FR2421888A1
(fr)
*
|
1978-02-06 |
1979-11-02 |
Synthelabo |
Amides d'alkylene-diamines et leur application en therapeutique
|
JPS6016948B2
(ja)
*
|
1978-03-29 |
1985-04-30 |
住友化学工業株式会社 |
新規なキナゾリン誘導体及びその製造法
|
US4287341A
(en)
*
|
1979-11-01 |
1981-09-01 |
Pfizer Inc. |
Alkoxy-substituted-6-chloro-quinazoline-2,4-diones
|
EP0022481A1
(de)
*
|
1979-06-21 |
1981-01-21 |
Mitsubishi Yuka Pharmaceutical Co., Ltd. |
5,6-Alkylenpyrimidin-Derivate, Verfahren zu ihrer Herstellung und pharmazeutische Zusammensetzungen
|
US4426382A
(en)
*
|
1980-02-13 |
1984-01-17 |
Sankyo Company Limited |
4-Amino-6,7-dimethoxy-2-piperazinylquinazoline derivatives, their preparation and use
|
US4377581A
(en)
*
|
1980-03-03 |
1983-03-22 |
Pfizer Inc. |
Chloro- and alkoxy-substituted-2,4-diaminoquinazolines
|
US4351940A
(en)
*
|
1980-03-03 |
1982-09-28 |
Pfizer Inc. |
Chloro- and alkoxy-substituted-2-chloro-4-aminodquinazolines
|
US4367335A
(en)
*
|
1981-08-03 |
1983-01-04 |
Mead Johnson & Company |
Thiazolidinylalkylene piperazine derivatives
|
DE3304292A1
(de)
*
|
1982-10-11 |
1984-04-12 |
Brown, Boveri & Cie Ag, 6800 Mannheim |
Verfahren und vorrichtung zum ausregeln von netzfrequenzeinbruechen bei einem gleitdruckbetriebenen dampfkraftwerkblock
|
DE3346675A1
(de)
*
|
1983-12-23 |
1985-07-04 |
Beiersdorf Ag, 2000 Hamburg |
Substituierte 1-(4-amino-6,7-dialkoxy-chinazolinyl)-4- cyclohexenyl-derivate des piperazins und homopiperazins, verfahren zu ihrer herstellung und ihre verwendung sowie diese verbindungen enthaltende zubereitungen und zwischenprodukte
|
AT384218B
(de)
*
|
1985-12-04 |
1987-10-12 |
Gerot Pharmazeutika |
Verfahren zur herstellung von neuen chinazolin-derivaten
|
JP2657760B2
(ja)
*
|
1992-07-15 |
1997-09-24 |
小野薬品工業株式会社 |
4−アミノキナゾリン誘導体およびそれを含有する医薬品
|
CA2077252C
(en)
*
|
1992-08-31 |
2001-04-10 |
Khashayar Karimian |
Methods of making ureas and guanidines, and intermediates therefor
|
US20060222647A1
(en)
*
|
1993-05-27 |
2006-10-05 |
Beavo Joseph A |
Methods and compositions for modulating the activity of PDE5
|
US5776962A
(en)
*
|
1994-08-03 |
1998-07-07 |
Cell Pathways, Inc. |
Lactone compounds for treating patient with precancerous lesions
|
US5696159A
(en)
*
|
1994-08-03 |
1997-12-09 |
Cell Pathways, Inc. |
Lactone compounds for treating patients with precancerous lesions
|
US5869486A
(en)
*
|
1995-02-24 |
1999-02-09 |
Ono Pharmaceutical Co., Ltd. |
Fused pyrimidines and pyriazines as pharmaceutical compounds
|
US6046216A
(en)
*
|
1995-06-07 |
2000-04-04 |
Cell Pathways, Inc. |
Method of treating a patient having precancerous lesions with phenyl pyridinone derivatives
|
US6262059B1
(en)
|
1995-06-07 |
2001-07-17 |
Cell Pathways, Inc. |
Method of treating a patient having precancerous lesions with quinazoline derivatives
|
US6200980B1
(en)
|
1995-06-07 |
2001-03-13 |
Cell Pathways, Inc. |
Method of treating a patient having precancerous lesions with phenyl purinone derivatives
|
US6060477A
(en)
*
|
1995-06-07 |
2000-05-09 |
Cell Pathways, Inc. |
Method of treating a patient having precancerous lesions with phenyl cycloamino pyrimidinone derivatives
|
US6046206A
(en)
*
|
1995-06-07 |
2000-04-04 |
Cell Pathways, Inc. |
Method of treating a patient having a precancerous lesions with amide quinazoline derivatives
