AR201880A1 - Procedimiento para la preparacion de nuevos derivados de 2-benzamido-5-nitrotiazol - Google Patents

Procedimiento para la preparacion de nuevos derivados de 2-benzamido-5-nitrotiazol

Info

Publication number
AR201880A1
AR201880A1 AR255045A AR25504574A AR201880A1 AR 201880 A1 AR201880 A1 AR 201880A1 AR 255045 A AR255045 A AR 255045A AR 25504574 A AR25504574 A AR 25504574A AR 201880 A1 AR201880 A1 AR 201880A1
Authority
AR
Argentina
Prior art keywords
nitrotiazol
benzamido
procedure
preparation
new derivatives
Prior art date
Application number
AR255045A
Other languages
English (en)
Original Assignee
Sprl
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sprl filed Critical Sprl
Application granted granted Critical
Publication of AR201880A1 publication Critical patent/AR201880A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/44—Acylated amino or imino radicals
    • C07D277/46—Acylated amino or imino radicals by carboxylic acids, or sulfur or nitrogen analogues thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/58—Nitro radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
AR255045A 1973-08-08 1974-08-05 Procedimiento para la preparacion de nuevos derivados de 2-benzamido-5-nitrotiazol AR201880A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB3760873A GB1437800A (en) 1973-08-08 1973-08-08 Derivatives of 2-benzamido-5-nitro-thiazoles

Publications (1)

Publication Number Publication Date
AR201880A1 true AR201880A1 (es) 1975-04-24

Family

ID=10397712

Family Applications (1)

Application Number Title Priority Date Filing Date
AR255045A AR201880A1 (es) 1973-08-08 1974-08-05 Procedimiento para la preparacion de nuevos derivados de 2-benzamido-5-nitrotiazol

Country Status (14)

Country Link
US (1) US3950351A (es)
JP (1) JPS5041858A (es)
AR (1) AR201880A1 (es)
BE (1) BE817878A (es)
CA (1) CA1041519A (es)
CH (1) CH583215A5 (es)
DE (1) DE2438037C2 (es)
ES (1) ES428906A1 (es)
FR (1) FR2240010B1 (es)
GB (1) GB1437800A (es)
IL (1) IL45194A (es)
NL (1) NL176779C (es)
OA (1) OA04761A (es)
ZA (1) ZA744409B (es)

