NL7409321A - Nieuwe derivaten van 2-benzamido-5-nitro-thia- - Google Patents

Nieuwe derivaten van 2-benzamido-5-nitro-thia-

Info

Publication number
NL7409321A
NL7409321A NL7409321A NL7409321A NL7409321A NL 7409321 A NL7409321 A NL 7409321A NL 7409321 A NL7409321 A NL 7409321A NL 7409321 A NL7409321 A NL 7409321A NL 7409321 A NL7409321 A NL 7409321A
Authority
NL
Netherlands
Prior art keywords
benzamido
thia
nitro
new derivatives
derivatives
Prior art date
Application number
NL7409321A
Other languages
English (en)
Other versions
NL176779B (nl
NL176779C (nl
Original Assignee
Phavic Sprl
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Phavic Sprl filed Critical Phavic Sprl
Publication of NL7409321A publication Critical patent/NL7409321A/nl
Publication of NL176779B publication Critical patent/NL176779B/nl
Application granted granted Critical
Publication of NL176779C publication Critical patent/NL176779C/nl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/44—Acylated amino or imino radicals
    • C07D277/46—Acylated amino or imino radicals by carboxylic acids, or sulfur or nitrogen analogues thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/58—Nitro radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
NLAANVRAGE7409321,A 1973-08-08 1974-07-10 Werkwijze voor het bereiden of vervaardigen van een preparaat voor het bestrijden van parasieten en werkwijze voor het bereiden van een 2-benzamido-5-nitrothiazoolderivaat met parasietenbestrijdende werking. NL176779C (nl)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB3760873A GB1437800A (en) 1973-08-08 1973-08-08 Derivatives of 2-benzamido-5-nitro-thiazoles

Publications (3)

Publication Number Publication Date
NL7409321A true NL7409321A (nl) 1975-02-11
NL176779B NL176779B (nl) 1985-01-02
NL176779C NL176779C (nl) 1985-06-03

Family

ID=10397712

Family Applications (1)

Application Number Title Priority Date Filing Date
NLAANVRAGE7409321,A NL176779C (nl) 1973-08-08 1974-07-10 Werkwijze voor het bereiden of vervaardigen van een preparaat voor het bestrijden van parasieten en werkwijze voor het bereiden van een 2-benzamido-5-nitrothiazoolderivaat met parasietenbestrijdende werking.

Country Status (14)

Country Link
US (1) US3950351A (nl)
JP (1) JPS5041858A (nl)
AR (1) AR201880A1 (nl)
BE (1) BE817878A (nl)
CA (1) CA1041519A (nl)
CH (1) CH583215A5 (nl)
DE (1) DE2438037C2 (nl)
ES (1) ES428906A1 (nl)
FR (1) FR2240010B1 (nl)
GB (1) GB1437800A (nl)
IL (1) IL45194A (nl)
NL (1) NL176779C (nl)
OA (1) OA04761A (nl)
ZA (1) ZA744409B (nl)

