NL195028C - Cyclosporinebevattend farmaceutisch preparaat. - Google Patents
Cyclosporinebevattend farmaceutisch preparaat. Download PDFInfo
- Publication number
- NL195028C NL195028C NL9000299A NL9000299A NL195028C NL 195028 C NL195028 C NL 195028C NL 9000299 A NL9000299 A NL 9000299A NL 9000299 A NL9000299 A NL 9000299A NL 195028 C NL195028 C NL 195028C
- Authority
- NL
- Netherlands
- Prior art keywords
- administration
- cyclosporin
- preparation
- ciclosporin
- blood
- Prior art date
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Landscapes
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- Inorganic Chemistry (AREA)
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- Neurology (AREA)
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- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
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Applications Claiming Priority (8)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB898902901A GB8902901D0 (en) | 1989-02-09 | 1989-02-09 | Improvements in or relating to organic compounds |
| GB8902901 | 1989-02-09 | ||
| GB8902898 | 1989-02-09 | ||
| GB898902898A GB8902898D0 (en) | 1989-02-09 | 1989-02-09 | Improvements in or relating to organic compounds |
| GB8903147 | 1989-02-13 | ||
| GB898903147A GB8903147D0 (en) | 1989-02-13 | 1989-02-13 | Improvements in or relating to organic compounds |
| GB8903663 | 1989-02-17 | ||
| GB898903663A GB8903663D0 (en) | 1989-02-17 | 1989-02-17 | Improvements in or relating to organic compounds |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NL9000299A NL9000299A (nl) | 1990-09-03 |
| NL195028B NL195028B (nl) | 2003-08-01 |
| NL195028C true NL195028C (nl) | 2003-12-02 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NL9000299A NL195028C (nl) | 1989-02-09 | 1990-02-08 | Cyclosporinebevattend farmaceutisch preparaat. |
Country Status (25)
Families Citing this family (34)
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| KR0148748B1 (ko) * | 1988-09-16 | 1998-08-17 | 장 크라메르, 한스 루돌프 하우스 | 사이클로스포린을 함유하는 약학조성물 |
| HU208491B (en) * | 1990-11-27 | 1993-11-29 | Gyogyszerkutato Intezet | Process for producing oral pharmaceutical composition containing cyclosporin |
| MX9201782A (es) † | 1991-04-19 | 1992-10-01 | Sandoz Ag | Particulas de sustancias biologicamente activas, sustancialmente insolubles en agua, proceso para su produccion y composicion farmaceutica que las contiene. |
| GB9113872D0 (en) * | 1991-06-27 | 1991-08-14 | Sandoz Ag | Improvements in or relating to organic compounds |
| US6262022B1 (en) | 1992-06-25 | 2001-07-17 | Novartis Ag | Pharmaceutical compositions containing cyclosporin as the active agent |
| JP3631490B2 (ja) | 1992-05-13 | 2005-03-23 | ノバルティス ファーマ株式会社 | シクロスポリン含有眼科用組成物 |
| US5759566A (en) * | 1992-07-28 | 1998-06-02 | Poli Industria Chimica Spa | Microemulsion pharmaceutical compositions for the delivery of pharmaceutically active agents |
| ES2168271T3 (es) | 1992-09-25 | 2002-06-16 | Novartis Ag | Composiciones farmaceuticas que contienen ciclosporinas. |
| ATE218878T1 (de) * | 1993-04-20 | 2002-06-15 | Novartis Erfind Verwalt Gmbh | Neue pharmazeutische zubereitungen zur oralen verabreichung enthaltend cyclosporin |
| DE4412201A1 (de) * | 1993-04-20 | 1994-11-10 | Rentschler Arzneimittel | Neue pharmazeutische Zubereitungen zur oralen Verabreichung enthaltend Cyclosporin |
