MXPA04005185A - Compuestos hexaciclicos. - Google Patents

Compuestos hexaciclicos.

Info

Publication number
MXPA04005185A
MXPA04005185A MXPA04005185A MXPA04005185A MXPA04005185A MX PA04005185 A MXPA04005185 A MX PA04005185A MX PA04005185 A MXPA04005185 A MX PA04005185A MX PA04005185 A MXPA04005185 A MX PA04005185A MX PA04005185 A MXPA04005185 A MX PA04005185A
Authority
MX
Mexico
Prior art keywords
camptothecins
condensed
antitumor agents
compounds
useful
Prior art date
Application number
MXPA04005185A
Other languages
English (en)
Spanish (es)
Inventor
Niizuma Satoshi
Original Assignee
Chugai Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chugai Pharmaceutical Co Ltd filed Critical Chugai Pharmaceutical Co Ltd
Publication of MXPA04005185A publication Critical patent/MXPA04005185A/es

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D491/00Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/22Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
MXPA04005185A 2001-11-30 2002-11-25 Compuestos hexaciclicos. MXPA04005185A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP01128361 2001-11-30
PCT/EP2002/013216 WO2003045952A2 (en) 2001-11-30 2002-11-25 Condensed camptothecins as antitumor agents

Publications (1)

Publication Number Publication Date
MXPA04005185A true MXPA04005185A (es) 2004-08-11

Family

ID=8179394

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA04005185A MXPA04005185A (es) 2001-11-30 2002-11-25 Compuestos hexaciclicos.

Country Status (28)

Country Link
US (2) US6825194B2 (https=)
EP (1) EP1480984B9 (https=)
JP (1) JP4305909B2 (https=)
KR (1) KR100895746B1 (https=)
CN (1) CN100338066C (https=)
AT (1) ATE398131T1 (https=)
AU (1) AU2002356720B2 (https=)
BR (1) BR0214615A (https=)
CA (1) CA2468824C (https=)
DE (1) DE60227113D1 (https=)
ES (1) ES2307830T3 (https=)
GT (1) GT200200250A (https=)
HU (1) HUP0500062A3 (https=)
IL (1) IL162058A0 (https=)
MX (1) MXPA04005185A (https=)
MY (1) MY136138A (https=)
NO (1) NO329005B1 (https=)
NZ (1) NZ533568A (https=)
PA (1) PA8558901A1 (https=)
PE (1) PE20030725A1 (https=)
PL (1) PL207510B1 (https=)
RS (1) RS51051B (https=)
RU (1) RU2299212C2 (https=)
TW (1) TWI258481B (https=)
UA (1) UA80409C2 (https=)
UY (1) UY27560A1 (https=)
WO (1) WO2003045952A2 (https=)
ZA (1) ZA200404522B (https=)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1599484A2 (en) * 2003-02-21 2005-11-30 Chugai Seiyaku Kabushiki Kaisha Process for the preparation of hexacyclic camptothecin derivatives
RU2413731C2 (ru) 2004-04-09 2011-03-10 Чугаи Сейяку Кабусики Кайся Новые растворимые в воде пролекарства
TW200744603A (en) * 2005-08-22 2007-12-16 Chugai Pharmaceutical Co Ltd Novel anticancer concomitant drug
CA2626330A1 (en) * 2005-10-19 2007-04-26 Chugai Seiyaku Kabushiki Kaisha Preventive or therapeutic agents for pancreatic cancer, ovarian cancer, or liver cancer comprising a novel water-solube prodrug
RU2439073C1 (ru) * 2010-07-13 2012-01-10 Государственное образовательное учреждение высшего профессионального образования "Кубанский государственный технологический университет" (ГОУ ВПО "КубГТУ") СПОСОБ ПОЛУЧЕНИЯ ПРОИЗВОДНЫХ ИНДОЛИЗИНО[7,6-b]ИНДОЛА
HUE060364T2 (hu) 2019-03-29 2023-02-28 Medimmune Ltd Vegyületek és konjugátumaik

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4473692A (en) 1981-09-04 1984-09-25 Kabushiki Kaisha Yakult Honsha Camptothecin derivatives and process for preparing same
US4939255A (en) * 1987-06-24 1990-07-03 Daiichi Pharmaceutical Co., Ltd. Hexa-cyclic camptothecin derivatives
HU213136B (en) * 1990-08-14 1997-02-28 Kyorin Seiyaku Kk Process for producing fluoroethyl camptothecin derivatives and pharmaceutical compositions containing them
JP3008226B2 (ja) * 1991-01-16 2000-02-14 第一製薬株式会社 六環性化合物
JP3359955B2 (ja) * 1992-07-16 2002-12-24 第一製薬株式会社 抗腫瘍剤
GB9402934D0 (en) * 1994-02-16 1994-04-06 Erba Carlo Spa Camptothecin derivatives and process for their preparation
US5663177A (en) * 1995-05-31 1997-09-02 Smithkline Beecham Corporation Water soluble camptothecin analogs
ATE329903T1 (de) 1997-02-14 2006-07-15 Bionumerik Pharmaceuticals Inc Hochgradig lipophile camptothecin-derivate
GB9715821D0 (en) * 1997-07-25 1997-10-01 Pharmacia & Upjohn Spa Amidino-camptothecin derivatives

