WO2005108355A3 - Dihydrobenzothiophene - Google Patents

Dihydrobenzothiophene Download PDF

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Publication number
WO2005108355A3
WO2005108355A3 PCT/EP2005/004554 EP2005004554W WO2005108355A3 WO 2005108355 A3 WO2005108355 A3 WO 2005108355A3 EP 2005004554 W EP2005004554 W EP 2005004554W WO 2005108355 A3 WO2005108355 A3 WO 2005108355A3
Authority
WO
WIPO (PCT)
Prior art keywords
dihydrobenzothiophenes
compounds
tumours
cited
formula
Prior art date
Application number
PCT/EP2005/004554
Other languages
English (en)
French (fr)
Other versions
WO2005108355A2 (de
Inventor
Dirk Finsinger
Soheila Anzali
Matthias Frech
Johannes Gleitz
Nina Heiss
Bjoern Hock
Kai Schiemann
Frank Zenke
Original Assignee
Merck Patent Gmbh
Dirk Finsinger
Soheila Anzali
Matthias Frech
Johannes Gleitz
Nina Heiss
Bjoern Hock
Kai Schiemann
Frank Zenke
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh, Dirk Finsinger, Soheila Anzali, Matthias Frech, Johannes Gleitz, Nina Heiss, Bjoern Hock, Kai Schiemann, Frank Zenke filed Critical Merck Patent Gmbh
Priority to US11/579,336 priority Critical patent/US20070219246A1/en
Priority to JP2007511968A priority patent/JP2007536306A/ja
Priority to CA002565367A priority patent/CA2565367A1/en
Priority to EP05751906A priority patent/EP1747214A2/de
Priority to AU2005240308A priority patent/AU2005240308A1/en
Publication of WO2005108355A2 publication Critical patent/WO2005108355A2/de
Publication of WO2005108355A3 publication Critical patent/WO2005108355A3/de

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/56—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/58—Radicals substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/60—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/64—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Rheumatology (AREA)
  • Neurosurgery (AREA)
  • Vascular Medicine (AREA)
  • Neurology (AREA)
  • Oncology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Hematology (AREA)
  • Pain & Pain Management (AREA)
  • Urology & Nephrology (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

Zusammenfassung Verbindungen der Formel (I) worin W, R1, R2, R3, R4, und q die in Anspruch 1 angegebenen Bedeutungen haben, können u.a. zur Behandlung von Tumoren eingesetzt werden.
PCT/EP2005/004554 2004-05-03 2005-04-28 Dihydrobenzothiophene WO2005108355A2 (de)

Priority Applications (5)

Application Number Priority Date Filing Date Title
US11/579,336 US20070219246A1 (en) 2004-05-03 2005-04-28 Dihydrobenzothiophenes
JP2007511968A JP2007536306A (ja) 2004-05-03 2005-04-28 ジヒドロベンゾチオフェン類
CA002565367A CA2565367A1 (en) 2004-05-03 2005-04-28 Dihydrobenzothiophenes
EP05751906A EP1747214A2 (de) 2004-05-03 2005-04-28 Dihydrobenzothiophene
AU2005240308A AU2005240308A1 (en) 2004-05-03 2005-04-28 Dihydrobenzothiophenes

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102004021637.1 2004-05-03
DE102004021637A DE102004021637A1 (de) 2004-05-03 2004-05-03 Dihydrobenzothiophene

Publications (2)

Publication Number Publication Date
WO2005108355A2 WO2005108355A2 (de) 2005-11-17
WO2005108355A3 true WO2005108355A3 (de) 2006-03-23

Family

ID=35267205

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2005/004554 WO2005108355A2 (de) 2004-05-03 2005-04-28 Dihydrobenzothiophene

Country Status (8)

