MXPA06002017A - Pirazolil-amidil-bencimidazolilo n-sustituidos, ibnhibidores de c-kit. - Google Patents
Pirazolil-amidil-bencimidazolilo n-sustituidos, ibnhibidores de c-kit.Info
- Publication number
- MXPA06002017A MXPA06002017A MXPA06002017A MXPA06002017A MXPA06002017A MX PA06002017 A MXPA06002017 A MX PA06002017A MX PA06002017 A MXPA06002017 A MX PA06002017A MX PA06002017 A MXPA06002017 A MX PA06002017A MX PA06002017 A MXPA06002017 A MX PA06002017A
- Authority
- MX
- Mexico
- Prior art keywords
- carbon atoms
- alkyl
- pharmaceutically acceptable
- carboxamide
- benzimidazole
- Prior art date
Links
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US49676603P | 2003-08-21 | 2003-08-21 | |
| PCT/US2004/026481 WO2005021537A1 (en) | 2003-08-21 | 2004-08-16 | N-substituted pyrazolyl-amidyl-benzimidazolyl c-kit inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MXPA06002017A true MXPA06002017A (es) | 2006-05-31 |
Family
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| Application Number | Title | Priority Date | Filing Date |
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| MXPA06002017A MXPA06002017A (es) | 2003-08-21 | 2004-08-16 | Pirazolil-amidil-bencimidazolilo n-sustituidos, ibnhibidores de c-kit. |
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| EP (1) | EP1664032B1 (OSRAM) |
| JP (1) | JP4795237B2 (OSRAM) |
| KR (1) | KR20060115346A (OSRAM) |
| CN (1) | CN1839130A (OSRAM) |
| AP (1) | AP2006003553A0 (OSRAM) |
| AR (1) | AR045389A1 (OSRAM) |
| AT (1) | ATE413395T1 (OSRAM) |
| AU (1) | AU2004268948A1 (OSRAM) |
| BR (1) | BRPI0413785A (OSRAM) |
| CA (1) | CA2536151A1 (OSRAM) |
| DE (1) | DE602004017623D1 (OSRAM) |
| IL (1) | IL173616A0 (OSRAM) |
| IS (1) | IS8320A (OSRAM) |
| MX (1) | MXPA06002017A (OSRAM) |
| NO (1) | NO20060665L (OSRAM) |
| RU (1) | RU2006108791A (OSRAM) |
| TW (1) | TW200524911A (OSRAM) |
| UA (1) | UA84712C2 (OSRAM) |
| WO (1) | WO2005021537A1 (OSRAM) |
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| WO2006030826A1 (ja) | 2004-09-17 | 2006-03-23 | Eisai R & D Management Co., Ltd. | 医薬組成物 |
| JP4989476B2 (ja) | 2005-08-02 | 2012-08-01 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 血管新生阻害物質の効果を検定する方法 |
| WO2007052849A1 (ja) | 2005-11-07 | 2007-05-10 | Eisai R & D Management Co., Ltd. | 血管新生阻害物質とc-kitキナーゼ阻害物質との併用 |
| JP5583346B2 (ja) * | 2006-01-18 | 2014-09-03 | エルジー ハウスホールド アンド ヘルスケア リミテッド | ｃ−Ｋｉｔ活性阻害剤、及び、肌美白剤 |
| TW200740776A (en) * | 2006-02-06 | 2007-11-01 | Osi Pharm Inc | N-phenylbenzotriazolyl c-kit inhibitors |
| CA2652442C (en) * | 2006-05-18 | 2014-12-09 | Eisai R & D Management Co., Ltd. | Antitumor agent for thyroid cancer |
| KR101472600B1 (ko) | 2006-08-28 | 2014-12-15 | 에자이 알앤드디 매니지먼트 가부시키가이샤 | 미분화형 위암에 대한 항종양제 |
| US7737149B2 (en) | 2006-12-21 | 2010-06-15 | Astrazeneca Ab | N-[5-[2-(3,5-dimethoxyphenyl)ethyl]-2H-pyrazol-3-yl]-4-(3,5-dimethylpiperazin-1-yl)benzamide and salts thereof |
