FR2240010B1 - - Google Patents

Info

Publication number
FR2240010B1
FR2240010B1 FR7427525A FR7427525A FR2240010B1 FR 2240010 B1 FR2240010 B1 FR 2240010B1 FR 7427525 A FR7427525 A FR 7427525A FR 7427525 A FR7427525 A FR 7427525A FR 2240010 B1 FR2240010 B1 FR 2240010B1
Authority
FR
France
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
FR7427525A
Other versions
FR2240010A1 (fr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Phavic Sprl
Original Assignee
Phavic Sprl
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Phavic Sprl filed Critical Phavic Sprl
Publication of FR2240010A1 publication Critical patent/FR2240010A1/fr
Application granted granted Critical
Publication of FR2240010B1 publication Critical patent/FR2240010B1/fr
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/44—Acylated amino or imino radicals
    • C07D277/46—Acylated amino or imino radicals by carboxylic acids, or sulfur or nitrogen analogues thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/58—Nitro radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
FR7427525A 1973-08-08 1974-08-08 Expired FR2240010B1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB3760873A GB1437800A (en) 1973-08-08 1973-08-08 Derivatives of 2-benzamido-5-nitro-thiazoles

Publications (2)

Publication Number Publication Date
FR2240010A1 FR2240010A1 (fr) 1975-03-07
FR2240010B1 true FR2240010B1 (fr) 1978-03-24

Family

ID=10397712

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7427525A Expired FR2240010B1 (fr) 1973-08-08 1974-08-08

Country Status (14)

Country Link
US (1) US3950351A (fr)
JP (1) JPS5041858A (fr)
AR (1) AR201880A1 (fr)
BE (1) BE817878A (fr)
CA (1) CA1041519A (fr)
CH (1) CH583215A5 (fr)
DE (1) DE2438037C2 (fr)
ES (1) ES428906A1 (fr)
FR (1) FR2240010B1 (fr)
GB (1) GB1437800A (fr)
IL (1) IL45194A (fr)
NL (1) NL176779C (fr)
OA (1) OA04761A (fr)
ZA (1) ZA744409B (fr)

Families Citing this family (73)