Families Citing this family (74)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2435905A1 (fr) * 1978-09-13 1980-04-11 Anvar Nouveaux agents molluscicides derives du benzamido-2 nitro-5 thiazole
US4315018A (en) * 1978-12-07 1982-02-09 Rossignol Jean F Specific parasiticidal use of 2-benzamido-5-nitro-thiazole derivatives
AU540080B2 (en) * 1979-12-21 1984-11-01 Wellcome Foundation Limited, The (2-benzoylimino-5 nitro -4-thiazolin-3-yl) acetamides
US5578621A (en) * 1994-09-08 1996-11-26 Romark Lab Lc Benzamide derivatives
ES2161201T3 (es) * 1994-04-13 2002-12-01 Romark Lab Lc Derivados de benzamida, composiciones que contienen dichos derivados ysu empleo.
US5387598A (en) * 1994-04-13 1995-02-07 Rossignol; Jean-Francois Composition and galenic formulation suitable for combatting affections of the lower abdomen
US5968961A (en) * 1997-05-07 1999-10-19 Romark Laboratories, L.C. Pharmaceutical compositions of tizoxanide and nitazoxanide
MX9604483A (es) * 1994-09-08 1998-02-28 Jean-Francois Rossignol Derivados de benzamida, composiciones que contienen dicho derivado y uso de las mismas.
US5859038A (en) * 1994-09-08 1999-01-12 Romark Laboratories, L.C. Method for treatment of helicobacter pylori infections
KR100426657B1 (ko) * 1997-05-07 2004-04-13 로마크 레버러토리즈, 엘.씨. 티족사나이드 및 니타족사나이드의 약제학적 조성물
AU756451B2 (en) * 1997-05-07 2003-01-16 Romark Laboratories, L.C. Pharmaceutical compositions of tizoxanide and nitazoxanide
US5935591A (en) * 1998-01-15 1999-08-10 Romark Laboratories, L.C. Method for treatment of equine protozoal myeloencephalitis with thiazolides
US5925622A (en) * 1998-07-13 1999-07-20 Romark Laboratories, L.C. Synthesis of aryl glucuronide of 2-hydroxy-N- (5-nitro-2-thiazolyl) benzamide, and pharmaceutical compositions comprising same
SE0102764D0 (sv) * 2001-08-17 2001-08-17 Astrazeneca Ab Compounds
US7125568B2 (en) 2001-08-23 2006-10-24 Sung Michael T Lipophilic drug compositions
GB0226930D0 (en) 2002-11-19 2002-12-24 Astrazeneca Ab Chemical compounds
GB0325402D0 (en) * 2003-10-31 2003-12-03 Astrazeneca Ab Compounds
GB0327761D0 (en) * 2003-11-29 2003-12-31 Astrazeneca Ab Compounds
GB0328178D0 (en) * 2003-12-05 2004-01-07 Astrazeneca Ab Compounds
ATE426597T1 (de) * 2004-02-18 2009-04-15 Astrazeneca Ab Benzamidderivate und deren verwendung als glucokinaseaktivierende mittel
BRPI0507734A (pt) * 2004-02-18 2007-07-10 Astrazeneca Ab composto ou um sal, pró-droga ou solvato do mesmo, método de tratar doenças mediadas por glk, e, processo para a preparação de um composto
TW200600086A (en) * 2004-06-05 2006-01-01 Astrazeneca Ab Chemical compound
UA90864C2 (en) * 2004-09-09 2010-06-10 Ромарк Лебораториз, Л.К. Halogenated benzamide derivatives
US20060194853A1 (en) * 2004-10-08 2006-08-31 Rossignol Jean F Alkyl benzamides
KR20070085371A (ko) 2004-10-16 2007-08-27 아스트라제네카 아베 페녹시 벤즈아미드 화합물의 제조 방법
GB0423044D0 (en) * 2004-10-16 2004-11-17 Astrazeneca Ab Compounds
GB0423043D0 (en) * 2004-10-16 2004-11-17 Astrazeneca Ab Compounds
EP1871365A2 (en) * 2005-04-12 2008-01-02 Romark Laboratories, L.C. Methods for treating diseases through inhibition the function of molecular chaperones such as protein disulfide isomerases , pharmaceutical compositions comprising them, and screening methods for identifying therapeutic agents
EP1891069A1 (en) * 2005-05-24 2008-02-27 AstraZeneca AB 2-phenyl substituted imidazol [4,5b]pyridine/ pyrazine and purine derivatives as glucokinase modulators
TW200714597A (en) * 2005-05-27 2007-04-16 Astrazeneca Ab Chemical compounds
JP2009500442A (ja) * 2005-07-09 2009-01-08 アストラゼネカ アクチボラグ ２型糖尿病を処置するためのグルコキナーゼのモジュレーターとしての２−ヘテロシクリルオキシベンゾイルアミノヘテロシクリル化合物
EP2027113A1 (en) * 2005-07-09 2009-02-25 AstraZeneca AB Heteroaryl benzamide derivatives for use as glk activators in the treatment of diabetes
US7642259B2 (en) * 2005-07-09 2010-01-05 Astrazeneca Ab Heteroaryl benzamide derivatives for use as GLK activators in the treatment of diabetes
US9202182B2 (en) * 2005-08-11 2015-12-01 International Business Machines Corporation Method and system for analyzing business architecture
TW200738621A (en) * 2005-11-28 2007-10-16 Astrazeneca Ab Chemical process
AP2907A (en) * 2006-01-09 2014-05-31 Romark Lab Lc Viral hepatitis treatment
US7678791B2 (en) * 2006-07-12 2010-03-16 Cumbre Ip Ventures, L.P. Nitroheteroaryl-containing rifamycin derivatives
