MXPA02003118A - Metodos para reducir los niveles de glucosa y trigliceridos en suero, y para inhibir la angiogenesis utilizando acidos indolalcanoicos substituidos. - Google Patents

Metodos para reducir los niveles de glucosa y trigliceridos en suero, y para inhibir la angiogenesis utilizando acidos indolalcanoicos substituidos.

Info

Publication number
MXPA02003118A
MXPA02003118A MXPA02003118A MXPA02003118A MXPA02003118A MX PA02003118 A MXPA02003118 A MX PA02003118A MX PA02003118 A MXPA02003118 A MX PA02003118A MX PA02003118 A MXPA02003118 A MX PA02003118A MX PA02003118 A MXPA02003118 A MX PA02003118A
Authority
MX
Mexico
Prior art keywords
methods
triglyceride levels
serum glucose
reducing serum
inhibiting angiogenesis
Prior art date
Application number
MXPA02003118A
Other languages
English (en)
Inventor
Janet Sredy
Original Assignee
Inst For Pharm Discovery Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Inst For Pharm Discovery Inc filed Critical Inst For Pharm Discovery Inc
Publication of MXPA02003118A publication Critical patent/MXPA02003118A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/428—Thiazoles condensed with carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Vascular Medicine (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Urology & Nephrology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

Se describen metodos para reducir niveles de glucosa y trigliceridos en suero y para inhibir angiogenesis, los metodos comprenden la administracion de acidos indolalcanoicos sustituidos a pacientes que requeiran de tal tratamiento. Se describen tambien compuestos utiles en el tratamiento de angiogenesis, hiperglucemia, hiperlipidemia y complicaciones cronicas que se originan de diabetes mellitus. Tambien se describen composiciones farmaceuticas que contienen los compuestos.
MXPA02003118A 1998-12-01 1999-12-01 Metodos para reducir los niveles de glucosa y trigliceridos en suero, y para inhibir la angiogenesis utilizando acidos indolalcanoicos substituidos. MXPA02003118A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11039598P 1998-12-01 1998-12-01
PCT/US1999/028483 WO2000032180A2 (en) 1998-12-01 1999-12-01 Antihypertriglyceridemic, antihyperglycemic, anti-angiogenic and wound healing substituted indolealkanoic acids

Publications (1)

Publication Number Publication Date
MXPA02003118A true MXPA02003118A (es) 2004-04-21

Family

ID=22332786

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA02003118A MXPA02003118A (es) 1998-12-01 1999-12-01 Metodos para reducir los niveles de glucosa y trigliceridos en suero, y para inhibir la angiogenesis utilizando acidos indolalcanoicos substituidos.

Country Status (30)

Country Link
US (5) US6555568B1 (es)
EP (1) EP1135124B1 (es)
JP (1) JP2002531398A (es)
KR (1) KR20010086075A (es)
CN (1) CN1368883A (es)
AP (1) AP2001002146A0 (es)
AT (1) ATE265210T1 (es)
AU (1) AU770925B2 (es)
BG (1) BG105531A (es)
BR (1) BR9915882A (es)
CA (1) CA2385845A1 (es)
CZ (1) CZ20011864A3 (es)
DE (1) DE69916881T2 (es)
DZ (1) DZ2953A1 (es)
EE (1) EE200100296A (es)
HK (1) HK1046372A1 (es)
HU (1) HUP0104953A3 (es)
ID (1) ID30037A (es)
IL (1) IL143247A0 (es)
MX (1) MXPA02003118A (es)
NO (1) NO20012690L (es)
OA (1) OA12035A (es)
PL (1) PL349016A1 (es)
SK (1) SK7352001A3 (es)
TN (1) TNSN99224A1 (es)
TR (1) TR200101539T2 (es)
TW (1) TW584560B (es)
WO (1) WO2000032180A2 (es)
YU (1) YU40101A (es)
ZA (1) ZA200104126B (es)

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Also Published As

Publication number Publication date
US6555568B1 (en) 2003-04-29
CZ20011864A3 (cs) 2002-03-13
EP1135124B1 (en) 2004-04-28
US6964980B2 (en) 2005-11-15
US20030216452A1 (en) 2003-11-20
YU40101A (sh) 2005-07-19
ID30037A (id) 2001-11-01
EE200100296A (et) 2003-02-17
BR9915882A (pt) 2001-08-21
SK7352001A3 (en) 2002-06-04
EP1135124A2 (en) 2001-09-26
CN1368883A (zh) 2002-09-11
WO2000032180A2 (en) 2000-06-08
NO20012690D0 (no) 2001-05-31
BG105531A (en) 2001-12-31
CA2385845A1 (en) 2000-06-08
ATE265210T1 (de) 2004-05-15
TW584560B (en) 2004-04-21
HK1046372A1 (zh) 2003-01-10
AP2001002146A0 (en) 2001-06-30
WO2000032180A3 (en) 2000-11-16
DE69916881D1 (de) 2004-06-03
JP2002531398A (ja) 2002-09-24
PL349016A1 (en) 2002-06-17
HUP0104953A2 (hu) 2002-07-29
DE69916881T2 (de) 2005-02-03
HUP0104953A3 (en) 2002-08-28
DZ2953A1 (fr) 2004-03-15
US20120065203A1 (en) 2012-03-15
IL143247A0 (en) 2002-04-21
TNSN99224A1 (fr) 2005-11-10
ZA200104126B (en) 2002-05-21
AU2161600A (en) 2000-06-19
US20060074114A1 (en) 2006-04-06
US20100324105A1 (en) 2010-12-23
KR20010086075A (ko) 2001-09-07
TR200101539T2 (tr) 2001-12-21
NO20012690L (no) 2001-07-27
AU770925B2 (en) 2004-03-11
OA12035A (en) 2006-05-02

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