ES8400388A1 - Metodo de preparar compuestos aminoalcoil heterociclicos de de actividad farmaceutica. - Google Patents

Metodo de preparar compuestos aminoalcoil heterociclicos de de actividad farmaceutica.

Info

Publication number
ES8400388A1
ES8400388A1 ES518693A ES518693A ES8400388A1 ES 8400388 A1 ES8400388 A1 ES 8400388A1 ES 518693 A ES518693 A ES 518693A ES 518693 A ES518693 A ES 518693A ES 8400388 A1 ES8400388 A1 ES 8400388A1
Authority
ES
Spain
Prior art keywords
naphthalenes
dihydro
compositions
nitrogen containing
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES518693A
Other languages
English (en)
Other versions
ES518693A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Synthelabo SA
Original Assignee
Delalande SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR8027252A external-priority patent/FR2496653A1/fr
Priority claimed from FR8123304A external-priority patent/FR2518087A2/fr
Application filed by Delalande SA filed Critical Delalande SA
Publication of ES518693A0 publication Critical patent/ES518693A0/es
Publication of ES8400388A1 publication Critical patent/ES8400388A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
    • C07D217/16—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D267/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D267/02—Seven-membered rings
    • C07D267/08—Seven-membered rings having the hetero atoms in positions 1 and 4
    • C07D267/12—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D267/14—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D317/28—Radicals substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D317/30—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE COMPUESTOS AMINOALCOHIL HETEROCICLICOS DE FORMULA (I) EN LA QUE N VALE 1-3; R ES FENILO Y R11 Y R21 PUEDEN SER VARIOS TIPOS DE RADICALES; COMPUESTOS QUE TIENEN APLICACIONES FARMACOLOGICAS COMO ANALGESICOS Y ANTIDEPRESORES.CONSISTE EN LA REACCION DE CONDENSACION DE DERIVADOS LITIADOS DEL BROMOBENCENO COMO COMPUESTOS DE FORMULA (II), EN LA QUE R1, R11 Y R21 TIENEN EL MISMO SIGNIFICADO QUE EN LA FORMULA (I). LA REACCION SE LLEVA A CABO EN MEDIO ETEREO, A LA TEMPERATURA DE REFLUJO, Y SE SIGUE DE UNA DESHIDRATACION MEDIANTE UN ACIDO MINERAL.
ES518693A 1980-12-22 1982-12-16 Metodo de preparar compuestos aminoalcoil heterociclicos de de actividad farmaceutica. Expired ES8400388A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR8027252A FR2496653A1 (fr) 1980-12-22 1980-12-22 Nouveaux derives aminoalcoyl heterocycliques, leurs procedes de preparation et leur application en therapeutique
FR8123304A FR2518087A2 (en) 1981-12-14 1981-12-14 Aminoalkyl di:hydro-naphthalene, isoquinoline and benzoxazepine cpds. - useful as analgesics and antidepressants

Publications (2)

Publication Number Publication Date
ES518693A0 ES518693A0 (es) 1983-11-01
ES8400388A1 true ES8400388A1 (es) 1983-11-01

Family

ID=26222136

Family Applications (3)

Application Number Title Priority Date Filing Date
ES508670A Granted ES508670A0 (es) 1980-12-22 1981-12-21 Procedimiento de preparacion de derivados aminoalcoil heterociclicos farmaceuticamente activos.
ES518692A Expired ES8400093A1 (es) 1980-12-22 1982-12-16 Metodo de preparacion de derivados farmaceuticamente activosaminoalcoil heterociclicos.
ES518693A Expired ES8400388A1 (es) 1980-12-22 1982-12-16 Metodo de preparar compuestos aminoalcoil heterociclicos de de actividad farmaceutica.

Family Applications Before (2)

Application Number Title Priority Date Filing Date
ES508670A Granted ES508670A0 (es) 1980-12-22 1981-12-21 Procedimiento de preparacion de derivados aminoalcoil heterociclicos farmaceuticamente activos.
ES518692A Expired ES8400093A1 (es) 1980-12-22 1982-12-16 Metodo de preparacion de derivados farmaceuticamente activosaminoalcoil heterociclicos.

