AR201880A1 - Procedimiento para la preparacion de nuevos derivados de 2-benzamido-5-nitrotiazol - Google Patents

Procedimiento para la preparacion de nuevos derivados de 2-benzamido-5-nitrotiazol

Info

Publication number
AR201880A1
AR201880A1 AR255045A AR25504574A AR201880A1 AR 201880 A1 AR201880 A1 AR 201880A1 AR 255045 A AR255045 A AR 255045A AR 25504574 A AR25504574 A AR 25504574A AR 201880 A1 AR201880 A1 AR 201880A1
Authority
AR
Argentina
Prior art keywords
nitrotiazol
benzamido
procedure
preparation
new derivatives
Prior art date
Application number
AR255045A
Other languages
English (en)
Original Assignee
Sprl
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sprl filed Critical Sprl
Application granted granted Critical
Publication of AR201880A1 publication Critical patent/AR201880A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/44—Acylated amino or imino radicals
    • C07D277/46—Acylated amino or imino radicals by carboxylic acids, or sulfur or nitrogen analogues thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/58—Nitro radicals
AR255045A 1973-08-08 1974-08-05 Procedimiento para la preparacion de nuevos derivados de 2-benzamido-5-nitrotiazol AR201880A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB3760873A GB1437800A (en) 1973-08-08 1973-08-08 Derivatives of 2-benzamido-5-nitro-thiazoles

Publications (1)

Publication Number Publication Date
AR201880A1 true AR201880A1 (es) 1975-04-24

Family

ID=10397712

Family Applications (1)

Application Number Title Priority Date Filing Date
AR255045A AR201880A1 (es) 1973-08-08 1974-08-05 Procedimiento para la preparacion de nuevos derivados de 2-benzamido-5-nitrotiazol

Country Status (14)

Country Link
US (1) US3950351A (es)
JP (1) JPS5041858A (es)
AR (1) AR201880A1 (es)
BE (1) BE817878A (es)
CA (1) CA1041519A (es)
CH (1) CH583215A5 (es)
DE (1) DE2438037C2 (es)
ES (1) ES428906A1 (es)
FR (1) FR2240010B1 (es)
GB (1) GB1437800A (es)
IL (1) IL45194A (es)
NL (1) NL176779C (es)
OA (1) OA04761A (es)
ZA (1) ZA744409B (es)