|
US5874440A
(en)
*
|
1995-06-07 |
1999-02-23 |
Cell Pathways, Inc. |
Method of treating a patient having precancerous lesions with phenyl pyrimidinone derivatives
|
US6232312B1
(en)
|
1995-06-07 |
2001-05-15 |
Cell Pathways, Inc. |
Method for treating patient having precancerous lesions with a combination of pyrimidopyrimidine derivatives and esters and amides of substituted indenyl acetic acides
|
US20050065161A1
(en)
*
|
1996-02-02 |
2005-03-24 |
Nitromed, Inc. |
Nitrosated and nitrosylated alpha-adrenergic receptor antagonist compounds, compositions and their uses
|
US5932538A
(en)
*
|
1996-02-02 |
1999-08-03 |
Nitromed, Inc. |
Nitrosated and nitrosylated α-adrenergic receptor antagonist compounds, compositions and their uses
|
US20020143007A1
(en)
*
|
1996-02-02 |
2002-10-03 |
Garvey David S. |
Nitrosated and nitrosylated alpha-adrenergic receptor antagonists, compositions and methods of use
|
GB9708917D0
(en)
*
|
1997-05-01 |
1997-06-25 |
Pfizer Ltd |
Compounds useful in therapy
|
US5858694A
(en)
*
|
1997-05-30 |
1999-01-12 |
Cell Pathways, Inc. |
Method for identifying compounds for inhibition of cancerous lesions
|
CA2238283C
(en)
*
|
1997-05-30 |
2002-08-20 |
Cell Pathways, Inc. |
Method for identifying compounds for inhibition of neoplastic lesions, pharmaceutical compositions from such compounds and uses of such compounds and compositions for treating neoplastic lesions
|
EP2295436A1
(de)
*
|
1997-11-12 |
2011-03-16 |
Bayer Schering Pharma AG |
2-Phenyl-substituierte Imidazotriazinone als Phosphodiesterase V Inhibitoren
|
US5852035A
(en)
*
|
1997-12-12 |
1998-12-22 |
Cell Pathways, Inc. |
Method for inhibiting neoplastic cells and related conditions by exposure to substituted N- arylmethyl and heterocyclmethyl-1H-pyrazolo (3,4-B) quinolin-4-amines
|
US6046199A
(en)
*
|
1998-01-14 |
2000-04-04 |
Cell Pathways, Inc. |
Method of inhibiting neoplastic cells with tetracyclic pyrido[3,4-B]indole derivatives
|
US6410584B1
(en)
*
|
1998-01-14 |
2002-06-25 |
Cell Pathways, Inc. |
Method for inhibiting neoplastic cells with indole derivatives
|
US5942520A
(en)
*
|
1998-01-27 |
1999-08-24 |
Cell Pathways, Inc. |
Method for inhibiting neoplastic cells by exposure to substituted N-cycloalkylmethyl-1-H-pyrazolo (3,4-B) quinolone-4 amines
|
US5990117A
(en)
*
|
1998-04-15 |
1999-11-23 |
Cell Pathways, Inc. |
Method for inhibiting neoplastic cells and related conditions by exposure to quinazoline derivatives
|
US6180629B1
(en)
|
1998-08-14 |
2001-01-30 |
Cell Pathways, Inc. |
[4,5]-Fused-1,3-disubstituted-1,2-diazine-6-one derivatives with nitrogen containing substitutents in position one for the treatment of neoplasia
|
US6124303A
(en)
*
|
1998-09-11 |
2000-09-26 |
Cell Pathways, Inc. |
Method for inhibiting neoplastic cells and related conditions by exposure to 9-substituted 2-(2-N-aloxyphenyl) purin-6-ones
|
US6268372B1
(en)
|
1998-09-11 |
2001-07-31 |
Cell Pathways, Inc. |
Method for inhibiting neoplastic cells and related conditions by exposure to 2,9-disubstituted purin-6-ones
|
US6200771B1
(en)
|
1998-10-15 |
2001-03-13 |
Cell Pathways, Inc. |
Method of using a novel phosphodiesterase in pharmaceutical screeing to identify compounds for treatment of neoplasia