Country Status (11)

Country Link
US (3) US4386090A (es)
AU (1) AU7875781A (es)
CA (1) CA1181748A (es)
DE (1) DE3150876A1 (es)
ES (3) ES508670A0 (es)
GB (2) GB2091250B (es)
GR (1) GR78081B (es)
IT (1) IT1168074B (es)
LU (1) LU83850A1 (es)
NL (1) NL8105791A (es)
SE (1) SE8107537L (es)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3244594A1 (de) * 1982-12-02 1984-06-07 Hoechst Ag, 6230 Frankfurt 1-phenylisochinolinderivate und verfahren zu ihrer herstellung, diese verbindung enthaltende pharmazeutische praeparate und deren anwendung
FR2544718B1 (fr) * 1983-04-21 1985-12-20 Hexachimie Diniflumate d'ester morpholinoethylique d'acide niflumique, preparation, utilisation en therapeutique comme analgesique et anti-inflammatoire
US4745222A (en) * 1983-05-25 1988-05-17 Merrell Dow Pharmaceuticals Inc. Novel aryloxycycloalkanolaminoalkylene aryl ketones
DE3413897A1 (de) * 1984-04-13 1985-10-17 Bayer Ag, 5090 Leverkusen (beta)-naphthylalkylamine
EP0261842B1 (en) * 1986-09-17 1990-11-22 Dr. Lo. Zambeletti S.p.A. N1-acylated-(1-(phenyl or benzyl))-1,2-ethylene diamines
US5561152A (en) * 1987-08-14 1996-10-01 Merrell Pharmaceuticals Inc. Antidepressants
US5149714A (en) * 1987-08-14 1992-09-22 Merrell Dow Pharmaceuticals Inc. Antidepressants
ZA885824B (en) * 1987-08-14 1989-04-26 Merrell Dow Pharma Novel antidepressants
US5229414A (en) * 1988-01-21 1993-07-20 Imperial Chemical Industries Plc Diamine compounds
DE68918832T2 (de) * 1988-12-28 1995-02-09 Suntory Ltd Benzoxazepinderivate.
US5948820A (en) 1994-08-22 1999-09-07 Yoshitomi Pharmaceutical Industries, Ltd. Benzene compound and pharmaceutical use thereof
IT1303737B1 (it) 1998-11-11 2001-02-23 Smithkline Beecham Spa Derivati fenilpiperidinici procedimento per la loro preparazione eloro uso come ligandi del recettore orl-1.
AU2002236775A1 (en) * 2001-01-16 2002-07-30 Seok-Ki Choi Sodium channel modulators
AU2002344820B2 (en) * 2001-06-20 2006-12-14 Merck & Co., Inc. Dipeptidyl peptidase inhibitors for the treatment of diabetes
DE60209348T2 (de) * 2001-06-20 2006-10-12 Merck & Co., Inc. Dipeptidylpeptidase-hemmer zur behandlung von diabetes
CA2473461C (en) * 2002-01-11 2011-11-01 Sankyo Company, Limited Amino alcohol derivative or phosphonic acid derivative and medicinal composition containing these
WO2004007468A1 (en) * 2002-07-15 2004-01-22 Merck & Co., Inc. Piperidino pyrimidine dipeptidyl peptidase inhibitors for the treatment of diabetes
CA2499586A1 (en) * 2002-10-07 2004-04-22 Merck & Co., Inc. Antidiabetic beta-amino heterocyclic dipeptidyl peptidase inhibitors
