DK0576211T3 - Fremgangsmåde til syntese af 4-hydroxy-5-halogenpyrrolo(2,3-d)-pyrimidin-mellemprodukter - Google Patents
Fremgangsmåde til syntese af 4-hydroxy-5-halogenpyrrolo(2,3-d)-pyrimidin-mellemprodukterInfo
- Publication number
- DK0576211T3 DK0576211T3 DK93304733T DK93304733T DK0576211T3 DK 0576211 T3 DK0576211 T3 DK 0576211T3 DK 93304733 T DK93304733 T DK 93304733T DK 93304733 T DK93304733 T DK 93304733T DK 0576211 T3 DK0576211 T3 DK 0576211T3
- Authority
- DK
- Denmark
- Prior art keywords
- pyrrolo
- halo
- hydroxy
- synthesis
- pyrimidine intermediates
- Prior art date
Links
- 230000015572 biosynthetic process Effects 0.000 title 1
- 239000000543 intermediate Substances 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
- FBMZEITWVNHWJW-UHFFFAOYSA-N 1,7-dihydropyrrolo[2,3-d]pyrimidin-4-one Chemical class OC1=NC=NC2=C1C=CN2 FBMZEITWVNHWJW-UHFFFAOYSA-N 0.000 abstract 1
- 230000031709 bromination Effects 0.000 abstract 1
- 238000005893 bromination reaction Methods 0.000 abstract 1
- 238000005660 chlorination reaction Methods 0.000 abstract 1
- 230000026045 iodination Effects 0.000 abstract 1
- 238000006192 iodination reaction Methods 0.000 abstract 1
- 239000003960 organic solvent Substances 0.000 abstract 1
- 238000006884 silylation reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/902,116 US5235053A (en) | 1992-06-22 | 1992-06-22 | Process for the synthesis of 4-hydroxy-5-halopyrrold[2,3-d]pyrimidine intermediates |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0576211T3 true DK0576211T3 (da) | 2001-10-08 |
Family
ID=25415324
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK93304733T DK0576211T3 (da) | 1992-06-22 | 1993-06-17 | Fremgangsmåde til syntese af 4-hydroxy-5-halogenpyrrolo(2,3-d)-pyrimidin-mellemprodukter |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US5235053A (da) |
| EP (1) | EP0576211B1 (da) |
| JP (1) | JPH0656838A (da) |
| KR (1) | KR100285891B1 (da) |
| AT (1) | ATE204577T1 (da) |
| BR (1) | BR9302432A (da) |
| CA (1) | CA2098694A1 (da) |
| DE (1) | DE69330627T2 (da) |
| DK (1) | DK0576211T3 (da) |
| ES (1) | ES2160589T3 (da) |
| HU (1) | HU214019B (da) |
| IL (3) | IL119053A (da) |
| MX (1) | MX9303671A (da) |
| PT (1) | PT576211E (da) |
| TW (1) | TW226376B (da) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL107041A (en) * | 1992-09-25 | 2000-02-17 | Lilly Co Eli | Process for preparing omega(2-amino-4,7-dihydro-4-oxo-3H-pyrrolo-6-¬2,3-d¾pyrimidin-5-YL)alkarylcarboxylic acids and N-(omega-(2-amino-4,7-dihydro-4-oxo-3H-pyrrolo¬2,3-d¾pyrimidin-5-YL)alk-aroyl-4-glutamic acids |
| US5426187A (en) * | 1993-11-30 | 1995-06-20 | Eli Lilly And Company | Process for the preparation of 4-hydroxy-5-substituted ethynylpyrrolo [2,3-d]pyrimidine intermediates |
| US6002004A (en) * | 1995-03-28 | 1999-12-14 | Witco Vinyl Additives Gmbh | Pyrrolodiazine derivatives as stabilizers for chilorine-containing polymers |
