ES8306093A1 - Procedimiento de preparacion de derivados aminoalcoil heterociclicos farmaceuticamente activos. - Google Patents
Procedimiento de preparacion de derivados aminoalcoil heterociclicos farmaceuticamente activos.Info
- Publication number
- ES8306093A1 ES8306093A1 ES508670A ES508670A ES8306093A1 ES 8306093 A1 ES8306093 A1 ES 8306093A1 ES 508670 A ES508670 A ES 508670A ES 508670 A ES508670 A ES 508670A ES 8306093 A1 ES8306093 A1 ES 8306093A1
- Authority
- ES
- Spain
- Prior art keywords
- naphthalenes
- dihydro
- compositions
- nitrogen containing
- derivatives
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- -1 Nitrogen containing 2,3-dihydro naphthalenes Chemical class 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 229940035676 analgesics Drugs 0.000 abstract 1
- 239000000730 antalgic agent Substances 0.000 abstract 1
- 239000000935 antidepressant agent Substances 0.000 abstract 1
- 229940005513 antidepressants Drugs 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 235000019256 formaldehyde Nutrition 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 1
- 125000000250 methylamino group Chemical group [H]N(*)C([H])([H])[H] 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
- C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
- C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
- C07D217/16—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D267/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D267/02—Seven-membered rings
- C07D267/08—Seven-membered rings having the hetero atoms in positions 1 and 4
- C07D267/12—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D267/14—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
- C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D317/28—Radicals substituted by nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
- C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D317/30—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR8027252A FR2496653A1 (fr) | 1980-12-22 | 1980-12-22 | Nouveaux derives aminoalcoyl heterocycliques, leurs procedes de preparation et leur application en therapeutique |
| FR8123304A FR2518087A2 (en) | 1981-12-14 | 1981-12-14 | Aminoalkyl di:hydro-naphthalene, isoquinoline and benzoxazepine cpds. - useful as analgesics and antidepressants |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES508670A0 ES508670A0 (es) | 1983-06-01 |
| ES8306093A1 true ES8306093A1 (es) | 1983-06-01 |
Family
ID=26222136
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES508670A Expired ES8306093A1 (es) | 1980-12-22 | 1981-12-21 | Procedimiento de preparacion de derivados aminoalcoil heterociclicos farmaceuticamente activos. |
| ES518693A Granted ES518693A0 (es) | 1980-12-22 | 1982-12-16 | Metodo de preparar compuestos aminoalcoil heterociclicos de de actividad farmaceutica. |
| ES518692A Expired ES8400093A1 (es) | 1980-12-22 | 1982-12-16 | Metodo de preparacion de derivados farmaceuticamente activosaminoalcoil heterociclicos. |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES518693A Granted ES518693A0 (es) | 1980-12-22 | 1982-12-16 | Metodo de preparar compuestos aminoalcoil heterociclicos de de actividad farmaceutica. |
| ES518692A Expired ES8400093A1 (es) | 1980-12-22 | 1982-12-16 | Metodo de preparacion de derivados farmaceuticamente activosaminoalcoil heterociclicos. |
Country Status (11)
| Country | Link |
|---|---|
| US (3) | US4386090A (OSRAM) |
| AU (1) | AU7875781A (OSRAM) |
| CA (1) | CA1181748A (OSRAM) |
| DE (1) | DE3150876A1 (OSRAM) |
| ES (3) | ES8306093A1 (OSRAM) |
| GB (2) | GB2091250B (OSRAM) |
| GR (1) | GR78081B (OSRAM) |
| IT (1) | IT1168074B (OSRAM) |
| LU (1) | LU83850A1 (OSRAM) |
| NL (1) | NL8105791A (OSRAM) |
| SE (1) | SE8107537L (OSRAM) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3244594A1 (de) * | 1982-12-02 | 1984-06-07 | Hoechst Ag, 6230 Frankfurt | 1-phenylisochinolinderivate und verfahren zu ihrer herstellung, diese verbindung enthaltende pharmazeutische praeparate und deren anwendung |