| DE4340781C3 (de) * | 1993-11-30 | 2000-01-27 | Novartis Ag | Cyclosporin enthaltende flüssige Zubereitungen und Verfahren zu ihrer Herstellung |
| KR0146671B1 (ko) * | 1994-02-25 | 1998-08-17 | 김충환 | 사이클로스포린-함유 분말 조성물 |
| BR9509550A (pt) | 1994-11-03 | 1997-09-16 | Dresden Arzneimittel | Formulações de ciclosporina para administração oral com composição simples e alta biodisponibilidade e processo para sua produção |
| US5679566A (en) * | 1995-01-20 | 1997-10-21 | University Of Massachusetts Medical Center | Yeast NMD2 gene |
| US5834017A (en) * | 1995-08-25 | 1998-11-10 | Sangstat Medical Corporation | Oral cyclopsporin formulations |
| US5766629A (en) | 1995-08-25 | 1998-06-16 | Sangstat Medical Corporation | Oral cyclosporin formulations |
| US5827822A (en) * | 1996-03-25 | 1998-10-27 | Sangstat Medical Corporation | Cyclosporin a formulations as nanoparticles |
| US5962019A (en) * | 1995-08-25 | 1999-10-05 | Sangstat Medical Corporation | Oral cyclosporin formulations |
| DE19544507B4 (de) | 1995-11-29 | 2007-11-15 | Novartis Ag | Cyclosporin enthaltende Präparate |
| US5798333A (en) * | 1996-09-17 | 1998-08-25 | Sherman; Bernard C. | Water-soluble concentrates containing cyclosporins |
| HUP0001013A3 (en) * | 1997-01-30 | 2004-10-28 | Novartis Ag | Oil-free pharmaceutical compositions containing cyclosporin a |
| AU762247B2 (en) * | 1997-01-30 | 2003-06-19 | Novartis Ag | Oil-free pharmaceutical compositions containing cyclosporin A |
| JP4718653B2 (ja) * | 1997-03-12 | 2011-07-06 | アボツト・ラボラトリーズ | シクロスポリンの投与のための親水性二成分系 |
| NZ328751A (en) * | 1997-09-16 | 1999-01-28 | Bernard Charles Sherman | Solid medicament containing an anionic surfactant and cyclosporin |
| US6447806B1 (en) | 1999-02-25 | 2002-09-10 | Novartis Ag | Pharmaceutical compositions comprised of stabilized peptide particles |
| NZ531946A (en) | 2001-10-19 | 2005-09-30 | Isotechnika Inc | Preconcentrate formulations comprising cyclosporin analogue microemulsions that reduce adverse effects while maintaining high bioavailability |
| US6979672B2 (en) | 2002-12-20 | 2005-12-27 | Polichem, S.A. | Cyclosporin-based pharmaceutical compositions |
| JP4521554B2 (ja) * | 2004-03-31 | 2010-08-11 | マイラン製薬株式会社 | シクロスポリン製剤 |
| CN101360485B (zh) * | 2005-10-26 | 2013-04-17 | 班纳制药公司 | 作为胶囊填充物的基于亲水性载体的双重控释基质系统 |
| US8580954B2 (en) | 2006-03-28 | 2013-11-12 | Hospira, Inc. | Formulations of low dose diclofenac and beta-cyclodextrin |
| US7495024B2 (en) | 2006-08-07 | 2009-02-24 | Via Pharmaceuticals, Inc. | Phenylalkyl N-hydroxyureas for combating atherosclerotic plaque |
| DE102008059201A1 (de) | 2008-11-27 | 2010-06-02 | GÖPFERICH, Achim, Prof. Dr. | In situ präzipitierende Arzneistofflösungen |
| KR102146704B1 (ko) | 2018-04-13 | 2020-08-21 | 가천대학교 산학협력단 | 사이클로스포린 A (CsA) 경피 및 피내 약물전달용 마이크로구조체 |
| KR20240070705A (ko) * | 2021-10-13 | 2024-05-21 | 추가이 세이야쿠 가부시키가이샤 | 펩타이드 화합물 및 계면활성제를 포함하는 조성물 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2907460A1 (de) * | 1978-03-07 | 1979-09-13 | Sandoz Ag | Neue resorbierbare galenische kompositionen |
| JPS61280435A (ja) * | 1985-04-04 | 1986-12-11 | Kanji Takada | サイクロスポリン類のリンパ指向性製剤 |
| NL8600050A (nl) * | 1986-01-13 | 1987-08-03 | Sanico Nv | Farmaceutisch preparaat met vertraagde afgifte van het werkzame bestanddeel en werkwijze voor de bereiding er van. |
| GB8602372D0 (en) * | 1986-01-31 | 1986-03-05 | Sandoz Ltd | Organic compounds |