Families Citing this family (72)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2435905A1 (fr) * 1978-09-13 1980-04-11 Anvar Nouveaux agents molluscicides derives du benzamido-2 nitro-5 thiazole
US4315018A (en) * 1978-12-07 1982-02-09 Rossignol Jean F Specific parasiticidal use of 2-benzamido-5-nitro-thiazole derivatives
FI64587C (fi) * 1979-12-21 1983-12-12 Wellcome Found Foerfarande foer framstaellning av farmaceutiskt anvaendbara 2-(substituerad-bensoyl-imino)-5-nitro-4-tiazoliner
NZ284800A (en) * 1994-04-13 1998-02-26 Rossignol Jean Francois 2-hydroxy-n-(5-nitro-thiazol-2-yl)-benzamide, medicaments particularly in conjunction with the acetylated form
US5578621A (en) * 1994-09-08 1996-11-26 Romark Lab Lc Benzamide derivatives
US5387598A (en) * 1994-04-13 1995-02-07 Rossignol; Jean-Francois Composition and galenic formulation suitable for combatting affections of the lower abdomen
MX9604483A (es) * 1994-09-08 1998-02-28 Jean-Francois Rossignol Derivados de benzamida, composiciones que contienen dicho derivado y uso de las mismas.
US5859038A (en) * 1994-09-08 1999-01-12 Romark Laboratories, L.C. Method for treatment of helicobacter pylori infections
US5968961A (en) * 1997-05-07 1999-10-19 Romark Laboratories, L.C. Pharmaceutical compositions of tizoxanide and nitazoxanide
NZ500149A (en) * 1997-05-07 2001-11-30 Romark Lab L Pharmaceutical compositions containing tizoxanide and/or nitazoxinade
AU756451B2 (en) * 1997-05-07 2003-01-16 Romark Laboratories, L.C. Pharmaceutical compositions of tizoxanide and nitazoxanide
US5935591A (en) * 1998-01-15 1999-08-10 Romark Laboratories, L.C. Method for treatment of equine protozoal myeloencephalitis with thiazolides
US5925622A (en) * 1998-07-13 1999-07-20 Romark Laboratories, L.C. Synthesis of aryl glucuronide of 2-hydroxy-N- (5-nitro-2-thiazolyl) benzamide, and pharmaceutical compositions comprising same
SE0102764D0 (sv) * 2001-08-17 2001-08-17 Astrazeneca Ab Compounds
US7125568B2 (en) 2001-08-23 2006-10-24 Sung Michael T Lipophilic drug compositions
GB0226930D0 (en) 2002-11-19 2002-12-24 Astrazeneca Ab Chemical compounds
GB0325402D0 (en) * 2003-10-31 2003-12-03 Astrazeneca Ab Compounds
GB0327761D0 (en) * 2003-11-29 2003-12-31 Astrazeneca Ab Compounds
GB0328178D0 (en) * 2003-12-05 2004-01-07 Astrazeneca Ab Compounds
US20080280872A1 (en) * 2004-02-18 2008-11-13 Craig Johnstone Benzamide Derivatives and Their Use as Glucokinase Activating Agents
US20080312207A1 (en) * 2004-02-18 2008-12-18 Craig Johnstone Compounds
TW200600086A (en) * 2004-06-05 2006-01-01 Astrazeneca Ab Chemical compound
UA90864C2 (en) * 2004-09-09 2010-06-10 Ромарк Лебораториз, Л.К. Halogenated benzamide derivatives
US20060194853A1 (en) * 2004-10-08 2006-08-31 Rossignol Jean F Alkyl benzamides
MX2007004560A (es) 2004-10-16 2007-06-08 Astrazeneca Ab Proceso para hacer compuestos de fenoxi benzamida.
GB0423044D0 (en) * 2004-10-16 2004-11-17 Astrazeneca Ab Compounds
GB0423043D0 (en) * 2004-10-16 2004-11-17 Astrazeneca Ab Compounds
US20070015803A1 (en) * 2005-04-12 2007-01-18 Romark Laboratories L.C. Methods for treating diseases through interruption of protein maturation, compounds that inhibit the function of molecular chaperones such as protein disulfide isomerases or interfere with glycosylation, pharmaceutical compositions comprising them, and screening methods for identifying therapeutic agents
EP1891069A1 (en) * 2005-05-24 2008-02-27 AstraZeneca AB 2-phenyl substituted imidazol [4,5b]pyridine/ pyrazine and purine derivatives as glucokinase modulators
TW200714597A (en) * 2005-05-27 2007-04-16 Astrazeneca Ab Chemical compounds
BRPI0622261A2 (pt) * 2005-07-09 2011-08-09 Astrazeneca Ab composto, composição farmacêutica, uso de um composto ou um sal farmaceuticamente aceitável do mesmo, e, processo para a preparação de um composto
US20080234273A1 (en) * 2005-07-09 2008-09-25 Mckerrecher Darren Heteroaryl Benzamide Derivatives for Use as Glk Activators in the Treatment of Diabetes
EP1910350A1 (en) * 2005-07-09 2008-04-16 AstraZeneca AB 2 -heterocyclyloxybenzoyl amino heterocyclyl compounds as modulators of glucokinase for the treatment of type 2 diabetes