|
US6130053A
(en)
*
|
1999-08-03 |
2000-10-10 |
Cell Pathways, Inc. |
Method for selecting compounds for inhibition of neoplastic lesions
|
US6133271A
(en)
*
|
1998-11-19 |
2000-10-17 |
Cell Pathways, Inc. |
Method for inhibiting neoplastic cells and related conditions by exposure thienopyrimidine derivatives
|
US6187779B1
(en)
|
1998-11-20 |
2001-02-13 |
Cell Pathways, Inc. |
Method for inhibiting neoplastic cells and related conditions by exposure to 2,8-disubstituted quinazoline derivatives
|
US6369092B1
(en)
|
1998-11-23 |
2002-04-09 |
Cell Pathways, Inc. |
Method for treating neoplasia by exposure to substituted benzimidazole derivatives
|
US6486155B1
(en)
|
1998-11-24 |
2002-11-26 |
Cell Pathways Inc |
Method of inhibiting neoplastic cells with isoquinoline derivatives
|
US6077842A
(en)
*
|
1998-11-24 |
2000-06-20 |
Cell Pathways, Inc. |
Method of inhibiting neoplastic cells with pyrazolopyridylpyridazinone derivatives
|
US6034099A
(en)
*
|
1998-11-24 |
2000-03-07 |
Cell Pathways, Inc. |
Method for inhibiting neoplastic lesions by administering 4-(arylmethylene)- 2, 3- dihydro-pyrazol-3-ones
|
US6025394A
(en)
|
1999-01-29 |
2000-02-15 |
Cell Pathways, Inc. |
Method for treating patients with acne by administering substituted sulfonyl indenyl acetic acids, amides and alcohols
|
US6020379A
(en)
*
|
1999-02-19 |
2000-02-01 |
Cell Pathways, Inc. |
Position 7 substituted indenyl-3-acetic acid derivatives and amides thereof for the treatment of neoplasia
|
US6555547B1
(en)
|
2000-02-28 |
2003-04-29 |
Cell Pathways, Inc. |
Method for treating a patient with neoplasia by treatment with a vinca alkaloid derivative
|
US6569638B1
(en)
|
2000-03-03 |
2003-05-27 |
Cell Pathways, Inc |
Method for screening compounds for the treatment of neoplasia
|
JP4166991B2
(ja)
*
|
2001-02-26 |
2008-10-15 |
田辺三菱製薬株式会社 |
ピリドピリミジンまたはナフチリジン誘導体
|
PL363679A1
(en)
*
|
2001-05-09 |
2004-11-29 |
Bayer Healthcare Ag |
Novel use of 2-phenyl-substituted imidazotriazinones
|
EP1312363A1
(de)
*
|
2001-09-28 |
2003-05-21 |
Pfizer Products Inc. |
Behandlungsverfahren und kits bestehend aus Wachstumshormonsekretionsförderern
|
US7342884B2
(en)
*
|
2002-03-13 |
2008-03-11 |
Harmonic, Inc. |
Method and apparatus for one directional communications in bidirectional communications channel
|
US7893101B2
(en)
|
2002-03-20 |
2011-02-22 |
Celgene Corporation |
Solid forms comprising (+)-2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione, compositions thereof, and uses thereof
|
US7276529B2
(en)
*
|
2002-03-20 |
2007-10-02 |
Celgene Corporation |
Methods of the treatment or prevention of exercise-induced asthma using (+)-2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione
|
US6962940B2
(en)
*
|
2002-03-20 |
2005-11-08 |
Celgene Corporation |
(+)-2-[1-(3-Ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione: methods of using and compositions thereof
|
US7208516B2
(en)
*
|
2002-03-20 |
2007-04-24 |
Celgene Corporation |
Methods of the treatment of psoriatic arthritis using (+)-2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione
|
CA2481385A1
(en)
*
|
2002-04-12 |
2003-10-23 |
Celgene Corporation |
Modulation of stem and progenitor cell differentiation, assays, and uses thereof
|
