MX9804954A - Proceso para la preparacion de hidrazidas. - Google Patents

Proceso para la preparacion de hidrazidas.

Info

Publication number
MX9804954A
MX9804954A MX9804954A MX9804954A MX9804954A MX 9804954 A MX9804954 A MX 9804954A MX 9804954 A MX9804954 A MX 9804954A MX 9804954 A MX9804954 A MX 9804954A MX 9804954 A MX9804954 A MX 9804954A
Authority
MX
Mexico
Prior art keywords
substituted
aryl
alkyl
hydrazone
formula
Prior art date
Application number
MX9804954A
Other languages
English (en)
Inventor
William Leong
Lyman Smith
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Publication of MX9804954A publication Critical patent/MX9804954A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C241/00—Preparation of compounds containing chains of nitrogen atoms singly-bound to each other, e.g. hydrazines, triazanes
    • C07C241/04—Preparation of hydrazides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Abstract

Se da a conocer un proceso para producir una hidrazida de la formula (1.0). El proceso comprende hacer reaccionar una hidrazona de la formula (2.0) o (2.1), en donde la hidrazona está en tolueno, con una mezcla de reactivos de Grignard, en donde los reactivos de Grignard están en un solvente orgánico apropiado; en donde; (A) Z es un grupo protector de carbonilo apropiado; (B) R es un grupo protector de -OH apropiado; (C) R1 se selecciona de: H, un alquilo no enolizable; un alquilo substituido no enolizable; arilo; arilo substituido; -S-arilo; -S- (arilo substituido); -S-alquilo; -S-(alquilo substituido); alcoxi; alcoxi substituido; ariloxi; o ariloxi substituido; (D) la mezcla de reactivos de Grignard comprende R2MgX en mezcla con R3MgX; (E) R2 es alquilo apropiado, alquilo substituido, alquenilo, alquinilo, arilo, arilo substituido, o un grupo de aralquilo capaz de añadirse al grupo de -C=N de la hidrazona para producir la hidrazida; (F) R3 es un alquilo apropiado, alquilo substituido, arilo o grupo de arilo substituido que está más impedido estéricamente que el grupo R2; (G) X se selecciona independientemente de Cl, Br o I para cada reactivo de Grignard; (H) cuando la hidrazona es un compuesto de la Formula 2.0 entonces la reaccion se lleva a cabo a una temperatura de aproximadamente +30 a aproximadamente -40 degree C; y (I) cuando la hidrazona es un compuesto de la Formula 2.1 entonces la reaccion se lleva a cabo a una temperatura de aproximadamente +40 degree C a aproximadamente -20 degree C.
MX9804954A 1995-12-20 1998-06-19 Proceso para la preparacion de hidrazidas. MX9804954A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US57556195A 1995-12-20 1995-12-20

Publications (1)

Publication Number Publication Date
MX9804954A true MX9804954A (es) 1998-09-30

Family

ID=24300808

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9804954A MX9804954A (es) 1995-12-20 1998-06-19 Proceso para la preparacion de hidrazidas.

Country Status (18)

Country Link
EP (1) EP0874806B1 (es)
JP (1) JP2000502103A (es)
KR (1) KR20000064469A (es)
CN (1) CN1209116A (es)
AT (1) ATE207881T1 (es)
AU (1) AU716872B2 (es)
BR (1) BR9612046A (es)
CA (1) CA2240406A1 (es)
CZ (1) CZ187798A3 (es)
DE (1) DE69616596D1 (es)
HU (1) HUP9902115A3 (es)
IL (1) IL125007A (es)
MX (1) MX9804954A (es)
NO (1) NO310864B1 (es)
NZ (1) NZ324616A (es)
PL (1) PL327142A1 (es)
SK (1) SK85998A3 (es)
WO (1) WO1997022579A1 (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2012013331A (es) 2010-05-19 2013-02-01 Sandoz Ag Purificacion de posaconazol y de intermediarios de posaconazol.
MX337804B (es) 2010-05-19 2016-03-18 Sandoz Ag Proceso para la preparacion de hidrazinas quirales.
EP2571868B1 (en) 2010-05-19 2016-05-04 Sandoz AG Preparation of posaconazole intermediates
EP2571871B1 (en) 2010-05-19 2017-06-21 Sandoz AG Process for the preparation of chiral triazolones
WO2012172015A1 (en) 2011-06-16 2012-12-20 Sandoz Ag Process for the preparation of a chiral compound
FR3054218B1 (fr) * 2016-07-22 2020-03-06 Universite De Rouen Procede de dedoublement de sels de baclofene

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1064685C (zh) * 1993-12-21 2001-04-18 先灵公司 四氢呋喃抗真菌剂

Also Published As

Publication number Publication date
AU716872B2 (en) 2000-03-09
CN1209116A (zh) 1999-02-24
KR20000064469A (ko) 2000-11-06
DE69616596D1 (de) 2001-12-06
EP0874806A1 (en) 1998-11-04
HUP9902115A3 (en) 2000-06-28
PL327142A1 (en) 1998-11-23
IL125007A0 (en) 1999-01-26
IL125007A (en) 2001-09-13
JP2000502103A (ja) 2000-02-22
NO982876D0 (no) 1998-06-19
ATE207881T1 (de) 2001-11-15
NO982876L (no) 1998-08-19
BR9612046A (pt) 1999-02-09
HUP9902115A2 (hu) 1999-11-29
CZ187798A3 (cs) 1998-09-16
AU1150297A (en) 1997-07-14
CA2240406A1 (en) 1997-06-20
SK85998A3 (en) 1999-02-11
NO310864B1 (no) 2001-09-10
NZ324616A (en) 1999-05-28
EP0874806B1 (en) 2001-10-31
WO1997022579A1 (en) 1997-06-26

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