DE69232776D1 - Verfahren zur Herstellung von Cephalosporinen und Zwischenverbindungen in diesem Verfahren - Google Patents

Verfahren zur Herstellung von Cephalosporinen und Zwischenverbindungen in diesem Verfahren

Info

Publication number
DE69232776D1
DE69232776D1 DE69232776T DE69232776T DE69232776D1 DE 69232776 D1 DE69232776 D1 DE 69232776D1 DE 69232776 T DE69232776 T DE 69232776T DE 69232776 T DE69232776 T DE 69232776T DE 69232776 D1 DE69232776 D1 DE 69232776D1
Authority
DE
Germany
Prior art keywords
hydrogen
cephalosporins
intermediates
preparation
protecting group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69232776T
Other languages
English (en)
Other versions
DE69232776T2 (de
Inventor
Johannes Ludescher
Hubert Sturm
Josef Wieser
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sandoz AG
Original Assignee
Biochemie GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biochemie GmbH filed Critical Biochemie GmbH
Publication of DE69232776D1 publication Critical patent/DE69232776D1/de
Application granted granted Critical
Publication of DE69232776T2 publication Critical patent/DE69232776T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic System
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/10—Compounds having one or more C—Si linkages containing nitrogen having a Si-N linkage
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Cephalosporin Compounds (AREA)
DE69232776T 1991-08-21 1992-08-12 Verfahren zur Herstellung von Cephalosporinen und Zwischenverbindungen in diesem Verfahren Expired - Fee Related DE69232776T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
AT0163691A AT396108B (de) 1991-08-21 1991-08-21 Neues verfahren und neue zwischenprodukte zur herstellung von 7-aminocephalosporansaeurederivaten

Publications (2)

Publication Number Publication Date
DE69232776D1 true DE69232776D1 (de) 2002-10-24
DE69232776T2 DE69232776T2 (de) 2003-04-30

Family

ID=3517697

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69232776T Expired - Fee Related DE69232776T2 (de) 1991-08-21 1992-08-12 Verfahren zur Herstellung von Cephalosporinen und Zwischenverbindungen in diesem Verfahren

Country Status (9)

Country Link
US (3) US5686604A (de)
EP (1) EP0528343B1 (de)
JP (1) JP2561780B2 (de)
KR (2) KR930004312A (de)
AT (2) AT396108B (de)
DE (1) DE69232776T2 (de)
ES (1) ES2183804T3 (de)
PT (1) PT528343E (de)
SG (1) SG52784A1 (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR0164458B1 (ko) * 1995-04-04 1999-01-15 김은영 암모니오세팔로스포린 계열 항생제 및 그의 제조방법
AT403161B (de) * 1995-07-19 1997-11-25 Biochemie Gmbh Verfahren zur herstellung von cephemverbindungen
US5872249A (en) * 1995-09-01 1999-02-16 Korea Institute Of Science And Technology 3-ammoniopropenyl cephalosporin compounds as antibacterial agents and process for preparing the same
US6011136A (en) * 1995-11-21 2000-01-04 Novartis Ag Cyclopeptolides
EP1090013A1 (de) 1998-06-22 2001-04-11 F. Hoffmann-La Roche Ag Propenyl-cephalosporin-derivate

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK154939C (da) * 1974-12-19 1989-06-12 Takeda Chemical Industries Ltd Analogifremgangsmaade til fremstilling af thiazolylacetamido-cephemforbindelser eller farmaceutisk acceptable salte eller estere deraf
US4049806A (en) * 1975-08-15 1977-09-20 Syntex (U.S.A.) Inc. Cephalosporin type antibacterials
US4112087A (en) * 1976-11-04 1978-09-05 Syntex (U.S.A.) Inc. Cephalosporin type antibacterials having a substituted propenyl group in the 3-position
DE2659288A1 (de) * 1976-12-29 1978-07-06 Schering Ag Mittel mit bakterizider und fungizider wirkung
NL162387C (nl) * 1977-09-06 1980-05-16 Gist Brocades Nv Werkwijze voor het bereiden van 6-(d-alpha-amino-p- -hydroxyfenylacetamido)penicillanzuur.
US4640798A (en) * 1982-05-26 1987-02-03 Lilly Industries Ltd. Intermediates for the preparation of penicillin and cephalosporin compounds
ZA84584B (en) * 1983-01-28 1984-09-26 Bristol Myers Co Substituted vinyl cephalosporins
US4486586A (en) * 1983-02-10 1984-12-04 Bristol-Myers Company Cephalosporin derivatives
CA1276929C (en) * 1984-04-09 1990-11-27 Masahisa Oka Cephalosporin antibacterial agents
ATE121746T1 (de) * 1984-11-23 1995-05-15 Biochemie Gmbh Verfahren zur herstellung bissilylierter 3- iodmethylcephalosporinderivaten.
AT382875B (de) * 1984-11-23 1987-04-27 Biochemie Gmbh Verfahren zur herstellung neuer cephalosporanderivate
US4703118A (en) * 1985-04-08 1987-10-27 Eli Lilly And Company Synthesis of 3-iodomethyl cephalosporins
WO1987003875A1 (en) * 1985-12-26 1987-07-02 Eisai Co., Ltd. Cephalosporin derivatives
IL84128A (en) * 1986-10-13 1992-12-01 Eisai Co Ltd 3-propenylcephem derivatives, their preparation and pharmaceutical compositions containing them
FR2622585B1 (fr) * 1987-11-03 1991-04-19 Roussel Uclaf Nouvelles cephalosporines comportant en position 3 un radical vinyle substitue, leur procede de preparation, leur application comme medicaments, les compositions les renfermant et les nouveaux intermediaires obtenus
EP0612751A3 (en) * 1988-03-16 1994-09-21 Eisai Co Ltd Compounds for the preparation of cephem derivatives.

Also Published As

Publication number Publication date
SG52784A1 (en) 1998-09-28
US6169180B1 (en) 2001-01-02
EP0528343B1 (de) 2002-09-18
KR930004312A (ko) 1993-03-22
EP0528343A3 (en) 1993-03-10
ATA163691A (de) 1992-10-15
KR100286422B1 (ko) 2001-03-15
US5686604A (en) 1997-11-11
JPH05194533A (ja) 1993-08-03
EP0528343A2 (de) 1993-02-24
ES2183804T3 (es) 2003-04-01
US5644052A (en) 1997-07-01
ATE224393T1 (de) 2002-10-15
DE69232776T2 (de) 2003-04-30
PT528343E (pt) 2002-12-31
AT396108B (de) 1993-06-25
JP2561780B2 (ja) 1996-12-11

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: SANDOZ AG, BASEL, CH

8328 Change in the person/name/address of the agent

Representative=s name: PFENNING MEINIG & PARTNER GBR, 80339 MUENCHEN

8328 Change in the person/name/address of the agent

Representative=s name: MAIWALD PATENTANWALTSGESELLSCHAFT MBH, 80335 MUENC

8339 Ceased/non-payment of the annual fee