CN100465169C (zh) * 2006-08-02 2009-03-04 杭州欣阳三友精细化工有限公司 硝唑尼特的制备方法
TW200825063A (en) * 2006-10-23 2008-06-16 Astrazeneca Ab Chemical compounds
SA07280576B1 (ar) * 2006-10-26 2011-06-22 استرازينيكا ايه بي مركبات بنزويل أمينو سيكليل غير متجانسة بأعتبارها عوامل منشطة للجلوكوكيناز
TW200833339A (en) * 2006-12-21 2008-08-16 Astrazeneca Ab Novel crystalline compound
CN101007792B (zh) * 2007-01-31 2010-05-26 浙江大学 一种合成硝基噻唑苯酰胺化合物的方法
ES2550755T3 (es) * 2007-08-03 2015-11-12 Romark Laboratories, L.C. Compuestos de tiazolida sustituidos con alquilsulfonilo
MX2011001333A (es) * 2008-08-04 2011-03-15 Astrazeneca Ab Derivados de pirazolo [3, 4] pirimidin-4-ilo y sus usos para tratar la diabetes y obesidad.
WO2010077613A1 (en) 2008-12-09 2010-07-08 Gilead Sciences, Inc. Modulators of toll-like receptors
GB0902434D0 (en) * 2009-02-13 2009-04-01 Astrazeneca Ab Chemical process
EP2395840B1 (en) 2009-02-13 2020-04-15 Romark Laboratories, L.C. Controlled release pharmaceutical formulations of nitazoxanide
GB0902406D0 (en) * 2009-02-13 2009-04-01 Astrazeneca Ab Crystalline polymorphic form
AR076221A1 (es) * 2009-04-09 2011-05-26 Astrazeneca Ab Derivado de pirazol [4,5-e] pirimidina y su uso para tratar diabetes y obesidad
WO2010116177A1 (en) 2009-04-09 2010-10-14 Astrazeneca Ab A pyrazolo [4,5-e] pyrimidine derivative and its use to treat diabetes and obesity
CN105853415A (zh) 2009-05-12 2016-08-17 罗马克实验室有限公司 卤代烷基杂芳基苯甲酰胺化合物
MX391013B (es) 2009-06-26 2025-03-21 Romark Laboratories Lc Compuestos y metodos para tratar influenza.
CN101602744B (zh) * 2009-06-30 2011-06-01 青岛康地恩药业有限公司 一种硝唑尼特的制备方法
WO2013110975A1 (es) 2012-01-27 2013-08-01 Siegfried Rhein S.A. De C.V. Composición de nitazoxanida mejorada y proceso para prepararla
MX340272B (es) 2012-09-27 2016-06-30 Rhein Siegfried Sa De Cv Composicion sinergica de nitazoxanida y mebendazol, procesos para prepararla y el uso de dicha composicion para el tratamiento de la parasitosis humana.
WO2014205414A1 (en) * 2013-06-21 2014-12-24 The Regents Of The University Of California Expanded therapeutic potential in nitroheteroaryl antimicrobials
EP4140485A1 (en) 2014-07-11 2023-03-01 Gilead Sciences, Inc. Modulators of toll-like receptors for the treatment of hiv
EA201790369A1 (ru) 2014-09-16 2017-10-31 Джилид Сайэнс, Инк. Твердые формы модулятора толл-подобного рецептора
EP3217795A4 (en) 2014-11-11 2018-08-22 Romark Laboratories, L.C. Compositions and methods of treatment with prodrugs of tizoxanide, an analogue or salt thereof
CN105175352A (zh) * 2015-10-27 2015-12-23 杭州澳医保灵药业有限公司 一种硝唑尼特的制备方法
CN106831640A (zh) * 2015-12-03 2017-06-13 江苏正大丰海制药有限公司 一种硝唑尼特晶体的制备方法
MX381896B (es) 2016-03-31 2025-03-13 Romark Laboratories Lc Compuestos de tiazolida para el tratamiento de infecciones virales.
SG10202004425XA (en) 2016-04-11 2020-06-29 Genfit Methods of treatment for cholestatic and fibrotic diseases
SG11201906041QA (en) 2017-01-27 2019-08-27 Genfit Pharmaceutical compositions for combination therapy
WO2018195035A1 (en) 2017-04-18 2018-10-25 Romark Laboratories L.C. Inhibition of protein disulfide-isomerase a3
WO2019241376A1 (en) 2018-06-14 2019-12-19 The Trustees Of Columbia University In The City Of New York Treatment of cognitive disorders using nitazoxanide (ntz), nitazoxanide (ntz) analogs, and metabolites thereof
BR112021020496A2 (pt) 2019-04-12 2021-12-07 Genfit Nitazoxanida e tiazolidas para uso no tratamento de doenças associadas ao estresse oxidativo
WO2021083912A1 (en) 2019-10-28 2021-05-06 Genfit Combination therapy having antioxydant properties
JP2023537237A (ja) 2020-07-20 2023-08-31 ロマーク ラボラトリーズ，リミティド カンパニー チゾキサニドおよび２－ヒドロキシ－ｎ－（５－クロロ－１，３－チアゾル－２－イル）ベンズアミド（ｒｍ－４８４８）とエタノールアミン、モルホリン、プロパノールアミン、ピペラジン、およびｎ－メチルピペラジンの結晶塩
WO2022046622A1 (en) 2020-08-24 2022-03-03 Romark Laboratories L.C. Use of thiazolides against coronaviruses
CN114044761B (zh) * 2021-02-24 2022-05-17 成都贝诺科成生物科技有限公司 一种新的硝基噻唑衍生物及其应用
WO2022218239A1 (zh) * 2021-04-12 2022-10-20 杜心赟 新型噻唑类化合物及其制备方法和用途
WO2023058046A1 (en) 2021-10-05 2023-04-13 Council Of Scientific And Industrial Research An Indian Registered Body Incorporated Under The Regn. Of Soc. Act (Act Xxi Of 1860) An improved process for the preparation of nitazoxanide and intermediates thereof
CN116898846B (zh) * 2022-04-12 2025-10-24 成都贝诺科成生物科技有限公司 一种硝基噻唑衍生物在制备抑制幽门螺杆菌的抑菌剂中的用途

