MX9201183A - Quinazolinas, procedimiento para su obtencion y composicion farmaceutica que las contiene. - Google Patents
Quinazolinas, procedimiento para su obtencion y composicion farmaceutica que las contiene.Info
- Publication number
- MX9201183A MX9201183A MX9201183A MX9201183A MX9201183A MX 9201183 A MX9201183 A MX 9201183A MX 9201183 A MX9201183 A MX 9201183A MX 9201183 A MX9201183 A MX 9201183A MX 9201183 A MX9201183 A MX 9201183A
- Authority
- MX
- Mexico
- Prior art keywords
- carbon atoms
- alkyl
- alkoxy
- hydrogen
- hydroxy
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 10
- 125000000217 alkyl group Chemical group 0.000 abstract 7
- 125000003545 alkoxy group Chemical group 0.000 abstract 5
- 229910052739 hydrogen Inorganic materials 0.000 abstract 5
- 239000001257 hydrogen Substances 0.000 abstract 5
- 229910052736 halogen Inorganic materials 0.000 abstract 4
- 150000002367 halogens Chemical group 0.000 abstract 4
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 4
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 3
- 125000001424 substituent group Chemical group 0.000 abstract 3
- -1 Marcaptoalkyl Chemical group 0.000 abstract 2
- 125000005236 alkanoylamino group Chemical group 0.000 abstract 2
- 125000004414 alkyl thio group Chemical group 0.000 abstract 2
- 125000000539 amino acid group Chemical group 0.000 abstract 2
- 229910052799 carbon Inorganic materials 0.000 abstract 2
- 125000001188 haloalkyl group Chemical group 0.000 abstract 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- 108010016626 Dipeptides Proteins 0.000 abstract 1
- 101100295738 Gallus gallus COR3 gene Proteins 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000004183 alkoxy alkyl group Chemical group 0.000 abstract 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
- 125000000278 alkyl amino alkyl group Chemical group 0.000 abstract 1
- 125000006350 alkyl thio alkyl group Chemical group 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 125000000304 alkynyl group Chemical group 0.000 abstract 1
- 150000001412 amines Chemical class 0.000 abstract 1
- 150000001413 amino acids Chemical class 0.000 abstract 1
- 125000004103 aminoalkyl group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000004104 aryloxy group Chemical group 0.000 abstract 1
- 125000004429 atom Chemical group 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 1
- 125000001589 carboacyl group Chemical group 0.000 abstract 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 1
- 125000004966 cyanoalkyl group Chemical group 0.000 abstract 1
- 125000004985 dialkyl amino alkyl group Chemical group 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 125000002768 hydroxyalkyl group Chemical group 0.000 abstract 1
- 125000000843 phenylene group Chemical group C1(=C(C=CC=C1)*)* 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 150000003246 quinazolines Chemical class 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
- 125000003396 thiol group Chemical group [H]S* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/95—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
- C07D239/88—Oxygen atoms
- C07D239/90—Oxygen atoms with acyclic radicals attached in position 2 or 3
