ES8507130A1 - Procedimiento para preparar derivados de piperazina - Google Patents

Procedimiento para preparar derivados de piperazina

Info

Publication number
ES8507130A1
ES8507130A1 ES533068A ES533068A ES8507130A1 ES 8507130 A1 ES8507130 A1 ES 8507130A1 ES 533068 A ES533068 A ES 533068A ES 533068 A ES533068 A ES 533068A ES 8507130 A1 ES8507130 A1 ES 8507130A1
Authority
ES
Spain
Prior art keywords
processes
preparation
pharmaceutical preparations
piperazine derivatives
preparations containing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES533068A
Other languages
English (en)
Other versions
ES533068A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Gist Brocades NV
Original Assignee
Gist Brocades NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gist Brocades NV filed Critical Gist Brocades NV
Publication of ES533068A0 publication Critical patent/ES533068A0/es
Publication of ES8507130A1 publication Critical patent/ES8507130A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/10—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms
    • C07D295/104—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/108—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/092—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings with aromatic radicals attached to the chain

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Hospice & Palliative Care (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Otolaryngology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

PROCEDIMIENTO PARA PREPARAR DERIVADOS DE PIPERAZINA.COMPRENDE: REDUCIR UN COMPUESTO DE FORMULA (II) CON BOROHIDRURO SODICO, EN PRESENCIA DE UN DISOLVENTE ORGANICO Y A LA TEMPERATURA DE REFLUJO DE LA MEZCLA DE REACCION, PARA OBTENER DERIVADOS DE PIPERAZINA DE FORMULA (I), EN DONDE R1 Y R2 SON DE 1 A 3 ATOMOS DE HALOGENO, R3 1 ATOMO DE H O 1-3 ATOMOS DE HALOGENO, M ES 1, 2 O 3, Y N ES 0 O 1, CON LA CONDICION DE QUE M B N SEA H3.SON UTILES EN EL TRATAMIENTO DE LA ENFERMEDAD DE PARKINSON.
ES533068A 1982-06-29 1984-06-01 Procedimiento para preparar derivados de piperazina Expired ES8507130A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
NL8202636A NL8202636A (nl) 1982-06-29 1982-06-29 Piperazinederivaten, werkwijzen ter bereiding daarvan en farmaceutische preparaten die deze verbindingen bevatten.

Publications (2)

Publication Number Publication Date
ES533068A0 ES533068A0 (es) 1985-08-16
ES8507130A1 true ES8507130A1 (es) 1985-08-16

Family

ID=19839950

Family Applications (3)

Application Number Title Priority Date Filing Date
ES523689A Granted ES523689A0 (es) 1982-06-29 1983-06-29 Procedimiento para preparar derivados de piperazina.
ES533068A Expired ES8507130A1 (es) 1982-06-29 1984-06-01 Procedimiento para preparar derivados de piperazina
ES533069A Granted ES533069A0 (es) 1982-06-29 1984-06-01 Procedimiento para preparar derivados de piperazina

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES523689A Granted ES523689A0 (es) 1982-06-29 1983-06-29 Procedimiento para preparar derivados de piperazina.

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES533069A Granted ES533069A0 (es) 1982-06-29 1984-06-01 Procedimiento para preparar derivados de piperazina

Country Status (10)

