MY154878A - Process for purifying staurosporine - Google Patents
Process for purifying staurosporineInfo
- Publication number
- MY154878A MY154878A MYPI20091911A MYPI20091911A MY154878A MY 154878 A MY154878 A MY 154878A MY PI20091911 A MYPI20091911 A MY PI20091911A MY PI20091911 A MYPI20091911 A MY PI20091911A MY 154878 A MY154878 A MY 154878A
- Authority
- MY
- Malaysia
- Prior art keywords
- staurosporine
- benzoyl
- warm
- processes
- preparation
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- HKSZLNNOFSGOKW-UHFFFAOYSA-N ent-staurosporine Natural products C12=C3N4C5=CC=CC=C5C3=C3CNC(=O)C3=C2C2=CC=CC=C2N1C1CC(NC)C(OC)C4(C)O1 HKSZLNNOFSGOKW-UHFFFAOYSA-N 0.000 title 1
- HKSZLNNOFSGOKW-FYTWVXJKSA-N staurosporine Chemical compound C12=C3N4C5=CC=CC=C5C3=C3CNC(=O)C3=C2C2=CC=CC=C2N1[C@H]1C[C@@H](NC)[C@@H](OC)[C@]4(C)O1 HKSZLNNOFSGOKW-FYTWVXJKSA-N 0.000 title 1
- CGPUWJWCVCFERF-UHFFFAOYSA-N staurosporine Natural products C12=C3N4C5=CC=CC=C5C3=C3CNC(=O)C3=C2C2=CC=CC=C2N1C1CC(NC)C(OC)C4(OC)O1 CGPUWJWCVCFERF-UHFFFAOYSA-N 0.000 title 1
- BMGQWWVMWDBQGC-IIFHNQTCSA-N midostaurin Chemical compound CN([C@H]1[C@H]([C@]2(C)O[C@@H](N3C4=CC=CC=C4C4=C5C(=O)NCC5=C5C6=CC=CC=C6N2C5=C43)C1)OC)C(=O)C1=CC=CC=C1 BMGQWWVMWDBQGC-IIFHNQTCSA-N 0.000 abstract 4
- 241001465754 Metazoa Species 0.000 abstract 2
- 238000002405 diagnostic procedure Methods 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 230000001225 therapeutic effect Effects 0.000 abstract 2
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/351—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom not condensed with another ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Oncology (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
- Extraction Or Liquid Replacement (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US62534304P | 2004-11-05 | 2004-11-05 | |
| US64213105P | 2005-01-07 | 2005-01-07 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MY154878A true MY154878A (en) | 2015-08-14 |
Family
ID=35501294
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MYPI20091911A MY154878A (en) | 2004-11-05 | 2005-10-28 | Process for purifying staurosporine |
| MYPI20055091A MY147404A (en) | 2004-11-05 | 2005-10-28 | Process for preparation of n-benzoyl-staurosporine |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MYPI20055091A MY147404A (en) | 2004-11-05 | 2005-10-28 | Process for preparation of n-benzoyl-staurosporine |
Country Status (31)
| Country | Link |
|---|---|
| US (2) | US8198435B2 (enExample) |
| EP (3) | EP1812448B1 (enExample) |
| JP (4) | JP5057986B2 (enExample) |
| KR (3) | KR101265850B1 (enExample) |
| CN (2) | CN102627658A (enExample) |
| AR (1) | AR052322A1 (enExample) |
| AU (2) | AU2005300693B2 (enExample) |
| BR (1) | BRPI0517689A (enExample) |
| CA (1) | CA2584911C (enExample) |
| CY (1) | CY1113059T1 (enExample) |
| DK (1) | DK1812448T3 (enExample) |
| EC (1) | ECSP12007431A (enExample) |
| ES (1) | ES2388142T3 (enExample) |
| GT (1) | GT200500311A (enExample) |
| HK (1) | HK1211587A1 (enExample) |
| HR (1) | HRP20120652T1 (enExample) |
| IL (3) | IL182691A (enExample) |
| JO (1) | JO2897B1 (enExample) |
| MA (1) | MA29033B1 (enExample) |
| MX (2) | MX2007005429A (enExample) |
| MY (2) | MY154878A (enExample) |
| NO (2) | NO338960B1 (enExample) |
| NZ (3) | NZ588025A (enExample) |
