MXPA04005158A - Antagonistas receptores de adenosina a2a biciclica de (1.2.4]- triazol. - Google Patents
Antagonistas receptores de adenosina a2a biciclica de (1.2.4]- triazol.Info
- Publication number
- MXPA04005158A MXPA04005158A MXPA04005158A MXPA04005158A MXPA04005158A MX PA04005158 A MXPA04005158 A MX PA04005158A MX PA04005158 A MXPA04005158 A MX PA04005158A MX PA04005158 A MXPA04005158 A MX PA04005158A MX PA04005158 A MXPA04005158 A MX PA04005158A
- Authority
- MX
- Mexico
- Prior art keywords
- optionally substituted
- adenosine
- heteroaryldiyl
- heteroaryl
- disease
- Prior art date
Links
- OIRDTQYFTABQOQ-KQYNXXCUSA-N adenosine Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O OIRDTQYFTABQOQ-KQYNXXCUSA-N 0.000 title 2
- NSPMIYGKQJPBQR-UHFFFAOYSA-N 4H-1,2,4-triazole Chemical compound C=1N=CNN=1 NSPMIYGKQJPBQR-UHFFFAOYSA-N 0.000 title 1
- 239000002126 C01EB10 - Adenosine Substances 0.000 title 1
- 229960005305 adenosine Drugs 0.000 title 1
- 208000018737 Parkinson disease Diseases 0.000 abstract 2
- 125000000732 arylene group Chemical group 0.000 abstract 2
- 125000001072 heteroaryl group Chemical group 0.000 abstract 2
- 125000003386 piperidinyl group Chemical group 0.000 abstract 2
- 125000003107 substituted aryl group Chemical group 0.000 abstract 2
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 125000001475 halogen functional group Chemical group 0.000 abstract 1
- 125000004446 heteroarylalkyl group Chemical group 0.000 abstract 1
- -1 methylene, imino Chemical group 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 125000004193 piperazinyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Psychiatry (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Psychology (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US33438501P | 2001-11-30 | 2001-11-30 | |
| PCT/US2002/037915 WO2003048163A1 (en) | 2001-11-30 | 2002-11-26 | [1,2,4]-TRIAZOLE BICYCLIC ADENOSINE A2a RECEPTOR ANTAGONISTS |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MXPA04005158A true MXPA04005158A (es) | 2004-08-11 |
Family
ID=23306955
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MXPA04005158A MXPA04005158A (es) | 2001-11-30 | 2002-11-26 | Antagonistas receptores de adenosina a2a biciclica de (1.2.4]- triazol. |
Country Status (18)
| Country | Link |
|---|---|
| US (2) | US6875772B2 (enExample) |
| EP (1) | EP1453836B1 (enExample) |
| JP (2) | JP4429724B2 (enExample) |
| KR (1) | KR20050044600A (enExample) |
| CN (1) | CN1688581A (enExample) |
| AR (1) | AR037681A1 (enExample) |
| AT (1) | ATE358130T1 (enExample) |
| AU (1) | AU2002352933A1 (enExample) |
| CA (1) | CA2468658C (enExample) |
| DE (1) | DE60219196T2 (enExample) |
| ES (1) | ES2283625T3 (enExample) |
| HU (1) | HUP0402324A3 (enExample) |
| IL (1) | IL161573A0 (enExample) |
| MX (1) | MXPA04005158A (enExample) |
| PE (1) | PE20030653A1 (enExample) |
| TW (1) | TW200300689A (enExample) |
| WO (1) | WO2003048163A1 (enExample) |
| ZA (1) | ZA200404168B (enExample) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW200300686A (en) | 2001-11-30 | 2003-06-16 | Schering Corp | Adenosine A2a receptor antagonists |
| CA2468658C (en) * | 2001-11-30 | 2009-04-14 | Schering Corporation | [1,2,4]-triazole bicyclic adenosine a2a receptor antagonists |
| CN101492383A (zh) * | 2002-03-12 | 2009-07-29 | 惠氏公司 | 制备手性1,4-二取代哌嗪的方法 |
| AU2003272886A1 (en) * | 2002-09-24 | 2004-04-19 | Kyowa Hakko Kogyo Co., Ltd. | (1,2,4)-TRIAZOLO(1,5-c)PYRIMIDINE DERIVATIVE |
