NL194999C - Vaste, snel uiteenvallende toedieningsvorm voor Diclofenac in de vorm van bruistabletten, alsmede de met een dergelijk bruistablet verkregen suspensie. - Google Patents
Vaste, snel uiteenvallende toedieningsvorm voor Diclofenac in de vorm van bruistabletten, alsmede de met een dergelijk bruistablet verkregen suspensie. Download PDFInfo
- Publication number
- NL194999C NL194999C NL8900734A NL8900734A NL194999C NL 194999 C NL194999 C NL 194999C NL 8900734 A NL8900734 A NL 8900734A NL 8900734 A NL8900734 A NL 8900734A NL 194999 C NL194999 C NL 194999C
- Authority
- NL
- Netherlands
- Prior art keywords
- diclofenac
- effervescent
- acid ester
- solid
- effervescent tablet
- Prior art date
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- 229960001259 diclofenac Drugs 0.000 title claims description 47
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- 239000002552 dosage form Substances 0.000 title claims description 7
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- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 36
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 claims description 34
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- 235000019326 ethyl hydroxyethyl cellulose Nutrition 0.000 description 1
- 230000007717 exclusion Effects 0.000 description 1
- 239000007888 film coating Substances 0.000 description 1
- 238000009501 film coating Methods 0.000 description 1
- 230000009969 flowable effect Effects 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 235000011389 fruit/vegetable juice Nutrition 0.000 description 1
- 239000001530 fumaric acid Substances 0.000 description 1
- 235000011087 fumaric acid Nutrition 0.000 description 1
- 125000000524 functional group Chemical group 0.000 description 1
- 210000001035 gastrointestinal tract Anatomy 0.000 description 1
- 230000014509 gene expression Effects 0.000 description 1
- 238000000227 grinding Methods 0.000 description 1
- 235000010417 guar gum Nutrition 0.000 description 1
- 239000000665 guar gum Substances 0.000 description 1
- 229960002154 guar gum Drugs 0.000 description 1
- IPCSVZSSVZVIGE-UHFFFAOYSA-M hexadecanoate Chemical compound CCCCCCCCCCCCCCCC([O-])=O IPCSVZSSVZVIGE-UHFFFAOYSA-M 0.000 description 1
- 238000009775 high-speed stirring Methods 0.000 description 1
- 125000004356 hydroxy functional group Chemical group O* 0.000 description 1
- 230000000968 intestinal effect Effects 0.000 description 1
- UQSXHKLRYXJYBZ-UHFFFAOYSA-N iron oxide Inorganic materials [Fe]=O UQSXHKLRYXJYBZ-UHFFFAOYSA-N 0.000 description 1
- 235000013980 iron oxide Nutrition 0.000 description 1
- VBMVTYDPPZVILR-UHFFFAOYSA-N iron(2+);oxygen(2-) Chemical class [O-2].[Fe+2] VBMVTYDPPZVILR-UHFFFAOYSA-N 0.000 description 1
- 235000010494 karaya gum Nutrition 0.000 description 1
- 239000000231 karaya gum Substances 0.000 description 1
- 229940039371 karaya gum Drugs 0.000 description 1
- 239000004922 lacquer Substances 0.000 description 1
- 229940116108 lactase Drugs 0.000 description 1
- 150000002597 lactoses Chemical class 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 238000012153 long-term therapy Methods 0.000 description 1
- 239000000314 lubricant Substances 0.000 description 1
- ZLNQQNXFFQJAID-UHFFFAOYSA-L magnesium carbonate Chemical compound [Mg+2].[O-]C([O-])=O ZLNQQNXFFQJAID-UHFFFAOYSA-L 0.000 description 1
- 239000001095 magnesium carbonate Substances 0.000 description 1
- 229910000021 magnesium carbonate Inorganic materials 0.000 description 1
- HBNDBUATLJAUQM-UHFFFAOYSA-L magnesium;dodecyl sulfate Chemical compound [Mg+2].CCCCCCCCCCCCOS([O-])(=O)=O.CCCCCCCCCCCCOS([O-])(=O)=O HBNDBUATLJAUQM-UHFFFAOYSA-L 0.000 description 1
- 239000001630 malic acid Substances 0.000 description 1