US9202182B2 (en) * 2005-08-11 2015-12-01 International Business Machines Corporation Method and system for analyzing business architecture
TW200738621A (en) * 2005-11-28 2007-10-16 Astrazeneca Ab Chemical process
CA2636527C (en) * 2006-01-09 2016-05-17 Romark Laboratories, L.C. Viral hepatitis treatment
US7678791B2 (en) * 2006-07-12 2010-03-16 Cumbre Ip Ventures, L.P. Nitroheteroaryl-containing rifamycin derivatives
CN100465169C (zh) * 2006-08-02 2009-03-04 杭州欣阳三友精细化工有限公司 硝唑尼特的制备方法
TW200825063A (en) * 2006-10-23 2008-06-16 Astrazeneca Ab Chemical compounds
SA07280576B1 (ar) * 2006-10-26 2011-06-22 استرازينيكا ايه بي مركبات بنزويل أمينو سيكليل غير متجانسة بأعتبارها عوامل منشطة للجلوكوكيناز
US20100094009A1 (en) * 2006-12-21 2010-04-15 Mccabe James Novel crystalline compound useful as glk activator
CN101007792B (zh) * 2007-01-31 2010-05-26 浙江大学 一种合成硝基噻唑苯酰胺化合物的方法
CA2695517C (en) 2007-08-03 2016-09-20 J. Edward Semple Alkylsulfonyl-substituted thiazolide compounds
MX2011001333A (es) * 2008-08-04 2011-03-15 Astrazeneca Ab Derivados de pirazolo [3, 4] pirimidin-4-ilo y sus usos para tratar la diabetes y obesidad.
KR101687841B1 (ko) 2008-12-09 2016-12-19 길리애드 사이언시즈, 인코포레이티드 톨-유사 수용체의 조절제
GB0902434D0 (en) * 2009-02-13 2009-04-01 Astrazeneca Ab Chemical process
GB0902406D0 (en) * 2009-02-13 2009-04-01 Astrazeneca Ab Crystalline polymorphic form
US8524278B2 (en) 2009-02-13 2013-09-03 Romark Laboratories L.C. Controlled release pharmaceutical formulations of nitazoxanide
WO2010116176A1 (en) * 2009-04-09 2010-10-14 Astrazeneca Ab Pyrazolo [4, 5-e] pyrimidine derivative and its use to treat diabetes and obesity
WO2010116177A1 (en) 2009-04-09 2010-10-14 Astrazeneca Ab A pyrazolo [4,5-e] pyrimidine derivative and its use to treat diabetes and obesity
CN105853415A (zh) 2009-05-12 2016-08-17 罗马克实验室有限公司 卤代烷基杂芳基苯甲酰胺化合物
CA2968113C (en) 2009-06-26 2019-05-14 Romark Laboratories L.C. Compounds and methods for treating influenza
CN101602744B (zh) * 2009-06-30 2011-06-01 青岛康地恩药业有限公司 一种硝唑尼特的制备方法
US9498441B2 (en) 2012-01-27 2016-11-22 Siegfried Rhein S.A. De C.V. Nitazoxadine composition and process to prepare same
US20150250765A1 (en) 2012-09-27 2015-09-10 Siegfried Rhein S.A. De C.V. Nitazoxanide and mebendazole synergic composition, processes for the preparation thereof, and use of said composition for the treatment of human parasitosis
US20160244435A1 (en) * 2013-06-21 2016-08-25 The Scripps Research Institute Expanded therapeutic potential in nitroheteroaryl antimicrobials
NZ728072A (en) 2014-07-11 2018-06-29 Gilead Sciences Inc Modulators of toll-like receptors for the treatment of hiv
KR20190125537A (ko) 2014-09-16 2019-11-06 길리애드 사이언시즈, 인코포레이티드 톨-유사 수용체 조정제의 고체 형태
WO2016077420A1 (en) 2014-11-11 2016-05-19 Romark Laboratories, L.C. Compositions and methods of treatment with prodrugs of tizoxanide, an analogue or salt thereof
CN105175352A (zh) * 2015-10-27 2015-12-23 杭州澳医保灵药业有限公司 一种硝唑尼特的制备方法
CN106831640A (zh) * 2015-12-03 2017-06-13 江苏正大丰海制药有限公司 一种硝唑尼特晶体的制备方法
WO2017173056A1 (en) 2016-03-31 2017-10-05 Romark Laboratories L.C. Thiazolide compounds for treating viral infections
EA201892298A1 (ru) 2016-04-11 2019-04-30 Женфит Способы лечения холестатических и фибротических заболеваний
CA3046158A1 (en) 2017-01-27 2018-08-02 Genfit Pharmaceutical compositions for combination therapy
US11173149B2 (en) 2017-04-18 2021-11-16 Romark Laboratories L.C. Inhibition of protein disulfide-isomerase A3
EP3952869A1 (en) 2019-04-12 2022-02-16 Genfit Nitazoxanide and thiazolides for use in the treatment of diseases associated with oxidative stress
EP4051257A1 (en) 2019-10-28 2022-09-07 Genfit Combination therapy having antioxydant properties
EP4182304A1 (en) 2020-07-20 2023-05-24 Romark Laboratories, L.C. Crystalline salts of tizoxanide and 2-hydroxy-n-(5-chloro-1,3-thiazol-2-yl)benzamide (rm-4848) with ethanolamine, morpholine, propanolamine, piperazine and n-methylpiperazine
WO2022046622A1 (en) 2020-08-24 2022-03-03 Romark Laboratories L.C. Use of thiazolides against coronaviruses
CN114044761B (zh) * 2021-02-24 2022-05-17 成都贝诺科成生物科技有限公司 一种新的硝基噻唑衍生物及其应用
CN115197164A (zh) * 2021-04-12 2022-10-18 杜心赟 新型噻唑类化合物及其制备方法和用途
WO2023198095A1 (zh) * 2022-04-12 2023-10-19 成都贝诺科成生物科技有限公司 一种硝基噻唑衍生物在制备抑制幽门螺杆菌的抑菌剂中的用途