Also Published As

Publication number Publication date
ATE398131T1 (de) 2008-07-15
HUP0500062A3 (en) 2012-12-28
EP1480984B9 (en) 2009-03-11
US7109195B2 (en) 2006-09-19
RS47004A (sr) 2007-02-05
BR0214615A (pt) 2004-09-14
RS51051B (sr) 2010-10-31
US20030144304A1 (en) 2003-07-31
HK1072935A1 (en) 2005-09-16
CN1617874A (zh) 2005-05-18
TW200408642A (en) 2004-06-01
ES2307830T3 (es) 2008-12-01
PA8558901A1 (es) 2003-06-30
DE60227113D1 (de) 2008-07-24
US20050059679A1 (en) 2005-03-17
PE20030725A1 (es) 2003-08-28
US6825194B2 (en) 2004-11-30
TWI258481B (en) 2006-07-21
PL370479A1 (en) 2005-05-30
CA2468824A1 (en) 2003-06-05
MY136138A (en) 2008-08-29
NZ533568A (en) 2006-01-27
EP1480984A2 (en) 2004-12-01
RU2299212C2 (ru) 2007-05-20
HUP0500062A2 (hu) 2005-04-28
RU2004119841A (ru) 2005-03-27
PL207510B1 (pl) 2010-12-31
UA80409C2 (en) 2007-09-25
WO2003045952A3 (en) 2003-10-16
WO2003045952A2 (en) 2003-06-05
KR20040062976A (ko) 2004-07-09
CA2468824C (en) 2011-01-11
NO20042729L (no) 2004-08-27
AU2002356720B2 (en) 2009-01-29
EP1480984B1 (en) 2008-06-11
IL162058A0 (en) 2005-11-20
GT200200250A (es) 2004-01-15
HK1077303A1 (en) 2006-02-10
CN100338066C (zh) 2007-09-19
JP2005511643A (ja) 2005-04-28
JP4305909B2 (ja) 2009-07-29
UY27560A1 (es) 2003-05-30
AU2002356720A1 (en) 2003-06-10
KR100895746B1 (ko) 2009-04-30
NO329005B1 (no) 2010-07-19
ZA200404522B (en) 2005-01-04

Similar Documents

Publication Publication Date Title
MY138478A (en) Benzazepine derivatives for the treatment of neurological disorders
JO2311B1 (en) Alkyl inhibitors Ariel phosphodiesterase-4
MY135841A (en) Novel benzodioxoles
NZ514873A (en) 4,5,6,7-tetrahydroindazole derivatives as antitumor agents
AP1655A (en) A method of preparing quinazoline derivatives useful as anti-cancer compounds.
AP2002002637A0 (en) Novel piperazine
GEP20084329B (en) 5,7-diaminopyrazolo [4,3-d] pyrimidines useful in the treatment of hypertension
MXPA06000716A (es) Derivados de quinolina y quinazolina que tienen afinidad hacia receptores del tipo 5ht1.
GEP20074099B (en) 3-β-D-RIBOFURANO-SYLTHIAZOLO[4,5-d]PYRIDIMINE NUCLEOSIDES AND USES THEREOF
BG108269A (en) Pyrazolopyrimidines as therapeutic agents
PL365783A1 (en) 4-amino-6-phenyl-pyrrolo[2,3-d]pyrimidine derivatives
IL172833A0 (en) Pyrimidine-2,4-dione derivatives and pharmaceutical compositions containing the same
BG108268A (en) Pyrazolopyrimidines as therapeutic agents
UA66825C2 (uk) Азаполіциклічні сполуки, конденсовані з арилом, фармацевтична композиція, спосіб лікування та спосіб зниження нікотинової залежності
WO2001066534A3 (en) Cyclic and bicyclic diamino histamine-3 receptor antagonists
YU55602A (sh) Amino derivati dihidro-1,3,5-triazina i njihova terapeutska primena
PL373414A1 (en) 8-methoxy-(1,2,4)triazolo(1,5-a)pyridine derivatives and their use as adenosine receptor ligands
MXPA03010142A (es) Nuevos derivados de arilheteroalquilamina.
YU78303A (sh) Postupak za dobijanje 1,3-supstituisanih indena i azapolicikličnih jedinjenja sa pripojenim arilom
WO2003022219A3 (en) Biarylamino purine antiproliferative agents
MXPA04006041A (es) Antivirales de piridoquinoxalina.
GEP20105095B (en) Phenylacetamido-thiazole derivatives, process for their preparation and their use as antitumor agents
AP2001002306A0 (en) Bridged piperazine derivatives.
CA2356985A1 (en) 5ht1 antagonists for antidepressant therapy
MXPA04001419A (es) Isoxazolopiridinonas y su uso en el tratamiento de enfermedad de parkinson.

Legal Events

Date Code Title Description
FG Grant or registration