DE60310991T2 (de) * 2002-11-07 2007-10-18 Merck & Co, Inc. Phenylalaninderivate als hemmer der dipeptidyl peptidase zur behandlung oder prävention von diabetes
AU2003297564A1 (en) * 2002-12-04 2004-06-23 Merck & Co., Inc. Phenylalanine derivatives as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes
US20060052382A1 (en) * 2002-12-20 2006-03-09 Duffy Joseph L 3-Amino-4-phenylbutanoic acid derivatives as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes
JP4564952B2 (ja) * 2003-01-17 2010-10-20 メルク・シャープ・エンド・ドーム・コーポレイション 糖尿病の治療および予防のためのジペプチジルペプチダーゼ阻害薬としての３−アミノ−４−フェニルブタン酸誘導体
WO2004069162A2 (en) * 2003-01-31 2004-08-19 Merck & Co., Inc. 3-amino-4-phenylbutanoic acid derivatives as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes
ATE447574T1 (de) * 2003-05-14 2009-11-15 Merck & Co Inc 3-amino-4-phenylbutansäurederivate als dipeptidylpeptidase-hemmer zur behandlung oder vorbeugung von diabetes
JP2006527194A (ja) * 2003-06-06 2006-11-30 メルク　エンド　カムパニー　インコーポレーテッド 糖尿病の治療又は予防のためのジペプチジルペプチダーゼ阻害剤としての縮合インドール
AU2004249163A1 (en) * 2003-06-17 2004-12-29 Merck & Co., Inc. Cyclohexylglycine derivatives as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes
WO2005011581A2 (en) * 2003-07-31 2005-02-10 Merck & Co., Inc. Hexahydrodiazepinones as dipeptidyl peptidase-iv inhibitors for the treatment or prevention of diabetes
DE602004025132D1 (de) * 2003-09-18 2010-03-04 Takasago Perfumery Co Ltd Asymmetrische reduktive aminierung von ketosäurederivaten zur herstellung von aminosäurederivaten
JP2007510651A (ja) * 2003-11-04 2007-04-26 メルク　エンド　カムパニー　インコーポレーテッド 糖尿病の治療又は予防のためのジペプチジルペプチダーゼ−ｉｖ阻害剤としての縮合フェニルアラニン誘導体
KR101182619B1 (ko) 2004-02-24 2012-09-18 상꾜 가부시키가이샤 아미노 알코올 화합물
WO2005108382A1 (en) * 2004-05-04 2005-11-17 Merck & Co., Inc. 1,2,4-oxadiazole derivatives as dipeptidyl peptidase-iv inhibitors for the treatment or prevention of diabetes
US7504413B2 (en) * 2004-05-06 2009-03-17 Cytokinetics, Inc. N-(4-(imidazo[1,2A]pyridin-YL)phenethyl)benzamide inhibitors of the mitotic kinesin CENP-E for treating certain cellular proliferation diseases
US7795448B2 (en) * 2004-05-06 2010-09-14 Cytokinetics, Incorporated Imidazoyl-benzamide anti-cancer agents
US7618981B2 (en) * 2004-05-06 2009-11-17 Cytokinetics, Inc. Imidazopyridinyl-benzamide anti-cancer agents
EP1604662A1 (en) * 2004-06-08 2005-12-14 Santhera Pharmaceuticals (Deutschland) Aktiengesellschaft 1-[(3R)-Amino-4-(2-fluoro-phenyl)-butyl]-pyrrolidine-(2R)-carboxylic acid benzyl amine derivatives and related compounds as dipeptidyl peptidase IV (DPP-IV) inhibitors for the treatment of type 2 diabetes mellitus
US20070197640A1 (en) * 2005-11-02 2007-08-23 Cytokinetics, Inc. Certain chemical entities, compositions, and methods