| CN101600694A (zh) | 2007-01-29 | 2009-12-09 | 卫材R&D管理有限公司 | 未分化型胃癌治疗用组合物 |
| WO2009060945A1 (ja) | 2007-11-09 | 2009-05-14 | Eisai R & D Management Co., Ltd. | 血管新生阻害物質と抗腫瘍性白金錯体との併用 |
| EP2400985A2 (en) | 2009-02-25 | 2012-01-04 | OSI Pharmaceuticals, LLC | Combination of an either an anti-igf-1r antibody or an igf binding protein and a small molecule igf-1r kinase inhibitor |
| JP2012519281A (ja) | 2009-02-27 | 2012-08-23 | オーエスアイ・ファーマシューティカルズ，エルエルシー | 間葉様腫瘍細胞またはその生成を阻害する薬剤を同定するための方法 |
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- 2004-08-16 EP EP04781203A patent/EP1664032B1/en not_active Expired - Lifetime
- 2004-08-16 RU RU2006108791/04A patent/RU2006108791A/ru not_active Application Discontinuation
- 2004-08-16 AP AP2006003553A patent/AP2006003553A0/xx unknown
- 2004-08-16 CA CA002536151A patent/CA2536151A1/en not_active Abandoned
- 2004-08-16 DE DE602004017623T patent/DE602004017623D1/de not_active Expired - Lifetime
- 2004-08-16 AT AT04781203T patent/ATE413395T1/de not_active IP Right Cessation
- 2004-08-16 BR BRPI0413785-0A patent/BRPI0413785A/pt not_active IP Right Cessation
- 2004-08-16 AU AU2004268948A patent/AU2004268948A1/en not_active Abandoned
- 2004-08-16 MX MXPA06002017A patent/MXPA06002017A/es unknown
- 2004-08-16 JP JP2006523954A patent/JP4795237B2/ja not_active Expired - Fee Related
- 2004-08-16 CN CNA2004800239977A patent/CN1839130A/zh active Pending
- 2004-08-16 UA UAA200602943A patent/UA84712C2/ru unknown
- 2004-08-16 KR KR1020067003094A patent/KR20060115346A/ko not_active Withdrawn
- 2004-08-16 WO PCT/US2004/026481 patent/WO2005021537A1/en not_active Ceased
- 2004-08-20 TW TW093125240A patent/TW200524911A/zh unknown
- 2004-08-20 AR ARP040103010A patent/AR045389A1/es not_active Application Discontinuation
-
2006
- 2006-02-08 IL IL173616A patent/IL173616A0/en unknown
- 2006-02-10 NO NO20060665A patent/NO20060665L/no not_active Application Discontinuation
- 2006-02-21 IS IS8320A patent/IS8320A/is unknown
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| AP2006003553A0 (en) | 2006-04-30 |
| IS8320A (is) | 2006-02-21 |
| AU2004268948A1 (en) | 2005-03-10 |
| CN1839130A (zh) | 2006-09-27 |
| CA2536151A1 (en) | 2005-03-10 |
| IL173616A0 (en) | 2006-07-05 |
| TW200524911A (en) | 2005-08-01 |
| JP2007502820A (ja) | 2007-02-15 |
| JP4795237B2 (ja) | 2011-10-19 |
| UA84712C2 (en) | 2008-11-25 |
| AR045389A1 (es) | 2005-10-26 |
| EP1664032A1 (en) | 2006-06-07 |
| DE602004017623D1 (de) | 2008-12-18 |
| WO2005021537A1 (en) | 2005-03-10 |
| BRPI0413785A (pt) | 2006-11-07 |
| KR20060115346A (ko) | 2006-11-08 |
| RU2006108791A (ru) | 2006-07-27 |
| EP1664032B1 (en) | 2008-11-05 |
| ATE413395T1 (de) | 2008-11-15 |
| NO20060665L (no) | 2006-05-16 |
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