MXPA04012636A - Agente antialergico, utilizacion del mismo para reducir la alergia y metodo para reducir la alergia. - Google Patents
Agente antialergico, utilizacion del mismo para reducir la alergia y metodo para reducir la alergia.Info
- Publication number
- MXPA04012636A MXPA04012636A MXPA04012636A MXPA04012636A MXPA04012636A MX PA04012636 A MXPA04012636 A MX PA04012636A MX PA04012636 A MXPA04012636 A MX PA04012636A MX PA04012636 A MXPA04012636 A MX PA04012636A MX PA04012636 A MXPA04012636 A MX PA04012636A
- Authority
- MX
- Mexico
- Prior art keywords
- lactic acid
- acid bacteria
- ige
- species
- antigen
- Prior art date
Links
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/74—Bacteria
- A61K35/741—Probiotics
- A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
- A61K35/747—Lactobacilli, e.g. L. acidophilus or L. brevis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/822—Microorganisms using bacteria or actinomycetales
- Y10S435/853—Lactobacillus
- Y10S435/854—Lactobacillus acidophilus
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Microbiology (AREA)
- Pulmonology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Dermatology (AREA)
- Immunology (AREA)
- Otolaryngology (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Plant Substances (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
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| JP2002185897A JP4212838B2 (ja) | 2002-06-26 | 2002-06-26 | 抗アレルギー剤 |
| PCT/JP2003/008094 WO2004002501A1 (ja) | 2002-06-26 | 2003-06-26 | 抗アレルギー剤、アレルギー低減のためのその使用及びアレルギー低減方法 |
Publications (1)
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| MXPA04012636A true MXPA04012636A (es) | 2005-03-23 |
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| MXPA04012636A MXPA04012636A (es) | 2002-06-26 | 2003-06-26 | Agente antialergico, utilizacion del mismo para reducir la alergia y metodo para reducir la alergia. |
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| EP (1) | EP1555028B1 (https=) |
| JP (1) | JP4212838B2 (https=) |
| KR (2) | KR20080018287A (https=) |
| CN (1) | CN100567489C (https=) |
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| AU (1) | AU2003246204B2 (https=) |
| BR (1) | BR0312052A (https=) |
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| UA (1) | UA86349C2 (https=) |
| WO (1) | WO2004002501A1 (https=) |
| ZA (1) | ZA200500715B (https=) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE1010487A6 (nl) | 1996-06-11 | 1998-10-06 | Unilin Beheer Bv | Vloerbekleding bestaande uit harde vloerpanelen en werkwijze voor het vervaardigen van dergelijke vloerpanelen. |
| JP4688457B2 (ja) * | 2004-09-10 | 2011-05-25 | 四国乳業株式会社 | 免疫増強組成物 |
| JP4823503B2 (ja) * | 2004-10-14 | 2011-11-24 | ジェンモント バイオテック インコーポレイテッド | Ｌａｃｔｏｂａｃｉｌｌｕｓｆｅｒｍｅｎｔｕｍの新規微生物株ＧＭ−０９０、およびＩＦＮ−γ分泌の刺激および／またはアレルギーの処置のためのその使用。 |
| US7351572B2 (en) | 2004-10-15 | 2008-04-01 | Genmont Biotech Inc. | Microorganism strain GM-090 of Lactobacillus fermentum and its use for stimulating IFN-γ secretion and/or treating allergy |
| TW200637908A (en) | 2005-01-04 | 2006-11-01 | Calpis Co Ltd | Method for preparation of lactic acid bacterium having anti-allergic activity |
| KR101312745B1 (ko) | 2005-03-03 | 2013-09-27 | 가부시키가이샤 메이지 | 면역기능 조정제 |
| TW200700074A (en) * | 2005-03-04 | 2007-01-01 | Calpis Co Ltd | Inducer of t cell apoptosis |
| ES2463724T3 (es) | 2005-10-11 | 2014-05-29 | Probiotical S.P.A. | Procedimiento de preparación de cultivos bacterianos probióticos analérgicos y uso relacionado |
| EP1961309A4 (en) | 2005-12-06 | 2010-01-20 | Otsuka Pharma Co Ltd | EMBRYONIC AXIS FERMENTATION PRODUCT OF SOYBEAN CONTAINING EQUOL, AND METHOD FOR PRODUCING THE SAME |
