DE69330627D1 - Verfahren zur Synthese von Zwischenprodukten von-4-Hydroxy-5-halopyrrolo (2,3-d) Pyrimidin - Google Patents

Verfahren zur Synthese von Zwischenprodukten von-4-Hydroxy-5-halopyrrolo (2,3-d) Pyrimidin

Info

Publication number
DE69330627D1
DE69330627D1 DE69330627T DE69330627T DE69330627D1 DE 69330627 D1 DE69330627 D1 DE 69330627D1 DE 69330627 T DE69330627 T DE 69330627T DE 69330627 T DE69330627 T DE 69330627T DE 69330627 D1 DE69330627 D1 DE 69330627D1
Authority
DE
Germany
Prior art keywords
halopyrrolo
pyrimidine
intermediates
hydroxy
synthesis
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69330627T
Other languages
English (en)
Other versions
DE69330627T2 (de
Inventor
Charles Jackson Barnett
Michael Edward Kobierski
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Application granted granted Critical
Publication of DE69330627D1 publication Critical patent/DE69330627D1/de
Publication of DE69330627T2 publication Critical patent/DE69330627T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
DE69330627T 1992-06-22 1993-06-17 Verfahren zur Synthese von Zwischenprodukten von-4-Hydroxy-5-halopyrrolo (2,3-d) Pyrimidin Expired - Fee Related DE69330627T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/902,116 US5235053A (en) 1992-06-22 1992-06-22 Process for the synthesis of 4-hydroxy-5-halopyrrold[2,3-d]pyrimidine intermediates

Publications (2)

Publication Number Publication Date
DE69330627D1 true DE69330627D1 (de) 2001-09-27
DE69330627T2 DE69330627T2 (de) 2002-06-13

Family

ID=25415324

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69330627T Expired - Fee Related DE69330627T2 (de) 1992-06-22 1993-06-17 Verfahren zur Synthese von Zwischenprodukten von-4-Hydroxy-5-halopyrrolo (2,3-d) Pyrimidin

Country Status (15)

Country Link
US (1) US5235053A (de)
EP (1) EP0576211B1 (de)
JP (1) JPH0656838A (de)
KR (1) KR100285891B1 (de)
AT (1) ATE204577T1 (de)
BR (1) BR9302432A (de)
CA (1) CA2098694A1 (de)
DE (1) DE69330627T2 (de)
DK (1) DK0576211T3 (de)
ES (1) ES2160589T3 (de)
HU (1) HU214019B (de)
IL (3) IL106054A (de)
MX (1) MX9303671A (de)
PT (1) PT576211E (de)
TW (1) TW226376B (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUT70208A (en) * 1992-09-25 1995-09-28 Lilly Co Eli Process for preparing 5-substituted pyrrolo[2,3-d]-pyrimidines
US5426187A (en) * 1993-11-30 1995-06-20 Eli Lilly And Company Process for the preparation of 4-hydroxy-5-substituted ethynylpyrrolo [2,3-d]pyrimidine intermediates
US6002004A (en) * 1995-03-28 1999-12-14 Witco Vinyl Additives Gmbh Pyrrolodiazine derivatives as stabilizers for chilorine-containing polymers
US6187778B1 (en) * 1997-08-05 2001-02-13 Pfizer Inc. 4-aminopyrrole (3, 2-D) pyrimidines as neuropeptide Y receptor antagonists
CN100374441C (zh) * 2003-06-06 2008-03-12 天津倍方科技发展有限公司 二氢吡咯[2，3-d]嘧啶-4-酮衍生物，其制备方法及其制药用途

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NO169490C (no) 1988-03-24 1992-07-01 Takeda Chemical Industries Ltd Analogifremgangsmaate for fremstilling av terapeutisk aktive pyrrolopyrimidinderivater
IL96531A (en) * 1989-12-11 1995-08-31 Univ Princeton History of Acid N- (Diomeric-H1-Pyrolo] D-2,3 [Pyrimidine-3-Ilacyl (-glutamic, preparation and pharmaceutical preparations containing them)
US5028608A (en) 1989-12-11 1991-07-02 The Trustees Of Princeton University N-(6-Amino-(pyrrolo(2,3-d)pyrimidin-3-ylacyl) )-glutamic acid derivatives