* Cited by examiner, † Cited by third party
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FR2435905A1 (fr) * 1978-09-13 1980-04-11 Anvar Nouveaux agents molluscicides derives du benzamido-2 nitro-5 thiazole
US4315018A (en) * 1978-12-07 1982-02-09 Rossignol Jean F Specific parasiticidal use of 2-benzamido-5-nitro-thiazole derivatives
HU180396B (en) * 1979-12-21 1983-02-28 Wellcome Found Process for producing nitro-thiazoline derivatives
RU2140915C1 (ru) * 1994-04-13 1999-11-10 Россиньоль Жан-Франсуа Производные бензамида, фармацевтическая композиция, галеновый препарат для перорального введения, мазь для лечения заболеваний нижнего отдела брюшной полости, смесь соединений, пищевая композиция
US5387598A (en) * 1994-04-13 1995-02-07 Rossignol; Jean-Francois Composition and galenic formulation suitable for combatting affections of the lower abdomen
US5578621A (en) * 1994-09-08 1996-11-26 Romark Lab Lc Benzamide derivatives
MX9604483A (es) * 1994-09-08 1998-02-28 Jean-Francois Rossignol Derivados de benzamida, composiciones que contienen dicho derivado y uso de las mismas.
US5859038A (en) * 1994-09-08 1999-01-12 Romark Laboratories, L.C. Method for treatment of helicobacter pylori infections
US5968961A (en) * 1997-05-07 1999-10-19 Romark Laboratories, L.C. Pharmaceutical compositions of tizoxanide and nitazoxanide
AU756451B2 (en) * 1997-05-07 2003-01-16 Romark Laboratories, L.C. Pharmaceutical compositions of tizoxanide and nitazoxanide
PL193275B1 (pl) * 1997-05-07 2007-01-31 Romark Lab Środek farmaceutyczny oraz zastosowanie deacetylo-nitazoksanidu i/lub nitazoksanidu
US5935591A (en) * 1998-01-15 1999-08-10 Romark Laboratories, L.C. Method for treatment of equine protozoal myeloencephalitis with thiazolides
US5925622A (en) * 1998-07-13 1999-07-20 Romark Laboratories, L.C. Synthesis of aryl glucuronide of 2-hydroxy-N- (5-nitro-2-thiazolyl) benzamide, and pharmaceutical compositions comprising same
SE0102764D0 (sv) * 2001-08-17 2001-08-17 Astrazeneca Ab Compounds
US7125568B2 (en) * 2001-08-23 2006-10-24 Sung Michael T Lipophilic drug compositions
GB0226930D0 (en) 2002-11-19 2002-12-24 Astrazeneca Ab Chemical compounds
GB0325402D0 (en) * 2003-10-31 2003-12-03 Astrazeneca Ab Compounds
GB0327761D0 (en) * 2003-11-29 2003-12-31 Astrazeneca Ab Compounds
GB0328178D0 (en) * 2003-12-05 2004-01-07 Astrazeneca Ab Compounds
WO2005080359A1 (fr) * 2004-02-18 2005-09-01 Astrazeneca Ab Dérivés de benzamide et leur utilisation en tant qu'activateurs de la glucokinase
BRPI0507734A (pt) * 2004-02-18 2007-07-10 Astrazeneca Ab composto ou um sal, pró-droga ou solvato do mesmo, método de tratar doenças mediadas por glk, e, processo para a preparação de um composto
TW200600086A (en) * 2004-06-05 2006-01-01 Astrazeneca Ab Chemical compound
UA90864C2 (en) * 2004-09-09 2010-06-10 Ромарк Лебораториз, Л.К. Halogenated benzamide derivatives
US20060194853A1 (en) * 2004-10-08 2006-08-31 Rossignol Jean F Alkyl benzamides
WO2006040527A1 (fr) 2004-10-16 2006-04-20 Astrazeneca Ab Procede de fabrication de composes de phenoxy benzamide
GB0423044D0 (en) * 2004-10-16 2004-11-17 Astrazeneca Ab Compounds
GB0423043D0 (en) * 2004-10-16 2004-11-17 Astrazeneca Ab Compounds
AU2006235490A1 (en) * 2005-04-12 2006-10-19 Romark Laboratories, L.C. Methods for treating diseases through the function of molecular chaperones such as protein disulfide isomerases, pharmaceutical compositions comprising them, and screening methods for identifying therapeutic agents
US20110059941A1 (en) * 2005-05-24 2011-03-10 Peter William Rodney Caulkett 2-phenyl substituted imidazol [4,5b] pyridine/pyrazine and purine derivatives as glucokinase modulators
TW200714597A (en) * 2005-05-27 2007-04-16 Astrazeneca Ab Chemical compounds
NZ575514A (en) * 2005-07-09 2009-11-27 Astrazeneca Ab Heteroaryl benzamide derivatives for use as GLK activators in the treatment of diabetes
US20080234273A1 (en) * 2005-07-09 2008-09-25 Mckerrecher Darren Heteroaryl Benzamide Derivatives for Use as Glk Activators in the Treatment of Diabetes
EP1910350A1 (fr) * 2005-07-09 2008-04-16 AstraZeneca AB Composés 2-hétérocyclyloxybenzoyl amino hétérocyclyle en tant que modulateurs de glucokinase pour le traitement du diabète de type 2
US9202182B2 (en) * 2005-08-11 2015-12-01 International Business Machines Corporation Method and system for analyzing business architecture