- 235000011090 malic acid Nutrition 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 description 1
- 229920003145 methacrylic acid copolymer Polymers 0.000 description 1
- 239000000178 monomer Substances 0.000 description 1
- 210000004400 mucous membrane Anatomy 0.000 description 1
- 239000002736 nonionic surfactant Substances 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 229940124531 pharmaceutical excipient Drugs 0.000 description 1
- 239000008363 phosphate buffer Substances 0.000 description 1
- 229920000191 poly(N-vinyl pyrrolidone) Polymers 0.000 description 1
- 239000004584 polyacrylic acid Substances 0.000 description 1
- 229920000151 polyglycol Polymers 0.000 description 1
- 239000010695 polyglycol Substances 0.000 description 1
- 150000007519 polyprotic acids Polymers 0.000 description 1
- 229920000136 polysorbate Polymers 0.000 description 1
- 229940068965 polysorbates Drugs 0.000 description 1
- 229920002689 polyvinyl acetate Polymers 0.000 description 1
- 239000011118 polyvinyl acetate Substances 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- XAEFZNCEHLXOMS-UHFFFAOYSA-M potassium benzoate Chemical compound [K+].[O-]C(=O)C1=CC=CC=C1 XAEFZNCEHLXOMS-UHFFFAOYSA-M 0.000 description 1
- 229910000027 potassium carbonate Inorganic materials 0.000 description 1
- 229920001592 potato starch Polymers 0.000 description 1
- 229940116317 potato starch Drugs 0.000 description 1
- 230000002028 premature Effects 0.000 description 1
- 239000000770 propane-1,2-diol alginate Chemical group 0.000 description 1
- 235000010409 propane-1,2-diol alginate Nutrition 0.000 description 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 239000011253 protective coating Substances 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 229940100486 rice starch Drugs 0.000 description 1
- 238000007873 sieving Methods 0.000 description 1
- 150000004760 silicates Chemical class 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- 235000010413 sodium alginate Nutrition 0.000 description 1
- 239000000661 sodium alginate Substances 0.000 description 1
- 229940005550 sodium alginate Drugs 0.000 description 1
- CDBYLPFSWZWCQE-UHFFFAOYSA-L sodium carbonate Substances [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 1
- 229910000029 sodium carbonate Inorganic materials 0.000 description 1
- 229960001462 sodium cyclamate Drugs 0.000 description 1
- OTNVGWMVOULBFZ-UHFFFAOYSA-N sodium;hydrochloride Chemical compound [Na].Cl OTNVGWMVOULBFZ-UHFFFAOYSA-N 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 235000011076 sorbitan monostearate Nutrition 0.000 description 1
- 239000001587 sorbitan monostearate Substances 0.000 description 1
- 229940035048 sorbitan monostearate Drugs 0.000 description 1
- 229950003429 sorbitan palmitate Drugs 0.000 description 1
- 235000011078 sorbitan tristearate Nutrition 0.000 description 1
- 239000001589 sorbitan tristearate Substances 0.000 description 1
- 229960004129 sorbitan tristearate Drugs 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 230000000087 stabilizing effect Effects 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 229940014800 succinic anhydride Drugs 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
- 229940100445 wheat starch Drugs 0.000 description 1
- 239000000811 xylitol Substances 0.000 description 1
- 235000010447 xylitol Nutrition 0.000 description 1
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 1
- 229960002675 xylitol Drugs 0.000 description 1
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
- A61K9/0007—Effervescent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
- A61K9/2081—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets with microcapsules or coated microparticles according to A61K9/50