| CA1290249C (en) * | 1986-04-09 | 1991-10-08 | Cetus Corporation | COMBINATION THERAPY USING INTERLEUKIN-2 AND/OR INTERFERON-.beta. AND TUMOR NECROSIS FACTOR |
| IE873057L (en) * | 1986-11-13 | 1988-05-13 | Tretorn Ab | Compositions and method for treatment of cancer using¹monoclonal antibody against gd3 ganglioside together eith¹il-2 |
| DE3884470T2 (de) * | 1987-06-17 | 1994-03-10 | Sandoz Ag | Cyclosporine und deren Benutzung als Arzneimittel. |
| JP2536876B2 (ja) * | 1987-07-31 | 1996-09-25 | 寛治 高田 | シクロスポリンの溶解性粉末状製剤 |
| DE3830494B4 (de) * | 1987-09-15 | 2006-05-18 | Novartis Ag | Wasserlösliche Monoester als Solubilisatoren für pharmakologische Wirkstoffe und pharmazeutische Hilfsstoffe |
| US5756450A (en) * | 1987-09-15 | 1998-05-26 | Novartis Corporation | Water soluble monoesters as solubilisers for pharmacologically active compounds and pharmaceutical excipients and novel cyclosporin galenic forms |
| HU205010B (en) * | 1987-09-15 | 1992-03-30 | Sandoz Ag | Process for producing pharmaceutical compositions comprising compounds soluble up to 1 per cent and having medical activity |
| JP2792862B2 (ja) * | 1988-07-30 | 1998-09-03 | 寛治 高田 | 経口腸溶製剤 |
| KR0148748B1 (ko) * | 1988-09-16 | 1998-08-17 | 장 크라메르, 한스 루돌프 하우스 | 사이클로스포린을 함유하는 약학조성물 |
| JPH1038029A (ja) * | 1996-07-26 | 1998-02-13 | Ebara Corp | 制振機能付き円板状構造物 |
| JPH10280435A (ja) * | 1997-04-03 | 1998-10-20 | Sekisui Chem Co Ltd | 地下室の構築方法 |
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1990
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- 1990-02-05 GB GB9002504A patent/GB2230440B/en not_active Expired - Lifetime
- 1990-02-05 FR FR9001389A patent/FR2642650B1/fr not_active Expired - Lifetime
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- 1990-02-07 NO NO900577A patent/NO301576B1/no not_active IP Right Cessation
- 1990-02-07 FI FI900604A patent/FI97524C/fi active IP Right Grant
- 1990-02-07 CA CA002009533A patent/CA2009533C/en not_active Expired - Lifetime
- 1990-02-07 DK DK199000327A patent/DK176209B1/da not_active IP Right Cessation
- 1990-02-07 LU LU87675A patent/LU87675A1/fr unknown
- 1990-02-07 HU HU90701A patent/HU213394B/hu unknown
- 1990-02-07 SE SE9000441A patent/SE511398C2/sv not_active Application Discontinuation
- 1990-02-07 MY MYPI90000191A patent/MY107377A/en unknown
- 1990-02-07 PH PH40014A patent/PH30917A/en unknown
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- 1990-02-07 PT PT93079A patent/PT93079B/pt not_active IP Right Cessation
- 1990-02-08 AT AT0027290A patent/AT404552B/de not_active IP Right Cessation
- 1990-02-08 JP JP03134890A patent/JP3484190B2/ja not_active Expired - Lifetime
- 1990-02-08 DE DE4003844A patent/DE4003844B4/de not_active Expired - Lifetime
- 1990-02-08 IT IT47609A patent/IT1240758B/it active IP Right Grant
- 1990-02-08 KR KR1019900001492A patent/KR0170769B1/ko not_active Expired - Lifetime
- 1990-02-08 NL NL9000299A patent/NL195028C/nl not_active IP Right Cessation
- 1990-02-08 AU AU49252/90A patent/AU630413B2/en not_active Expired
- 1990-02-09 ES ES9000397A patent/ES2021942A6/es not_active Expired - Lifetime
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1996
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- 1996-11-22 CY CY190396A patent/CY1903A/en unknown
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2001
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2005
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