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2829084A (en) * 1958-04-01 Certain alkyl-n
CA497537A (en) * 1953-11-10 H. Clark Joe 2-substituted amino-5-nitrothiazoles
US2735798A (en) * 1956-02-21 Acyl amevo-nitrothiazole compositions
US2401522A (en) * 1942-04-17 1946-06-04 Firm Sandoz Ltd Aromatic carboxylic acid amides and a process for their manufacture
GB577418A (en) * 1942-04-17 1946-05-17 Sandoz Ltd Process for the preparation of amides of aromatic carboxylic acids
FR1306603A (fr) * 1958-08-14 1962-10-19 Innothera Lab Sa Dérivés thiazoliques et leur procédé de préparation
US3475446A (en) * 1967-06-27 1969-10-28 Parke Davis & Co N-(5-nitro-2-thiazolyl)-cycloalkanecarboxamides

Also Published As

Publication number Publication date
CA1041519A (en) 1978-10-31
FR2240010A1 (es) 1975-03-07
JPS5041858A (es) 1975-04-16
ZA744409B (en) 1975-07-30
AU7135574A (en) 1976-01-22
NL176779B (nl) 1985-01-02
BE817878A (fr) 1975-01-20
US3950351A (en) 1976-04-13
NL176779C (nl) 1985-06-03
DE2438037C2 (de) 1982-06-09
IL45194A0 (en) 1974-10-22
ES428906A1 (es) 1976-08-16
GB1437800A (en) 1976-06-03
DE2438037A1 (de) 1975-02-20
CH583215A5 (es) 1976-12-31
NL7409321A (nl) 1975-02-11
IL45194A (en) 1977-10-31
FR2240010B1 (es) 1978-03-24
OA04761A (fr) 1980-08-31

Similar Documents

Publication Publication Date Title
AR201880A1 (es) Procedimiento para la preparacion de nuevos derivados de 2-benzamido-5-nitrotiazol
AR207133A1 (es) Procedimiento para la elaboracion de derivados de 1-piridiloxi 1-pirimidiniloxi y 1-piraziniloxi-2-hidroxi-3-amino-propano
MX152550A (es) Procedimiento para la preparacion de derivados de fenilnonatetraenos substituidos
AR202617A1 (es) Procedimiento para la preparacion de metitioetilclanoguanidinas heterociclicas
MX4592E (es) Procedimiento para la preparacion de 1-ariloxi-2-hidroxi-3-alquinilaminopropanos
AR210725A1 (es) Procedimiento para la preparacion de derivados de dibenzoxepina
MX3765E (es) Procedimiento para la preparacion de derivados de piperidina
MX5768E (es) Procedimiento para la preparacion de derivados del alpha-etil-benzhidrol
AR203188A1 (es) Procedimiento para la preparacion de derivados de tienotriazolodiacepina
AR203653A1 (es) Procedimiento para la obtencion de derivados de 3,4-dihidro-2h-naftalinona-(1)-5-oxi-propil-piperazina
AR207022A1 (es) Procedimiento para la preparacion de poli-n-dimetiliminoalano
AR207744A1 (es) Procedimiento para la preparacion de nuevos derivados de isotiocianopiridinas
AR206632A1 (es) Procedimiento para la preparacion de d-homoesteroides
AR208187A1 (es) Metodo para la preparacion derivados de n-carbamoil-2-feniletensulfonamida
AR203196A1 (es) Procedimiento para la preparacion de derivados de imidazol-5-carboxamidoxima
AR200441A1 (es) Procedimiento para la obtencion de nuevos derivados de alfa-l-arabinosido de digitoxigenina
AR210133A1 (es) Procedimiento para preparar nuevos derivados de 3-amino-5-metil-pirrol
AR207450A1 (es) Procedimiento para la produccion de derivados de 4-fenilsulfonil-metil-prehidroindan-5-onas
AR205800A1 (es) Procedimiento para la preparacion de nuevos derivados de 3,4-difenil-imidazolina
AR207633Q (es) Procedimiento para la elaboracion de nuevos derivados de 2-benzoil-3-amino-6-cloro-piridinas
AR206653A1 (es) Procedimiento para preparar nuevos derivados de n-aminoalquil-2-amino-indano
AR209616A1 (es) Procedimiento para la preparacion de derivados de 17alpha-aciloxi-d-homo-pregn-4-eno-3,20-diona
AR211695A1 (es) Procedimiento para la preparacion de derivados de aminoscilanilidas primarias
AR202848A1 (es) Procedimiento para la preparacion de derivados de triazolobenzodiacepinas
AR201032A1 (es) Un procedimiento para la preparacion de derivados de 5-feniltienodiazepinona