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH113888 | 1988-03-25 | ||
| CH1138/88A CH675537A5 (pt) | 1988-03-25 | 1988-03-25 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NL8900734A NL8900734A (nl) | 1989-10-16 |
| NL194999C true NL194999C (nl) | 2003-05-08 |
Family
ID=4203378
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NL8900734A NL194999C (nl) | 1988-03-25 | 1989-03-23 | Vaste, snel uiteenvallende toedieningsvorm voor Diclofenac in de vorm van bruistabletten, alsmede de met een dergelijk bruistablet verkregen suspensie. |
Country Status (17)
| Country | Link |
|---|---|
| JP (1) | JP2774135B2 (pt) |
| AT (1) | AT400299B (pt) |
| AU (1) | AU619261B2 (pt) |
| BE (1) | BE1001706A3 (pt) |
| CA (1) | CA1323837C (pt) |
| CH (1) | CH675537A5 (pt) |
| DE (1) | DE3909520C2 (pt) |
| DK (1) | DK175517B1 (pt) |
| ES (1) | ES2010466A6 (pt) |
| FR (1) | FR2628971B1 (pt) |
| GB (1) | GB2217598B (pt) |
| GR (1) | GR890100182A (pt) |
| IE (1) | IE61221B1 (pt) |
| IT (1) | IT1232823B (pt) |
| NL (1) | NL194999C (pt) |
| PT (1) | PT90104B (pt) |
| SE (1) | SE8901003L (pt) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE509029C2 (sv) * | 1988-08-16 | 1998-11-30 | Ss Pharmaceutical Co | Långtidsverkande diklofenak-natriumpreparat |
| GB8824392D0 (en) * | 1988-10-18 | 1988-11-23 | Ciba Geigy Ag | Dispersible formulation |
| DE4403943A1 (de) * | 1994-02-08 | 1995-08-10 | Hexal Pharma Gmbh | Orale Azrneimittelzubereitung mit Diclofenac-Natrium |
| DE19530575A1 (de) * | 1995-08-19 | 1997-02-20 | Gruenenthal Gmbh | Schnell zerfallende Arzneiform von Tramadol oder einem Tramadolsalz |
| IL128043A (en) * | 1997-05-30 | 2004-08-31 | Osmotica Corp | Multi-layered osmotic device for controlled delivery of active agents |
| IT1293764B1 (it) * | 1997-07-23 | 1999-03-10 | Chiesi Farma Spa | Composizioni farmaceutiche sotto forma di compresse effervescenti contenenti un principio attivo instabile in presenza di acqua |
| AP2002002410A0 (en) * | 1999-08-04 | 2002-03-31 | Ranbaxy Laboratories Ltd | Hydrodynamically Balancing Oral Drug Delivery System |
| WO2004089343A1 (en) * | 2003-04-09 | 2004-10-21 | Ranbaxy Laboratories Limited | Water soluble tablets |
| JP4575654B2 (ja) * | 2003-09-05 | 2010-11-04 | エスエス製薬株式会社 | 溶解性と流動性を改善した医薬組成物 |
| FR2902657B1 (fr) * | 2006-06-21 | 2009-01-16 | Virbac Sa Sa | Granules ou granules effervescents |
| WO2009106824A2 (en) * | 2008-02-25 | 2009-09-03 | Cipla Limited | Pharmaceutical formulations |
| CN104254249B (zh) | 2011-10-31 | 2017-02-15 | 诺华股份有限公司 | 帕唑帕尼制剂 |
| WO2013109224A1 (en) * | 2012-01-18 | 2013-07-25 | Mahmut Bilgic | Pharmaceutical compositions comprising diclofenac |
| US11957792B2 (en) * | 2012-04-19 | 2024-04-16 | Glatt Ag | Taste-masked pharmaceutical compositions containing diclofenac |
| DE202022100544U1 (de) | 2022-01-31 | 2022-02-16 | Ranjitsing Babasing Bayas | Neue orale Streifen- oder Dünnfilmform von Diclofenac-Natrium |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS4826204A (pt) * | 1971-08-11 | 1973-04-06 | ||
| GB1371035A (en) * | 1971-09-21 | 1974-10-23 | Rolls Royce | Method of etching aluminium alloys |
| US4265874A (en) * | 1980-04-25 | 1981-05-05 | Alza Corporation | Method of delivering drug with aid of effervescent activity generated in environment of use |
| EP0052075A1 (de) * | 1980-11-12 | 1982-05-19 | Ciba-Geigy Ag | Körnige Arzneimittel-Retardform |
| EP0052076B1 (de) * | 1980-11-12 | 1985-05-29 | Ciba-Geigy Ag | Schnellzerfallende Arzneimittel-Presslinge |
| CH655507B (pt) * | 1983-01-12 | 1986-04-30 | ||
| DE3446873A1 (de) * | 1984-12-21 | 1986-07-10 | Merckle Gmbh | Fluessige diclofenac-zubereitungen |