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Se describen quinazolinas de la fórmula: (General I), en donde R1 es hidrógeno o amino, o R1 es alquilo, alcoxi o alquiltio, cada uno de los átomos de carbono; o R1 es arilo o ariloxi, cada uno de hasta 10 átomos de carbono; o R1 es halógeno, hidroxi o mercapto; o R1 es alquilo de hasta 3 átomos de carbono, que lleva uno o más sustituyentes, seleccionados de halógeno, hidroxi y alcanoilamino, cada uno de hasta 6 átomos de carbono; o R1 ea alcoxi de hasta 3 átomos de carbono, que lleva uno o más sustituyentes, seleccionados de hidroxi y alcoxi de hasta 6 átomos de carbono; en donde R2 es hidrógeno o alquilo, alquenilo, alquinilo, hidroxialquilo, alcoxialquilo, marcaptoalquilo, alquiltioalquilo, halogenoalquilo, cianoalquilo, aminoalquilo, alquilaminoalquilo, dialquilaminoalquilo, alcanoilalquilo, carboxialquilo carbamoilalquilo o alcanoilo cada uno de hasta 6 átomos de carbono; en donde Ar es fenileo o heterocicleno, que está sin sustituir o que lleva uno o más sustituyentes seleccionados de halógeno, ciano, nitro, hidroxi, amino y carbamoilo y alquilo, alcoxi, halogenoalquilo, alcanoilamino, alquiltio y alcoxicarbonilo cada uno hasta 6 átomos de carbono; R3 es el residuo de un dipéptido, en el cual el primer residuo de aminoácido con terminación de N, del mismo, unido al grupo carbonilo de COR3 es un residuo de L-o Daminoácido, -NHCH(CO2H)-A-CO-,en el cual A es un grupo alquileno de hasta 6 átomos de carbono, y el segundo residuo de aminoácido es de un aminoácido que tiene la configuración D en su átomo de -carbono asimétrico; en donde R4 es hidrógeno o alquilo de hasta 4 átomos de carbono; en donde R5 es hidrógeno o alquilo de hasta 4 átomos de carbono; y en donde cada uno de R6, R7 y R8 es hidrógeno o alquilo o alcoxi, cada uno de hasta de 4 átomos de carbono; o es halógeno; o una sal, éster o amina farmaceúticamente aceptable de las mismas, que son de valor terapéutico, particularmente en el tratamiento del cáncer.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB919105771A GB9105771D0 (en) | 1991-03-19 | 1991-03-19 | Anti-cancer compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX9201183A true MX9201183A (es) | 1994-06-30 |
Family
ID=10691801
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX9201183A MX9201183A (es) | 1991-03-19 | 1992-03-18 | Quinazolinas, procedimiento para su obtencion y composicion farmaceutica que las contiene. |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US5444061A (es) |
| EP (1) | EP0509643A1 (es) |
| JP (1) | JPH06505974A (es) |
| AU (1) | AU655970B2 (es) |
| CA (1) | CA2106583A1 (es) |
| CZ (1) | CZ195393A3 (es) |
| FI (1) | FI934106A (es) |
| GB (2) | GB9105771D0 (es) |
| HU (1) | HUT67177A (es) |
| IE (1) | IE920853A1 (es) |
| IL (1) | IL101281A0 (es) |
| MX (1) | MX9201183A (es) |
| NO (1) | NO933341L (es) |
| NZ (1) | NZ242023A (es) |
| SK (1) | SK100993A3 (es) |
| TW (1) | TW203608B (es) |
| WO (1) | WO1992016512A1 (es) |
| ZA (1) | ZA921985B (es) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9205907D0 (en) * | 1992-03-18 | 1992-04-29 | Cancer Res Inst Royal | Anti-cancer compounds |
| GB9223352D0 (en) * | 1992-11-06 | 1992-12-23 | Ici Plc | Tricyclic compounds |
