BR0111793A - Método para preparação de derivados de pirazolopirimidinona para o tratamento de impotência - Google Patents
Método para preparação de derivados de pirazolopirimidinona para o tratamento de impotênciaInfo
- Publication number
- BR0111793A BR0111793A BR0111793-9A BRPI0111793A BR0111793A BR 0111793 A BR0111793 A BR 0111793A BR PI0111793 A BRPI0111793 A BR PI0111793A BR 0111793 A BR0111793 A BR 0111793A
- Authority
- BR
- Brazil
- Prior art keywords
- treatment
- impotence
- preparing
- derivatives
- pharmaceutically acceptable
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 5
- DOTPSQVYOBAWPQ-UHFFFAOYSA-N pyrazolo[4,3-d]pyrimidin-3-one Chemical class N1=CN=C2C(=O)N=NC2=C1 DOTPSQVYOBAWPQ-UHFFFAOYSA-N 0.000 title abstract 3
- 201000001881 impotence Diseases 0.000 title abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- BNYCHCAYYYRJSH-UHFFFAOYSA-N 1h-pyrazole-5-carboxamide Chemical compound NC(=O)C1=CC=NN1 BNYCHCAYYYRJSH-UHFFFAOYSA-N 0.000 abstract 1
- 206010057672 Male sexual dysfunction Diseases 0.000 abstract 1
- 238000005576 amination reaction Methods 0.000 abstract 1
- 150000001412 amines Chemical class 0.000 abstract 1
- 238000003402 intramolecular cyclocondensation reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
"MéTODO PARA PREPARAçãO DE DERIVADOS DE PIRAZOLO- PIRIMIDINONA PARA TRATAMENTO DE IMPOTêNCIA". A presente invenção se refere ao método para preparação de pirazolopirimidinona e seus sais farmaceuticamente aceitáveis tendo eficácia no tratamento de impotênica, uma das disfunções sexuais masculinas. O método de acordo com a presente invenção compreende as etapas de clorosulfonatação de pirazolamida, seguido por aminação com amina e ciclização intramolecular. O método provê derivados pirazolopirimidinona e seus sais farmaceuticamente aceitáveis com alto rendimento e de uma maneira económica.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR2000/34966 | 2000-06-23 | ||
| KR10-2000-0034966A KR100377782B1 (ko) | 2000-06-23 | 2000-06-23 | 발기부전 치료에 효과를 갖는 피라졸로피리미디논화합물의 제조방법 |
| PCT/KR2001/000819 WO2001098304A1 (en) | 2000-06-23 | 2001-05-18 | A process for preparing pyrazolopyrimidinone derivatives for the treatment of impotence |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| BR0111793A true BR0111793A (pt) | 2003-05-27 |
| BRPI0111793B1 BRPI0111793B1 (pt) | 2019-07-16 |
| BRPI0111793B8 BRPI0111793B8 (pt) | 2021-05-25 |
Family
ID=36087864
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0111793-9 BRPI0111793B8 (pt) | 2000-06-23 | 2001-05-18 | método para preparação de derivados de pirazolopirimidinona para o tratamento de impotência |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US6844436B2 (pt) |
| EP (1) | EP1299389B1 (pt) |
| JP (1) | JP3939646B2 (pt) |
| KR (1) | KR100377782B1 (pt) |
| CN (1) | CN1217946C (pt) |
| AT (1) | ATE341549T1 (pt) |
| AU (2) | AU2001258896B2 (pt) |
| BR (1) | BRPI0111793B8 (pt) |
| CA (1) | CA2413761C (pt) |
| CY (1) | CY1105769T1 (pt) |
| DE (1) | DE60123616T2 (pt) |
| DK (1) | DK1299389T3 (pt) |
| ES (1) | ES2272475T3 (pt) |
| HK (1) | HK1055732A1 (pt) |
| MX (1) | MXPA02012420A (pt) |
| NZ (1) | NZ523238A (pt) |
| PT (1) | PT1299389E (pt) |
| RU (1) | RU2236410C2 (pt) |
| WO (1) | WO2001098304A1 (pt) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100377782B1 (ko) * | 2000-06-23 | 2003-03-29 | 동아제약 주식회사 | 발기부전 치료에 효과를 갖는 피라졸로피리미디논화합물의 제조방법 |
| CN100374441C (zh) | 2003-06-06 | 2008-03-12 | 天津倍方科技发展有限公司 | 二氢吡咯[2，3-d]嘧啶-4-酮衍生物，其制备方法及其制药用途 |
| EP1888074B1 (en) | 2005-06-10 | 2011-12-21 | Dong-A Pharmaceutical Co., Ltd. | Agent for the prevention and treatment of liver diseases containing pyrazolopyrimidine derivative |
| KR100963644B1 (ko) | 2007-11-23 | 2010-06-15 | 한국과학기술연구원 | 피라졸로피리미딘온 유도체 및 그의 제조방법 |
| CA3201054A1 (en) | 2020-12-11 | 2022-06-16 | Yoon-Suk Lee | Novel compounds as androgen receptor and phosphodiesterase dual inhibitor |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9013750D0 (en) | 1990-06-20 | 1990-08-08 | Pfizer Ltd | Therapeutic agents |
| GB9119704D0 (en) | 1991-09-14 | 1991-10-30 | Pfizer Ltd | Therapeutic agents |
| TR199902646T2 (xx) * | 1997-04-25 | 2000-05-22 | Pfizer Inc. | Seks�el bozuklu�un tedavisi i�in pirazolopirimidinonlar. |
| GB9708831D0 (en) | 1997-04-30 | 1997-06-25 | Unilever Plc | Suspensions with high storage stability, comprising an aqueous silicate solution and filler material |
| CA2342830C (en) * | 1998-09-04 | 2008-11-25 | Ortho-Mcneil Pharmaceutical, Inc. | 5-heterocyclyl pyrazolo[4,3-d]pyrimidin-7-ones for the treatment of male erectile dysfunction |
