MX9303671A - Procedimiento para la preparacion de una 4-hidroxi-5-halopirrolo[2,3-d] pirimidina - Google Patents

Procedimiento para la preparacion de una 4-hidroxi-5-halopirrolo[2,3-d] pirimidina

Info

Publication number
MX9303671A
MX9303671A MX9303671A MX9303671A MX9303671A MX 9303671 A MX9303671 A MX 9303671A MX 9303671 A MX9303671 A MX 9303671A MX 9303671 A MX9303671 A MX 9303671A MX 9303671 A MX9303671 A MX 9303671A
Authority
MX
Mexico
Prior art keywords
halopyrolle
pirimidine
hydroxy
procedure
preparation
Prior art date
Application number
MX9303671A
Other languages
English (en)
Inventor
Charles Jackson Barnett
Michael Edward Kobierski
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of MX9303671A publication Critical patent/MX9303671A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

Se halogenan 4-hidroxipirrolo[2,3-d]pirimidinas regioespecíficamente en la posición C-5 por sililación en presencia de un disolvente orgánico inerte y yodación, bromación o cloración.
MX9303671A 1992-06-22 1993-06-18 Procedimiento para la preparacion de una 4-hidroxi-5-halopirrolo[2,3-d] pirimidina MX9303671A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/902,116 US5235053A (en) 1992-06-22 1992-06-22 Process for the synthesis of 4-hydroxy-5-halopyrrold[2,3-d]pyrimidine intermediates

Publications (1)

Publication Number Publication Date
MX9303671A true MX9303671A (es) 1993-12-01

Family

ID=25415324

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9303671A MX9303671A (es) 1992-06-22 1993-06-18 Procedimiento para la preparacion de una 4-hidroxi-5-halopirrolo[2,3-d] pirimidina

Country Status (15)

Country Link
US (1) US5235053A (es)
EP (1) EP0576211B1 (es)
JP (1) JPH0656838A (es)
KR (1) KR100285891B1 (es)
AT (1) ATE204577T1 (es)
BR (1) BR9302432A (es)
CA (1) CA2098694A1 (es)
DE (1) DE69330627T2 (es)
DK (1) DK0576211T3 (es)
ES (1) ES2160589T3 (es)
HU (1) HU214019B (es)
IL (3) IL106054A (es)
MX (1) MX9303671A (es)
PT (1) PT576211E (es)
TW (1) TW226376B (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUT70208A (en) * 1992-09-25 1995-09-28 Lilly Co Eli Process for preparing 5-substituted pyrrolo[2,3-d]-pyrimidines
US5426187A (en) * 1993-11-30 1995-06-20 Eli Lilly And Company Process for the preparation of 4-hydroxy-5-substituted ethynylpyrrolo [2,3-d]pyrimidine intermediates
US6002004A (en) * 1995-03-28 1999-12-14 Witco Vinyl Additives Gmbh Pyrrolodiazine derivatives as stabilizers for chilorine-containing polymers
ATE296825T1 (de) * 1997-08-05 2005-06-15 Pfizer Prod Inc 4-aminopyrrole(3,2-d)pyrimidine als neuropeptid rezeptor antagonisten
CN100374441C (zh) * 2003-06-06 2008-03-12 天津倍方科技发展有限公司 二氢吡咯[2，3-d]嘧啶-4-酮衍生物，其制备方法及其制药用途

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NO169490C (no) 1988-03-24 1992-07-01 Takeda Chemical Industries Ltd Analogifremgangsmaate for fremstilling av terapeutisk aktive pyrrolopyrimidinderivater
US5028608A (en) 1989-12-11 1991-07-02 The Trustees Of Princeton University N-(6-Amino-(pyrrolo(2,3-d)pyrimidin-3-ylacyl) )-glutamic acid derivatives
IL96531A (en) * 1989-12-11 1995-08-31 Univ Princeton History of Acid N- (Diomeric-H1-Pyrolo] D-2,3 [Pyrimidine-3-Ilacyl (-glutamic, preparation and pharmaceutical preparations containing them)

Also Published As

Publication number Publication date
IL106054A (en) 1997-07-13
CA2098694A1 (en) 1993-12-23
HU214019B (hu) 2000-06-28
KR940000461A (ko) 1994-01-03
US5235053A (en) 1993-08-10
DE69330627D1 (de) 2001-09-27
EP0576211A2 (en) 1993-12-29
DE69330627T2 (de) 2002-06-13
KR100285891B1 (ko) 2001-04-16
PT576211E (pt) 2001-12-28
IL106054A0 (en) 1993-10-20
IL119053A (en) 1998-12-06
BR9302432A (pt) 1994-01-11
HU9301829D0 (en) 1993-09-28
EP0576211B1 (en) 2001-08-22
EP0576211A3 (en) 1994-06-15
JPH0656838A (ja) 1994-03-01
IL119053A0 (en) 1996-11-14
HUT65439A (en) 1994-06-28
ES2160589T3 (es) 2001-11-16
TW226376B (es) 1994-07-11
DK0576211T3 (da) 2001-10-08
ATE204577T1 (de) 2001-09-15

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Legal Events

Date Code Title Description
FG Grant or registration
MM Annulment or lapse due to non-payment of fees