Country Link
US (1) US4476129A (es)
EP (1) EP0099148B1 (es)
JP (1) JPS5920275A (es)
AT (1) ATE32512T1 (es)
DE (1) DE3375690D1 (es)
DK (1) DK297383A (es)
ES (3) ES523689A0 (es)
GR (1) GR77523B (es)
NL (1) NL8202636A (es)
PT (1) PT76909B (es)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU196194B (en) * 1986-04-28 1988-10-28 Richter Gedeon Vegyeszet Process for producing new 1-4 disubstituted piperazines and pharmaceuticals comprising the compounds
HU196195B (en) * 1986-04-28 1988-10-28 Richter Gedeon Vegyeszet Process for producing 1,4-disubstituted piperazine derivatives and pharmaceuticals comprising the compounds
FR2601366B1 (fr) * 1986-07-10 1988-11-25 Andre Buzas Derives de la benzhydryloxyethyl-piperazine, procedes d'obtention et de compositions pharmaceutiques les contenant.
US5001160A (en) * 1988-04-28 1991-03-19 Marion Laboratories, Inc. 1-aryl-1-hydroxy-1-substituted-3-(4-substituted-1-piperazinyl)-2-propanones and their use in treatment of neurogenic bladder disorders
WO1990013539A1 (en) * 1989-04-28 1990-11-15 Meiji Seika Kaisha, Ltd. New n-substituted piperazine derivatives and drug for improving functional disorder of brain
DK178490D0 (da) * 1990-07-26 1990-07-26 Novo Nordisk As 1,4-disubstituerede piperaziner
US5276035A (en) * 1990-07-26 1994-01-04 Novo Nordisk A/S 1,4-disubstituted piperazines
GB9523526D0 (en) * 1995-11-17 1996-01-17 Zeneca Ltd Therapeutic compounds
WO1998018769A1 (en) 1996-10-31 1998-05-07 The United States Of America, Represented By The Secretary, Department Of Health And Human Services Sustained-release derivatives of hydroxylated analogs of substituted 1-[2[bis(aryl)methoxy]ethyl]-piperazines and -homopiperazines and their use as noncompetitive antagonists of dopamine reuptake
US6743797B2 (en) * 2002-02-22 2004-06-01 Chantest, Inc. Methods for treating cardiac arrhythmia
CN1181065C (zh) * 2002-05-08 2004-12-22 上海医药工业研究院 芳烷甲酰烷基哌嗪衍生物及其作为脑神经保护剂的应用
GB0220214D0 (en) * 2002-08-30 2002-10-09 Novo Pharmaceuticals De Ltd Compounds and their use
AU2003300147A1 (en) * 2003-01-06 2004-08-10 The General Hospital Corporation Diagnostic and therapeutic alkyl piperidine/piperazine compounds and process
US20050054010A1 (en) * 2003-07-15 2005-03-10 Brown Arthur M. High throughput assay systems and methods for identifying agents that alter surface expression of integral membrane proteins
US7211407B2 (en) * 2003-07-15 2007-05-01 Chan Test, Inc. High throughput assay systems and methods for identifying agents that alter surface expression of integral membrane proteins
US20050208595A1 (en) * 2004-03-19 2005-09-22 Brown Arthur M High throughput assay systems and methods for identifying agents that alter expression of cellular proteins
US7381822B2 (en) * 2004-03-31 2008-06-03 The General Hospital Corporation Diagnostic and therapeutic alkyl piperidine/piperazine compounds and process
WO2008140198A1 (en) * 2007-05-14 2008-11-20 Sk Holdings Co., Ltd. Novel carbamoyloxy arylalkanoyl arylpiperazine compound, pharmaceutical compositions comprising the compound and method for treating pain, anxiety and depression by administering the compound
US8673920B2 (en) 2009-05-06 2014-03-18 Merck Sharp & Dohme Corp. Inhibitors of the renal outer medullary potassium channel
EP2632465B1 (en) 2010-10-27 2015-12-30 Merck Sharp & Dohme Corp. Inhibitors of the renal outer medullary potassium channel
EP2632464B1 (en) 2010-10-29 2015-04-29 Merck Sharp & Dohme Corp. Inhibitors of the renal outer medullary potassium channel
RU2014110401A (ru) 2011-08-19 2015-09-27 Мерк Шарп И Доум Корп. Ингибиторы внешнего медуллярного калиевого канала почек
WO2013039802A1 (en) 2011-09-16 2013-03-21 Merck Sharp & Dohme Corp. Inhibitors of the renal outer medullary potassium channel
WO2013062900A1 (en) 2011-10-25 2013-05-02 Merck Sharp & Dohme Corp. Inhibitors of the renal outer medullary potassium channel
EP2771005B1 (en) 2011-10-25 2016-05-18 Merck Sharp & Dohme Corp. Inhibitors of the renal outer medullary potassium channel
WO2013066714A1 (en) 2011-10-31 2013-05-10 Merck Sharp & Dohme Corp. Inhibitors of the renal outer medullary potassium channel
EP2773206B1 (en) 2011-10-31 2018-02-21 Merck Sharp & Dohme Corp. Inhibitors of the renal outer medullary potassium channel
US9493474B2 (en) 2011-10-31 2016-11-15 Merck Sharp & Dohme Corp. Inhibitors of the renal outer medullary potassium channel
EP2790511B1 (en) 2011-12-16 2016-09-14 Merck Sharp & Dohme Corp. Inhibitors of the renal outer medullary potassium channel
AR092031A1 (es) 2012-07-26 2015-03-18 Merck Sharp & Dohme Inhibidores del canal de potasio medular externo renal
WO2014059338A1 (en) * 2012-10-11 2014-04-17 Chanrx Corporation Novel piperazine compounds, pharmaceutical compositions containing the same and methods of terminating acute episodes of cardiac arrhythmia, restoring normal sinus rhythm, preventing recurrence of cardiac arrhythmia and maintaining normal sinus rhythm in mammals
WO2014059367A1 (en) * 2012-10-11 2014-04-17 Chanrx Corporation Pharmaceutical compositions containing enantiomerically pure and/or racemic mixtures of chiral piperazine compounds and methods of terminating acute episodes of cardiac arrhythmia, restoring normal sinus rhythm, preventing recurrence of cardiac arrhythmia and maintaining normal sinus rhythm in mammals through administration of said compositions
WO2014059346A1 (en) * 2012-10-11 2014-04-17 Brown Arthur M Methods for the treatment of conditions involving dopamine through administration of piperazine compounds
EP2925322B1 (en) 2012-11-29 2018-10-24 Merck Sharp & Dohme Corp. Inhibitors of the renal outer medullary potassium channel
US9573961B2 (en) 2012-12-19 2017-02-21 Merck Sharp & Dohme Corp. Inhibitors of the renal outer medullary potassium channel
WO2014126944A2 (en) 2013-02-18 2014-08-21 Merck Sharp & Dohme Corp. Inhibitors of the renal outer medullary potassium channel
WO2014150132A1 (en) 2013-03-15 2014-09-25 Merck Sharp & Dohme Corp. Inhibitors of the renal outer medullary potassium channel
WO2014176497A1 (en) * 2013-04-26 2014-10-30 Chanrx Corporation Novel metabolites of vanoxerine compounds, pharmaceutical compositions containing the same and methods of terminating acute episodes of cardiac arrhythmia, restoring normal sinus rhythm, preventing recurrence of cardiac arrhythmia and maintaining normal sinus rhythm in mammals
US9751881B2 (en) 2013-07-31 2017-09-05 Merck Sharp & Dohme Corp. Inhibitors of the renal outer medullary potassium channel
WO2015073967A1 (en) * 2013-11-15 2015-05-21 Brown Arthur M Novel metabolites of vanoxerine compounds for the treatment of dopaminergic diseases
CN108329282B (zh) * 2018-01-16 2022-01-07 新乡医学院 一种苯基哌嗪类衍生物及其制备方法和应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2350100A1 (fr) * 1976-05-06 1977-12-02 Sauba Lab Derives disubstitues de la piperazine, leur procede de preparation et leurs applications therapeutiques
GB1545094A (en) * 1976-12-14 1979-05-02 Gist Brocades Nv Piperazine derivatives
FR2374318A1 (en) * 1976-12-14 1978-07-13 Gist Brocades Nv 1-Benzhydryl:oxy-alkyl-4-phenylalkyl- or cinnamyl-piperazine derivs. - with dopaminergic, anticholinergic and antiparkinson activity (BE 14.6.78)