| FR2544718B1 (fr) * | 1983-04-21 | 1985-12-20 | Hexachimie | Diniflumate d'ester morpholinoethylique d'acide niflumique, preparation, utilisation en therapeutique comme analgesique et anti-inflammatoire |
| US4745222A (en) * | 1983-05-25 | 1988-05-17 | Merrell Dow Pharmaceuticals Inc. | Novel aryloxycycloalkanolaminoalkylene aryl ketones |
| DE3413897A1 (de) * | 1984-04-13 | 1985-10-17 | Bayer Ag, 5090 Leverkusen | (beta)-naphthylalkylamine |
| EP0261842B1 (en) * | 1986-09-17 | 1990-11-22 | Dr. Lo. Zambeletti S.p.A. | N1-acylated-(1-(phenyl or benzyl))-1,2-ethylene diamines |
| CA1327795C (en) * | 1987-08-14 | 1994-03-15 | Jules Freedman | Antidepressants which are aryloxy inadanamines |
| US5561152A (en) * | 1987-08-14 | 1996-10-01 | Merrell Pharmaceuticals Inc. | Antidepressants |
| US5149714A (en) * | 1987-08-14 | 1992-09-22 | Merrell Dow Pharmaceuticals Inc. | Antidepressants |
| US5229414A (en) * | 1988-01-21 | 1993-07-20 | Imperial Chemical Industries Plc | Diamine compounds |
| ATE112769T1 (de) * | 1988-12-28 | 1994-10-15 | Suntory Ltd | Benzoxazepinderivate. |
| US5948820A (en) * | 1994-08-22 | 1999-09-07 | Yoshitomi Pharmaceutical Industries, Ltd. | Benzene compound and pharmaceutical use thereof |
| IT1303737B1 (it) * | 1998-11-11 | 2001-02-23 | Smithkline Beecham Spa | Derivati fenilpiperidinici procedimento per la loro preparazione eloro uso come ligandi del recettore orl-1. |
| US6646012B2 (en) * | 2001-01-16 | 2003-11-11 | Theravance, Inc. | Sodium channel modulators |
| DE60224189T2 (de) * | 2001-06-20 | 2008-12-11 | Merck & Co., Inc. | Dipeptidylpeptidase-hemmer zur behandlung von diabetes |
| WO2003000181A2 (en) * | 2001-06-20 | 2003-01-03 | Merck & Co., Inc. | Dipeptidyl peptidase inhibitors for the treatment of diabetes |
| PL211954B1 (pl) | 2002-01-11 | 2012-07-31 | Sankyo Co | Związek, kompozycja farmaceutyczna oraz zastosowanie kompozycji farmaceutycznej |
| US7208498B2 (en) * | 2002-07-15 | 2007-04-24 | Merck & Co., Inc. | Piperidino pyrimidine dipeptidyl peptidase inhibitors for the treatment of diabetes |
| DE60315687T2 (de) * | 2002-10-07 | 2008-06-05 | Merck & Co., Inc. | Antidiabetische heterocyclische beta-aminoverbindungen als inhibitoren von dipeptidylpeptidase |
| EP1562925B1 (en) * | 2002-11-07 | 2007-01-03 | Merck & Co., Inc. | Phenylalanine derivatives as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes |
| CA2508487A1 (en) * | 2002-12-04 | 2004-06-17 | Merck & Co., Inc. | Phenylalanine derivatives as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes |
| WO2004058266A1 (en) * | 2002-12-20 | 2004-07-15 | Merck & Co., Inc. | 3-amino-4-phenylbutanoic acid derivatives as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes |
| US7265128B2 (en) * | 2003-01-17 | 2007-09-04 | Merck & Co., Inc. | 3-amino-4-phenylbutanoic acid derivatives as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes |
| AU2004210149A1 (en) * | 2003-01-31 | 2004-08-19 | Merck & Co., Inc. | 3-amino-4-phenylbutanoic acid derivatives as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes |
| CN1787823A (zh) * | 2003-05-14 | 2006-06-14 | 麦克公司 | 作为二肽基肽酶抑制剂用于治疗或预防糖尿病的3－氨基－4－苯基丁酸衍生物 |
| CN1798556A (zh) * | 2003-06-06 | 2006-07-05 | 麦克公司 | 作为治疗或者预防糖尿病的二肽基肽酶抑制剂的稠合吲哚 |
| JP4579239B2 (ja) * | 2003-06-17 | 2010-11-10 | メルク・シャープ・エンド・ドーム・コーポレイション | 糖尿病の治療または予防するためのジペプチジルペプチダーゼ阻害剤としてのシクロヘキシルグリシン誘導体 |
| WO2005011581A2 (en) * | 2003-07-31 | 2005-02-10 | Merck & Co., Inc. | Hexahydrodiazepinones as dipeptidyl peptidase-iv inhibitors for the treatment or prevention of diabetes |
| US7626034B2 (en) * | 2003-09-18 | 2009-12-01 | Takasago International Corporation | Asymmetric reductive amination of keto acid derivatives for producing amino acid derivatives |
