NL8105791A - Nieuwe heterocyclische aminoalkylverbindingen, werkwijze voor hun bereiding alsmede de therapeutische toepassing van deze verbindingen. - Google Patents
Nieuwe heterocyclische aminoalkylverbindingen, werkwijze voor hun bereiding alsmede de therapeutische toepassing van deze verbindingen. Download PDFInfo
- Publication number
- NL8105791A NL8105791A NL8105791A NL8105791A NL8105791A NL 8105791 A NL8105791 A NL 8105791A NL 8105791 A NL8105791 A NL 8105791A NL 8105791 A NL8105791 A NL 8105791A NL 8105791 A NL8105791 A NL 8105791A
- Authority
- NL
- Netherlands
- Prior art keywords
- compounds
- preparation
- therapeutic use
- novel heterocyclic
- heterocyclic aminoalkyl
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title 1
- 230000001225 therapeutic effect Effects 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
- C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
- C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
- C07D217/16—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D267/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D267/02—Seven-membered rings
- C07D267/08—Seven-membered rings having the hetero atoms in positions 1 and 4
- C07D267/12—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D267/14—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
- C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D317/28—Radicals substituted by nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
- C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D317/30—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR8027252A FR2496653A1 (fr) | 1980-12-22 | 1980-12-22 | Nouveaux derives aminoalcoyl heterocycliques, leurs procedes de preparation et leur application en therapeutique |
| FR8123304A FR2518087A2 (en) | 1981-12-14 | 1981-12-14 | Aminoalkyl di:hydro-naphthalene, isoquinoline and benzoxazepine cpds. - useful as analgesics and antidepressants |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NL8105791A true NL8105791A (nl) | 1982-07-16 |
Family
ID=26222136
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NL8105791A NL8105791A (nl) | 1980-12-22 | 1981-12-22 | Nieuwe heterocyclische aminoalkylverbindingen, werkwijze voor hun bereiding alsmede de therapeutische toepassing van deze verbindingen. |
Country Status (11)
| Country | Link |
|---|---|
| US (3) | US4386090A (OSRAM) |
| AU (1) | AU7875781A (OSRAM) |
| CA (1) | CA1181748A (OSRAM) |
| DE (1) | DE3150876A1 (OSRAM) |
| ES (3) | ES8306093A1 (OSRAM) |
| GB (2) | GB2091250B (OSRAM) |
| GR (1) | GR78081B (OSRAM) |
| IT (1) | IT1168074B (OSRAM) |
| LU (1) | LU83850A1 (OSRAM) |
| NL (1) | NL8105791A (OSRAM) |
| SE (1) | SE8107537L (OSRAM) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3244594A1 (de) * | 1982-12-02 | 1984-06-07 | Hoechst Ag, 6230 Frankfurt | 1-phenylisochinolinderivate und verfahren zu ihrer herstellung, diese verbindung enthaltende pharmazeutische praeparate und deren anwendung |
| FR2544718B1 (fr) * | 1983-04-21 | 1985-12-20 | Hexachimie | Diniflumate d'ester morpholinoethylique d'acide niflumique, preparation, utilisation en therapeutique comme analgesique et anti-inflammatoire |
| US4745222A (en) * | 1983-05-25 | 1988-05-17 | Merrell Dow Pharmaceuticals Inc. | Novel aryloxycycloalkanolaminoalkylene aryl ketones |
