 1986-07-10 | 1988-11-25 | Andre Buzas | Derives de la benzhydryloxyethyl-piperazine, procedes d'obtention et de compositions pharmaceutiques les contenant. |
US5001160A (en) * | 1988-04-28 | 1991-03-19 | Marion Laboratories, Inc. | 1-aryl-1-hydroxy-1-substituted-3-(4-substituted-1-piperazinyl)-2-propanones and their use in treatment of neurogenic bladder disorders |
WO1990013539A1 (en) * | 1989-04-28 | 1990-11-15 | Meiji Seika Kaisha, Ltd. | New n-substituted piperazine derivatives and drug for improving functional disorder of brain |
DK178490D0 (da) * | 1990-07-26 | 1990-07-26 | Novo Nordisk As | 1,4-disubstituerede piperaziner |
US5276035A (en) * | 1990-07-26 | 1994-01-04 | Novo Nordisk A/S | 1,4-disubstituted piperazines |
GB9523526D0 (en) * | 1995-11-17 | 1996-01-17 | Zeneca Ltd | Therapeutic compounds |
JP2001506978A (ja) | 1996-10-31 | 2001-05-29 | アメリカ合衆国 | 置換1―[2[ビス(アリール)メトキシ]エチル]―ピペラジンおよび―ホモピペラジンのヒドロキシル化類似物の持続性放出誘導体およびそのドパミン再アップテイクの非競合的拮抗物質としての使用 |
US6743797B2 (en) * | 2002-02-22 | 2004-06-01 | Chantest, Inc. | Methods for treating cardiac arrhythmia |
CN1181065C (zh) * | 2002-05-08 | 2004-12-22 | 上海医药工业研究院 | 芳烷甲酰烷基哌嗪衍生物及其作为脑神经保护剂的应用 |
GB0220214D0 (en) * | 2002-08-30 | 2002-10-09 | Novo Pharmaceuticals De Ltd | Compounds and their use |
AU2003300147A1 (en) * | 2003-01-06 | 2004-08-10 | The General Hospital Corporation | Diagnostic and therapeutic alkyl piperidine/piperazine compounds and process |
US7211407B2 (en) * | 2003-07-15 | 2007-05-01 | Chan Test, Inc. | High throughput assay systems and methods for identifying agents that alter surface expression of integral membrane proteins |
US20050054010A1 (en) * | 2003-07-15 | 2005-03-10 | Brown Arthur M. | High throughput assay systems and methods for identifying agents that alter surface expression of integral membrane proteins |
US20050208595A1 (en) * | 2004-03-19 | 2005-09-22 | Brown Arthur M | High throughput assay systems and methods for identifying agents that alter expression of cellular proteins |
US7381822B2 (en) * | 2004-03-31 | 2008-06-03 | The General Hospital Corporation | Diagnostic and therapeutic alkyl piperidine/piperazine compounds and process |
AU2008251259B2 (en) * | 2007-05-14 | 2013-02-14 | Sk Biopharmaceuticals Co., Ltd. | Novel carbamoyloxy arylalkanoyl arylpiperazine compound, pharmaceutical compositions comprising the compound and method for treating pain, anxiety and depression by administering the compound |
US8673920B2 (en) | 2009-05-06 | 2014-03-18 | Merck Sharp & Dohme Corp. | Inhibitors of the renal outer medullary potassium channel |
US9073882B2 (en) | 2010-10-27 | 2015-07-07 | Merck Sharp & Dohme Corp. | Inhibitors of the renal outer medullary potassium channel |
US9056859B2 (en) | 2010-10-29 | 2015-06-16 | Merck Sharp & Dohme Corp. | Inhibitors of the renal outer medullary potassium channel |
EP2744499B1 (de) | 2011-08-19 | 2016-09-28 | Merck Sharp & Dohme Corp. | Inhibitoren des renalen kaliumkanals der äusseren medulla |
TW201317213A (zh) | 2011-09-16 | 2013-05-01 | Merck Sharp & Dohme | 腎外髓質鉀通道抑制劑 |
WO2013062892A1 (en) | 2011-10-25 | 2013-05-02 | Merck Sharp & Dohme Corp. | Inhibitors of the renal outer medullary potassium channel |
US8999991B2 (en) | 2011-10-25 | 2015-04-07 | Merck Sharp & Dohme Corp. | Inhibitors of the renal outer medullary potassium channel |
EP2773206B1 (de) | 2011-10-31 | 2018-02-21 | Merck Sharp & Dohme Corp. | Inhibitoren des renalen kaliumkanals der äusseren medulla |
US9139585B2 (en) | 2011-10-31 | 2015-09-22 | Merck Sharp & Dohme Corp. | Inhibitors of the Renal Outer Medullary Potassium channel |
WO2013066718A2 (en) | 2011-10-31 | 2013-05-10 | Merck Sharp & Dohme Corp. | Inhibitors of the renal outer medullary potassium channel |
WO2013090271A1 (en) | 2011-12-16 | 2013-06-20 | Merck Sharp & Dohme Corp. | Inhibitors of the renal outer medullary potassium channel |
AR092031A1 (es) | 2012-07-26 | 2015-03-18 | Merck Sharp & Dohme | Inhibidores del canal de potasio medular externo renal |
WO2014059346A1 (en) * | 2012-10-11 | 2014-04-17 | Brown Arthur M | Methods for the treatment of conditions involving dopamine through administration of piperazine compounds |