| CH664085A5 (de) * | 1985-02-08 | 1988-02-15 | Ciba Geigy Ag | Pharmazeutische praeparate mit analgetischer wirksamkeit, sowie deren herstellung. |
| IE59106B1 (en) * | 1985-05-31 | 1994-01-12 | Warner Lambert Co | A therapeutic effervescent composition and a method of preparing the same |
| LU85943A1 (fr) * | 1985-06-12 | 1987-01-13 | Galephar | Comprimes pharmaceutiques permettant l'administration aisee de pellets, leur preparation et leur utilisation |
| DE3607339A1 (de) * | 1986-03-06 | 1987-09-10 | Merck Patent Gmbh | Pharmazeutische zubereitung |
| DE3612537C1 (de) * | 1986-04-14 | 1987-07-16 | Dispersa Ag | Arzneimittel zur Behandlung von Entzuendungen im Auge |
| EP0243521A1 (de) * | 1986-04-30 | 1987-11-04 | Werner Prof. Dr. Thorn | Oral verabreichbares Präparat |
| IT1200178B (it) * | 1986-07-23 | 1989-01-05 | Alfa Farmaceutici Spa | Formulazioni galeniche a cessione programmata contenenti farmaci ad attivita' antiflogistica |
| US4710384A (en) * | 1986-07-28 | 1987-12-01 | Avner Rotman | Sustained release tablets made from microcapsules |
| CH673395A5 (pt) * | 1987-01-30 | 1990-03-15 | Ciba Geigy Ag |
-
1988
- 1988-03-25 CH CH1138/88A patent/CH675537A5/de not_active IP Right Cessation
-
1989
- 1989-03-20 IT IT8947756A patent/IT1232823B/it active
- 1989-03-21 SE SE8901003A patent/SE8901003L/ unknown
- 1989-03-21 GB GB8906414A patent/GB2217598B/en not_active Expired - Lifetime
- 1989-03-22 ES ES8901046A patent/ES2010466A6/es not_active Expired
- 1989-03-22 DE DE3909520A patent/DE3909520C2/de not_active Expired - Lifetime
- 1989-03-22 DK DK198901471A patent/DK175517B1/da not_active IP Right Cessation
- 1989-03-23 AT AT0069089A patent/AT400299B/de not_active IP Right Cessation
- 1989-03-23 IE IE93489A patent/IE61221B1/en not_active IP Right Cessation
- 1989-03-23 BE BE8900323A patent/BE1001706A3/fr not_active IP Right Cessation
- 1989-03-23 NL NL8900734A patent/NL194999C/nl not_active IP Right Cessation
- 1989-03-23 GR GR890100182A patent/GR890100182A/el not_active IP Right Cessation
- 1989-03-23 PT PT90104A patent/PT90104B/pt not_active IP Right Cessation
- 1989-03-23 FR FR8903820A patent/FR2628971B1/fr not_active Expired - Lifetime
- 1989-03-23 CA CA000594713A patent/CA1323837C/en not_active Expired - Lifetime
- 1989-03-23 AU AU31634/89A patent/AU619261B2/en not_active Expired
- 1989-03-24 JP JP1070719A patent/JP2774135B2/ja not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| FR2628971A1 (fr) | 1989-09-29 |
| CA1323837C (en) | 1993-11-02 |
| GB2217598A (en) | 1989-11-01 |
| ES2010466A6 (es) | 1989-11-01 |
| ATA69089A (de) | 1995-04-15 |
| IT8947756A0 (it) | 1989-03-20 |
| PT90104A (pt) | 1989-11-10 |
| AU619261B2 (en) | 1992-01-23 |
| IE61221B1 (en) | 1994-10-19 |
| FR2628971B1 (fr) | 1994-02-18 |
| DE3909520C2 (de) | 1998-12-10 |
| DK147189A (da) | 1989-09-26 |
| GR890100182A (el) | 1990-01-19 |
| SE8901003D0 (sv) | 1989-03-21 |
| SE8901003L (sv) | 1989-09-26 |
| NL8900734A (nl) | 1989-10-16 |
| IT1232823B (it) | 1992-03-05 |
| AU3163489A (en) | 1989-09-28 |
| PT90104B (pt) | 1994-06-30 |
| JP2774135B2 (ja) | 1998-07-09 |
| AT400299B (de) | 1995-11-27 |
| DK175517B1 (da) | 2004-11-15 |
| IE890934L (en) | 1989-09-25 |
| CH675537A5 (pt) | 1990-10-15 |
| JPH01283219A (ja) | 1989-11-14 |
| DK147189D0 (da) | 1989-03-22 |
| GB8906414D0 (en) | 1989-05-04 |
| DE3909520A1 (de) | 1989-10-05 |
| GB2217598B (en) | 1992-01-08 |
| BE1001706A3 (fr) | 1990-02-13 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| BC | A request for examination has been filed | ||
| CNR | Transfer of rights (patent application after its laying open for public inspection) |
Free format text: NOVARTIS AG |
|
| V4 | Discontinued because of reaching the maximum lifetime of a patent |
Effective date: 20090323 |