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US4315018A (en) * 1978-12-07 1982-02-09 Rossignol Jean F Specific parasiticidal use of 2-benzamido-5-nitro-thiazole derivatives
ZA807940B (en) * 1979-12-21 1982-07-28 Wellcome Found Heterocyclic chemicals,their preparation and use
CZ287002B6 (en) * 1994-04-13 2000-08-16 Rossignol Jean Franaois Benzamide derivative, pharmaceutical preparation containing thereof and use of the derivative
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US5859038A (en) * 1994-09-08 1999-01-12 Romark Laboratories, L.C. Method for treatment of helicobacter pylori infections
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US7125568B2 (en) * 2001-08-23 2006-10-24 Sung Michael T Lipophilic drug compositions
GB0226930D0 (en) 2002-11-19 2002-12-24 Astrazeneca Ab Chemical compounds
GB0325402D0 (en) * 2003-10-31 2003-12-03 Astrazeneca Ab Compounds
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GB0328178D0 (en) * 2003-12-05 2004-01-07 Astrazeneca Ab Compounds
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UA90864C2 (en) * 2004-09-09 2010-06-10 Ромарк Лебораториз, Л.К. Halogenated benzamide derivatives
US20060194853A1 (en) * 2004-10-08 2006-08-31 Rossignol Jean F Alkyl benzamides
GB0423043D0 (en) * 2004-10-16 2004-11-17 Astrazeneca Ab Compounds
AU2005293343B2 (en) 2004-10-16 2009-03-19 Astrazeneca Ab Process for making phenoxy benzamide compounds
GB0423044D0 (en) * 2004-10-16 2004-11-17 Astrazeneca Ab Compounds
WO2006110814A2 (en) * 2005-04-12 2006-10-19 Romark Laboratories, L.C. Methods for treating diseases through inhibition the function of molecular chaperones such as protein disulfide isomerases, pharmaceutical compositions comprising them, and screening methods for identifying therapeutic agents
US20110059941A1 (en) * 2005-05-24 2011-03-10 Peter William Rodney Caulkett 2-phenyl substituted imidazol [4,5b] pyridine/pyrazine and purine derivatives as glucokinase modulators
TW200714597A (en) * 2005-05-27 2007-04-16 Astrazeneca Ab Chemical compounds
WO2007007040A1 (en) * 2005-07-09 2007-01-18 Astrazeneca Ab 2 -heterocyclyloxybenzoyl amino heterocyclyl compounds as modulators of glucokinase for the treatment of type 2 diabetes
EP1902052B1 (en) * 2005-07-09 2012-11-28 AstraZeneca AB Heteroaryl benzamide derivatives for use as glk activators in the treatment of diabetes
EP2027113A1 (en) * 2005-07-09 2009-02-25 AstraZeneca AB Heteroaryl benzamide derivatives for use as glk activators in the treatment of diabetes
US9202182B2 (en) * 2005-08-11 2015-12-01 International Business Machines Corporation Method and system for analyzing business architecture
TW200738621A (en) * 2005-11-28 2007-10-16 Astrazeneca Ab Chemical process
DK1976516T3 (da) 2006-01-09 2013-07-15 Romark Lab Lc Behandling af viral hepatitis
WO2008008480A2 (en) * 2006-07-12 2008-01-17 Cumbre Pharmaceuticals Inc. Nitroheteroaryl-containing rifamycin derivatives
CN100465169C (zh) * 2006-08-02 2009-03-04 杭州欣阳三友精细化工有限公司 硝唑尼特的制备方法
TW200825063A (en) * 2006-10-23 2008-06-16 Astrazeneca Ab Chemical compounds
CL2007003061A1 (es) * 2006-10-26 2008-08-01 Astrazeneca Ab Compuestos derivados de 3,5-dioxi-benzamida; proceso de preparacion; composicion farmaceutica que comprende a dichos compuestos; y su uso para tratar una enfermedad mediada a traves de glk, tal como la diabetes tipo 2.
BRPI0721143A2 (pt) * 2006-12-21 2014-03-11 Astrazeneca Ab Forma cristalina do composto processo para a formação da mesma, uso de um composto, método para tratar doenças mediadas por ativador de glicocinase
CN101007792B (zh) * 2007-01-31 2010-05-26 浙江大学 一种合成硝基噻唑苯酰胺化合物的方法
ES2550755T3 (es) 2007-08-03 2015-11-12 Romark Laboratories, L.C. Compuestos de tiazolida sustituidos con alquilsulfonilo
AU2009278929B2 (en) * 2008-08-04 2012-07-05 Astrazeneca Ab Pyrazolo [3,4] pyrimidin-4-yl derivatives and their uses to treat diabetes and obesity
TWI432436B (zh) 2008-12-09 2014-04-01 Gilead Sciences Inc 類鐸受體的調節劑
GB0902434D0 (en) * 2009-02-13 2009-04-01 Astrazeneca Ab Chemical process
GB0902406D0 (en) * 2009-02-13 2009-04-01 Astrazeneca Ab Crystalline polymorphic form
CA2752233C (en) 2009-02-13 2017-01-03 Romark Laboratories L.C. Controlled release pharmaceutical formulations of nitazoxanide
WO2010116176A1 (en) * 2009-04-09 2010-10-14 Astrazeneca Ab Pyrazolo [4, 5-e] pyrimidine derivative and its use to treat diabetes and obesity
AR076220A1 (es) 2009-04-09 2011-05-26 Astrazeneca Ab Derivados de pirazol [4,5 - e] pirimidina
CN105853415A (zh) 2009-05-12 2016-08-17 罗马克实验室有限公司 卤代烷基杂芳基苯甲酰胺化合物
KR20170141830A (ko) * 2009-06-26 2017-12-26 로마크 레버러토리즈, 엘.씨. 인플루엔자를 치료하기 위한 화합물 및 방법
CN101602744B (zh) * 2009-06-30 2011-06-01 青岛康地恩药业有限公司 一种硝唑尼特的制备方法
WO2013110975A1 (es) 2012-01-27 2013-08-01 Siegfried Rhein S.A. De C.V. Composición de nitazoxanida mejorada y proceso para prepararla
EP2902024B1 (en) 2012-09-27 2017-11-29 Siegfried Rhein S.A. De C.V. Synergic composition of nitazoxanide and mebendazole, methods for the preparation thereof, and use of said composition for the treatment of human parasitosis
EP3010345A4 (en) * 2013-06-21 2017-04-12 The Regents of The University of California Expanded therapeutic potential in nitroheteroaryl antimicrobials
EP3166607B1 (en) 2014-07-11 2022-08-31 Gilead Sciences, Inc. Modulators of toll-like receptors for the treatment of hiv
EA201790369A1 (ru) 2014-09-16 2017-10-31 Джилид Сайэнс, Инк. Твердые формы модулятора толл-подобного рецептора
CA2967333A1 (en) 2014-11-11 2016-05-19 Romark Laboratories, L.C. Compositions and methods of treatment with prodrugs of tizoxanide, an analogue or salt thereof
CN105175352A (zh) * 2015-10-27 2015-12-23 杭州澳医保灵药业有限公司 一种硝唑尼特的制备方法
CN106831640A (zh) * 2015-12-03 2017-06-13 江苏正大丰海制药有限公司 一种硝唑尼特晶体的制备方法
UA126114C2 (uk) 2016-03-31 2022-08-17 Ромарк Лебореторіз Ел.Сі. Спосіб лікування захворювання або стану, викликаного вірусом, що належить до сімейства picornaviridae, тіазолідними сполуками
MX2018012287A (es) 2016-04-11 2019-02-07 Genfit Metodos de tratamiento para enfermedades colestasicas y fibroticas.
CA3046158A1 (en) 2017-01-27 2018-08-02 Genfit Pharmaceutical compositions for combination therapy
US11173149B2 (en) 2017-04-18 2021-11-16 Romark Laboratories L.C. Inhibition of protein disulfide-isomerase A3
CA3130518A1 (en) 2019-04-12 2020-10-15 Nicolas STANKOVIC-VALENTIN Nitazoxanide and thiazolides for use in the treatment of diseases associated with oxidative stress
CN114630660A (zh) 2019-10-28 2022-06-14 基恩菲特公司 具有抗氧化特性的联合疗法
WO2022020243A1 (en) 2020-07-20 2022-01-27 Romark Laboratories L.C. Crystalline salts of tizoxanide and 2-hydroxy-n-(5-chloro-1,3-thiazol-2-yl)benzamide (rm-4848) with ethanolamine, morpholine, propanolamine, piperazine and n-methylpiperazine
US20230330069A1 (en) 2020-08-24 2023-10-19 Romark Laboratories, L.C. Use of thiazolides against coronaviruses
CN114044761B (zh) * 2021-02-24 2022-05-17 成都贝诺科成生物科技有限公司 一种新的硝基噻唑衍生物及其应用
WO2022218239A1 (zh) * 2021-04-12 2022-10-20 杜心赟 新型噻唑类化合物及其制备方法和用途
CN116898846A (zh) * 2022-04-12 2023-10-20 成都贝诺科成生物科技有限公司 一种硝基噻唑衍生物在制备抑制幽门螺杆菌的抑菌剂中的用途

