MXPA04004741A - Derivados de tiazol que tienen actividad antagonista, agonista o agonista parcial alcanabinoide1. - Google Patents

Derivados de tiazol que tienen actividad antagonista, agonista o agonista parcial alcanabinoide1.

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Publication number
MXPA04004741A
MXPA04004741A MXPA04004741A MXPA04004741A MXPA04004741A MX PA04004741 A MXPA04004741 A MX PA04004741A MX PA04004741 A MXPA04004741 A MX PA04004741A MX PA04004741 A MXPA04004741 A MX PA04004741A MX PA04004741 A MXPA04004741 A MX PA04004741A
Authority
MX
Mexico
Prior art keywords
thiazole derivatives
agonists
cannabinoid
receptor
compounds
Prior art date
Application number
MXPA04004741A
Other languages
English (en)
Inventor
Andrew C Maccreary
Original Assignee
Solvay Pharm Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Solvay Pharm Bv filed Critical Solvay Pharm Bv
Publication of MXPA04004741A publication Critical patent/MXPA04004741A/es

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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
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    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2

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Abstract

La presente invencion se refiere a un grupo de derivados de tiazol los cuales son potentes antagonistas, agonistas o agonistas parciales del receptor de canabinoide CB1; los compuestos tienen la formula general (I) ver formula (I), en donde R y R1-R4 tienen los significados dados en la especificacion.
MXPA04004741A 2002-03-18 2003-03-17 Derivados de tiazol que tienen actividad antagonista, agonista o agonista parcial alcanabinoide1. MXPA04004741A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP02076481 2002-03-18
PCT/EP2003/050063 WO2003078413A1 (en) 2002-03-18 2003-03-17 Thiazole derivatives having cb1-antagonistic, agonistic or partial agonistic activity

Publications (1)

Publication Number Publication Date
MXPA04004741A true MXPA04004741A (es) 2004-08-02

Family

ID=27838121

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA04004741A MXPA04004741A (es) 2002-03-18 2003-03-17 Derivados de tiazol que tienen actividad antagonista, agonista o agonista parcial alcanabinoide1.

Country Status (18)

Country Link
US (1) US7342032B2 (es)
EP (1) EP1492779A1 (es)
JP (2) JP2005529855A (es)
KR (1) KR100942672B1 (es)
CN (2) CN101550114A (es)
AR (1) AR038966A1 (es)
AU (1) AU2003219164B2 (es)
BR (1) BR0306150A (es)
CA (1) CA2462692C (es)
HR (1) HRP20040274A2 (es)
IL (2) IL160945A0 (es)
MX (1) MXPA04004741A (es)
NO (1) NO329617B1 (es)
PL (1) PL371429A1 (es)
RU (1) RU2301804C2 (es)
UA (1) UA77280C2 (es)
WO (1) WO2003078413A1 (es)
ZA (1) ZA200404742B (es)

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US7342032B2 (en) 2008-03-11
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