MX9709986A - N-hidroxiureas, su uso y composiciones antiiflamatorias que los contienen. - Google Patents
N-hidroxiureas, su uso y composiciones antiiflamatorias que los contienen.Info
- Publication number
- MX9709986A MX9709986A MX9709986A MX9709986A MX9709986A MX 9709986 A MX9709986 A MX 9709986A MX 9709986 A MX9709986 A MX 9709986A MX 9709986 A MX9709986 A MX 9709986A MX 9709986 A MX9709986 A MX 9709986A
- Authority
- MX
- Mexico
- Prior art keywords
- alkyl
- halo
- substituted
- alkoxy
- treatment
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D263/10—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D263/10—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D263/14—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/08—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D277/10—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Ciertos nuevos compuestos de N-hidroxiurea que tienen la capacidad de inhibir la enzima 5-lipooxigenasa y que tienen la siguiente formula (I): y sus sales farmacéuticamente aceptables en las que A es alquileno de C1-C4, CH(R), CH(R)CH2 o CH(R)CH2CH2, en los cuales R es metilo o etilo; m y n son cada uno cero o uno; R1 y R2 son cada uno hidrogeno, alquilo de C1-C4 o alquenilo de C2-C6; X es O u S; Y es O, S, CH-CH o C=_C; Ar1 es fenilo o fenilo monosustituido con halogeno, alquilo de C1-C4, alcoxi de C1-C4, alquilo de C1-C4 sustituido con halo o lacoxi de C1-C4 sustituido con halo; y AR2 es fenileno, piridileno o fenileno mono- o disustituido con halogeno, alquilo de C1-C4, alcoxi de C1-C4, alquilo de C1-C4 sustituido con halo alcoxi de C1-C4 sustituido con halo; estos compuestos son utiles en el tratamiento o alivio de enfermedades inflamatorias, alergia y enfermedades cardiovasculares en mamíferos y como el ingrediente activo en composiciones farmacéuticas para el tratamiento de tales trastornos.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP12810594A JP3179286B2 (ja) | 1994-05-19 | 1994-05-19 | Ｎ−ヒドロキシ尿素系抗炎症剤 |
| PCT/JP1995/001127 WO1996040659A1 (en) | 1994-05-19 | 1995-06-07 | N-hydroxyureas as antiinflammatory agents |
| CA002223023A CA2223023C (en) | 1994-05-19 | 1995-06-07 | N-hydroxyureas as antiinflammatory agents |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX9709986A true MX9709986A (es) | 1998-03-29 |
| MXPA97009986A MXPA97009986A (es) | 1998-10-15 |
Family
ID=
Also Published As
| Publication number | Publication date |
|---|---|
| NO310288B1 (no) | 2001-06-18 |
| JP3179286B2 (ja) | 2001-06-25 |
| AU2629495A (en) | 1996-12-30 |
| HUT77950A (hu) | 1998-12-28 |
| BR9502072A (pt) | 1996-04-09 |
| CA2223023A1 (en) | 1996-12-19 |
| DE69512940T2 (de) | 2000-02-17 |
| FI974444A7 (fi) | 1998-02-04 |
| PL179853B1 (pl) | 2000-11-30 |
| DK0832078T3 (da) | 2000-04-25 |
| JPH07309849A (ja) | 1995-11-28 |
| EP0832078A1 (en) | 1998-04-01 |
| GR3032301T3 (en) | 2000-04-27 |
| US5814648A (en) | 1998-09-29 |
| PL324012A1 (en) | 1998-04-27 |
| NO975726D0 (no) | 1997-12-05 |
| IL113706A (en) | 1999-08-17 |
| ATE185803T1 (de) | 1999-11-15 |
| CA2223023C (en) | 2001-07-17 |
| NZ287551A (en) | 1999-02-25 |
| EP0832078B1 (en) | 1999-10-20 |
| AU705505B2 (en) | 1999-05-27 |
| CZ382497A3 (cs) | 1999-03-17 |
| DE69512940D1 (de) | 1999-11-25 |
| WO1996040659A1 (en) | 1996-12-19 |
| NO975726L (no) | 1998-02-03 |
| IL113706A0 (en) | 1995-08-31 |
| JPH10506649A (ja) | 1998-06-30 |
| FI974444A0 (fi) | 1997-12-05 |
| FI974444L (fi) | 1998-02-04 |
| CZ286331B6 (cs) | 2000-03-15 |
| ES2138211T3 (es) | 2000-01-01 |
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