| MXPA05006790A (es) | 2002-12-19 | 2005-09-08 | Schering Corp | Usos de antagonistas del receptor adenosina a2a. |
| WO2004092170A2 (en) | 2003-04-09 | 2004-10-28 | Biogen Idec Ma Inc. | Triazolotriazines and pyrazolotriazines useful as a2a adenosine receptor antagon ists |
| EP1633756B1 (en) | 2003-04-09 | 2008-12-24 | Biogen Idec MA Inc. | A2a adenosine receptor antagonists |
| EP1615931A1 (en) | 2003-04-09 | 2006-01-18 | Biogen Idec MA Inc. | Triazolopyrazines and methods of making and using the same |
| EP1618109A2 (en) * | 2003-04-09 | 2006-01-25 | Biogen Idec MA Inc. | Triazolo[1,5-c]pyrimidines and pyrazolo[1,5-c]pyrimidines useful as a2a adenosine receptor antagonists |
| TW200507850A (en) | 2003-07-25 | 2005-03-01 | Kyowa Hakko Kogyo Kk | Pharmaceutical composition |
| WO2006129626A1 (ja) * | 2005-05-30 | 2006-12-07 | Kyowa Hakko Kogyo Co., Ltd. | [1,2,4]トリアゾロ[1,5-c]ピリミジン誘導体の製造法 |
| JPWO2006132275A1 (ja) | 2005-06-07 | 2009-01-08 | 協和醗酵工業株式会社 | 運動障害の予防および／または治療剤 |
| EP1896415A1 (en) * | 2005-06-08 | 2008-03-12 | NeuroSearch A/S | Novel n-phenyl-piperidine derivatives and their use as monoamine neurotransmitter re-uptake inhibitors |
| TW200803856A (en) | 2005-09-02 | 2008-01-16 | Mount Cook Biosciences Inc | Method of treating parkinson's disease with diarylmethylpiperazine compounds exhibiting delta receptor agonist activity |
| ES2273599B1 (es) | 2005-10-14 | 2008-06-01 | Universidad De Barcelona | Compuestos para el tratamiento de la fibrilacion auricular. |
| US7615556B2 (en) * | 2006-01-27 | 2009-11-10 | Bristol-Myers Squibb Company | Piperazinyl derivatives as modulators of chemokine receptor activity |
| US20110064671A1 (en) | 2008-03-10 | 2011-03-17 | Cornell University | Modulation of blood brain barrier permeability |
| WO2010008775A1 (en) * | 2008-06-23 | 2010-01-21 | Ligand Pharmaceuticals Inc. | Aminopyridopyrazinone derivatives for treating neurodegenerative diseases |
| GB201214106D0 (en) * | 2012-08-07 | 2012-09-19 | Univ Strathclyde | Immunomodulatory compounds |
| EP3436013A4 (en) | 2016-03-31 | 2019-11-13 | Versi Group, LLC | DELTA OPIOID AGONIST, MU OPIOID ANTAGONIST COMPOSITIONS AND METHOD FOR TREATING MORBUS PARKINSON |
| CN106866582A (zh) * | 2017-01-10 | 2017-06-20 | 广州隽沐生物科技有限公司 | 一种氟班色林中间体的制备方法 |
| JP7175034B2 (ja) * | 2018-06-26 | 2022-11-18 | チョーチヤン ビムグリーン ファーマシューティカルズ、リミテッド | Ａ２ａ受容体拮抗薬として用いられるトリアゾロトリアジン誘導体 |
| US12325708B2 (en) | 2019-05-03 | 2025-06-10 | Nektar Therapeutics | Adenosine 2 receptor antagonists |
| EP4083044A4 (en) * | 2019-12-26 | 2024-03-27 | Zhejiang Vimgreen Pharmaceuticals, Ltd | USE OF TRIAZOLOTRIAZINE DERIVATIVES TO TREAT DISEASES |
| EP4326724A4 (en) * | 2021-04-23 | 2025-03-26 | Chong Kun Dang Pharmaceutical Corp. | COMPOUND CONSTITUTING AN ANTAGONIST OF THE ADENOSINE A2A RECEPTOR AND PHARMACEUTICAL COMPOSITION COMPRISING SAME |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1264901B1 (it) | 1993-06-29 | 1996-10-17 | Schering Plough S P A | Analoghi eterociclici di 1,2,4-triazolo(15-c)pirimidine ad attivita' antagonista per il recettore a2 dell'adenosina |
| US5565460A (en) * | 1993-07-27 | 1996-10-15 | Kyowa Hakko Koygo Co., Ltd. | Therapeutic purine agents for parkinson's disease |
| IT1277392B1 (it) | 1995-07-28 | 1997-11-10 | Schering Plough S P A | Analoghi eterociclici di 1,2,4-triazolo(1,5-c]pirimidine ad attivita' antagonista per il recettore a2a dell'adenosina |
| WO1998042711A1 (en) * | 1997-03-24 | 1998-10-01 | Kyowa Hakko Kogyo Co., Ltd. | [1,2,4]TRIAZOLO[1,5-c]PYRIMIDINE DERIVATIVES |