WO2014059367A1 (en) * | 2012-10-11 | 2014-04-17 | Chanrx Corporation | Pharmaceutical compositions containing enantiomerically pure and/or racemic mixtures of chiral piperazine compounds and methods of terminating acute episodes of cardiac arrhythmia, restoring normal sinus rhythm, preventing recurrence of cardiac arrhythmia and maintaining normal sinus rhythm in mammals through administration of said compositions |
WO2014059338A1 (en) * | 2012-10-11 | 2014-04-17 | Chanrx Corporation | Novel piperazine compounds, pharmaceutical compositions containing the same and methods of terminating acute episodes of cardiac arrhythmia, restoring normal sinus rhythm, preventing recurrence of cardiac arrhythmia and maintaining normal sinus rhythm in mammals |
EP2925322B1 (de) | 2012-11-29 | 2018-10-24 | Merck Sharp & Dohme Corp. | Inhibitoren des renalen kaliumkanals der äusseren medulla |
EP2934533B1 (de) | 2012-12-19 | 2017-11-15 | Merck Sharp & Dohme Corp. | Inhibitoren des kaliumkanals des äusseren nierenmarks |
US9604998B2 (en) | 2013-02-18 | 2017-03-28 | Merck Sharp & Dohme Corp. | Inhibitors of the renal outer medullary potassium channel |
EP2968288B1 (de) | 2013-03-15 | 2018-07-04 | Merck Sharp & Dohme Corp. | Inhibitoren des renalen kaliumkanals der äusseren medulla |
US20160304477A1 (en) * | 2013-04-26 | 2016-10-20 | Laguna Pharmaceuticals, Inc. | Novel metabolites of vanoxerine compounds, pharmaceutical compositions containing the same and methods of terminating acute episodes of cardiac arrhythmia, restoring normal sinus rhythm, preventing recurrence of cardiac arrhythmia and maintaining normal sinus rhythm in mammals |
US9751881B2 (en) | 2013-07-31 | 2017-09-05 | Merck Sharp & Dohme Corp. | Inhibitors of the renal outer medullary potassium channel |
WO2015073967A1 (en) * | 2013-11-15 | 2015-05-21 | Brown Arthur M | Novel metabolites of vanoxerine compounds for the treatment of dopaminergic diseases |
CN108329282B (zh) * | 2018-01-16 | 2022-01-07 | 新乡医学院 | 一种苯基哌嗪类衍生物及其制备方法和应用 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2350100A1 (fr) * | 1976-05-06 | 1977-12-02 | Sauba Lab | Derives disubstitues de la piperazine, leur procede de preparation et leurs applications therapeutiques |
FR2374318A1 (en) * | 1976-12-14 | 1978-07-13 | Gist Brocades Nv | 1-Benzhydryl:oxy-alkyl-4-phenylalkyl- or cinnamyl-piperazine derivs. - with dopaminergic, anticholinergic and antiparkinson activity (BE 14.6.78) |
GB1545094A (en) * | 1976-12-14 | 1979-05-02 | Gist Brocades Nv | Piperazine derivatives |
-
1982
- 1982-06-29 NL NL8202636A patent/NL8202636A/nl not_active Application Discontinuation
-
1983
- 1983-06-21 PT PT76909A patent/PT76909B/pt unknown
- 1983-06-21 JP JP58111752A patent/JPS5920275A/ja active Pending
- 1983-06-23 EP EP83200941A patent/EP0099148B1/de not_active Expired
- 1983-06-23 DE DE8383200941T patent/DE3375690D1/de not_active Expired
- 1983-06-23 AT AT83200941T patent/ATE32512T1/de not_active IP Right Cessation
- 1983-06-28 DK DK297383A patent/DK297383A/da not_active Application Discontinuation
- 1983-06-28 GR GR71785A patent/GR77523B/el unknown
- 1983-06-29 ES ES523689A patent/ES523689A0/es active Granted
- 1983-06-29 US US06/509,168 patent/US4476129A/en not_active Expired - Fee Related
-
1984
- 1984-06-01 ES ES533069A patent/ES8502982A1/es not_active Expired
- 1984-06-01 ES ES533068A patent/ES8507130A1/es not_active Expired
Also Published As
Publication number | Publication date |
---|---|
GR77523B (de) | 1984-09-24 |
ES8500252A1 (es) | 1984-10-01 |
DE3375690D1 (en) | 1988-03-24 |
ES533068A0 (es) | 1985-08-16 |
ES533069A0 (es) | 1985-02-01 |
PT76909A (en) | 1983-07-01 |
JPS5920275A (ja) | 1984-02-01 |
EP0099148A1 (de) | 1984-01-25 |
DK297383A (da) | 1983-12-30 |
ES8502982A1 (es) | 1985-02-01 |
DK297383D0 (da) | 1983-06-28 |
EP0099148B1 (de) | 1988-02-17 |
ES8507130A1 (es) | 1985-08-16 |
ATE32512T1 (de) | 1988-03-15 |
PT76909B (en) | 1986-01-24 |
US4476129A (en) | 1984-10-09 |
ES523689A0 (es) | 1984-10-01 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
A1B | A search report has been drawn up | ||
A85 | Still pending on 85-01-01 | ||
BV | The patent application has lapsed |