MXPA00002658A - Sales de adicion acida de alcaloides morfinicos y su aplicacion. - Google Patents

Sales de adicion acida de alcaloides morfinicos y su aplicacion.

Info

Publication number
MXPA00002658A
MXPA00002658A MXPA00002658A MXPA00002658A MXPA00002658A MX PA00002658 A MXPA00002658 A MX PA00002658A MX PA00002658 A MXPA00002658 A MX PA00002658A MX PA00002658 A MXPA00002658 A MX PA00002658A MX PA00002658 A MXPA00002658 A MX PA00002658A
Authority
MX
Mexico
Prior art keywords
substituted
acids
alternatively
group
amino
Prior art date
Application number
MXPA00002658A
Other languages
English (en)
Inventor
Thomas Hille
Original Assignee
Lohmann Therapie Syst Lts
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19834005A external-priority patent/DE19834005A1/de
Application filed by Lohmann Therapie Syst Lts filed Critical Lohmann Therapie Syst Lts
Publication of MXPA00002658A publication Critical patent/MXPA00002658A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone
    • C07D489/04—Salts; Organic complexes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A61P23/02—Local anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse

Abstract

Se proporciona una sustancia constituida por la sal de adicion acida de un alcaloide morfinico y un acido organico.El acido organico se selecciona entre: -monoesteres de acido dicarboxilicos C3- a C16- con alcoholes monovalentes C1-C4. Acido sulfonicos C2 a C16, acidos benzoicos substituidos, seleccionados del grupo de los acidos benzoicos halogeno-, hidroxi-, alquilo-, hidroxialquilo-, alcoxialquilo-y/o alcoxi - substituidos, asi como de los acidos benzoicos amino-substituidos alquilados opcionalmente en el atomo N, -heterociclos de 5 o 6 anillos con por lo menos un atomo N o un atomo N o un atomo S y una funcion de grupo carboxilo, acidos oxo- carboxilico saturados o no saturados, opcionalmente substituidos con 5 a 10 atomos de C, acidos carboxilicos C2 C4 saturados, fenilo-o fenoxi- substituidos, - aminacidos C2-12- alifaticos ,aromaticos o heterociclicos, donde se ha substituido un grupo amino por un grupo alcanoilo C2-C6 opcionalmente substituido o un grupo benzoilo opcionalmente substituidos.
MXPA00002658A 1997-09-25 1998-09-05 Sales de adicion acida de alcaloides morfinicos y su aplicacion. MXPA00002658A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE19742296 1997-09-25
DE19834005A DE19834005A1 (de) 1997-09-25 1998-07-29 Säureadditionssalze von Morphin-Alkaloiden und deren Verwendung
PCT/EP1998/005652 WO1999015528A1 (de) 1997-09-25 1998-09-05 Säureadditionssalze von morphin-alkaloiden und deren verwendung

Publications (1)

Publication Number Publication Date
MXPA00002658A true MXPA00002658A (es) 2004-03-10

Family

ID=26040297

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA00002658A MXPA00002658A (es) 1997-09-25 1998-09-05 Sales de adicion acida de alcaloides morfinicos y su aplicacion.

Country Status (20)

Country Link
EP (1) EP1017696B1 (es)
JP (1) JP2001517669A (es)
AT (1) ATE214702T1 (es)
AU (1) AU741434B2 (es)
CA (1) CA2304722C (es)
CZ (1) CZ300532B6 (es)
DK (1) DK1017696T3 (es)
ES (1) ES2174490T3 (es)
HU (1) HUP0003686A3 (es)
ID (1) ID26296A (es)
IL (1) IL134787A (es)
MX (1) MXPA00002658A (es)
NO (1) NO20001465L (es)
NZ (1) NZ503459A (es)
PL (1) PL193321B1 (es)
PT (1) PT1017696E (es)
SK (1) SK4322000A3 (es)
TR (1) TR200000653T2 (es)
TW (1) TW576836B (es)
WO (1) WO1999015528A1 (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9924797D0 (en) 1999-10-20 1999-12-22 West Pharm Serv Drug Res Ltd Compound
GB0218811D0 (en) * 2002-08-14 2002-09-18 Cenes Ltd Salts of morphine-6-glucuronide
DE102006054732B4 (de) 2006-11-21 2010-12-30 Lts Lohmann Therapie-Systeme Ag Transdermales therapeutisches System mit Ionenpaar-Mikroreservoiren
JP5544544B2 (ja) * 2008-08-05 2014-07-09 株式会社 メドレックス 塩基性薬効成分の脂肪酸塩、安息香酸塩を含有する外用剤とその製造方法
WO2013019825A1 (en) * 2011-08-02 2013-02-07 Mallinckrodt Llc Stepwise process for the production of alkaloid salts