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CA497537A (en) * 1953-11-10 H. Clark Joe 2-substituted amino-5-nitrothiazoles
US2829084A (en) * 1958-04-01 Certain alkyl-n
US2735798A (en) * 1956-02-21 Acyl amevo-nitrothiazole compositions
GB577418A (en) * 1942-04-17 1946-05-17 Sandoz Ltd Process for the preparation of amides of aromatic carboxylic acids
US2401522A (en) * 1942-04-17 1946-06-04 Firm Sandoz Ltd Aromatic carboxylic acid amides and a process for their manufacture
FR1306603A (fr) * 1958-08-14 1962-10-19 Innothera Lab Sa Dérivés thiazoliques et leur procédé de préparation
US3475446A (en) * 1967-06-27 1969-10-28 Parke Davis & Co N-(5-nitro-2-thiazolyl)-cycloalkanecarboxamides

Also Published As

Publication number Publication date
NL176779B (nl) 1985-01-02
CA1041519A (en) 1978-10-31
CH583215A5 (nl) 1976-12-31
AR201880A1 (es) 1975-04-24
JPS5041858A (nl) 1975-04-16
ES428906A1 (es) 1976-08-16
IL45194A0 (en) 1974-10-22
FR2240010B1 (nl) 1978-03-24
GB1437800A (en) 1976-06-03
DE2438037A1 (de) 1975-02-20
US3950351A (en) 1976-04-13
NL176779C (nl) 1985-06-03
BE817878A (fr) 1975-01-20
FR2240010A1 (nl) 1975-03-07
ZA744409B (en) 1975-07-30
DE2438037C2 (de) 1982-06-09
OA04761A (fr) 1980-08-31
AU7135574A (en) 1976-01-22
IL45194A (en) 1977-10-31

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Legal Events

Date Code Title Description
BA A request for search or an international-type search has been filed
CNR Transfer of rights (patent application after its laying open for public inspection)

Free format text: JEAN-FRANCOIS ROSSIGNOL

BB A search report has been drawn up
BC A request for examination has been filed
A85 Still pending on 85-01-01
V1 Lapsed because of non-payment of the annual fee