| PE (3) | PE20060947A1 (enExample) |
| PL (1) | PL1812448T3 (enExample) |
| PT (1) | PT1812448E (enExample) |
| RU (2) | RU2394038C2 (enExample) |
| SI (1) | SI1812448T1 (enExample) |
| TN (1) | TNSN07165A1 (enExample) |
| TW (4) | TWI433852B (enExample) |
| WO (1) | WO2006048296A1 (enExample) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT2054040E (pt) * | 2006-08-16 | 2011-06-30 | Novartis Ag | Método para produzir dispersões sólidas de compostos terapêuticos altamente cristalinos |
| EP2327706A1 (en) * | 2009-11-30 | 2011-06-01 | Novartis AG | Polymorphous forms III and IV of N-benzoyl-staurosporine |
| KR20160008267A (ko) | 2014-07-14 | 2016-01-22 | 주식회사 윈스 | 네트워크 기반 영상감시체계에서의 사용자 행위 분석 시스템 |
| US20200010481A1 (en) * | 2017-03-06 | 2020-01-09 | Teva Pharmaceutical Works Ltd. | Solid state forms of midostaurin |
| WO2019215759A1 (en) * | 2018-05-09 | 2019-11-14 | Alaparthi Lakshmi Prasad | An improved process for preparation of midostaurin |
| IT201900004729A1 (it) | 2019-03-29 | 2020-09-29 | Procos Spa | Processo per la preparazione di midostaurina ad elevato grado di purezza |
| WO2020261293A1 (en) * | 2019-06-24 | 2020-12-30 | Dr. Reddy's Laboratories Limited | Process for preparation of midostaurin |
| IT201900014346A1 (it) * | 2019-08-08 | 2021-02-08 | Procos Spa | Processo per la preparazione di midostaurina amorfa con un basso contenuto di solvente organico residuo |
| IT202000004291A1 (it) | 2020-03-02 | 2021-09-02 | Indena Spa | Processo per la purificazione di alcaloidi indolo carbazolici |
| CN111393454A (zh) * | 2020-05-07 | 2020-07-10 | 奥锐特药业(天津)有限公司 | 米哚妥林的新晶型及其制备方法 |
| CN115124551B (zh) * | 2021-03-24 | 2024-04-30 | 奥锐特药业(天津)有限公司 | 一种高纯度米哚妥林的制备方法 |
| WO2023205504A1 (en) * | 2022-04-22 | 2023-10-26 | Rutgers, The State University Of New Jersey | Formulations and methods for treating epidermolysis bullosa simplex and related conditions |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5373501A (en) * | 1976-12-11 | 1978-06-30 | Kitasato Inst | Novel antibiotics amm2282 and process for preparing same |
| JPS60185719A (ja) | 1984-03-06 | 1985-09-21 | Ajinomoto Co Inc | 抗腫瘍剤 |
| IL86632A0 (en) * | 1987-06-15 | 1988-11-30 | Ciba Geigy Ag | Derivatives substituted at methyl-amino nitrogen |
| US5093330A (en) * | 1987-06-15 | 1992-03-03 | Ciba-Geigy Corporation | Staurosporine derivatives substituted at methylamino nitrogen |
| US5073633A (en) * | 1989-03-23 | 1991-12-17 | Bristol-Myers Company | BMY-41950 antitumor antibiotic |
| US5096330A (en) * | 1990-06-21 | 1992-03-17 | M-B-W Inc. | Pitch control mechanism for a surface finishing machine |
| JPH05247055A (ja) * | 1992-03-03 | 1993-09-24 | Meiji Seika Kaisha Ltd | スタウロスポリン誘導体及びそれを含有する抗腫瘍効果増強剤 |
| JPH05247955A (ja) | 1992-03-06 | 1993-09-24 | Taisei Corp | 擁壁の施工方法 |
| EP0575955B1 (en) | 1992-06-22 | 1999-09-15 | Kyowa Hakko Kogyo Co., Ltd. | Process for producing staurosporine derivatives |
| EP0763041A1 (en) * | 1994-06-01 | 1997-03-19 | Novartis AG | Indolocarbazole derivatives for sensitizing multidrug-resistant cells to antitumor agents |
| JP4070810B2 (ja) | 1995-12-11 | 2008-04-02 | セファロン・インコーポレイテッド | タンパク質キナーゼｃの阻害剤としての縮合イソインドロン |
| US6878804B1 (en) | 1999-08-30 | 2005-04-12 | University Of Zurich | Synthesis of template-fixed β-hairpin loop mimetics |