TW200738621A (en) * 2005-11-28 2007-10-16 Astrazeneca Ab Chemical process
BRPI0706379A2 (pt) 2006-01-09 2011-03-22 Romark Lab Lc tratamento de hepatite viral
US7678791B2 (en) * 2006-07-12 2010-03-16 Cumbre Ip Ventures, L.P. Nitroheteroaryl-containing rifamycin derivatives
CN100465169C (zh) * 2006-08-02 2009-03-04 杭州欣阳三友精细化工有限公司 硝唑尼特的制备方法
TW200825063A (en) * 2006-10-23 2008-06-16 Astrazeneca Ab Chemical compounds
CL2007003061A1 (es) * 2006-10-26 2008-08-01 Astrazeneca Ab Compuestos derivados de 3,5-dioxi-benzamida; proceso de preparacion; composicion farmaceutica que comprende a dichos compuestos; y su uso para tratar una enfermedad mediada a traves de glk, tal como la diabetes tipo 2.
TW200833339A (en) * 2006-12-21 2008-08-16 Astrazeneca Ab Novel crystalline compound
CN101007792B (zh) * 2007-01-31 2010-05-26 浙江大学 一种合成硝基噻唑苯酰胺化合物的方法
CN101835765B (zh) * 2007-08-03 2013-05-29 罗马克实验室有限公司 烷基磺酰基取代的噻唑化物类化合物
WO2010015849A2 (fr) * 2008-08-04 2010-02-11 Astrazeneca Ab Agents thérapeutiques 414
TW201639852A (zh) 2008-12-09 2016-11-16 吉李德科學股份有限公司 用於製備可用作類鐸受體調節劑之化合物的中間體化合物
AU2010213678B2 (en) 2009-02-13 2015-11-26 Romark Laboratories L.C. Controlled release pharmaceutical formulations of nitazoxanide
GB0902434D0 (en) * 2009-02-13 2009-04-01 Astrazeneca Ab Chemical process
GB0902406D0 (en) * 2009-02-13 2009-04-01 Astrazeneca Ab Crystalline polymorphic form
AR076220A1 (es) 2009-04-09 2011-05-26 Astrazeneca Ab Derivados de pirazol [4,5 - e] pirimidina
AR076221A1 (es) * 2009-04-09 2011-05-26 Astrazeneca Ab Derivado de pirazol [4,5-e] pirimidina y su uso para tratar diabetes y obesidad
NZ596538A (en) * 2009-05-12 2014-04-30 Romark Lab Lc Haloalkyl heteroaryl benzamide compounds
CN108042535A (zh) * 2009-06-26 2018-05-18 罗马克实验室有限公司 用于治疗流感的化合物和方法
CN101602744B (zh) * 2009-06-30 2011-06-01 青岛康地恩药业有限公司 一种硝唑尼特的制备方法
US9498441B2 (en) 2012-01-27 2016-11-22 Siegfried Rhein S.A. De C.V. Nitazoxadine composition and process to prepare same
WO2014049397A1 (fr) 2012-09-27 2014-04-03 Siegfried Rhein S.A. De C.V. Composition synergique de nitazoxanide et de mébendazole, procédés de préparation correspondants et utilisation de cette composition dans le traitement de la parasitose humaine
US20160244435A1 (en) * 2013-06-21 2016-08-25 The Scripps Research Institute Expanded therapeutic potential in nitroheteroaryl antimicrobials
MX2017000026A (es) 2014-07-11 2017-05-01 Gilead Sciences Inc Moduladores de receptores tipo toll para el tratamiento de virus de inmunodeficiencia humana (vih).
SI3194401T1 (sl) 2014-09-16 2020-12-31 Gilead Sciences, Inc. Trdne oblike modulatorja toličnega receptorja
CN107105660A (zh) 2014-11-11 2017-08-29 罗马克实验室有限公司 使用替唑尼特、其类似物或盐的前药的治疗组合物和治疗方法
CN105175352A (zh) * 2015-10-27 2015-12-23 杭州澳医保灵药业有限公司 一种硝唑尼特的制备方法
CN106831640A (zh) * 2015-12-03 2017-06-13 江苏正大丰海制药有限公司 一种硝唑尼特晶体的制备方法
DK3436074T3 (da) 2016-03-31 2020-08-03 Romark Laboratories Lc Thiazolidforbindelser til behandling af virale infektioner
EP3442580B1 (fr) 2016-04-11 2020-09-23 Genfit Procédés de traitement de la fibrose
SG11201906041QA (en) 2017-01-27 2019-08-27 Genfit Pharmaceutical compositions for combination therapy
US11173149B2 (en) 2017-04-18 2021-11-16 Romark Laboratories L.C. Inhibition of protein disulfide-isomerase A3
JP2022528727A (ja) 2019-04-12 2022-06-15 ジェンフィット 酸化ストレスに関連する疾患の治療に使用するためのニタゾキサニド及びチアゾリド
CA3153784A1 (fr) 2019-10-28 2021-05-06 Nicolas STANKOVIC-VALENTIN Polytherapie d'elafibranor et de nitazoxanide comportant des caracteristiques antioxydantes
WO2022020243A1 (fr) 2020-07-20 2022-01-27 Romark Laboratories L.C. Sels cristallins de tizoxanide et de 2-hydroxy-n-(5-chloro-1,3-thiazol-2-yl)benzamide (rm-4848) avec de l'éthanolamine, de la morpholine, de la propanolamine, de la pipérazine et de la n-méthylpipérazine
JP2023538136A (ja) 2020-08-24 2023-09-06 ロマーク ラボラトリーズ，リミティド カンパニー コロナウイルスに対するチアゾリドの利用
CN114044761B (zh) * 2021-02-24 2022-05-17 成都贝诺科成生物科技有限公司 一种新的硝基噻唑衍生物及其应用
WO2022218239A1 (fr) * 2021-04-12 2022-10-20 杜心赟 Nouveau composé de thiazole, son procédé de préparation et son utilisation
CA3233848A1 (fr) 2021-10-05 2023-04-13 Sasidhar Balappa SOMAPPA Procede ameliore pour preparer du nitazoxanide et de ses intermediaires
CN116898846A (zh) * 2022-04-12 2023-10-20 成都贝诺科成生物科技有限公司 一种硝基噻唑衍生物在制备抑制幽门螺杆菌的抑菌剂中的用途