| MX2009003260A (es) * | 2006-10-02 | 2009-05-11 | Danisco | Probioticos para el uso en la reduccion de la incidencia y duracion de la enfermedad. |
| EA016734B1 (ru) * | 2006-12-21 | 2012-07-30 | Калпис Ко., Лтд. | СРЕДСТВА ДЛЯ СТИМУЛЯЦИИ ПРОДУЦИРОВАНИЯ IgA НА ОСНОВЕ БАКТЕРИЙ LACTOBACILLUS AMYLOVORUS И ШТАММ БАКТЕРИЙ LACTOBACILLUS AMYLOVORUS CP1750 FERM BP-10532 |
| CN101796187A (zh) | 2007-07-04 | 2010-08-04 | 龟甲万株式会社 | 乳酸菌来源的双链rna |
| RU2431663C2 (ru) * | 2008-01-28 | 2011-10-20 | Общество с ограниченной ответственностью "ИнноПроб" (ООО "ИнноПроб") | ИММУНОБИОЛОГИЧЕСКОЕ ПРОТИВОАЛЛЕРГИЧЕСКОЕ СРЕДСТВО (ВАРИАНТЫ) И ШТАММ Lactobacillus acidophilus 100 аш ПА, ИСПОЛЬЗУЕМЫЙ ДЛЯ ПРОИЗВОДСТВА ИММУНОБИОЛОГИЧЕСКОГО ПРОТИВОАЛЛЕРГИЧЕСКОГО СРЕДСТВА |
| US20100055082A1 (en) * | 2008-09-04 | 2010-03-04 | Jacques Alain Bauer | Immunomodulatory extracts from lactobacillus bacteria and methods of manufacturing and use thereof |
| RU2460781C2 (ru) * | 2009-01-29 | 2012-09-10 | Общество с ограниченной ответственностью "ИнноПроб" (ООО "ИнноПроб") | Иммунобиологическое противоаллергическое средство (варианты), штамм lactobacillus acidophilus, используемый при приготовлении иммунобиологического противоаллергического средства |
| RU2393214C1 (ru) * | 2009-01-29 | 2010-06-27 | Общество с ограниченной ответственностью "ИнноПроб"(ООО"ИнноПроб") | Иммунобиологическое противоаллергическое средство (варианты), штамм lactobacillus acidophilus nkjc, штамм lactobacillus acidophilus jch, штамм lactobacillus acidophilus kaa |
| EP2332557A1 (en) | 2009-12-08 | 2011-06-15 | Campina Nederland Holding B.V. | Probiotic lactic acid bacteria |
| TW201300526A (zh) * | 2011-03-25 | 2013-01-01 | Calpis Co Ltd | 培養基之製造方法及該方法所製造之培養基 |
| KR101166798B1 (ko) | 2011-12-19 | 2012-07-26 | 김대현 | 락토바실러스 애시도필러스 엘비의 사균을 포함하는 알레르기 질환의 치료 또는 예방용 의약 조성물 |
| US9636326B2 (en) | 2011-12-28 | 2017-05-02 | Maruha Nichiro Corporation | Chlorophyll c containing degranulation suppressor |
| JP6149228B2 (ja) * | 2013-04-11 | 2017-06-21 | アサヒグループホールディングス株式会社 | 免疫調節作用を有する乳酸菌のスクリーニング方法 |
| JP5927730B2 (ja) * | 2013-04-11 | 2016-06-01 | アサヒグループホールディングス株式会社 | 免疫調節作用を有する乳酸菌のスクリーニング方法 |
| KR101688224B1 (ko) * | 2015-05-01 | 2016-12-20 | 일동바이오사이언스(주) | 관절염 예방 및 치료 효과를 갖는 아이디-씨비티5101(id-cbt5101) 및 이의 용도 |
| CN109195612A (zh) * | 2016-05-09 | 2019-01-11 | 拜奥加亚公司 | 可用于过敏反应治疗的细菌菌株的选择 |
| EP3511409A4 (en) | 2016-09-12 | 2020-05-06 | Ichibiki Co Ltd. | SALT-TOLERANT LACTOBACILLA, SALT-TOLERANT LACTOBACIL CULTURE AND IMMUNOSTIMULATOR |
| EP3738599B1 (en) | 2018-01-12 | 2023-12-27 | GI Innovation, Inc. | Composition comprising probiotics and polypeptide having binding affinity for ige and use thereof |
| JP2021059522A (ja) * | 2019-03-20 | 2021-04-15 | キユーピー株式会社 | アレルギー症状改善用組成物 |
| CN116035187B (zh) * | 2022-12-30 | 2025-02-07 | 江南大学 | 一种使用植物乳杆菌发酵降低苦杏仁蛋白致敏性的方法 |
Family Cites Families (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
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| US959766A (en) * | 1909-05-14 | 1910-05-31 | Lewis Life | Wire-fastener. |
| US1048383A (en) * | 1911-06-16 | 1912-12-24 | Charles J Carroll | Manifolding sales-book. |
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| US4840406A (en) * | 1987-05-29 | 1989-06-20 | Dennison Manufacturing Company | Method of mounting index tabs upon stenographic notebooks |
| US4816884A (en) * | 1987-07-20 | 1989-03-28 | International Business Machines Corporation | High density vertical trench transistor and capacitor memory cell structure and fabrication method therefor |
| AU1076595A (en) * | 1993-11-23 | 1995-06-13 | Kabushiki Kaisha Wado Doctors Group | Intestinal flora improver composition, and apparatus and system for producing the same |