| JP2007510651A (ja) * | 2003-11-04 | 2007-04-26 | メルク エンド カムパニー インコーポレーテッド | 糖尿病の治療又は予防のためのジペプチジルペプチダーゼ−ｉｖ阻害剤としての縮合フェニルアラニン誘導体 |
| JP2005272453A (ja) | 2004-02-24 | 2005-10-06 | Sankyo Co Ltd | アミノアルコール化合物 |
| CN1950349A (zh) * | 2004-05-04 | 2007-04-18 | 默克公司 | 作为用于治疗或预防糖尿病的二肽基肽酶－ⅳ抑制剂的1,2,4－噁二唑衍生物 |
| US7795448B2 (en) * | 2004-05-06 | 2010-09-14 | Cytokinetics, Incorporated | Imidazoyl-benzamide anti-cancer agents |
| US7618981B2 (en) * | 2004-05-06 | 2009-11-17 | Cytokinetics, Inc. | Imidazopyridinyl-benzamide anti-cancer agents |
| US7504413B2 (en) * | 2004-05-06 | 2009-03-17 | Cytokinetics, Inc. | N-(4-(imidazo[1,2A]pyridin-YL)phenethyl)benzamide inhibitors of the mitotic kinesin CENP-E for treating certain cellular proliferation diseases |
| EP1604662A1 (en) * | 2004-06-08 | 2005-12-14 | Santhera Pharmaceuticals (Deutschland) Aktiengesellschaft | 1-[(3R)-Amino-4-(2-fluoro-phenyl)-butyl]-pyrrolidine-(2R)-carboxylic acid benzyl amine derivatives and related compounds as dipeptidyl peptidase IV (DPP-IV) inhibitors for the treatment of type 2 diabetes mellitus |
| EP1942899A4 (en) * | 2005-11-02 | 2010-04-28 | Cytokinetics Inc | INHIBITORS OF MITOTIC KINESINE |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2168929A (en) * | 1936-12-12 | 1939-08-08 | Winthrop Chem Co Inc | Isoquinoline compounds and derivatives thereof |
| US3663608A (en) * | 1969-12-10 | 1972-05-16 | Bristol Myers Co | 1-phenyl-3-aminoalkyl-1,2,3,4-tetrahydronaphthalenes and the salts thereof |
| US3704328A (en) * | 1970-01-21 | 1972-11-28 | James S Kaltenbronn | 4- and 5-aryl-1-naphthaleneethanol compounds |
| US3663627A (en) * | 1970-06-01 | 1972-05-16 | Bristol Myers Co | 1-indanmethanols |
| GB1400425A (en) * | 1971-09-22 | 1975-07-16 | Rolland Sa A | Substituted 3-hydroxymethyl-isoquinolines and derivatives |
| US4022791A (en) * | 1975-06-03 | 1977-05-10 | Pfizer Inc. | 2-Aminomethyl-3,4-dihydronaphthalenes |
-
1981
- 1981-12-16 SE SE8107537A patent/SE8107537L/xx not_active Application Discontinuation
- 1981-12-16 US US06/331,484 patent/US4386090A/en not_active Expired - Fee Related
- 1981-12-21 IT IT25722/81A patent/IT1168074B/it active
- 1981-12-21 GB GB8138399A patent/GB2091250B/en not_active Expired
- 1981-12-21 ES ES508670A patent/ES8306093A1/es not_active Expired
- 1981-12-21 CA CA000392859A patent/CA1181748A/en not_active Expired
- 1981-12-22 AU AU78757/81A patent/AU7875781A/en not_active Abandoned
- 1981-12-22 NL NL8105791A patent/NL8105791A/xx not_active Application Discontinuation
- 1981-12-22 DE DE19813150876 patent/DE3150876A1/de not_active Withdrawn
- 1981-12-22 LU LU83850A patent/LU83850A1/fr unknown
-
1982
- 1982-12-16 ES ES518693A patent/ES518693A0/es active Granted
- 1982-12-16 ES ES518692A patent/ES8400093A1/es not_active Expired
-
1983
- 1983-02-03 GR GR66782A patent/GR78081B/el unknown
- 1983-03-08 US US06/473,182 patent/US4431851A/en not_active Expired - Fee Related
- 1983-11-15 US US06/552,181 patent/US4504663A/en not_active Expired - Fee Related
-
1984
- 1984-04-09 GB GB08409163A patent/GB2137992B/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| GR78081B (OSRAM) | 1984-09-26 |
| GB2137992B (en) | 1985-05-09 |
| US4431851A (en) | 1984-02-14 |
| ES8400388A1 (es) | 1983-11-01 |
| NL8105791A (nl) | 1982-07-16 |
| GB2137992A (en) | 1984-10-17 |
| ES518692A0 (es) | 1983-11-01 |
| GB2091250A (en) | 1982-07-28 |
| GB8409163D0 (en) | 1984-05-16 |
| ES518693A0 (es) | 1983-11-01 |
| ES8400093A1 (es) | 1983-11-01 |
| US4504663A (en) | 1985-03-12 |
| AU7875781A (en) | 1982-07-01 |
| CA1181748A (en) | 1985-01-29 |
| US4386090A (en) | 1983-05-31 |
| LU83850A1 (fr) | 1983-09-02 |
| DE3150876A1 (de) | 1982-07-29 |
| IT1168074B (it) | 1987-05-20 |
| SE8107537L (sv) | 1982-06-23 |
| GB2091250B (en) | 1984-11-14 |
| ES508670A0 (es) | 1983-06-01 |
| IT8125722A0 (it) | 1981-12-21 |
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