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2735798A (en) * 1956-02-21 Acyl amevo-nitrothiazole compositions
US2829084A (en) * 1958-04-01 Certain alkyl-n
CA497537A (fr) * 1953-11-10 H. Clark Joe Amino-5-nitrothiazoles 2-substitues
GB577418A (en) * 1942-04-17 1946-05-17 Sandoz Ltd Process for the preparation of amides of aromatic carboxylic acids
US2401522A (en) * 1942-04-17 1946-06-04 Firm Sandoz Ltd Aromatic carboxylic acid amides and a process for their manufacture
FR1306603A (fr) * 1958-08-14 1962-10-19 Innothera Lab Sa Dérivés thiazoliques et leur procédé de préparation
US3475446A (en) * 1967-06-27 1969-10-28 Parke Davis & Co N-(5-nitro-2-thiazolyl)-cycloalkanecarboxamides

Also Published As

Publication number Publication date
JPS5041858A (fr) 1975-04-16
ES428906A1 (es) 1976-08-16
ZA744409B (en) 1975-07-30
CH583215A5 (fr) 1976-12-31
NL176779C (nl) 1985-06-03
IL45194A0 (en) 1974-10-22
GB1437800A (en) 1976-06-03
US3950351A (en) 1976-04-13
CA1041519A (fr) 1978-10-31
FR2240010A1 (fr) 1975-03-07
DE2438037C2 (de) 1982-06-09
AR201880A1 (es) 1975-04-24
OA04761A (fr) 1980-08-31
DE2438037A1 (de) 1975-02-20
NL7409321A (nl) 1975-02-11
IL45194A (en) 1977-10-31
AU7135574A (en) 1976-01-22
NL176779B (nl) 1985-01-02
BE817878A (fr) 1975-01-20

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Legal Events

Date Code Title Description
TP Transmission of property
TP Transmission of property
TP Transmission of property
CL Concession to grant licences
ST Notification of lapse