MXPA02012420A - Proceso para preparar derivados de pirazolopirimidinona para el tratamiento de la impotencia. - Google Patents
Proceso para preparar derivados de pirazolopirimidinona para el tratamiento de la impotencia.Info
- Publication number
- MXPA02012420A MXPA02012420A MXPA02012420A MXPA02012420A MXPA02012420A MX PA02012420 A MXPA02012420 A MX PA02012420A MX PA02012420 A MXPA02012420 A MX PA02012420A MX PA02012420 A MXPA02012420 A MX PA02012420A MX PA02012420 A MXPA02012420 A MX PA02012420A
- Authority
- MX
- Mexico
- Prior art keywords
- impotence
- treatment
- pyrazolopyrimidinone derivatives
- preparing
- derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
La presente invencion se relaciona con un metodo para preparar derivados de pirazolopirimidinona y sus sales farmaceuticamente aceptables que tienen eficacia para el tratamiento de la impotencia, una de las disfunciones sexuales masculinas. El metodo de conformidad con la presente invencion comprende los pasos de clorosulfonacion de pirazolamida, seguido por la aminacion con amina y la ciclizacion intramolecular. El metodo provee los derivados de pirazolopirimidinona y sus sales farmaceuticamente aceptables con alto rendimiento y de manera economica.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR10-2000-0034966A KR100377782B1 (ko) | 2000-06-23 | 2000-06-23 | 발기부전 치료에 효과를 갖는 피라졸로피리미디논화합물의 제조방법 |
PCT/KR2001/000819 WO2001098304A1 (en) | 2000-06-23 | 2001-05-18 | A process for preparing pyrazolopyrimidinone derivatives for the treatment of impotence |
Publications (1)
Publication Number | Publication Date |
---|---|
MXPA02012420A true MXPA02012420A (es) | 2004-02-26 |
Family
ID=36087864
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MXPA02012420A MXPA02012420A (es) | 2000-06-23 | 2001-05-18 | Proceso para preparar derivados de pirazolopirimidinona para el tratamiento de la impotencia. |
Country Status (19)
Country | Link |
---|---|
US (1) | US6844436B2 (es) |
EP (1) | EP1299389B1 (es) |
JP (1) | JP3939646B2 (es) |
KR (1) | KR100377782B1 (es) |
CN (1) | CN1217946C (es) |
AT (1) | ATE341549T1 (es) |
AU (2) | AU2001258896B2 (es) |
BR (1) | BRPI0111793B8 (es) |
CA (1) | CA2413761C (es) |
CY (1) | CY1105769T1 (es) |
DE (1) | DE60123616T2 (es) |
DK (1) | DK1299389T3 (es) |
ES (1) | ES2272475T3 (es) |
HK (1) | HK1055732A1 (es) |
MX (1) | MXPA02012420A (es) |
NZ (1) | NZ523238A (es) |
PT (1) | PT1299389E (es) |
RU (1) | RU2236410C2 (es) |
WO (1) | WO2001098304A1 (es) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR100377782B1 (ko) * | 2000-06-23 | 2003-03-29 | 동아제약 주식회사 | 발기부전 치료에 효과를 갖는 피라졸로피리미디논화합물의 제조방법 |
CN100374441C (zh) | 2003-06-06 | 2008-03-12 | 天津倍方科技发展有限公司 | 二氢吡咯[2,3-d]嘧啶-4-酮衍生物,其制备方法及其制药用途 |
EP1888074B1 (en) | 2005-06-10 | 2011-12-21 | Dong-A Pharmaceutical Co., Ltd. | Agent for the prevention and treatment of liver diseases containing pyrazolopyrimidine derivative |
KR100963644B1 (ko) | 2007-11-23 | 2010-06-15 | 한국과학기술연구원 | 피라졸로피리미딘온 유도체 및 그의 제조방법 |
CA3201054A1 (en) | 2020-12-11 | 2022-06-16 | Yoon-Suk Lee | Novel compounds as androgen receptor and phosphodiesterase dual inhibitor |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9013750D0 (en) | 1990-06-20 | 1990-08-08 | Pfizer Ltd | Therapeutic agents |
GB9119704D0 (en) | 1991-09-14 | 1991-10-30 | Pfizer Ltd | Therapeutic agents |
TR199902646T2 (xx) * | 1997-04-25 | 2000-05-22 | Pfizer Inc. | Seks�el bozuklu�un tedavisi i�in pirazolopirimidinonlar. |