| GB9408936D0 (en) * | 1994-05-05 | 1994-06-22 | Cancer Res Inst | Anti-cancer compounds |
| DE69613985T2 (de) * | 1995-08-30 | 2002-06-13 | G.D. Searle & Co., Chicago | Meta-guanidine, harnstoff, thioharnstoff oder azacyklische aminobenzoesäure-derivate als integrin antagonisten |
| GB9904275D0 (en) | 1999-02-24 | 1999-04-21 | Cancer Res Campaign Tech | Anti-cancer compounds |
| US7230000B1 (en) | 1999-10-27 | 2007-06-12 | Cytokinetics, Incorporated | Methods and compositions utilizing quinazolinones |
| US6545004B1 (en) | 1999-10-27 | 2003-04-08 | Cytokinetics, Inc. | Methods and compositions utilizing quinazolinones |
| US7671200B2 (en) * | 1999-10-27 | 2010-03-02 | Cytokinetics, Inc. | Quinazolinone KSP inhibitors |
| AU2003213092A1 (en) * | 2002-02-15 | 2003-09-09 | Smithkline Beecham Corporation | Syntheses of quinazolinones |
| JP2005530785A (ja) * | 2002-05-09 | 2005-10-13 | サイトキネティクス・インコーポレーテッド | 化合物、組成物、及び方法 |
| BR0309892A2 (pt) * | 2002-05-09 | 2011-04-05 | Cytokinetics Inc | composto, composição, métodos para modular a atividade da cinesina de ksp, para inibir a ksp, e para o tratamento de uma doença proliferativa celular, e, uso de um composto |
| US7038048B2 (en) * | 2002-05-23 | 2006-05-02 | Cytokinetics, Inc. | 3H-pyridopyrimidin-4-one compounds, compositions, and methods of their use |
| EP1556357A4 (en) * | 2002-06-14 | 2006-09-13 | Cytokinetics Inc | COMPOUNDS, COMPOSITIONS AND METHODS |
| US20030236430A1 (en) * | 2002-06-21 | 2003-12-25 | Allen David Robert | Preparation of protected amino acids |
| AU2003256805A1 (en) * | 2002-07-23 | 2004-02-09 | Cytokinetics, Inc. | Compounds compositions and methods |
| US20040048853A1 (en) * | 2002-08-21 | 2004-03-11 | Gustave Bergnes | Compounds, compositions, and methods |
| EP1558083A4 (en) * | 2002-09-30 | 2008-04-16 | Cytokinetics Inc | COMPOUNDS, COMPOSITIONS AND METHODS |
| JP2007510652A (ja) * | 2003-11-03 | 2007-04-26 | サイトキネティクス・インコーポレーテッド | ピリミジン−４−オン化合物、組成物、および方法 |
| EP1680420A4 (en) * | 2003-11-07 | 2008-09-24 | Cytokinetics Inc | COMPOUNDS, COMPOSITIONS AND METHODS |
| JP2007513154A (ja) * | 2003-12-08 | 2007-05-24 | サイトキネティクス・インコーポレーテッド | 化合物、組成物及び方法 |
| JP5693950B2 (ja) | 2007-04-11 | 2015-04-01 | メルク エ カンパニー | １８ｆ標識葉酸 |
| CA2959208C (en) | 2014-08-29 | 2023-09-19 | Tes Pharma S.R.L. | Pyrimidine derivatives and their use as inhibitors of alpha-amino-beta-carboxymuconate-epsilon-semialdehyde decarboxylase |
| EP3846793B1 (en) | 2018-09-07 | 2024-01-24 | PIC Therapeutics, Inc. | Eif4e inhibitors and uses thereof |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2065653B (en) * | 1979-12-19 | 1983-03-09 | Nat Res Dev | Anti-cancer quinazoline derivatives |
| GB8513754D0 (en) * | 1985-05-31 | 1985-07-03 | Jones T R | Anti-cancer quinazoline derivatives |
| US4746659A (en) * | 1985-12-30 | 1988-05-24 | Sri International | Diastereomers of 10-alkyl-10-deazaminopterins and process for preparing the same |
| US5187167A (en) * | 1986-03-27 | 1993-02-16 | Imperial Chemical Industries Plc | Pharmaceutical compositions comprising quinazolin-4-one derivatives |
| GB8607683D0 (en) * | 1986-03-27 | 1986-04-30 | Ici Plc | Anti-tumor agents |