| IT1291372B1 (it) | 1997-05-21 | 1999-01-07 | Schering Plough S P A | Uso di analoghi eterociclici di 1,2,4-triazolo (1,5-c) pirimidine per la preparazione di medicamenti utili per il trattamento delle malattie |
| AU2639299A (en) | 1998-02-24 | 1999-09-15 | Kyowa Hakko Kogyo Co. Ltd. | Remedies/preventives for parkinson's disease |
| KR20010087361A (ko) * | 1998-09-22 | 2001-09-15 | 히라타 다다시 | [1,2,4]트리아졸로[1,5-ｃ]피리미딘 유도체 |
| US6355653B1 (en) | 1999-09-06 | 2002-03-12 | Hoffmann-La Roche Inc. | Amino-triazolopyridine derivatives |
| JP2002037787A (ja) * | 2000-05-16 | 2002-02-06 | Kyowa Hakko Kogyo Co Ltd | ［１，２，４］トリアゾロ［１，５−ｃ］ピリミジン誘導体の製造法 |
| PT1283839E (pt) | 2000-05-26 | 2005-08-31 | Schering Corp | Antagonistas do receptor a2a da adenosina |
| JP4545437B2 (ja) * | 2001-10-15 | 2010-09-15 | シェーリング コーポレイション | アデノシンａ２ａ受容体アンタゴニストとしてのイミダゾ（４，３−ｅ）−１，２，４−トリアゾロ（１，５−ｃ）ピリミジン |
| CA2468658C (en) * | 2001-11-30 | 2009-04-14 | Schering Corporation | [1,2,4]-triazole bicyclic adenosine a2a receptor antagonists |
-
2002
- 2002-11-26 CA CA002468658A patent/CA2468658C/en not_active Expired - Fee Related
- 2002-11-26 US US10/304,939 patent/US6875772B2/en not_active Expired - Lifetime
- 2002-11-26 JP JP2003549353A patent/JP4429724B2/ja not_active Expired - Fee Related
- 2002-11-26 HU HU0402324A patent/HUP0402324A3/hu unknown
- 2002-11-26 EP EP02789893A patent/EP1453836B1/en not_active Expired - Lifetime
- 2002-11-26 IL IL16157302A patent/IL161573A0/xx unknown
- 2002-11-26 WO PCT/US2002/037915 patent/WO2003048163A1/en not_active Ceased
- 2002-11-26 MX MXPA04005158A patent/MXPA04005158A/es active IP Right Grant
- 2002-11-26 ES ES02789893T patent/ES2283625T3/es not_active Expired - Lifetime
- 2002-11-26 AU AU2002352933A patent/AU2002352933A1/en not_active Abandoned
- 2002-11-26 AT AT02789893T patent/ATE358130T1/de not_active IP Right Cessation
- 2002-11-26 DE DE60219196T patent/DE60219196T2/de not_active Expired - Lifetime
- 2002-11-26 KR KR1020047007953A patent/KR20050044600A/ko not_active Withdrawn
- 2002-11-26 CN CNA028239679A patent/CN1688581A/zh active Pending
- 2002-11-27 AR ARP020104562A patent/AR037681A1/es unknown
- 2002-11-27 TW TW091134487A patent/TW200300689A/zh unknown
- 2002-11-28 PE PE2002001149A patent/PE20030653A1/es not_active Application Discontinuation
-
2004
- 2004-05-27 ZA ZA200404168A patent/ZA200404168B/en unknown
- 2004-10-26 US US10/973,642 patent/US7078408B2/en not_active Expired - Lifetime
-
2009
- 2009-10-26 JP JP2009245977A patent/JP2010018634A/ja not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| CN1688581A (zh) | 2005-10-26 |
| EP1453836B1 (en) | 2007-03-28 |
| HUP0402324A2 (hu) | 2005-02-28 |
| EP1453836A1 (en) | 2004-09-08 |
| HUP0402324A3 (en) | 2008-09-29 |
| DE60219196D1 (de) | 2007-05-10 |
| PE20030653A1 (es) | 2003-08-04 |
| ES2283625T3 (es) | 2007-11-01 |
| US7078408B2 (en) | 2006-07-18 |
| DE60219196T2 (de) | 2008-01-03 |
| US6875772B2 (en) | 2005-04-05 |
| JP2010018634A (ja) | 2010-01-28 |
| JP4429724B2 (ja) | 2010-03-10 |
| US20030191130A1 (en) | 2003-10-09 |
| US20050113380A1 (en) | 2005-05-26 |
| AR037681A1 (es) | 2004-12-01 |
| TW200300689A (en) | 2003-06-16 |
| HK1064097A1 (en) | 2005-01-21 |
| KR20050044600A (ko) | 2005-05-12 |
| ATE358130T1 (de) | 2007-04-15 |
| CA2468658C (en) | 2009-04-14 |
| AU2002352933A1 (en) | 2003-06-17 |
| IL161573A0 (en) | 2004-09-27 |
| WO2003048163A1 (en) | 2003-06-12 |
| CA2468658A1 (en) | 2003-06-12 |
| JP2005511697A (ja) | 2005-04-28 |
| ZA200404168B (en) | 2005-09-02 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant or registration |