Also Published As

Publication number Publication date
GR77523B (es) 1984-09-24
PT76909A (en) 1983-07-01
ATE32512T1 (de) 1988-03-15
ES8502982A1 (es) 1985-02-01
ES8500252A1 (es) 1984-10-01
US4476129A (en) 1984-10-09
ES533069A0 (es) 1985-02-01
NL8202636A (nl) 1984-01-16
PT76909B (en) 1986-01-24
EP0099148B1 (en) 1988-02-17
EP0099148A1 (en) 1984-01-25
JPS5920275A (ja) 1984-02-01
DK297383D0 (da) 1983-06-28
DK297383A (da) 1983-12-30
ES533068A0 (es) 1985-08-16
DE3375690D1 (en) 1988-03-24
ES523689A0 (es) 1984-10-01

Similar Documents

Publication Publication Date Title
ES8507130A1 (es) Procedimiento para preparar derivados de piperazina
IL70550A (en) Diethylaminoalkoxybenzhydrol derivatives,their preparation and pharmaceutical compositions containing them
GR78771B (es)
SE8600086L (sv) Naftalenderivat av bensonorbornen, forfarande for framstellning derav och lekemedel och kosmetika innehallande dessa
ES8603845A1 (es) Procedimiento de preparacion de nuevos derivados a-etilami- noetoxibencilalcoholicos con un grupo fenil sustituido en situacion a y de sus sales de adicion acida y amobica cua- ternaria
GR78773B (es)
ES485333A1 (es) Procedimiento para preparar derivados 5,6,7,8-tetrahidro-4 (3h)-quinazolinonicos y sus sales