GB9708831D0 (en) | 1997-04-30 | 1997-06-25 | Unilever Plc | Suspensions with high storage stability, comprising an aqueous silicate solution and filler material |
CA2342830C (en) * | 1998-09-04 | 2008-11-25 | Ortho-Mcneil Pharmaceutical, Inc. | 5-heterocyclyl pyrazolo[4,3-d]pyrimidin-7-ones for the treatment of male erectile dysfunction |
KR100353014B1 (ko) * | 1998-11-11 | 2002-09-18 | 동아제약 주식회사 | 발기부전 치료에 효과를 갖는 피라졸로피리미디논 화합물 |
EP1002798A1 (en) * | 1998-11-20 | 2000-05-24 | Orchid Chemicals & Pharmaceuticals Ltd. | An improved process for preparing a therapeutically active pyrazolopyrimidinone derivative |
KR100377782B1 (ko) * | 2000-06-23 | 2003-03-29 | 동아제약 주식회사 | 발기부전 치료에 효과를 갖는 피라졸로피리미디논화합물의 제조방법 |
-
2000
- 2000-06-23 KR KR10-2000-0034966A patent/KR100377782B1/ko active IP Right Grant
-
2001
- 2001-05-18 CN CN018114008A patent/CN1217946C/zh not_active Expired - Lifetime
- 2001-05-18 CA CA002413761A patent/CA2413761C/en not_active Expired - Lifetime
- 2001-05-18 JP JP2002504260A patent/JP3939646B2/ja not_active Expired - Lifetime
- 2001-05-18 AU AU2001258896A patent/AU2001258896B2/en not_active Expired
- 2001-05-18 PT PT01932366T patent/PT1299389E/pt unknown
- 2001-05-18 DE DE60123616T patent/DE60123616T2/de not_active Expired - Lifetime
- 2001-05-18 ES ES01932366T patent/ES2272475T3/es not_active Expired - Lifetime
- 2001-05-18 AT AT01932366T patent/ATE341549T1/de active
- 2001-05-18 RU RU2003101910/04A patent/RU2236410C2/ru active
- 2001-05-18 EP EP01932366A patent/EP1299389B1/en not_active Expired - Lifetime
- 2001-05-18 US US10/311,397 patent/US6844436B2/en not_active Expired - Lifetime
- 2001-05-18 WO PCT/KR2001/000819 patent/WO2001098304A1/en active IP Right Grant
- 2001-05-18 BR BRPI0111793-9 patent/BRPI0111793B8/pt not_active IP Right Cessation
- 2001-05-18 DK DK01932366T patent/DK1299389T3/da active
- 2001-05-18 MX MXPA02012420A patent/MXPA02012420A/es active IP Right Grant
- 2001-05-18 AU AU5889601A patent/AU5889601A/xx not_active Withdrawn
- 2001-05-18 NZ NZ523238A patent/NZ523238A/en not_active IP Right Cessation
-
2003
- 2003-11-06 HK HK03108011A patent/HK1055732A1/xx not_active IP Right Cessation
-
2006
- 2006-11-09 CY CY20061101614T patent/CY1105769T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
EP1299389B1 (en) | 2006-10-04 |
US6844436B2 (en) | 2005-01-18 |
BR0111793A (pt) | 2003-05-27 |
US20030176696A1 (en) | 2003-09-18 |
WO2001098304A1 (en) | 2001-12-27 |
CA2413761A1 (en) | 2001-12-27 |
PT1299389E (pt) | 2006-12-29 |
JP2004501155A (ja) | 2004-01-15 |
DK1299389T3 (da) | 2007-02-05 |
BRPI0111793B1 (pt) | 2019-07-16 |
JP3939646B2 (ja) | 2007-07-04 |
ES2272475T3 (es) | 2007-05-01 |
EP1299389A1 (en) | 2003-04-09 |
NZ523238A (en) | 2003-11-28 |
EP1299389A4 (en) | 2005-02-02 |
HK1055732A1 (en) | 2004-01-21 |
KR100377782B1 (ko) | 2003-03-29 |
CN1441802A (zh) | 2003-09-10 |
KR20020001041A (ko) | 2002-01-09 |
RU2236410C2 (ru) | 2004-09-20 |
CA2413761C (en) | 2007-09-04 |
CN1217946C (zh) | 2005-09-07 |
DE60123616T2 (de) | 2007-01-18 |
CY1105769T1 (el) | 2011-02-02 |
ATE341549T1 (de) | 2006-10-15 |
DE60123616D1 (de) | 2006-11-16 |
AU2001258896B2 (en) | 2005-12-08 |
AU5889601A (en) | 2002-01-02 |
BRPI0111793B8 (pt) | 2021-05-25 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG | Grant or registration | ||
GB | Transfer or rights | ||
HC | Change of company name or juridical status |