| JP2992945B2 (ja) * | 1994-03-11 | 1999-12-20 | カルピス株式会社 | ラクトバチルス・アシドフィルス乳酸菌 |
| CN1110147A (zh) * | 1994-04-09 | 1995-10-18 | 山田武敏 | 抗变态反应组合物 |
| JPH092959A (ja) * | 1995-06-16 | 1997-01-07 | Yakult Honsha Co Ltd | ＩｇＥ抗体産生抑制剤および抗アレルギー剤 |
| JP4064480B2 (ja) * | 1996-10-11 | 2008-03-19 | ハウスウェルネスフーズ株式会社 | ＩｇＧ抗体産生抑制剤 |
| JPH10309178A (ja) * | 1997-05-09 | 1998-11-24 | Wakamoto Pharmaceut Co Ltd | ビフィズス菌を有効成分とする抗アレルギー剤および醗酵食品 |
| USD393841S (en) * | 1997-05-27 | 1998-04-28 | Fujitsu Limited | Renewal of document to make alterations icon for a display screen |
| US6657642B1 (en) * | 1997-07-03 | 2003-12-02 | International Business Machines Corporation | User interactive display interfaces with means for interactive formation of combination display objects representative of combined interactive functions |
| JP2000086524A (ja) * | 1998-09-05 | 2000-03-28 | Shadan Seirankai | 生きた腸内細菌を含有する抗アレルギー剤 |
| JP2000095697A (ja) * | 1998-09-18 | 2000-04-04 | Advance Co Ltd | 抗アレルギー剤 |
| JP2000239175A (ja) * | 1999-02-18 | 2000-09-05 | Calpis Co Ltd | 抗アレルギー剤 |
| US6217443B1 (en) * | 1999-03-11 | 2001-04-17 | Leonard C. Green, Jr. | Carbonless paper notepad |
| IT1306716B1 (it) * | 1999-06-21 | 2001-10-02 | Mendes S U R L | Associazione di batteri lattici e suo uso per la prevenzione e/o iltrattamento terapeutico di infezioni e di stati infiammatori. |
| AUPQ415899A0 (en) * | 1999-11-19 | 1999-12-16 | Vasse Research Institute Pty Ltd | Compositions for and methods of treatment of allergic diseases |
| GB2365659B (en) * | 2000-02-25 | 2002-07-24 | Red Fig Ltd | Serving hypermedia documents |
| FI110668B (fi) * | 2000-06-20 | 2003-03-14 | Aboatech Ab Oy | Probioottien käyttö atooppisten sairauksien primaariseen ehkäisyyn |
| JP3944076B2 (ja) * | 2000-08-25 | 2007-07-11 | わかもと製薬株式会社 | 乳酸菌含有プロバイオティクス製品 |
| US20030021624A1 (en) * | 2001-06-29 | 2003-01-30 | Dorsey Cheryl L. | Article and method for making a notebook with permanent and disposable elements |
| DE20202562U1 (de) * | 2002-02-19 | 2002-05-23 | Orthomol pharmazeutische Vertriebs GmbH, 40764 Langenfeld | Mikronährstoffkombinationsprodukt mit Pro- und Prebiotika |
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- 2003-06-26 WO PCT/JP2003/008094 patent/WO2004002501A1/ja not_active Ceased
- 2003-06-26 PL PL375158A patent/PL204931B1/pl not_active IP Right Cessation
- 2003-06-26 DK DK03738524.2T patent/DK1555028T3/da active
- 2003-06-26 MX MXPA04012636A patent/MXPA04012636A/es active IP Right Grant
- 2003-06-26 AT AT03738524T patent/ATE444074T1/de not_active IP Right Cessation
- 2003-06-26 CA CA2490896A patent/CA2490896C/en not_active Expired - Fee Related
- 2003-06-26 TW TW092117451A patent/TW200402304A/zh not_active IP Right Cessation
- 2003-06-26 UA UAA200500663A patent/UA86349C2/ru unknown
- 2003-06-26 US US10/518,801 patent/US20050214270A1/en not_active Abandoned
- 2003-06-26 KR KR1020087003560A patent/KR20080018287A/ko not_active Ceased
- 2003-06-26 BR BR0312052-0A patent/BR0312052A/pt not_active IP Right Cessation
- 2003-06-26 CN CNB038203723A patent/CN100567489C/zh not_active Expired - Lifetime
- 2003-06-26 DE DE60329516T patent/DE60329516D1/de not_active Expired - Lifetime
- 2003-06-26 EP EP03738524A patent/EP1555028B1/en not_active Expired - Lifetime
- 2003-06-26 KR KR1020047020995A patent/KR100836727B1/ko not_active Expired - Lifetime
- 2003-06-26 AU AU2003246204A patent/AU2003246204B2/en not_active Ceased
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2005
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2008
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