| JP3711238B2 (ja) * | 1997-08-05 | 2005-11-02 | ファイザー・プロダクツ・インク | 神経ペプチドＹ受容体アンタゴニストとしての４−アミノピロ−ル（３，２−ｄ）ピリミジン |
| CN100374441C (zh) * | 2003-06-06 | 2008-03-12 | 天津倍方科技发展有限公司 | 二氢吡咯[2，3-d]嘧啶-4-酮衍生物，其制备方法及其制药用途 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NO169490C (no) | 1988-03-24 | 1992-07-01 | Takeda Chemical Industries Ltd | Analogifremgangsmaate for fremstilling av terapeutisk aktive pyrrolopyrimidinderivater |
| IL96531A (en) * | 1989-12-11 | 1995-08-31 | Univ Princeton | History of Acid N- (Diomeric-H1-Pyrolo] D-2,3 [Pyrimidine-3-Ilacyl (-glutamic, preparation and pharmaceutical preparations containing them) |
| US5028608A (en) | 1989-12-11 | 1991-07-02 | The Trustees Of Princeton University | N-(6-Amino-(pyrrolo(2,3-d)pyrimidin-3-ylacyl) )-glutamic acid derivatives |
-
1992
- 1992-06-22 US US07/902,116 patent/US5235053A/en not_active Expired - Fee Related
-
1993
- 1993-06-16 TW TW082104794A patent/TW226376B/zh active
- 1993-06-17 IL IL11905393A patent/IL119053A/en not_active IP Right Cessation
- 1993-06-17 AT AT93304733T patent/ATE204577T1/de not_active IP Right Cessation
- 1993-06-17 IL IL106054A patent/IL106054A/xx not_active IP Right Cessation
- 1993-06-17 ES ES93304733T patent/ES2160589T3/es not_active Expired - Lifetime
- 1993-06-17 DK DK93304733T patent/DK0576211T3/da active
- 1993-06-17 EP EP93304733A patent/EP0576211B1/en not_active Expired - Lifetime
- 1993-06-17 DE DE69330627T patent/DE69330627T2/de not_active Expired - Fee Related
- 1993-06-17 PT PT93304733T patent/PT576211E/pt unknown
- 1993-06-17 CA CA002098694A patent/CA2098694A1/en not_active Abandoned
- 1993-06-18 MX MX9303671A patent/MX9303671A/es not_active IP Right Cessation
- 1993-06-19 KR KR1019930011267A patent/KR100285891B1/ko not_active IP Right Cessation
- 1993-06-21 HU HU9301829A patent/HU214019B/hu not_active IP Right Cessation
- 1993-06-21 JP JP5149141A patent/JPH0656838A/ja active Pending
- 1993-06-21 BR BR9302432A patent/BR9302432A/pt not_active Application Discontinuation
-
1996
- 1996-08-12 IL IL11905396A patent/IL119053A0/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US5235053A (en) | 1993-08-10 |
| JPH0656838A (ja) | 1994-03-01 |
| IL119053A (en) | 1998-12-06 |
| IL106054A0 (en) | 1993-10-20 |
| BR9302432A (pt) | 1994-01-11 |
| TW226376B (da) | 1994-07-11 |
| IL119053A0 (en) | 1996-11-14 |
| EP0576211B1 (en) | 2001-08-22 |
| PT576211E (pt) | 2001-12-28 |
| MX9303671A (es) | 1993-12-01 |
| IL106054A (en) | 1997-07-13 |
| EP0576211A3 (en) | 1994-06-15 |
| ES2160589T3 (es) | 2001-11-16 |
| CA2098694A1 (en) | 1993-12-23 |
| HUT65439A (en) | 1994-06-28 |
| DE69330627T2 (de) | 2002-06-13 |
| KR100285891B1 (ko) | 2001-04-16 |
| EP0576211A2 (en) | 1993-12-29 |
| KR940000461A (ko) | 1994-01-03 |
| DE69330627D1 (de) | 2001-09-27 |
| HU214019B (hu) | 2000-06-28 |
| HU9301829D0 (en) | 1993-09-28 |
| ATE204577T1 (de) | 2001-09-15 |
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