| KR100353014B1 (ko) * | 1998-11-11 | 2002-09-18 | 동아제약 주식회사 | 발기부전 치료에 효과를 갖는 피라졸로피리미디논 화합물 |
| EP1002798A1 (en) * | 1998-11-20 | 2000-05-24 | Orchid Chemicals & Pharmaceuticals Ltd. | An improved process for preparing a therapeutically active pyrazolopyrimidinone derivative |
| KR100377782B1 (ko) * | 2000-06-23 | 2003-03-29 | 동아제약 주식회사 | 발기부전 치료에 효과를 갖는 피라졸로피리미디논화합물의 제조방법 |
-
2000
- 2000-06-23 KR KR10-2000-0034966A patent/KR100377782B1/ko active IP Right Grant
-
2001
- 2001-05-18 CN CN018114008A patent/CN1217946C/zh not_active Expired - Lifetime
- 2001-05-18 CA CA002413761A patent/CA2413761C/en not_active Expired - Lifetime
- 2001-05-18 JP JP2002504260A patent/JP3939646B2/ja not_active Expired - Lifetime
- 2001-05-18 AU AU2001258896A patent/AU2001258896B2/en not_active Expired
- 2001-05-18 PT PT01932366T patent/PT1299389E/pt unknown
- 2001-05-18 DE DE60123616T patent/DE60123616T2/de not_active Expired - Lifetime
- 2001-05-18 ES ES01932366T patent/ES2272475T3/es not_active Expired - Lifetime
- 2001-05-18 AT AT01932366T patent/ATE341549T1/de active
- 2001-05-18 RU RU2003101910/04A patent/RU2236410C2/ru active
- 2001-05-18 EP EP01932366A patent/EP1299389B1/en not_active Expired - Lifetime
- 2001-05-18 US US10/311,397 patent/US6844436B2/en not_active Expired - Lifetime
- 2001-05-18 WO PCT/KR2001/000819 patent/WO2001098304A1/en active IP Right Grant
- 2001-05-18 BR BRPI0111793-9 patent/BRPI0111793B8/pt not_active IP Right Cessation
- 2001-05-18 DK DK01932366T patent/DK1299389T3/da active
- 2001-05-18 MX MXPA02012420A patent/MXPA02012420A/es active IP Right Grant
- 2001-05-18 AU AU5889601A patent/AU5889601A/xx not_active Withdrawn
- 2001-05-18 NZ NZ523238A patent/NZ523238A/en not_active IP Right Cessation
-
2003
- 2003-11-06 HK HK03108011A patent/HK1055732A1/xx not_active IP Right Cessation
-
2006
- 2006-11-09 CY CY20061101614T patent/CY1105769T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP1299389B1 (en) | 2006-10-04 |
| US6844436B2 (en) | 2005-01-18 |
| MXPA02012420A (es) | 2004-02-26 |
| US20030176696A1 (en) | 2003-09-18 |
| WO2001098304A1 (en) | 2001-12-27 |
| CA2413761A1 (en) | 2001-12-27 |
| PT1299389E (pt) | 2006-12-29 |
| JP2004501155A (ja) | 2004-01-15 |
| DK1299389T3 (da) | 2007-02-05 |
| BRPI0111793B1 (pt) | 2019-07-16 |
| JP3939646B2 (ja) | 2007-07-04 |
| ES2272475T3 (es) | 2007-05-01 |
| EP1299389A1 (en) | 2003-04-09 |
| NZ523238A (en) | 2003-11-28 |
| EP1299389A4 (en) | 2005-02-02 |
| HK1055732A1 (en) | 2004-01-21 |
| KR100377782B1 (ko) | 2003-03-29 |
| CN1441802A (zh) | 2003-09-10 |
| KR20020001041A (ko) | 2002-01-09 |
| RU2236410C2 (ru) | 2004-09-20 |
| CA2413761C (en) | 2007-09-04 |
| CN1217946C (zh) | 2005-09-07 |
| DE60123616T2 (de) | 2007-01-18 |
| CY1105769T1 (el) | 2011-02-02 |
| ATE341549T1 (de) | 2006-10-15 |
| DE60123616D1 (de) | 2006-11-16 |
| AU2001258896B2 (en) | 2005-12-08 |
| AU5889601A (en) | 2002-01-02 |
| BRPI0111793B8 (pt) | 2021-05-25 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
| B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
| B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] |
Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI |
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| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 14A ANUIDADE. |
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| B08G | Application fees: restoration [chapter 8.7 patent gazette] | ||
| B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
| B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] |
Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 16/07/2019, OBSERVADAS AS CONDICOES LEGAIS. (CO) 10 (DEZ) ANOS CONTADOS A PARTIR DE 16/07/2019, OBSERVADAS AS CONDICOES LEGAIS |
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| B16C | Correction of notification of the grant [chapter 16.3 patent gazette] |
Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 18/05/2001 OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF |
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| B21F | Lapse acc. art. 78, item iv - on non-payment of the annual fees in time |
Free format text: REFERENTE A 22A ANUIDADE. |
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| B24J | Lapse because of non-payment of annual fees (definitively: art 78 iv lpi, resolution 113/2013 art. 12) |
Free format text: EM VIRTUDE DA EXTINCAO PUBLICADA NA RPI 2724 DE 21-03-2023 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDA A EXTINCAO DA PATENTE E SEUS CERTIFICADOS, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013. |