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2168929A (en) * 1936-12-12 1939-08-08 Winthrop Chem Co Inc Isoquinoline compounds and derivatives thereof
US3663608A (en) * 1969-12-10 1972-05-16 Bristol Myers Co 1-phenyl-3-aminoalkyl-1,2,3,4-tetrahydronaphthalenes and the salts thereof
US3704328A (en) * 1970-01-21 1972-11-28 James S Kaltenbronn 4- and 5-aryl-1-naphthaleneethanol compounds
US3663627A (en) * 1970-06-01 1972-05-16 Bristol Myers Co 1-indanmethanols
GB1400425A (en) * 1971-09-22 1975-07-16 Rolland Sa A Substituted 3-hydroxymethyl-isoquinolines and derivatives
US4022791A (en) * 1975-06-03 1977-05-10 Pfizer Inc. 2-Aminomethyl-3,4-dihydronaphthalenes

Also Published As

Publication number Publication date
US4431851A (en) 1984-02-14
SE8107537L (sv) 1982-06-23
GB8409163D0 (en) 1984-05-16
US4386090A (en) 1983-05-31
ES8306093A1 (es) 1983-06-01
GB2137992A (en) 1984-10-17
AU7875781A (en) 1982-07-01
ES518692A0 (es) 1983-11-01
DE3150876A1 (de) 1982-07-29
IT8125722A0 (it) 1981-12-21
ES518693A0 (es) 1983-11-01
LU83850A1 (fr) 1983-09-02
US4504663A (en) 1985-03-12
GB2137992B (en) 1985-05-09
GB2091250A (en) 1982-07-28
IT1168074B (it) 1987-05-20
ES8400093A1 (es) 1983-11-01
GR78081B (es) 1984-09-26
ES508670A0 (es) 1983-06-01
NL8105791A (nl) 1982-07-16
GB2091250B (en) 1984-11-14
CA1181748A (en) 1985-01-29

Similar Documents

Publication Publication Date Title
ES8400093A1 (es) Metodo de preparacion de derivados farmaceuticamente activosaminoalcoil heterociclicos.
EP0163599A3 (en) Pyrimidopyrimidine derivatives, processes for producing them, pharmaceutical compositions containing them and their use as anti-allergic agents
MY109737A (en) Treatment and compounds.
FI954105A (fi) Uusia 4-aminopyridiinejä, niiden valmistusmenetelmä sekä näitä yhdisteitä sisältäviä lääkkeitä
GR3018182T3 (en) Derivatives of amidinophenylalanine, procedure for their preparation, their utilisation and anticoagulant compositions comprising them.
ES2081120T3 (es) Procedimiento para la preparacion de derivados de la bacatina iii y la desacetil-10 bacatina iii.
IL106387A (en) Indole derivatives, their preparation and pharmaceutical compositions containing them
ES2091359T3 (es) Nuevo compuesto peptidico y un procedimiento para su preparacion.
IE851205L (en) Beta-carbolines
IL98262A0 (en) Chromone derivatives and pharmaceutical compositions containing them
ES551990A0 (es) Procedimiento para preparar un derivados de cefalosporina.
IL96643A0 (en) Morpholinyl derivatives of doxorubicin,their preparation and pharmaceutical compositions containing them
FI892344A0 (fi) 6-fenyl-3-piperazinylalkyl-1h,3h -pyrimidin-2-4-dionderivat, deras framstaellning och deras terapeutiska anvaendning.
ES2008962A6 (es) Proceso para la preparacion de nuevos compuestos de 2-guanidinotiazol
ZA919752B (en) Fluorine compounds
SE8303913L (sv) Heterocykliska foreningar
EP0398702A3 (en) Dye couplers
NZ212614A (en) Acetylenic phenoxypropanol derivatives and pharmaceutical compositions
YU25699A (sh) Novi derivati eritromicina, postupak za njihovu izradu i njihova primena
SE8305307D0 (sv) Sulfurerade bensylidenderivat
EP0579836A4 (es)
NZ221004A (en) 2,6-piperazinediones and pharamceutical compositions
AU1234588A (en) New acetamides derived from 2,3-dihydro-3-phenyl-2-benzofuranone, processes for preparing them and the pharmaceutical compositions which contain them
EP0214566A3 (en) 3-propenyl pyridines and their use as fungicides
ES2001701A6 (es) Un metodo para preparar compuesto de benzoilurea

Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19981001