| DE3413897A1 (de) * | 1984-04-13 | 1985-10-17 | Bayer Ag, 5090 Leverkusen | (beta)-naphthylalkylamine |
| EP0261842B1 (en) * | 1986-09-17 | 1990-11-22 | Dr. Lo. Zambeletti S.p.A. | N1-acylated-(1-(phenyl or benzyl))-1,2-ethylene diamines |
| CA1327795C (en) * | 1987-08-14 | 1994-03-15 | Jules Freedman | Antidepressants which are aryloxy inadanamines |
| US5561152A (en) * | 1987-08-14 | 1996-10-01 | Merrell Pharmaceuticals Inc. | Antidepressants |
| US5149714A (en) * | 1987-08-14 | 1992-09-22 | Merrell Dow Pharmaceuticals Inc. | Antidepressants |
| US5229414A (en) * | 1988-01-21 | 1993-07-20 | Imperial Chemical Industries Plc | Diamine compounds |
| ATE112769T1 (de) * | 1988-12-28 | 1994-10-15 | Suntory Ltd | Benzoxazepinderivate. |
| US5948820A (en) * | 1994-08-22 | 1999-09-07 | Yoshitomi Pharmaceutical Industries, Ltd. | Benzene compound and pharmaceutical use thereof |
| IT1303737B1 (it) * | 1998-11-11 | 2001-02-23 | Smithkline Beecham Spa | Derivati fenilpiperidinici procedimento per la loro preparazione eloro uso come ligandi del recettore orl-1. |
| US6646012B2 (en) * | 2001-01-16 | 2003-11-11 | Theravance, Inc. | Sodium channel modulators |
| DE60224189T2 (de) * | 2001-06-20 | 2008-12-11 | Merck & Co., Inc. | Dipeptidylpeptidase-hemmer zur behandlung von diabetes |
| WO2003000181A2 (en) * | 2001-06-20 | 2003-01-03 | Merck & Co., Inc. | Dipeptidyl peptidase inhibitors for the treatment of diabetes |
| PL211954B1 (pl) | 2002-01-11 | 2012-07-31 | Sankyo Co | Związek, kompozycja farmaceutyczna oraz zastosowanie kompozycji farmaceutycznej |
| US7208498B2 (en) * | 2002-07-15 | 2007-04-24 | Merck & Co., Inc. | Piperidino pyrimidine dipeptidyl peptidase inhibitors for the treatment of diabetes |
| DE60315687T2 (de) * | 2002-10-07 | 2008-06-05 | Merck & Co., Inc. | Antidiabetische heterocyclische beta-aminoverbindungen als inhibitoren von dipeptidylpeptidase |
| EP1562925B1 (en) * | 2002-11-07 | 2007-01-03 | Merck & Co., Inc. | Phenylalanine derivatives as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes |
| CA2508487A1 (en) * | 2002-12-04 | 2004-06-17 | Merck & Co., Inc. | Phenylalanine derivatives as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes |
| WO2004058266A1 (en) * | 2002-12-20 | 2004-07-15 | Merck & Co., Inc. | 3-amino-4-phenylbutanoic acid derivatives as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes |
| US7265128B2 (en) * | 2003-01-17 | 2007-09-04 | Merck & Co., Inc. | 3-amino-4-phenylbutanoic acid derivatives as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes |
| AU2004210149A1 (en) * | 2003-01-31 | 2004-08-19 | Merck & Co., Inc. | 3-amino-4-phenylbutanoic acid derivatives as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes |
| CN1787823A (zh) * | 2003-05-14 | 2006-06-14 | 麦克公司 | 作为二肽基肽酶抑制剂用于治疗或预防糖尿病的3－氨基－4－苯基丁酸衍生物 |
| CN1798556A (zh) * | 2003-06-06 | 2006-07-05 | 麦克公司 | 作为治疗或者预防糖尿病的二肽基肽酶抑制剂的稠合吲哚 |
| JP4579239B2 (ja) * | 2003-06-17 | 2010-11-10 | メルク・シャープ・エンド・ドーム・コーポレイション | 糖尿病の治療または予防するためのジペプチジルペプチダーゼ阻害剤としてのシクロヘキシルグリシン誘導体 |
| WO2005011581A2 (en) * | 2003-07-31 | 2005-02-10 | Merck & Co., Inc. | Hexahydrodiazepinones as dipeptidyl peptidase-iv inhibitors for the treatment or prevention of diabetes |
| US7626034B2 (en) * | 2003-09-18 | 2009-12-01 | Takasago International Corporation | Asymmetric reductive amination of keto acid derivatives for producing amino acid derivatives |