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE524639C (de) * 1929-05-25 1931-05-09 Chem Fab Vorm Sandoz Verfahren zur Darstellung von leichtloeslichen Salzen des Benzylmorphons
DE728804C (de) * 1935-04-02 1942-12-03 Jean Lucien Regnier Verfahren zur Herstellung von Salzen des Morphins mit Aralkylcarbonsaeuren
DE1172267B (de) * 1961-09-19 1964-06-18 Dausse S A Lab Verfahren zur Herstellung des bis-guajakol-sulfonsauren Salzes des Morphin-ª‰-morpholyl-aethylaethers
FR6598M (es) * 1967-07-28 1969-01-06
US4626539A (en) * 1984-08-10 1986-12-02 E. I. Dupont De Nemours And Company Trandermal delivery of opioids
US4908389A (en) * 1986-08-27 1990-03-13 Warner-Lambert Company Penetration enhancement system
US4879297A (en) * 1987-06-01 1989-11-07 Warner-Lambert Company Fatty acids and their small chain esters as penetration enhancers in aqueous systems
US5374645A (en) * 1990-01-22 1994-12-20 Ciba-Geigy Corporation Transdermal administation of ionic pharmaceutically active agents via aqueous isopropanol
TW225536B (es) * 1990-08-23 1994-06-21 Ciba Geigy Ag
FR2708611B1 (fr) * 1993-07-29 1995-10-27 Meram Lab Sel de codéine de l'acide 2-(3-benzoylphényl)propionique, procédé d'obtention et compositions pharmaceutiques le contenant.
DE19607395C2 (de) * 1996-02-28 2002-11-21 Lohmann Therapie Syst Lts Salze aus einem kationischen narkotischen Analgetikum mit einem anionischen nichtnarkotischen Analgetikum, Verfahren zu deren Herstellung und die diese Salze enthaltenden pharmazeutischen Präparate

Also Published As

Publication number Publication date
NO20001465D0 (no) 2000-03-21
EP1017696A1 (de) 2000-07-12
SK4322000A3 (en) 2000-10-09
PT1017696E (pt) 2002-09-30
PL193321B1 (pl) 2007-01-31
EP1017696B1 (de) 2002-03-20
CA2304722A1 (en) 1999-04-01
AU9266698A (en) 1999-04-12
HUP0003686A2 (hu) 2001-09-28
IL134787A0 (en) 2001-04-30
AU741434B2 (en) 2001-11-29
NZ503459A (en) 2001-12-21
JP2001517669A (ja) 2001-10-09
PL339516A1 (en) 2000-12-18
NO20001465L (no) 2000-03-21
TR200000653T2 (tr) 2000-07-21
ES2174490T3 (es) 2002-11-01
ID26296A (id) 2000-12-14
DK1017696T3 (da) 2002-07-08
IL134787A (en) 2007-05-15
HUP0003686A3 (en) 2003-04-28
CZ300532B6 (cs) 2009-06-10
ATE214702T1 (de) 2002-04-15
WO1999015528A1 (de) 1999-04-01
CA2304722C (en) 2005-11-22
TW576836B (en) 2004-02-21
CZ20001048A3 (cs) 2000-08-16

Similar Documents

Publication Publication Date Title
RU94028109A (ru) Новые замещенные салициловые кислоты, способ их получения
NL300251I2 (nl) Thiënyl-, furyl-, pyrrolyl- en bifenyl-sulfonamiden en derivaten voor het moduleren van de endotheline-activiteit.
DE3769618D1 (de) Durch ethinyl substituierte heteroaromatische saeuren mit retinoesaeureaehnlicher aktivitaet.
ES2058351T3 (es) Un procedimiento para producir una formulacion de liberacion sostenida que es adecuada para el uso humano y veterinario.
NO904377D0 (no) Tricykliske karbapenemforbindelser.
WO1999000116A3 (en) Carboxylic acids and derivatives thereof and pharmaceutical compositions containing them
EP0378936A3 (en) Use of salicylic-acid derivatives in the treatment of aging of the skin
CA2307551A1 (en) Pleuromutilin derivatives as antimicrobials
ZA928864B (en) Substituted salicylic acids.
NO177428C (no) Anvendelse av salter av metaller med carboxylsyrer for stabilisering av organopolysiloxanmasser
IE880293L (en) Adenosine 5'-carboxamides
PT1124893E (pt) Produtos de poliadicao de poliisocianatos
MXPA00002658A (es) Sales de adicion acida de alcaloides morfinicos y su aplicacion.
CA2313878A1 (en) Composition for suppressing behavior problems of pets
TR199902727T2 (xx) Aromatik s�lfonik asitlerin tuzlar�.
TW221431B (es)
MY128486A (en) Acid addition salts of morphine alkaloids and the use thereof
ES2115916T3 (es) Procedimiento para la preparacion de compuestos de triazolona.
ATE231491T1 (de) Inhibitor des erwerbs der abhängigkeit/resistenz gegen betäaubende analgetika
IL59992A0 (en) Morphinan-6-one derivatives and their use as medicines
EP0325428A3 (en) 6' carbamate esters of zearalanol and its derivatives
KR890002116A (ko) 7-(아자비스클로알킬)-퀴놀론카르복실산 및 7-(아자비시클로알킬)-나프티리돈카르복실산 유도체
EP0826663A3 (en) Alkynylamino acid derivatives and their use as pharmaceutical compounds
KR920021561A (ko) 신규의 세팔로스포린 및 그의 제조 방법

Legal Events

Date Code Title Description
FG Grant or registration