IS8320A - N-staðgengnir pýrasólýl-amidýl-bensimidasólýl - Google Patents

N-staðgengnir pýrasólýl-amidýl-bensimidasólýl

Info

Publication number
IS8320A
IS8320A IS8320A IS8320A IS8320A IS 8320 A IS8320 A IS 8320A IS 8320 A IS8320 A IS 8320A IS 8320 A IS8320 A IS 8320A IS 8320 A IS8320 A IS 8320A
Authority
IS
Iceland
Prior art keywords
amidyl
benzimidazolyl
substituted pyrazolyl
pyrazolyl
substituted
Prior art date
Application number
IS8320A
Other languages
English (en)
Icelandic (is)
Inventor
Bolger Joshua
L. Castelhano Arlindo
Phillip Crew Andrew
Laufer Radoslaw
Li An-Hu
Peter Sambrook Smith Colin
Sun Yingchuan
Original Assignee
Osi Pharmaceuticals, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Osi Pharmaceuticals, Inc. filed Critical Osi Pharmaceuticals, Inc.
Publication of IS8320A publication Critical patent/IS8320A/is

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
IS8320A 2003-08-21 2006-02-21 N-staðgengnir pýrasólýl-amidýl-bensimidasólýl IS8320A (is)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US49676603P 2003-08-21 2003-08-21
PCT/US2004/026481 WO2005021537A1 (en) 2003-08-21 2004-08-16 N-substituted pyrazolyl-amidyl-benzimidazolyl c-kit inhibitors

Publications (1)

Publication Number Publication Date
IS8320A true IS8320A (is) 2006-02-21

Family

ID=34272512

Family Applications (1)

Application Number Title Priority Date Filing Date
IS8320A IS8320A (is) 2003-08-21 2006-02-21 N-staðgengnir pýrasólýl-amidýl-bensimidasólýl

Country Status (19)

Country Link
EP (1) EP1664032B1 (OSRAM)
JP (1) JP4795237B2 (OSRAM)
KR (1) KR20060115346A (OSRAM)
CN (1) CN1839130A (OSRAM)
AP (1) AP2006003553A0 (OSRAM)
AR (1) AR045389A1 (OSRAM)
AT (1) ATE413395T1 (OSRAM)
AU (1) AU2004268948A1 (OSRAM)
BR (1) BRPI0413785A (OSRAM)
CA (1) CA2536151A1 (OSRAM)
DE (1) DE602004017623D1 (OSRAM)
IL (1) IL173616A0 (OSRAM)
IS (1) IS8320A (OSRAM)
MX (1) MXPA06002017A (OSRAM)
NO (1) NO20060665L (OSRAM)
RU (1) RU2006108791A (OSRAM)
TW (1) TW200524911A (OSRAM)
UA (1) UA84712C2 (OSRAM)
WO (1) WO2005021537A1 (OSRAM)

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CA2802644C (en) 2010-06-25 2017-02-21 Eisai R & D Management Co., Ltd. Antitumor agent using compounds having kinase inhibitory effect in combination
JPWO2012121168A1 (ja) * 2011-03-04 2014-07-17 国立大学法人京都大学 キナーゼ阻害剤
CA2828946C (en) 2011-04-18 2016-06-21 Eisai R&D Management Co., Ltd. Therapeutic agent for tumor
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US9945862B2 (en) 2011-06-03 2018-04-17 Eisai R&D Management Co., Ltd. Biomarkers for predicting and assessing responsiveness of thyroid and kidney cancer subjects to lenvatinib compounds
WO2013152252A1 (en) 2012-04-06 2013-10-10 OSI Pharmaceuticals, LLC Combination anti-cancer therapy
MX2015004979A (es) 2012-12-21 2015-07-17 Eisai R&D Man Co Ltd Forma amorfa de derivado de quinolina y metodo para su produccion.
US20140179712A1 (en) 2012-12-21 2014-06-26 Astrazeneca Ab Pharmaceutical formulation of n-[5-[2-(3,5-dimethoxyphenyl)ethyl]-2h-pyrazol-3-yl]-4-[(3r,5s)-3,5-dimethylpiperazin-1-yl]benzamide
CN105102448B (zh) 2013-02-28 2018-03-06 百时美施贵宝公司 作为rock1和rock2抑制剂的苯基吡唑衍生物
AR094929A1 (es) 2013-02-28 2015-09-09 Bristol Myers Squibb Co Derivados de fenilpirazol como inhibidores potentes de rock1 y rock2
SG11201509278XA (en) 2013-05-14 2015-12-30 Eisai R&D Man Co Ltd Biomarkers for predicting and assessing responsiveness of endometrial cancer subjects to lenvatinib compounds
TW201534597A (zh) * 2013-06-20 2015-09-16 Ab Science 作為選擇性蛋白質激酶抑制劑之苯并咪唑衍生物
IL302218B2 (en) 2014-08-28 2024-10-01 Eisai R&D Man Co Ltd Methods for manufacturing high-purity lenvatinib and its derivatives
JP6792546B2 (ja) 2015-02-25 2020-11-25 エーザイ・アール・アンド・ディー・マネジメント株式会社 キノリン誘導体の苦味抑制方法
AU2015384801B2 (en) 2015-03-04 2022-01-06 Eisai R&D Management Co., Ltd. Combination of a PD-1 antagonist and a VEGFR/FGFR/RET tyrosine kinase inhibitor for treating cancer
EP3311841B1 (en) 2015-06-16 2021-07-28 PRISM BioLab Co., Ltd. Anticancer agent
CN108135894B (zh) 2015-08-20 2021-02-19 卫材R&D管理有限公司 肿瘤治疗剂
RU2750539C2 (ru) 2017-02-08 2021-06-29 Эйсай Ар Энд Ди Менеджмент Ко., Лтд. Фармацевтическая композиция для лечения опухоли
AU2018269996A1 (en) 2017-05-16 2019-11-21 Eisai R&D Management Co., Ltd. Treatment of hepatocellular carcinoma
AU2020242287A1 (en) 2019-03-21 2021-09-02 INSERM (Institut National de la Santé et de la Recherche Médicale) A Dbait molecule in combination with kinase inhibitor for the treatment of cancer
KR20220098759A (ko) 2019-11-08 2022-07-12 인쎄름 (엥스띠뛰 나씨오날 드 라 쌍떼 에 드 라 흐쉐르슈 메디깔) 키나제 억제제에 대해 내성을 획득한 암의 치료 방법
WO2021148581A1 (en) 2020-01-22 2021-07-29 Onxeo Novel dbait molecule and its use

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Also Published As

Publication number Publication date
AP2006003553A0 (en) 2006-04-30
MXPA06002017A (es) 2006-05-31
AU2004268948A1 (en) 2005-03-10
CN1839130A (zh) 2006-09-27
CA2536151A1 (en) 2005-03-10
IL173616A0 (en) 2006-07-05
TW200524911A (en) 2005-08-01
JP2007502820A (ja) 2007-02-15
JP4795237B2 (ja) 2011-10-19
UA84712C2 (en) 2008-11-25
AR045389A1 (es) 2005-10-26
EP1664032A1 (en) 2006-06-07
DE602004017623D1 (de) 2008-12-18
WO2005021537A1 (en) 2005-03-10
BRPI0413785A (pt) 2006-11-07
KR20060115346A (ko) 2006-11-08
RU2006108791A (ru) 2006-07-27
EP1664032B1 (en) 2008-11-05
ATE413395T1 (de) 2008-11-15
NO20060665L (no) 2006-05-16

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