| EP1372611B1 (en) | 2001-03-26 | 2006-05-17 | Novartis AG | Pharmaceutical composition comprising a poorly water-soluble staurosporine, a surfactant and a water-soluble polymer |
| KR100407758B1 (ko) * | 2001-08-27 | 2003-12-01 | 씨제이 주식회사 | 스타틴의 제조에 있어서 락톤화 방법 |
| US7608420B2 (en) * | 2003-04-22 | 2009-10-27 | Lonza Ag | Process for the recovery of staurosporine from a fermentation broth |
-
2005
- 2005-10-26 JO JO2005162A patent/JO2897B1/en active
- 2005-10-28 GT GT200500311A patent/GT200500311A/es unknown
- 2005-10-28 MY MYPI20091911A patent/MY154878A/en unknown
- 2005-10-28 MY MYPI20055091A patent/MY147404A/en unknown
- 2005-11-03 RU RU2007120695/04A patent/RU2394038C2/ru active
- 2005-11-03 DK DK05803350.7T patent/DK1812448T3/da active
- 2005-11-03 SI SI200531555T patent/SI1812448T1/sl unknown
- 2005-11-03 EP EP05803350A patent/EP1812448B1/en not_active Expired - Lifetime
- 2005-11-03 KR KR1020127022582A patent/KR101265850B1/ko not_active Expired - Lifetime
- 2005-11-03 KR KR1020077010191A patent/KR101333851B1/ko not_active Expired - Lifetime
- 2005-11-03 MX MX2007005429A patent/MX2007005429A/es active IP Right Grant
- 2005-11-03 CN CN2012101018747A patent/CN102627658A/zh active Pending
- 2005-11-03 PL PL05803350T patent/PL1812448T3/pl unknown
- 2005-11-03 CA CA2584911A patent/CA2584911C/en not_active Expired - Lifetime
- 2005-11-03 HR HRP20120652TT patent/HRP20120652T1/hr unknown
- 2005-11-03 NZ NZ588025A patent/NZ588025A/en not_active IP Right Cessation
- 2005-11-03 MX MX2011007303A patent/MX346525B/es unknown
- 2005-11-03 NZ NZ554653A patent/NZ554653A/en not_active IP Right Cessation
- 2005-11-03 PT PT05803350T patent/PT1812448E/pt unknown
- 2005-11-03 ES ES05803350T patent/ES2388142T3/es not_active Expired - Lifetime
- 2005-11-03 BR BRPI0517689-1A patent/BRPI0517689A/pt not_active IP Right Cessation
- 2005-11-03 AU AU2005300693A patent/AU2005300693B2/en not_active Expired
- 2005-11-03 EP EP10173464.8A patent/EP2272850B1/en not_active Expired - Lifetime
- 2005-11-03 KR KR1020127022584A patent/KR101289998B1/ko not_active Expired - Lifetime
- 2005-11-03 WO PCT/EP2005/011789 patent/WO2006048296A1/en not_active Ceased
- 2005-11-03 EP EP15171908.5A patent/EP2955186A1/en not_active Withdrawn
- 2005-11-03 CN CN2012104320940A patent/CN102993213A/zh active Pending
- 2005-11-03 JP JP2007539535A patent/JP5057986B2/ja not_active Expired - Lifetime
- 2005-11-03 NZ NZ599033A patent/NZ599033A/xx not_active IP Right Cessation
- 2005-11-03 US US11/718,029 patent/US8198435B2/en active Active
- 2005-11-04 PE PE2005001297A patent/PE20060947A1/es not_active Application Discontinuation
- 2005-11-04 TW TW094138677A patent/TWI433852B/zh not_active IP Right Cessation
- 2005-11-04 TW TW101122880A patent/TWI530500B/zh not_active IP Right Cessation
- 2005-11-04 PE PE2012002519A patent/PE20130377A1/es not_active Application Discontinuation
- 2005-11-04 PE PE2009000199A patent/PE20090433A1/es not_active Application Discontinuation
- 2005-11-04 TW TW103130302A patent/TWI530501B/zh not_active IP Right Cessation
- 2005-11-04 TW TW101122882A patent/TWI455941B/zh not_active IP Right Cessation
- 2005-11-04 AR ARP050104637A patent/AR052322A1/es not_active Application Discontinuation
-
2007
- 2007-04-19 IL IL182691A patent/IL182691A/en active IP Right Grant
- 2007-05-02 NO NO20072290A patent/NO338960B1/no unknown