EP1496878A4
(de)
*
|
2002-04-12 |
2007-12-26 |
Celgene Corp |
Verfahren zur identifikation von angiogenese-modulatoren, damit entdeckte verbindungen und behandlungsverfahren unter verwendung dieser verbindungen
|
DE10232113A1
(de)
|
2002-07-16 |
2004-01-29 |
Bayer Ag |
Vardenafil Hydrochlorid Trihydrat enthaltende Arzneimittel
|
RU2006121990A
(ru)
|
2003-11-21 |
2007-12-27 |
Эррэй Биофарма Инк. (Us) |
Ингибиторы протеинкиназ акт
|
DE102005001989A1
(de)
*
|
2005-01-15 |
2006-07-20 |
Bayer Healthcare Ag |
Intravenöse Formulierungen von PDE-Inhibitoren
|
DE102005009240A1
(de)
*
|
2005-03-01 |
2006-09-07 |
Bayer Healthcare Ag |
Arzneiformen mit verbesserten pharmakokinetischen Eigenschaften
|
DE102005009241A1
(de)
*
|
2005-03-01 |
2006-09-07 |
Bayer Healthcare Ag |
Arzneiformen mit kontrollierter Bioverfügbarkeit
|
EP1931797A2
(de)
*
|
2005-09-29 |
2008-06-18 |
Bayer HealthCare AG |
Pde-inhibitoren und kombinationen davon zur behandlung urologischer störungen
|
GB0601951D0
(en)
|
2006-01-31 |
2006-03-15 |
Novartis Ag |
Organic compounds
|
US8063050B2
(en)
|
2006-07-06 |
2011-11-22 |
Array Biopharma Inc. |
Hydroxylated and methoxylated pyrimidyl cyclopentanes as AKT protein kinase inhibitors
|
MY147628A
(en)
|
2006-07-06 |
2012-12-31 |
Array Biopharma Inc |
Cyclopenta [d] pyrimidines as akt protein kinase inhibitors
|
WO2008006039A1
(en)
|
2006-07-06 |
2008-01-10 |
Array Biopharma Inc. |
Dihydrothieno pyrimidines as akt protein kinase inhibitors
|
WO2008006025A1
(en)
|
2006-07-06 |
2008-01-10 |
Array Biopharma Inc. |
Dihydrofuro pyrimidines as akt protein kinase inhibitors
|
KR20100029762A
(ko)
*
|
2007-06-13 |
2010-03-17 |
바이엘 쉐링 파마 악티엔게젤샤프트 |
청력 장애 치료용 pde 억제제
|
BRPI0813993A2
(pt)
*
|
2007-07-05 |
2015-06-16 |
Array Biopharma Inc |
Ciclopentanos de pirimidila como inibidores de proteína quinase akt
|
US9409886B2
(en)
|
2007-07-05 |
2016-08-09 |
Array Biopharma Inc. |
Pyrimidyl cyclopentanes as AKT protein kinase inhibitors
|
JP5628028B2
(ja)
|
2007-07-05 |
2014-11-19 |
アレイ バイオファーマ、インコーポレイテッド |
Aktプロテインキナーゼ阻害剤としてのピリミジルシクロペンタン
|
US8846683B2
(en)
|
2007-07-05 |
2014-09-30 |
Array Biopharma, Inc. |
Pyrimidyl cyclopentanes as Akt protein kinase inhibitors
|
EP2240455B1
(de)
*
|
2008-01-09 |
2012-12-26 |
Array Biopharma, Inc. |
Hydroxylierte pyrimidyl-cyclopentane als akt-proteinkinasehemmer
|
BRPI0906798A2
(pt)
*
|
2008-01-09 |
2015-07-14 |
Array Biopharma Inc |
Pirimidil ciclopentanos hidroxilados como inibidores de proteína quinase akt
|
CA2718412A1
(en)
*
|
2008-03-24 |
2009-10-01 |
Celgene Corporation |
Treatment of psoriasis or psoriatic arthritis using cyclopropyl-n-{2-{(1s)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl]-3-oxoisoindoline-4-yl}carboxamide
|
PL2694073T3
(pl)
|
2011-04-01 |
2019-06-28 |
Genentech, Inc. |
Kombinacje inhibitorów AKT i MEK do leczenia nowotworu
|
JP6143739B2
(ja)
|
2011-04-01 |
2017-06-07 |
ジェネンテック, インコーポレイテッド |
Akt阻害剤化合物及びベムラフェニブの組み合わせ、及び使用方法
|
ES2749433T3
(es)
|
2014-06-23 |
2020-03-20 |
Celgene Corp |
Apremilast para el tratamiento de una enfermedad hepática o una anomalía de la función hepática
|
WO2019010180A1
(en)
*
|
2017-07-06 |
2019-01-10 |
Case Western Reserve University |
PEPTIDE AND SMALL MOLECULE AGONISTS OF EPHA AND USES THEREOF
|