| GB8625019D0 (en) * | 1986-10-18 | 1986-11-19 | Wellcome Found | Compounds |
| GB8707053D0 (en) * | 1987-03-25 | 1987-04-29 | Ici Plc | Anti-tumour agents |
| US4767761A (en) * | 1987-11-04 | 1988-08-30 | Dana-Farber Cancer Institute, Inc. | Ornithine derivatives and their use as methotrexate-resistant cell inhibitors |
| GB8727737D0 (en) * | 1987-11-26 | 1987-12-31 | Ici Plc | Antitumour agents |
| GB8809978D0 (en) * | 1988-04-27 | 1988-06-02 | Ici Plc | Anti-tumour agents |
| US5252573A (en) * | 1988-12-15 | 1993-10-12 | Imperial Chemical Industries Plc | Anti-tumor agents |
| GB8829296D0 (en) * | 1988-12-15 | 1989-01-25 | Ici Plc | Anti-tumour compounds |
| US4996207A (en) * | 1990-01-18 | 1991-02-26 | Nair Madhavan G | Three new non-polyglutamatable deazaaminopterins |
| DE69111891T2 (de) * | 1990-05-17 | 1996-04-04 | Smith & Nephew United Inc | Elektrisch leitender und adstringierender Film sowie filmbildende Zusammensetzung zur Verwendung auf der Haut. |
| AU640016B2 (en) * | 1990-05-30 | 1993-08-12 | Imperial Chemical Industries Plc | Hydroquinazoline derivatives |
-
1991
- 1991-03-19 GB GB919105771A patent/GB9105771D0/en active Pending
-
1992
- 1992-03-18 IL IL101281A patent/IL101281A0/xx unknown
- 1992-03-18 GB GB9205906A patent/GB2253849B/en not_active Expired - Fee Related
- 1992-03-18 SK SK1009-93A patent/SK100993A3/sk unknown
- 1992-03-18 HU HU9302636A patent/HUT67177A/hu unknown
- 1992-03-18 AU AU13716/92A patent/AU655970B2/en not_active Expired - Fee Related
- 1992-03-18 WO PCT/GB1992/000476 patent/WO1992016512A1/en not_active Application Discontinuation
- 1992-03-18 MX MX9201183A patent/MX9201183A/es unknown
- 1992-03-18 JP JP4506050A patent/JPH06505974A/ja active Pending
- 1992-03-18 US US08/122,473 patent/US5444061A/en not_active Expired - Fee Related
- 1992-03-18 CA CA002106583A patent/CA2106583A1/en not_active Abandoned
- 1992-03-18 EP EP92302304A patent/EP0509643A1/en not_active Withdrawn
- 1992-03-18 IE IE085392A patent/IE920853A1/en unknown
- 1992-03-18 ZA ZA921985A patent/ZA921985B/xx unknown
- 1992-03-19 CZ CS931953A patent/CZ195393A3/cs unknown
- 1992-04-27 TW TW081103276A patent/TW203608B/zh active
- 1992-05-18 NZ NZ242023A patent/NZ242023A/en unknown
-
1993
- 1993-09-20 NO NO933341A patent/NO933341L/no unknown
- 1993-09-20 FI FI934106A patent/FI934106A/fi not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| TW203608B (es) | 1993-04-11 |
| WO1992016512A1 (en) | 1992-10-01 |
| NO933341L (no) | 1993-11-18 |
| ZA921985B (en) | 1993-09-20 |
| GB2253849B (en) | 1995-01-18 |
| GB9105771D0 (en) | 1991-05-01 |
| HUT67177A (en) | 1995-02-28 |
| JPH06505974A (ja) | 1994-07-07 |
| CA2106583A1 (en) | 1992-09-20 |
| NZ242023A (en) | 1993-12-23 |
| FI934106A (fi) | 1993-11-18 |
| CZ195393A3 (en) | 1994-07-13 |
| GB2253849A (en) | 1992-09-23 |
| IL101281A0 (en) | 1992-11-15 |
| FI934106A0 (fi) | 1993-09-20 |
| IE920853A1 (en) | 1992-09-23 |
| HU9302636D0 (en) | 1993-12-28 |
| US5444061A (en) | 1995-08-22 |
| GB9205906D0 (en) | 1992-04-29 |
| EP0509643A1 (en) | 1992-10-21 |
| AU655970B2 (en) | 1995-01-19 |
| AU1371692A (en) | 1992-10-21 |
| NO933341D0 (no) | 1993-09-20 |
| SK100993A3 (en) | 1994-08-10 |
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