| JP2007510651A (ja) * | 2003-11-04 | 2007-04-26 | メルク エンド カムパニー インコーポレーテッド | 糖尿病の治療又は予防のためのジペプチジルペプチダーゼ−ｉｖ阻害剤としての縮合フェニルアラニン誘導体 |
| JP2005272453A (ja) | 2004-02-24 | 2005-10-06 | Sankyo Co Ltd | アミノアルコール化合物 |
| CN1950349A (zh) * | 2004-05-04 | 2007-04-18 | 默克公司 | 作为用于治疗或预防糖尿病的二肽基肽酶－ⅳ抑制剂的1,2,4－噁二唑衍生物 |
| US7795448B2 (en) * | 2004-05-06 | 2010-09-14 | Cytokinetics, Incorporated | Imidazoyl-benzamide anti-cancer agents |
| US7618981B2 (en) * | 2004-05-06 | 2009-11-17 | Cytokinetics, Inc. | Imidazopyridinyl-benzamide anti-cancer agents |
| US7504413B2 (en) * | 2004-05-06 | 2009-03-17 | Cytokinetics, Inc. | N-(4-(imidazo[1,2A]pyridin-YL)phenethyl)benzamide inhibitors of the mitotic kinesin CENP-E for treating certain cellular proliferation diseases |
| EP1604662A1 (en) * | 2004-06-08 | 2005-12-14 | Santhera Pharmaceuticals (Deutschland) Aktiengesellschaft | 1-[(3R)-Amino-4-(2-fluoro-phenyl)-butyl]-pyrrolidine-(2R)-carboxylic acid benzyl amine derivatives and related compounds as dipeptidyl peptidase IV (DPP-IV) inhibitors for the treatment of type 2 diabetes mellitus |
| EP1942899A4 (en) * | 2005-11-02 | 2010-04-28 | Cytokinetics Inc | INHIBITORS OF MITOTIC KINESINE |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2168929A (en) * | 1936-12-12 | 1939-08-08 | Winthrop Chem Co Inc | Isoquinoline compounds and derivatives thereof |
| US3663608A (en) * | 1969-12-10 | 1972-05-16 | Bristol Myers Co | 1-phenyl-3-aminoalkyl-1,2,3,4-tetrahydronaphthalenes and the salts thereof |
| US3704328A (en) * | 1970-01-21 | 1972-11-28 | James S Kaltenbronn | 4- and 5-aryl-1-naphthaleneethanol compounds |
| US3663627A (en) * | 1970-06-01 | 1972-05-16 | Bristol Myers Co | 1-indanmethanols |
| GB1400425A (en) * | 1971-09-22 | 1975-07-16 | Rolland Sa A | Substituted 3-hydroxymethyl-isoquinolines and derivatives |
| US4022791A (en) * | 1975-06-03 | 1977-05-10 | Pfizer Inc. | 2-Aminomethyl-3,4-dihydronaphthalenes |
-
1981
- 1981-12-16 SE SE8107537A patent/SE8107537L/xx not_active Application Discontinuation
- 1981-12-16 US US06/331,484 patent/US4386090A/en not_active Expired - Fee Related
- 1981-12-21 IT IT25722/81A patent/IT1168074B/it active
- 1981-12-21 GB GB8138399A patent/GB2091250B/en not_active Expired
- 1981-12-21 ES ES508670A patent/ES8306093A1/es not_active Expired
- 1981-12-21 CA CA000392859A patent/CA1181748A/en not_active Expired
- 1981-12-22 AU AU78757/81A patent/AU7875781A/en not_active Abandoned
- 1981-12-22 NL NL8105791A patent/NL8105791A/xx not_active Application Discontinuation
- 1981-12-22 DE DE19813150876 patent/DE3150876A1/de not_active Withdrawn
- 1981-12-22 LU LU83850A patent/LU83850A1/fr unknown
-
1982
- 1982-12-16 ES ES518693A patent/ES518693A0/es active Granted
- 1982-12-16 ES ES518692A patent/ES8400093A1/es not_active Expired
-
1983
- 1983-02-03 GR GR66782A patent/GR78081B/el unknown
- 1983-03-08 US US06/473,182 patent/US4431851A/en not_active Expired - Fee Related
- 1983-11-15 US US06/552,181 patent/US4504663A/en not_active Expired - Fee Related
-
1984
- 1984-04-09 GB GB08409163A patent/GB2137992B/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| GR78081B (OSRAM) | 1984-09-26 |
| GB2137992B (en) | 1985-05-09 |
| US4431851A (en) | 1984-02-14 |
| ES8400388A1 (es) | 1983-11-01 |
| GB2137992A (en) | 1984-10-17 |
| ES518692A0 (es) | 1983-11-01 |