Country Link
US (1) US20070219246A1 (de)
EP (1) EP1747214A2 (de)
JP (1) JP2007536306A (de)
AR (1) AR049086A1 (de)
AU (1) AU2005240308A1 (de)
CA (1) CA2565367A1 (de)
DE (1) DE102004021637A1 (de)
WO (1) WO2005108355A2 (de)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI0818605A2 (pt) 2007-10-19 2015-04-22 Schering Corp Derivados de 1,3,4-tiadiazl espiro-condensados para inibir a atividade de ksp cinesima

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3328411A (en) * 1963-12-07 1967-06-27 Merck Ag E Novel piperidine derivatives
WO2002071827A2 (en) * 2001-03-14 2002-09-19 Eli Lilly And Company Retinoid x receptor modulators
WO2002078639A2 (en) * 2001-03-29 2002-10-10 Bristol-Myers Squibb Company A method of treating proliferative diseases using eg5 inhibitors
WO2004067529A1 (en) * 2003-01-22 2004-08-12 Eli Lilly And Company Indole-derivative modulators of steroid hormone nuclear receptors

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3702320B2 (ja) * 1994-11-15 2005-10-05 味の素株式会社 ２，３−ジヒドロベンゾ［ｂ］チオフェン誘導体
DE60216753T2 (de) * 2001-02-16 2008-01-03 Aventis Pharmaceuticals Inc. Heterocyclische harnstoffderivate und deren verwendung als dopamine d3 receptor liganden
NZ522150A (en) * 2001-02-22 2006-03-31 Teijin Ltd Benzo[b]thiophene derivatives and processes for preparing the same

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3328411A (en) * 1963-12-07 1967-06-27 Merck Ag E Novel piperidine derivatives
WO2002071827A2 (en) * 2001-03-14 2002-09-19 Eli Lilly And Company Retinoid x receptor modulators
WO2002078639A2 (en) * 2001-03-29 2002-10-10 Bristol-Myers Squibb Company A method of treating proliferative diseases using eg5 inhibitors
WO2004067529A1 (en) * 2003-01-22 2004-08-12 Eli Lilly And Company Indole-derivative modulators of steroid hormone nuclear receptors

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
BERGMAN J., EGESTAD B.: "Cyclocondensation of 3(2H)-Benzo[b]thiophenone and Oxidation Products obtained during these Reactions", TETRAHEDRON, vol. 42, no. 2, 1986, pages 763 - 773, XP002364168 *
LEARDINI R., ET AL.: "Synthesis and Rearrangement of Diaryl-hydroxy-benzo[b]thiophens. A New synthesis of 2,3-Diaryl-benzo[b]thiophens", TETRAHEDRON LETTERS, vol. 24, no. 32, 1983, pages 3381 - 3382, XP009060171 *
TAMURA ET AL.: "Novel Conversion of Benzo[b]thiophen-3(2H)-ones into 1,2-Benzoisothiazole and Tetrahydro-1,2-benzothiazepin-5-one Systems via Sulphimide Intermediates", J. CHEM. SOC. PERKIN TRANS. 1, 1980, pages 2830 - 2834, XP009060174 *
TAMURA Y., ET AL.: "Photolysis and Thermolysis of 3-Diazothiochroman-4-one and Related Compounds", CHEM. PHARM. BULL., vol. 28, no. 11, 1980, pages 3430 - 3433, XP001208247 *
TAMURA Y., ET AL.: "Sulfilimines in Organic syntheses: New Entries into Tetrahydro-1,2-Benzothiazepine and 1,2-Benzisothiazole Systems", TETRAHEDRON LETTERS, vol. 21, 1980, pages 533 - 536, XP002364169 *

Also Published As

Publication number Publication date
AU2005240308A1 (en) 2005-11-17
JP2007536306A (ja) 2007-12-13
CA2565367A1 (en) 2005-11-17
AR049086A1 (es) 2006-06-28
WO2005108355A2 (de) 2005-11-17
DE102004021637A1 (de) 2005-12-01
US20070219246A1 (en) 2007-09-20
EP1747214A2 (de) 2007-01-31

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