- 2007-05-04 TN TNP2007000165A patent/TNSN07165A1/fr unknown
- 2007-05-22 MA MA29924A patent/MA29033B1/fr unknown
- 2007-12-19 HK HK15112508.3A patent/HK1211587A1/en unknown
-
2009
- 2009-10-13 RU RU2009137788/04A patent/RU2467012C2/ru active
- 2009-12-07 AU AU2009245817A patent/AU2009245817B2/en not_active Expired
-
2010
- 2010-08-19 IL IL207702A patent/IL207702A/en active IP Right Grant
-
2012
- 2012-01-16 IL IL217571A patent/IL217571A/en active IP Right Grant
- 2012-03-12 EC ECSP12007431 patent/ECSP12007431A/es unknown
- 2012-05-11 JP JP2012109447A patent/JP5701246B2/ja not_active Expired - Lifetime
- 2012-05-15 US US13/472,130 patent/US8710216B2/en not_active Expired - Lifetime
- 2012-08-21 CY CY20121100747T patent/CY1113059T1/el unknown
-
2015
- 2015-01-09 JP JP2015003634A patent/JP2015063569A/ja not_active Withdrawn
-
2016
- 2016-07-12 NO NO20161152A patent/NO340404B1/no unknown
-
2017
- 2017-01-13 JP JP2017004320A patent/JP2017061578A/ja active Pending
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| TNSN07165A1 (en) | Organic compounds | |
| WO2005013892A3 (en) | Hydrolytically-resistant boron-containing therapeutics and methods of use | |
| TW200606162A (en) | Pyrazolopyridine derivatives | |
| IL233634A0 (en) | Methods, compositions and kits for treating medical conditions | |
| TW200633980A (en) | Pyridones useful as inhibitors of kinases | |
| GEP20084551B (en) | 4-phenylamino-quinazolin-6-yl-amides | |
| NO20054905L (no) | 2-acylamino-4-fenyltiazolderivater, fremgangsmate for deres fremstilling og anvendelse av de samme som i terapeutika | |
| TW200510343A (en) | Substituted dihydroquinazolines | |
| MX2009005413A (es) | Formas cristalinas del acido zoledronico. | |
| UA88645C2 (ru) | Гетероарильные соединения как бета-миметики для лечения заболеваний дыхательных путей | |
| WO2007050587A3 (en) | Therapeutic compositions and methods | |
| MXPA05011785A (es) | Moduladores positivos de receptores de acetilcolina nicotinicos. | |
| TW200510449A (en) | Acylated nonadepsipeptides | |
| PT1730147E (pt) | Compostos de 1,4,8-triazaspiro[4.5]decan-2-ona substituídos para utilização no tratamento da obesidade | |
| WO2004087700A8 (fr) | Derives du benzenesulfonamide, leur procede de preparation et leur utilisation de la douleur | |
| IL178094A0 (en) | Improvements in or relating to compounds for use in the treatment of aids and other viral diseases and hiv-related infections and compositions containing such compounds, methods of treating such diseases and infections and methods of making such compounds and compositions | |
| TW200621799A (en) | Acylated nonadepsipeptides II | |
| IL194353A0 (en) | Lysobactin amides | |
| MXPA06007007A (es) | Derivados de prolina usados como ingredientes farmaceuticos activos para el tratamiento de tumores. | |
| WO2006089664A3 (de) | Heterocyclylamid-substituierte imidazole | |
| BRPI0509667A (pt) | azaquinazolinas substituìdas com eficácia antiviral | |
| TW200833708A (en) | Pharmaceutically acceptable salts of thymodepressin and processes for their manufacture | |
| EP1597234A4 (en) | NEW COMPOUNDS | |
| WO2008130321A3 (en) | Novel n-tetrahydronaphtalene or 5-heterocyclyl-chromane or 8-heterocyclyl-tetrahydronaphtalene derivatives for the treatment of pain | |
| TW200635920A (en) | Pyrazinedicarboxamides and their use |