| GB2091250A (en) | 1982-07-28 |
| GB8409163D0 (en) | 1984-05-16 |
| ES518693A0 (es) | 1983-11-01 |
| ES8400093A1 (es) | 1983-11-01 |
| US4504663A (en) | 1985-03-12 |
| AU7875781A (en) | 1982-07-01 |
| CA1181748A (en) | 1985-01-29 |
| US4386090A (en) | 1983-05-31 |
| LU83850A1 (fr) | 1983-09-02 |
| DE3150876A1 (de) | 1982-07-29 |
| IT1168074B (it) | 1987-05-20 |
| SE8107537L (sv) | 1982-06-23 |
| GB2091250B (en) | 1984-11-14 |
| ES508670A0 (es) | 1983-06-01 |
| IT8125722A0 (it) | 1981-12-21 |
| ES8306093A1 (es) | 1983-06-01 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| NL8105791A (nl) | Nieuwe heterocyclische aminoalkylverbindingen, werkwijze voor hun bereiding alsmede de therapeutische toepassing van deze verbindingen. | |
| NO154764C (no) | Gel for behandling av underjordiske formasjoner. | |
| NL189757C (nl) | Werkwijze voor het continu bereiden van nitrobenzeen. | |
| NL930056I2 (nl) | Imidazodiazepine-derivaten, werkwijze en tussenpr odukten voor de bereiding ervan, deze bevattende geneesmiddelen en de therapeutische toepassing ervan. | |
| NL7900871A (nl) | Werkwijze voor de therapeutische behandeling van hyperlipidemie en hyperlipiproteinemie. | |
| NO156864B (no) | Analogifremgangsmaate for fremstilling av terapeutisk aktive piperinderivater. | |
| JPS56103113A (en) | Drug for shock treatment | |
| NO166320C (no) | Analogifremgangsmaate ved fremstilling av terapeutisk aktive tetrazolderivater. | |
| NL191149C (nl) | Werkwijze voor de bereiding van 3-trifluormethylpyridinederivaten. | |
| ES269846Y (es) | Disposicion de tratamiento de pestanas. | |
| TR20880A (tr) | Akrilonitrilin aritilmasi | |
| FI800089A7 (fi) | Viherkaihin hoitoon tarkoitettuja valmisteita. | |
| NL7903853A (nl) | Nieuwe derivaten van 4-amino-2-piperidinochinazoline en werkwijzen voor hun bereiding en toepassing. | |
| NL7805849A (nl) | Nieuwe benzodiazepin-6-on derivaten en werkwijzen voor hun bereiding en toepassing. | |
| NL7803896A (nl) | Nieuwe pyrrolochinoxalineverbindingen, werkwijze voor hun bereiding en geneesmiddelen. | |
| NL7801887A (nl) | Nieuwe 20,21-dinoreburnamenine-verbindingen, werkwijze voor hun bereiding en farmaceutische preparaten. | |
| NL7808276A (nl) | Nieuwe 1,3-difenoxypropaan-2-on derivaten, werkwijze voor het bereiden daarvan alsmede voornoemde derivaten bevattende geneesmiddelen. | |
| GB2044311B (en) | Process for the treatment of wood | |
| NO803403L (no) | Anordning for behandling av virke. | |
| NO782574L (no) | Fremgangsmaate til behandling av tobakk | |
| NO154052C (no) | Analogifremgangsmaate for fremstilling av terapeutisk aktive kinolon-derivater. | |
| NL7800001A (nl) | Werkwijze voor de bereiding van nieuwe chromoon- derivaten en de toepassing hiervan als genees- middel tegen hartziekten. | |
| NL7808944A (nl) | Werkwijze voor de bereiding van heterocyclische zuur- stofverbindingen. | |
| NL7606238A (nl) | Werkwijze voor de bereiding van nieuwe cyclo- propanolderivaten, alsmede de toepassing ervan. | |
| NL7607073A (nl) | Werkwijze voor het bereiden van nieuwe verbin- dingen, alsmede deze verbindingen bevattende preparaten en de toepassing daarvan voor de bestrijding van schadelijk ongedierte. |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A85 | Still pending on 85-01-01 | ||
| BV | The patent application has lapsed |