MX9305715A - Preparacion de intermediarios de beta-metil carbapenem. - Google Patents

Preparacion de intermediarios de beta-metil carbapenem.

Info

Publication number
MX9305715A
MX9305715A MX9305715A MX9305715A MX9305715A MX 9305715 A MX9305715 A MX 9305715A MX 9305715 A MX9305715 A MX 9305715A MX 9305715 A MX9305715 A MX 9305715A MX 9305715 A MX9305715 A MX 9305715A
Authority
MX
Mexico
Prior art keywords
intermediaries
beta
preparation
methyl carbapenem
formula
Prior art date
Application number
MX9305715A
Other languages
English (en)
Inventor
Paul J Reider
Andrew S Thompson
Ralph P Volante
Woo-Baeg Choi
Guy R Humphrey
Ichiro Shinkai
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of MX9305715A publication Critical patent/MX9305715A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

La presente invención se refiere a un procedimiento para producir un intermediario del 1-Beta-metil carbapenem de fórmula VI a partir de un compuesto de fórmula I: (Ver fórmula); en donde R y P' son grupos protectores, R1 es un éster de ácido metilmalónico y Nu es un grupo nucleofilico. También se describen intermediarios del procedimiento.
MX9305715A 1992-09-18 1993-09-17 Preparacion de intermediarios de beta-metil carbapenem. MX9305715A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US94718692A 1992-09-18 1992-09-18

Publications (1)

Publication Number Publication Date
MX9305715A true MX9305715A (es) 1994-03-31

Family

ID=25485687

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9305715A MX9305715A (es) 1992-09-18 1993-09-17 Preparacion de intermediarios de beta-metil carbapenem.

Country Status (24)

Country Link
US (2) US6242596B1 (es)
EP (1) EP0589626B1 (es)
JP (1) JP3252032B2 (es)
CN (2) CN1066438C (es)
AR (1) AR000394A2 (es)
AT (1) ATE214048T1 (es)
AU (1) AU667571B2 (es)
CA (1) CA2106248A1 (es)
CZ (1) CZ286267B6 (es)
DE (1) DE69331650T2 (es)
DK (1) DK0589626T3 (es)
ES (1) ES2173884T3 (es)
FI (1) FI951212A (es)
HK (1) HK1008336A1 (es)
HR (1) HRP931199B1 (es)
MX (1) MX9305715A (es)
PT (1) PT589626E (es)
RO (1) RO116087B1 (es)
RU (1) RU2130927C1 (es)
SI (1) SI9300486B (es)
SK (1) SK282164B6 (es)
TW (1) TW406073B (es)
UA (1) UA50705C2 (es)
WO (1) WO1994006764A1 (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1061233C (zh) * 1996-12-13 2001-01-31 高琳 一种保健口服液及其生产工艺
KR100335848B1 (ko) * 2000-03-31 2002-05-08 윤재승 아제티디논 유도체, 그 제조방법 및 이를 이용한1-β-알킬아제티디논의 제조방법
US6625203B2 (en) * 2001-04-30 2003-09-23 Interdigital Technology Corporation Fast joint detection
EP1878829A1 (de) 2006-07-12 2008-01-16 Papierfabriken Cham-Tenero AG Beschichtetes Trägerpapier

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1982001705A1 (en) * 1980-11-13 1982-05-27 Takeda Chemical Industries Ltd 4-substituted-2-oxoazetidine derivatives and process for their preparation
AU548727B2 (en) * 1981-03-12 1986-01-02 Gruppo Lepetit S.P.A. Beta-lactam acetic acid derivatives
US4576747A (en) * 1984-05-07 1986-03-18 The Upjohn Company Isocyanato-azetidinediones
DE3566888D1 (en) * 1984-10-04 1989-01-26 Ciba Geigy Ag Silanes, process for their preparation and their use
DE3879791T2 (de) 1987-07-17 1993-10-14 Merck & Co Inc 4-Substituierte 3-Oxobutanoat-Esterderivate.
ATE125543T1 (de) * 1987-09-22 1995-08-15 Shionogi & Co Alkenylsilylazetidinon-zwischenprodukte für carbapeneme.
US4992545A (en) * 1989-09-20 1991-02-12 Eli Lilly And Company Process for preparing 4-substituted azetidinones
DE69231883T2 (de) * 1991-12-09 2001-10-04 Takasago International Corp., Tokio/Tokyo 4-(1,1-Dialkoxycarbonyl-Alkyl)Azetidin-2-on-Derivate zur Herstellung von 4-(1-Carboxy-Alkyl)Azetidin-2-on-Derivaten

Also Published As

Publication number Publication date
FI951212A0 (fi) 1995-03-15
EP0589626B1 (en) 2002-03-06
US5654424A (en) 1997-08-05
PT589626E (pt) 2002-07-31
HRP931199B1 (en) 2003-02-28
CN1101397C (zh) 2003-02-12
CZ286267B6 (cs) 2000-03-15
EP0589626A1 (en) 1994-03-30
JP3252032B2 (ja) 2002-01-28
UA50705C2 (uk) 2002-11-15
AR000394A2 (es) 1997-06-18
HK1008336A1 (en) 1999-05-07
FI951212A (fi) 1995-03-15
JPH06192220A (ja) 1994-07-12
ES2173884T3 (es) 2002-11-01
RO116087B1 (ro) 2000-10-30
RU2130927C1 (ru) 1999-05-27
CA2106248A1 (en) 1994-03-19
CN1066438C (zh) 2001-05-30
CN1232035A (zh) 1999-10-20
SK34995A3 (en) 1995-08-09
US6242596B1 (en) 2001-06-05
AU667571B2 (en) 1996-03-28
WO1994006764A1 (en) 1994-03-31
SI9300486B (sl) 2003-02-28
CN1092763A (zh) 1994-09-28
SI9300486A (en) 1994-03-31
DE69331650T2 (de) 2002-08-22
TW406073B (en) 2000-09-21
CZ34695A3 (en) 1995-11-15
AU4743393A (en) 1994-03-24
DK0589626T3 (da) 2002-04-02
ATE214048T1 (de) 2002-03-15
DE69331650D1 (de) 2002-04-11
HRP931199A2 (en) 1995-02-28
RU95108544A (ru) 1997-01-10
SK282164B6 (sk) 2001-11-06

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Legal Events

Date Code Title Description
FG Grant or registration
MM Annulment or lapse due to non-payment of fees