Also Published As

Publication number Publication date
BR9302432A (pt) 1994-01-11
EP0576211A2 (de) 1993-12-29
EP0576211A3 (en) 1994-06-15
TW226376B (de) 1994-07-11
DK0576211T3 (da) 2001-10-08
KR100285891B1 (ko) 2001-04-16
PT576211E (pt) 2001-12-28
EP0576211B1 (de) 2001-08-22
MX9303671A (es) 1993-12-01
JPH0656838A (ja) 1994-03-01
DE69330627T2 (de) 2002-06-13
HUT65439A (en) 1994-06-28
US5235053A (en) 1993-08-10
HU9301829D0 (en) 1993-09-28
IL119053A0 (en) 1996-11-14
IL106054A (en) 1997-07-13
ES2160589T3 (es) 2001-11-16
ATE204577T1 (de) 2001-09-15
IL119053A (en) 1998-12-06
IL106054A0 (en) 1993-10-20
HU214019B (hu) 2000-06-28
KR940000461A (ko) 1994-01-03
CA2098694A1 (en) 1993-12-23

Similar Documents

Publication Publication Date Title
DK1002534T3 (da) Anvendelse af fire K-252a-derivater
ZA936945B (en) Process for preparing 5-substituted pyrrolo[2,3-d] pyrimidine intermediates.
ITRM930805A0 (it) Procedimento per la ottimizzazione iterativa di processi si imbutituraalla pressa.
DE69702705T2 (de) Kondensierte pyrrolo(2,3-c) carbazole-6-one die die aktivität von gamma interferon potenzieren
NO933395L (no) Fremgangsmåte for fremtilling av 5-substituerte pyrrolo(2,3-d)pyrimidiner
DE69330627D1 (de) Verfahren zur Synthese von Zwischenprodukten von-4-Hydroxy-5-halopyrrolo (2,3-d) Pyrimidin
DE69621788T2 (de) Pyrimidin verbindungen
IT239858Y1 (it) Gruppo di sostegno per il parafango anteriore di un trattore agricolo.
DK0593286T3 (da) Mellemprodukter til fremstilling af antifolatforbindelser og fremgangsmåder dertil
DE69007775D1 (de) 5'-alkylphosphonylnukleoside als antivirale verbindungen.
EA199800090A1 (ru) Способ получения 4,6-диметокси-2-((феноксикарбонил)амино)пиримидина
DK0593285T3 (da) Mellemprodukter og fremgangsmåder dertil til fremstilling af 5,6-dihydropyrrolo-(2,3-d)pyrimidiner
ATE71946T1 (de) 2,3-dihydro-1-(8-methyl-1,2,4-triazolo(4,3b>pyridazin-6-yl)-4(1h)-pyridinon.
OA08742A (fr) Dérivés de pyrimidine.
FI934153A (fi) N1-substituerade 1H-1,2,3-triazolo(4,5-d)pyrimidiner, foerfarande foer framstaellning av dessa samt deras anvaendning som antivirala medel
FR2679558B1 (fr) Procede de preparation de la cinnamoyl-13alpha baccatine iii ou desacetyl-10 baccatine iii.
DE9306047U1 (de) Einrichtung zur Höhenverstellung bzw. Abstandeinstellung von Möbelteilen
FI954340A0 (fi) Foerfarande foer framstaellning av nya terapeutiskt anvaendbara 1,2,4-triazolo(1,5-a)-pyrimidinderivat
TR27040A (tr) Halojenlenmis alkeniltio sübstitüeli pirimidin bilesikleri.
FR2693163B1 (fr) Col de cygne amovible.
NO964146L (no) Fremgangsmåte for fremstilling av 5-substituerte pyrrolo(2,3-d)pyrimidiner
FR2680628B1 (fr) Chassis de jardin.
ES1024101Y (es) Cerradero de posicionamiento regulable.
NO912552L (no) Fremgangsmaate for fremstilling av pyrimidinnukleosider.
ES1020266Y (es) Recipiente receptor de pequenos residuos.

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee