MXPA05013521A - Derivados de tiazolilpiperidina como inhibidores de mtp. - Google Patents

Derivados de tiazolilpiperidina como inhibidores de mtp.

Info

Publication number
MXPA05013521A
MXPA05013521A MXPA05013521A MXPA05013521A MXPA05013521A MX PA05013521 A MXPA05013521 A MX PA05013521A MX PA05013521 A MXPA05013521 A MX PA05013521A MX PA05013521 A MXPA05013521 A MX PA05013521A MX PA05013521 A MXPA05013521 A MX PA05013521A
Authority
MX
Mexico
Prior art keywords
mtp inhibitors
thiazolylpiperidine derivatives
thiazolylpiperidine
derivatives
radical chosen
Prior art date
Application number
MXPA05013521A
Other languages
English (en)
Inventor
Philippe Guedat
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of MXPA05013521A publication Critical patent/MXPA05013521A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

Derivados de tiazolilpiperidina de la siguiente formula general (I): (ver formula I) donde: A representa un radical seleccionado entre los siguientes radicales a1 y a2: (ver formulas a1, a2) G representa un enlace o un radical divalente seleccionado entre los siguientes grupos g1, g2 y g3: (ver formulas g1, g2, g3) y R1, R2, R2, R3, R4, R5, Y y Z tienen los valores definidos en la memoria descriptiva. Los compuestos de la formula (I) se aplican en el tratamiento de hipertrigliceridemia, hipercolesterolemia y dislipidemia.
MXPA05013521A 2003-06-25 2004-06-02 Derivados de tiazolilpiperidina como inhibidores de mtp. MXPA05013521A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0307670A FR2856685B1 (fr) 2003-06-25 2003-06-25 Derives de thiazolylpiperidine, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent
PCT/EP2004/005931 WO2005003128A1 (en) 2003-06-25 2004-06-02 Thiazolylpiperidine derivatives as mtp inhibitors

Publications (1)

Publication Number Publication Date
MXPA05013521A true MXPA05013521A (es) 2006-03-09

Family

ID=33515396

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA05013521A MXPA05013521A (es) 2003-06-25 2004-06-02 Derivados de tiazolilpiperidina como inhibidores de mtp.

Country Status (18)

Country Link
US (1) US7674803B2 (es)
EP (1) EP1636218B1 (es)
JP (1) JP4629666B2 (es)
KR (1) KR20060024812A (es)
CN (1) CN1809560A (es)
AR (1) AR044909A1 (es)
AT (1) ATE426599T1 (es)
AU (1) AU2004253649B2 (es)
BR (1) BRPI0411721A (es)
CA (1) CA2531011C (es)
DE (1) DE602004020223D1 (es)
ES (1) ES2323463T3 (es)
FR (1) FR2856685B1 (es)
MX (1) MXPA05013521A (es)
RU (1) RU2006101890A (es)
TW (1) TW200518751A (es)
WO (1) WO2005003128A1 (es)
ZA (1) ZA200600690B (es)

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US7601745B2 (en) 2004-09-27 2009-10-13 4Sc Ag Heterocyclic NF-kB inhibitors
US20100267717A1 (en) * 2005-07-29 2010-10-21 4Sc Ag Novel Heterocyclic NF-kB Inhibitors
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EP1945635B1 (en) * 2005-08-18 2009-05-06 F.Hoffmann-La Roche Ag Thiazolyl piperidine derivatives useful as h3 receptor modulators
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EA201001699A1 (ru) 2008-04-30 2011-04-29 Байер Кропсайенс Аг Сложные эфиры и тиоэфиры тиазол-4-карбоновой кислоты в качестве средств защиты растений
KR20110067052A (ko) * 2008-10-01 2011-06-20 바이엘 크롭사이언스 아게 식물 보호제로서의 헤테로사이클릴 치환된 티아졸
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Also Published As

Publication number Publication date
ATE426599T1 (de) 2009-04-15
TW200518751A (en) 2005-06-16
US7674803B2 (en) 2010-03-09
FR2856685A1 (fr) 2004-12-31
AR044909A1 (es) 2005-10-05
EP1636218B1 (en) 2009-03-25
WO2005003128A1 (en) 2005-01-13
ES2323463T3 (es) 2009-07-16
KR20060024812A (ko) 2006-03-17
ZA200600690B (en) 2007-05-30
AU2004253649B2 (en) 2009-09-24
CA2531011A1 (en) 2005-01-13
FR2856685B1 (fr) 2005-09-23
DE602004020223D1 (de) 2009-05-07
RU2006101890A (ru) 2007-07-27
CN1809560A (zh) 2006-07-26
BRPI0411721A (pt) 2006-05-23
CA2531011C (en) 2012-10-09
JP2007506651A (ja) 2007-03-22
JP4629666B2 (ja) 2011-02-09
US20070054939A1 (en) 2007-03-08
EP1636218A1 (en) 2006-03-22
AU2004253649A1 (en) 2005-01-13

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