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA497537A (en) * 1953-11-10 H. Clark Joe 2-substituted amino-5-nitrothiazoles
US2735798A (en) * 1956-02-21 Acyl amevo-nitrothiazole compositions
US2829084A (en) * 1958-04-01 Certain alkyl-n
US2401522A (en) * 1942-04-17 1946-06-04 Firm Sandoz Ltd Aromatic carboxylic acid amides and a process for their manufacture
GB577418A (en) * 1942-04-17 1946-05-17 Sandoz Ltd Process for the preparation of amides of aromatic carboxylic acids
FR1306603A (fr) * 1958-08-14 1962-10-19 Innothera Lab Sa Dérivés thiazoliques et leur procédé de préparation
US3475446A (en) * 1967-06-27 1969-10-28 Parke Davis & Co N-(5-nitro-2-thiazolyl)-cycloalkanecarboxamides

Also Published As

Publication number Publication date
CA1041519A (en) 1978-10-31
CH583215A5 (es) 1976-12-31
AU7135574A (en) 1976-01-22
OA04761A (fr) 1980-08-31
BE817878A (fr) 1975-01-20
FR2240010B1 (es) 1978-03-24
ZA744409B (en) 1975-07-30
FR2240010A1 (es) 1975-03-07
IL45194A0 (en) 1974-10-22
NL176779B (nl) 1985-01-02
JPS5041858A (es) 1975-04-16
US3950351A (en) 1976-04-13
DE2438037C2 (de) 1982-06-09
ES428906A1 (es) 1976-08-16
IL45194A (en) 1977-10-31
DE2438037A1 (de) 1975-02-20
NL176779C (nl) 1985-06-03
GB1437800A (en) 1976-06-03
NL7409321A (nl) 1975-02-11

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